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Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor

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World Journal of Gastroenterology 2004年第14期10卷 2010-2013页

作者： HongGao Ji-YaoWang Xi-ZhongShen Yong-HuiDeng WeiZhang DepartmentofGastroenterology ZhongshanHospitalFudanUniversityShanghai200032China DepartmentofMacromolecularSciences FudanUniversityShanghai200032China DepartmentofGastroenterology HuadongHospitalShanghai200040China

AIM: To evaluate the effect of aclacinomycin A-loaded magnetic polybutylcyanoacrylate nanoparticles on gastric tumor growth in vivo and in ***: Magnetic polybutylcyanoacrylate (PBCA)nanospheres encapsulated with aclacinomycin A (MPNS-ACM) were prepared by interracial polymerization. Particle size, shape and drug content were examined. Female BABL/c nude mice were implanted with MKN-45 gastric carcinoma tissues subcutaneously to establish human gastric carcinoma model. The mice were randomly divided into 5 groups of 6 each: ACM group (8 mg/kg bin); group of high dosage of MPNS-ACM (8 mg/kg bin); group of low dosage of MPNS-ACM (1.6 mg/kg bin); group of magnetic PBCA nanosphere (MPNS) and control group(normal saline). Magnets (2.5 T) were implanted into the tumor masses in all of the mice one day before the ***-mentioned drugs were administered intravenously to the mice of every group on the first day and sixth *** the mice were sacrificed, tumor weight was measured, and the assay of granulocyte- macrophage colony forming-unit (CFU-GM) was performed on semi-solid culture. White blood cell, alanine aminotransferase and creatine were examined. 3-[4-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was used to examine the viability of MKN-45 cells afger incubation with different concentrations of ACM, MPNS and MPNS-ACM suspension respectively for 48 ***: Content of ACM in MPNS-ACM was 12.0% and the average diameter of the particles was 210 nm. The inhibitory rates of ACM (8 mg/kg bin), high dosage of MPNS-ACM (8 mg/kg bin), low dosage of MPNS-ACM (1.6 mg/kg bin)and MPNS on human gastric carcinoma in nude mice were 22.63%, 52.55%, 30.66% and 10.22%, respectively. There was a significant decrease in the number of CFU-GM of bone marrow in ACM group compared with control group,whereas no obvious change was observed in that of the nanosphere groups. The values of 50% inhibition concentration (IC50) of ACM, MPNS and MPNS-ACM were 0.09,

关键词：聚丁烯氰丙烯酸酯胶囊阿克拉霉素A 胃癌肿瘤

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