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数学的实践与认识 1989年第4期19卷 36-40页

作者：李建立上海第二医科大学

当样本较小时,列联表分析需作精确概率检验.本文着重就三维列联表讨论多维列联表的精确概率检验方法,并讨论了可用观察频数直接算得概率值的条件.

关键词：列联表精确概率检验观察频数

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预后良好的近视性脉络膜新生血管患者的特征

世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 42-42页

作者： Hayashi K. Ohno-Matsui K. Yoshida T. 张磊 Dept. of Ophthalmol./Visual Science Graduate School Tokyo Medical and Dental University 1- 5- 45 Yushima Bunkyo-ku Tokyo 113- 8519 Japan

Objective: To identify the characteristics of patients with myopic choroidal neovascularization (CNV) who had a favorable visual prognosis without treatment. Methods: We reviewed the medical records of 52 conse cutive patients (57 eyes) with myopic CNV who were followed for at least 5 years after the onset of CNV. Clinical characteristics (patient age, CNV size and location, visual acuity at onset, chorioretinal atrophy development around CNV, and degree of myopia) were compared between patients whose visual acuity 5 years after CNV onset was better than 20/40 and those whose visual acuity was worse than 20/200. Results: Among 57 eyes, eight eyes (14.0% ; 8 patients) had a final visual acuity better than 20/40. On the other hand,37 eyes (64.9% ;33 patients) had a final visual acuity worse than 20/200. Statistical analysis revealed that the patients with a good prognosis (final visual acuity better than 20/40) were significantly younger, had significantly smaller CNV, and significantly better initial visual acuity (Mann-Whitney U-test, P < 0.05). Juxtafoveal CNV was more frequently observed in patients with a good prognosis than in those with a poor prognosis (Fisher’ s exact probability test, P < 0.05). Only one patient (12.5% ) in the good prognosis group developed a very limited area of chorioretinal atrophy around the regressed CNV, while 91.9% of the patients in the poor prognosis group developed chorioretinal atrophy. Refractive status and the axial length measurements did not differ between the two groups. Conclusions: Some young patients with myopic CNV retain favorable vision over the long term without active treatment. These informationmight be useful to predict the visual outcome of patients with myopic CNV.

关键词：脉络膜新生血管近视性预后良好近视程度屈光状态中心凹精确概率检验轴长较差者统计学分析

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囊性纤维病病人结肠壁冗余的CT表现

国际医学放射学杂志 2008年第A6期31卷 487-487页

作者： E.M.Webb M.E.Kleinhenz F.V.Coakley C.I.B.Chang A.C.West-phalen B.M.Yeh 郭欢仪 Department of Radiology University of California San FranciscoM372Box 0628505 Parnassus AveSan FranciscoCA 94143-0628USA.

目的描述囊性纤维病(cystic fibrosis,CF)病人结肠壁冗余的表现、患病率和可能的并发症。材料与方法本研究得到临床医学伦理委员会同意,并遵从HIPAA。

关键词：囊性纤维病 CT 结肠壁肠壁厚度医学伦理委员会结肠病变突变体等位基因精确概率检验基因突变

新型ELISA系统检测大疱性类天疱疮患者抗-BP180 IgG和纯化自身抗体

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 6-6页

作者： Mariotti F. Grosso F. Terracina M. G. Zambruno 冯义国 Molec. and Cell Biology Laboratory Istituto Dermopatico dellImmacolata IDI-IRCCS via Monti di Creta 104 00167 Rome Italy Dr.

Background: The NC16A immunodominant region of the bullous pemphigoid (BP) antigen BP180 has been used to develop several enzyme-linked immunosorbent assays (ELISAs) as diagnostic tools for BP autoantibody detection. Objectives: Because BP180 autoantibody reactivity is not restricted toNC16A, we have investigated the possibility of developing an ELISA based on selected epitopes additional to this immunodominant region. Methods: Initially 78 BP sera were tested using an NC16A ELISA and IgG reactivity was detected in 64 BP sera (82%). The 14 NC16A-negative BP sera were then analysed by immunological screening against seven BP180-specific epitopes. Recombinant phages displaying BP180 epitopes were grown as plaques, blotted onto a nitrocellulose filter and incubated with BP sera. Results: Three and five NC16A-negative BP sera reacted with epitopes AA 1080-1107 and AA 1331-1404 of the BP180 ectodomain, respectively. Thus, a novel ELISA with GST-1080 and GST-1331 (GST-1080/1331) was developed: 32 of 78 BP sera (41%) proved positive by this assay. The combined use of ELISAs with GST-NC16A and GST-1080/1331 detected IgG reactivity in 72 of 78 BP sera, increasing the sensitivity from 82%to 92%. In addition, autoreactivity against the three extracellular epitopes appeared to be related to the presence of both skin and mucosal involvement as assessed by Fisher‘s exact probability test. Conclusions: Our findings further characterize the autoimmune response in BP by identifying a subgroup of NC16A-negative patients who react with different BP180 extracellular epitopes. The developed ELISA system appearsmore sensitive than the ELISA based on NC16A alone and also informative about the epitope profile of BP patients.

关键词：大疱性类天疱疮 BP180 IgG 自身抗体酶联免疫试验重组噬菌体免疫学方法精确概率检验自身免疫反应硝酸纤维素自身反应性