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类脂质渐进性坏死1例

临床皮肤科杂志 2009年第5期38卷 316-317页

作者：付兰龙庭凤柴燕杰杨智姚露何黎昆明医学院第一附属医院皮肤科云南昆明650032 昆明医学院第三附属医院肿瘤内科云南昆明650118

类脂质渐进性坏死是一种真皮结缔组织变性疾病，临床上常表现为胫前出现大片硬皮病样斑块。笔者最近收治1例，现报告如下。

关键词：坏死类脂质渐进性

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类脂质渐进性坏死

临床皮肤科杂志 2006年第7期35卷 483-484页

作者：朱国兴陆春赖维顾有守苏向阳中山大学附属第三医院皮肤性病科广东广州510630 广东省皮肤性病防治中心广东广州510500

病例资料患者女,40岁,因双侧胫前卵圆形,渐进性,浸润性斑块3年,于2005年8月来我院就诊,患者3年前无明显诱因双侧胫前出现红斑,逐渐扩大,增多,班块中央逐渐凹陷,变硬,边缘向外呈浸润性扩展,局部无任何不适,无全身症状,否认有糖尿病史。[... 详细信息

病例资料患者女,40岁,因双侧胫前卵圆形,渐进性,浸润性斑块3年,于2005年8月来我院就诊,患者3年前无明显诱因双侧胫前出现红斑,逐渐扩大,增多,班块中央逐渐凹陷,变硬,边缘向外呈浸润性扩展,局部无任何不适,无全身症状,否认有糖尿病史。[第一段]

关键词：坏死渐进性类脂质

多效唑在鱼体内的分布、积累与类脂质含量相关性研究

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环境化学 1994年第2期13卷 152-156页

作者：周风帆刘征涛吴晓辉金洪钧王新光南京大学环境科学系南京210008 南京大学现代分析中心

实验水系统中，植物生长调节剂多效唑在鲤科类金鱼体内分布、积累的研究结果表明，＾３Ｈ－ＭＥＴ主要积累在鱼体消化系统；各器官／组织的积累量依次为：肠＞肝＞鳃＞皮＞肉＞骨；多效唑效生物积累因子（ＢＣＦ）和鱼体类脂质含量之间... 详细信息

实验水系统中，植物生长调节剂多效唑在鲤科类金鱼体内分布、积累的研究结果表明，＾３Ｈ－ＭＥＴ主要积累在鱼体消化系统；各器官／组织的积累量依次为：肠＞肝＞鳃＞皮＞肉＞骨；多效唑效生物积累因子（ＢＣＦ）和鱼体类脂质含量之间有较高的正相关性。

关键词：多效唑分布积累类脂质

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头部类脂质渐进性坏死一例

中华皮肤科杂志 1995年第5期28卷 330+356-330+356页

作者：李国阳张衍波李承新车乃增第四军医大学西京医院皮肤科解放军第二三O医院皮肤!辽宁省丹东市118000

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皮质类固醇激素治疗类脂质渐进性坏死

International Journal of Dermatology And Venereology 1993年第5期 310-311页

作者：方方

报道短期应用皮质类固醇治疗类脂质渐进性坏死的结果:6例患者,病程至少3年,平均5年,临床及组织病理切片均符合类脂质渐进性坏死的诊断,无溃疡形成,各例都曾接受过多种治疗,无明显效果,病情不能控制。6例中4例有糖尿病,2例有高血压,治疗... 详细信息

报道短期应用皮质类固醇治疗类脂质渐进性坏死的结果:6例患者,病程至少3年,平均5年,临床及组织病理切片均符合类脂质渐进性坏死的诊断,无溃疡形成,各例都曾接受过多种治疗,无明显效果,病情不能控制。6例中4例有糖尿病,2例有高血压,治疗方案:甲基强的松1mg/kg/d 1周,后改为40mg/d 4周,然后很快减量,在2周内停止给药。治疗后,所有病人的损害在临床及组织病理学上均得到消退,病情控制,

关键词：渐进性坏死皮质类固醇类脂质

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扁平苔藓伴发硬皮病、类脂质渐进性坏死1例

临床皮肤科杂志 1996年第6期25卷 39-40页

作者：蒋建华石得仁新疆维吾尔自治区人民医院皮肤科

扁平苔藓伴发硬皮病、类脂质渐进性坏死１例蒋建华①石得仁①＊一人同患扁平苔藓、硬皮病及类脂质渐进性坏死的病例罕见。我们收治１例，报告如下。患者女，３９岁。于１９９１年１２月、１９９２年１月及９月因“全身渐出红疹，痒２０... 详细信息

扁平苔藓伴发硬皮病、类脂质渐进性坏死１例蒋建华①石得仁①＊一人同患扁平苔藓、硬皮病及类脂质渐进性坏死的病例罕见。我们收治１例，报告如下。患者女，３９岁。于１９９１年１２月、１９９２年１月及９月因“全身渐出红疹，痒２０年”“双手遇冷变紫、疼痛，渐硬１２...

关键词：扁平苔藓渐进性坏死系统性硬皮病类脂质复方丹参注射液十二指肠溃疡淋巴细胞转化率补体消耗试验维脑路通注射液病理检查

类脂质蛋白质沉积症在南非Namaqualand人中的临床及分子特征

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 21-22页

作者： Van Hougenhouck-Tulleken W. Hamada T. M.Ramsay 田中伟 Division of Human Genetics School of Pathology University of the Witwatersrand P.O. Box 1038 Johannesburg South Africa Prof.

Background: Lipoid proteinosis (LiP) is a rare autosomal recessive disorder characterized by a hoarse voice, warty skin infiltration and scarring. Mutations within the extracellular matrix protein 1 (ECM1) gene cause LiP. Since the early 1970s it has been recognized that South Africa has one of the largest groups of LiP patientsworldwide, suggesting a probable founder effect. As LiP patients present with considerable clinical variability, this group of patients offers a unique opportunity for genotype-phenotype correlation. Objectives: To assess the clinical features and the molecular basis of LiP in patients from the Namaqualand area of the Northern Cape province of South Africa and to examine molecular evidence for a founder effect. Subjects and methods: The LiP patient cohort consisted of 29 Coloured patients from Namaqualand and a further seven Caucasoid patients from other areas of South Africa. The control group included 100 healthy geographically and ethnically matched individuals from Namaqualand. Samples were collected after informed consent and with ethics committee approval from the University of the Witwatersrand. LiP patients were examined clinically and a structured recording sheet was completed. Abrief neurological evaluationwas also performed. The LiP founder effect was investigated at the molecular level by ECM1 mutation detection and haplotype analysis. Results: The most consistent clinical signs for a diagnosis of LiP in this group were a hoarse voice and thickened sublingual frenulum leading to restricted tongue movement. Homozygosity for a nonsense mutation in exon 7 of the ECM1 gene, Q276X, was identified in all patients (Coloured and Caucasoid). Despite this genetic homogeneity, considerable clinical variability in skin presentation and psychiatric involvement was observed. Haplotype analysis usingmarkers from a 9.98-Mb region around the ECM1 locus confirmed the founder effect with a founder core haplotype, 19-Q276X-12 (ND1-ECM1-D1S2343), in a

关键词：类脂质 Namaqualand 分子特征皮肤疣状浸润高加索人突变检测分子学单倍型分析细胞外基质蛋白瘢痕形成

类脂质性渐进性坏死出现限制性轻链浆细胞浸润暗示潜在的单克隆免疫球蛋白病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 59-60页

作者： CiocA.M. FrambachG.E. MagroC.M. 李政霄 Department of Pathology Ohio State University Columbus OH United States

Background: Necrobiosis lipoidica (NL) is a member of the palisading granulomatous dermatitides that is associated, in most cases, with diabetes mellitus. However, there are an increasing number of cases of NL associated with other forms of systemic disease. We describe a novel case of NL associated with a light- chain- restricted plasmacellular infiltrate; subsequent investigations established an underlying monoclonal gammopathy. Methods: Skin biopsy material was obtained and was processed in the usual fashion for hematoxylin and eosin (H& E) examination. Immunohistochemical staining was performed by utilizing kappa and lambda monoclonal antibodies (DakoCorporation,Carpentiera,CA,USA).Kappaandlambda in situ hybridization was also performed (Ventana Medical Systems, Tucson, AZ, USA). Results: A 55- year- old woman with a 5- year history of bilateral thigh subcutaneous nodules underwent a skin biopsy, showing typical changes of NL; there was a concomitant prominent perivascular plasmacellular infiltrate. Kappa light chain restriction was observed amid the plasmacellular infiltrate. Bone marrow biopsy and immunophenotyping studies revealed a clonal plasmacytosis with kappa light chain restriction. Conclusions: Granulomatous inflammation, including NL, may be a cutaneous paraneoplastic expression of low- grade B- cell lymphoproliferative disease in the context of an underlying plasma cell dyscrasia.

关键词：渐进性坏死类脂质轻链浆细胞浸润细胞恶性增生皮肤活组织检查 κ链皮肤活检全身性疾病肉芽肿性

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类脂质肺炎的CT诊断

国际医学放射学杂志 1983年第1期 38-39页

作者：杜建颍

本文报告一例少见的类脂质肺炎,其诊断首先由CT 提出,并得到了长期矿物油吸入史的支持和针吸活检及特殊染色的证实。患者男性,68岁。因慢性荨麻疹为排除隐匿性肺癌摄胸片。结果发现右肺中叶内下方有一3厘米

关键词：类脂质肺炎呼吸道感染针吸活检 CT