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中国处方药 2020年第7期18卷 140-142页

作者：胡夷胡司中国人民解放军陆军第七十二集团军医院神经外二科浙江湖州313000 湖州市福音医院神经外科浙江湖州313000

目的分析拉莫三嗪预处理对重症颅脑损伤患者术后癫痫风险及简易智能精神状态检查量表(MMSE)评分的影响。方法回顾性分析2018年1月~2019年11月重症颅脑损伤患者109例,对照组53例采用丙戊酸钠预处理,研究组56例采用拉莫三嗪预处理。对比... 详细信息

目的分析拉莫三嗪预处理对重症颅脑损伤患者术后癫痫风险及简易智能精神状态检查量表(MMSE)评分的影响。方法回顾性分析2018年1月~2019年11月重症颅脑损伤患者109例,对照组53例采用丙戊酸钠预处理,研究组56例采用拉莫三嗪预处理。对比两组癫痫发生率及术前、术后3个月MMSE评分、血清神经元特异性烯醇化酶(NSE)水平。结果术后3个月,两组MMSE评分均较术前升高,且研究组高于对照组,差异有统计学意义(P癫痫发生率5.36%(3/56)、晚期癫痫发生率3.57%(2/56)较对照组18.87%(10/53)、15.09%(8/53)低,差异有统计学意义(P癫痫发生风险,产生脑神经保护作用,改善患者神经功能、认知功能。

关键词：重症颅脑损伤拉莫三嗪丙戊酸钠癫痫发生率简易智能精神状态检查量表评分

MMR疫苗接种后高热惊厥易感人群及长期预后的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 3-4页

作者： Vestergaard M. Hviid A. Madsen K.M. 黄卫东 Dept. of Epidemiol. and Social Med Danish Epidemiology Science Centre Aarhus University Vennelyst Blvd 6 DK-8000 Aarhus C Denmark

Context: The rate of febrile seizures increases following measles, mumps, and rubella (MMR) vaccination but it is unknown whether the rate varies according to personal or family history of seizures, perinatal factors, or socioeconomic status. Furthermore, little is known about the long term outcome of febrile seizures following vaccination. Objectives: To estimate incidence rate ratios (RRs) and risk differences of febrile seizures following MMR vaccination within subgroups of children and to evaluate the clinical outcome of febrile seizures following vaccination. Design, Setting, and Participants: A population based cohort study of all children born in Denmark between January 1, 1991, and December 31, 1998, who were alive at 3 months; 537171 children were followed up until December 31, 1999, by using data from the Danish Civil Registration System and 4 other national registries. Main Outcome Measures: Incidence of first febrile seizure, recurrent febrile seizures, and subsequent epilepsy. Results: A total of 439251 children (82% ) received MMR vaccination and 17986 children developed febrile seizures at least once; 973 of these febrile seizures occurred within 2 weeks of MMR vaccination. The RR of febrile seizures increased during the 2 weeks following MMR vaccination (2.75; 95% confidence interval , 2.55- 2.97), and thereafter was close to the observed RR for nonvaccinated children. The RR did not vary signifi cantly in the subgroups of children that had been defined by their family history of seizures, perinatal factors, or socioeconomic status. At 15 to 17 months, the risk difference of febrile seizures within 2 weeks following MMR vaccination was 1.56 per 1000 children overall (95% CI, 1.44- 1.68), 3.97 per 1000 (95% CI, 2.90- 5.40) for siblings of children with a history of febrile seizures, and 19.47 per 1000 (95% CI, 16.05- 23.55) for children with a personal history of febrile seizures. Children with febrile seizures following MMR vaccinations had a slightl

关键词：疫苗接种 MMR疫苗高热惊厥易感人群惊厥发生率癫痫病史癫痫发生率围生期注册系统亚群

以癫痫发作为主的颅内海绵状血管瘤内外科治疗方式对比分析

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山西医药杂志 2015年第15期44卷 1815-1817页

作者：张小冬史静李伟荣何芙蓉太原市中心医院神经内科 030009

颅内海绵状血管瘤（cavernous malformation,CM）是一种临床常见的先天性血管畸形,约占颅内血管畸形的5%~16%[1]。发病高峰年龄为30~50岁,临床上常以癫痫发作、局灶性神经功能缺损、头痛等症状为主要或唯一表现,可并发颅内出血。其中,... 详细信息

颅内海绵状血管瘤（cavernous malformation,CM）是一种临床常见的先天性血管畸形,约占颅内血管畸形的5%~16%[1]。发病高峰年龄为30~50岁,临床上常以癫痫发作、局灶性神经功能缺损、头痛等症状为主要或唯一表现,可并发颅内出血。其中,癫痫发生率高达48.1%~79%[2],痫性发作常为CM的首发症状。

关键词：先天性血管畸形颅内血管畸形内外科治疗痫性发作癫痫发生率 malformation 全面性发作耐药性癫痫发作类型高峰年龄

以癫痫为首发症状的特发性甲状旁腺功能减退一例

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河南科技大学学报（医学版） 1994年第1期20卷 59-59页

作者：董平栓

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手术治疗难治性癫痫的荟萃分析

世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 59-59页

作者： Cucherat M. 张玉龙 Service de Biostatistique Faculte de Medecine Lyon Laennec rue Guillaume Paradin 69008 LyonFrance

Objective: To examine the evidence for efficacy of surgery in the treatment of intractable epilepsy. Method: Meta analysis of randomized clinical trials. Res ults: One randomized clinical trial (n=80) and 3 observational studies are avail able. Interpretation: Compared to medical treatment, the surgery increases the p roportion of patients who were free of seizure imparing awareness at 1 year (rel ative risk: 7.67, IC 95%2.5 `a 23.51) Conclusion: The available evidence abou t the clinical efficacy of surgery for patient with intractable epilepsies is li mited to an unique open randomized clinical trial, that enrolled patient in a si ngle centre, without concealment of the randomization and with a partially subje ctive primary edpoint. However, this trial shows a substantial effect correspond ing to a 8 fold incrase in the number of patient without seizure at 1 year. The informational situation will be better whent the results of a currently ongoing trial will be available.

关键词：难治性癫痫荟萃分析癫痫发生率观察性研究随机临床试验试验结果随机化盲法研究中心