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比较Becker's痣用铒:YAG和Q开关钕∶YAG治疗的临床和组织病理学结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 9-10页

作者： Trelles M.A. Allones I. Moreno-Arias G.A. Vélez M. 罗素菊冯义国 Instituto M'edico Vilafortuny Antoni de Gimbernat Foundation Av. Vilafortuny 31 E-43850 Cambrils Spain

Background: Becker’ s naevus (BN) may represent a distressing cosmetic handicap and a challenging issue regarding treatment. Objectives: To compare clinical and histopathological findings of patients with BN treated with two different lasers: an erbium: yttrium-aluminium-garnet (Er: YAG) system vs. a neodymium: YAG (Nd: YAG) laser. Patients and methods: In this prospective and comparative study we present the clinical and histopathological evolution during a 2-year follow-up of 22 patients with BN treated with only one pass of the Er: YAG laser (n=11) or three treatment sessions with the Q-switched Nd: YAG system (n=11). Results: Clinical evaluation 2 years after treatment with the Er: YAG laser showed complete clearance (100% ) in 54% of the patients (n=6) and clearance of>50% in 100% of the subjects. In relation to Nd: YAG laser treatments our results echo those of other authors. Numerous sessions are necessary to get an acceptable clinical clearance rate. Only one patient showed marked clearance(51-99% )after three treatment sessions. Moderate (26- 50% ) and mild (1-25% ) clearance was observed in 45- 5% (n=5) and 27-3% (n=3) of the patients. Conclusions: Both Er: YAG and Nd: YAG are safe tools to treat BN. However, in terms of pigment removal, one pass with Er: YAG is a superior technique to three treatment sessions with the Nd: YAG.

关键词： Becker’s 病理学结果 Q开关 YAG 皮损消退消退率除色素次后令人

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斜坡骨巨细胞瘤1例

中华神经外科杂志 2023年第9期39卷 944-946页

作者：林英聪王耿焕褚正民沈建国张李涛浙江中医药大学嘉兴学院联培基地嘉兴314000 嘉兴学院附属第二医院神经外科嘉兴314000

原发性斜坡骨巨细胞瘤极其罕见,容易误诊。2021年1月嘉兴学院附属第二医院神经外科收治1例斜坡骨巨细胞瘤,患者表现为头痛伴复视,头颅MRI提示颅底斜坡占位,初步诊断为软骨肉瘤,予手术部分切除,病理学结果证实为骨巨细胞瘤。术后1年病变... 详细信息

原发性斜坡骨巨细胞瘤极其罕见,容易误诊。2021年1月嘉兴学院附属第二医院神经外科收治1例斜坡骨巨细胞瘤,患者表现为头痛伴复视,头颅MRI提示颅底斜坡占位,初步诊断为软骨肉瘤,予手术部分切除,病理学结果证实为骨巨细胞瘤。术后1年病变增大,伴颅内转移。患者于术后1.5年死亡。

关键词：骨巨细胞瘤软骨肉瘤颅内转移病理学结果头颅MRI 部分切除神经外科复视

执行美国结直肠外科医师学会手术核查单中术前核查内容的高依从性可改善病理学及术后结果

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结直肠肛门外科 2020年第1期26卷 97-97页

作者：陈致奋 GARFINKLE R VASILEVSKY C A GHITULESCU G 福建医科大学附属协和医院结直肠外科

目的:美国结直肠外科医师学会于2016年推出了一份直肠癌手术的手术核查单,本研究的目的是评估执行核查单中术前核查内容的依从性是否与改善直肠癌手术的病理学结果及术后30天内手术结果有关。方法:本研究是一项回顾性队列研究,纳入了参... 详细信息

目的:美国结直肠外科医师学会于2016年推出了一份直肠癌手术的手术核查单,本研究的目的是评估执行核查单中术前核查内容的依从性是否与改善直肠癌手术的病理学结果及术后30天内手术结果有关。方法:本研究是一项回顾性队列研究,纳入了参加美国外科医生学院国家外科手术质量改善计划(NSQIP)的医院,研究对象为2016-2017年接受择期直肠癌手术的成年患者,研究执行手术核查单中的6项术前指标的依从情况,包括:术前完全的结肠镜评估、治疗前肿瘤位置、治疗前肿瘤分期及区域淋巴结情况、治疗前远处转移的临床评估、适当使用新辅助放疗和术前造口标记情况。评估病理学结果 (环周切缘情况、远切缘情况及淋巴结清扫数是否≥12枚)、术后30天内的并发症发生率及住院天数。

关键词：医师学会病理学结果结直肠外科区域淋巴结肿瘤分期淋巴结清扫临床评估外科手术

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内镜下经鼻确诊眼眶颅底炎性假瘤一例

中华耳鼻咽喉头颈外科杂志 2021年第3期56卷 292-294页

作者：袁璇章华蒋卫红中南大学湘雅医院耳鼻咽喉头颈外科长沙410008

本文报道了1例中南大学湘雅医院耳鼻咽喉头颈外科收治的眼眶颅底炎性假瘤患者。患者中年男性,以"左侧眼眶疼痛2个月,左眼视力下降1个月"入院,入院诊断为眼眶颅底肿瘤(左)。行鼻内镜下颅底病变活检术,临床表现结合影像学及病理学结果,考... 详细信息

本文报道了1例中南大学湘雅医院耳鼻咽喉头颈外科收治的眼眶颅底炎性假瘤患者。患者中年男性,以"左侧眼眶疼痛2个月,左眼视力下降1个月"入院,入院诊断为眼眶颅底肿瘤(左)。行鼻内镜下颅底病变活检术,临床表现结合影像学及病理学结果,考虑诊断为眼眶颅底炎性假瘤(左)。术后予以泼尼松口服,密切随访1年无复发。

关键词：耳鼻咽喉头颈外科炎性假瘤左眼视力颅底肿瘤病理学结果泼尼松口服中年男性活检术

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光化性唇炎:组织病理学和p53

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 17-18页

作者： Neto Pimentel D.R. Michalany N. Alchorne M. 任建文 Departamento de Dermatologia Universidade Federal de So Paulo-Escola Paulista de MedicinaRua Dr Sodré 158 apto 131 B So Paulo 04535-110 Brazil

Background: Chronic actinic cheilitis (AC) is a precursor of squamous cell carcinoma (SCC) of the lip. Objectives: To evaluate the histopathological characteristics that may help to identify AC more susceptible to carcinomatous transformation, to assess the p53 protein expression in AC, and to determine the value of the p53 expression as a marker of transformation into SCC of the lip. Methods: Seventy cases of chronic AC were reviewed, 31 of which were associated with SCCs. The samples were obtained from pathology reports of AC and SCC of the lip. Histopathology and immunohistochemical expression of the p53 protein were evaluated in isolated AC and in AC adjacent to SCC. Results: The intensity of the inflammatory infiltrate in the corium was the only histopathological finding significantly associated both with the presence of an invasive tumor and with the degree of epithelial atypia. Most AC(85%)were immunoreactive to the p53 protein. The p53 protein expression in cheilitis was not statistically associated with any other histopathological criteria. Conclusions: An intense inflammatory infiltrate in AC was predictive of an adjacent invasive SCC. In this study, the p53 protein immunoreactivity was not a marker of malignant transformation.

关键词：光化性唇炎 p53 组织病理学鳞状细胞癌病理学结果炎性浸润唇部免疫反应性侵袭性肿瘤

窄波UVB光疗早期蕈样肉芽肿:评价临床和组织病理学改变

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 22-23页

作者： Gkdemir G. Barutcuo■lu D. Sakiz D. K■ylüt A. 刘艳 Fulya mah Mevlüt Pehlivan sok Sisli Istanbul Turkey

Background: Early-stagemycosis fungoides(IA, IB, IIA) (MF) has long been treated with various agents including topical potent steroids, nitrogenmustard, carmustine, oral psoralen plus UVA (PUVA)broadband UVB, electron-beam radiotherapy, interferon-αand retinoids. However, each of these modalities is associated with various side-effects. Narrowband UVB (NBUVB) therapy has the same effect but is safer to use than the other methods. Objective: Our purpose in this prospective study was to determine the effects of NB-UVB in early-stage MF both clinically and histopathologically. Materials andmethods: Twenty-three patients (20 men, three women, aged 27-78 years) with clinically and histologically confirmed MF were enrolled. Patients received NB-UVB therapy three times a week. Clinical and histological responses, cumulative doses, total number of treatments, side-effects and duration of remission period were noted. Results: Six patients had stage IA MF, 15 patients stage IB and two patients stage IIA. Eighteen patients had patch stage and five patients had plaque stage histopathologically. All of the patients in the patch group had a complete response (CR). In the plaque group, three patients (60%) had a CR and two (40%) had partial (PR) or no clinical response (NR). The clinical response between patch and plaque groups was statistically significant. Regarding the histopathological findings, 17 (94.4%) had complete clearing and only one (5.6%) patient had a partial improvement in the patch group. In the plaque group, one (20%) patient had complete clearing and four (80%) patients had partial or no improvement. The difference between the two groups was statistically significant. In the patch group, the mean cumulative dose was 90.15 J/cm2 and the mean number of treatments was 35.33. In the plaque group, themean cumulative dosewas 90.67 J/cm2 and themean total number of treatments was 39.40. The differenceswere not statistically significant, either between the mean cumulative dose or the mean number of treatments. The mea

关键词：蕈样肉芽肿 UVB 组织病理学改变平均累积剂量干扰素-α 组织学检查放射疗法病理学结果临床

氢对脓毒症相关性脑病小鼠海马A1型星形胶质细胞活化的影响

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中华麻醉学杂志 2021年第10期41卷 1247-1251页

作者：戚博林华颖汪智玮连娜琪王瑶琪谢克亮天津医科大学总医院麻醉科天津市麻醉研究所 300052 天津医科大学总医院重症医学科 300052

目的评价氢对脓毒症相关性脑病(SAE)小鼠海马A1型星形胶质细胞活化的影响。方法清洁级健康雄性C57BL/6J小鼠164只,6~8周龄,体重20~25 g。采用随机数字表法分为4组(n=41):假手术组(Sham组)、假手术+氢气组(Sham+H2组)、SAE组和SAE+氢气组... 详细信息

目的评价氢对脓毒症相关性脑病(SAE)小鼠海马A1型星形胶质细胞活化的影响。方法清洁级健康雄性C57BL/6J小鼠164只,6~8周龄,体重20~25 g。采用随机数字表法分为4组(n=41):假手术组(Sham组)、假手术+氢气组(Sham+H2组)、SAE组和SAE+氢气组(SAE+H2组)。采用盲肠穿孔结扎法制备SAE模型。Sham+H2组和SAE+H2组分别于术后1和6 h时吸入2%氢气1 h。每组取20只小鼠,观察术后7 d生存率。于术后12 h处死其余小鼠,取脑组织,光镜下观察海马CA1区病理学结果,计算异常神经元比率;TUNEL法确定神经元凋亡率;采用免疫荧光染色法检测海马胶原纤维酸性蛋白(GFAP)与补体C3共表达情况;采用Western blot法测定海马C3表达水平,采用ELISA法检测海马TNF-α、IL-6、高迁移率族蛋白1(HMGB1)含量;于术后7 d,每组取6只小鼠行Y迷宫新异臂探索实验。结果与Sham组比较,SAE组术后7 d生存率降低,海马CA1区异常神经元比率和神经元凋亡率升高,TNF-α、IL-6、HMGB1含量升高,C3表达上调,GFAP/C3共表达细胞计数增多,新异臂探索时间缩短,偏好指数降低(P0.05)。结论氢改善脓毒症小鼠SAE的机制可能与抑制海马A1型星形胶质细胞活化有关。

关键词：脓毒症相关性脑病星形胶质细胞活化胶原纤维酸性蛋白病理学结果 C57BL/6J小鼠细胞计数海马CA1区补体C3

发现位于泪腺窝外的泪腺组织:临床和组织病理学结果比较

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 17-17页

作者： Alyahya G.A. Bangsgaard R. Prause J.U. Heegaard S. 司冰心 Eye Pathology Institute University of Copenhagen Frederik V's Vej 11-1 DK-2100 Cop enhagen Denmark Dr.

Purpose: To analyse clinical referral diagnoses and the location of lesions wi th histologically verified lacrimal gland tissue occurring outside the fossa of the lacrimal gland. Methods: Sections of lesions excised from areas outside the fossa of the lacrimal gland containing lacrimal gland tissue on histological exa mination were collected from the files of the Eye Pathology Institute, Copenhage n, Denmark. Specimens spanned a period of 50 years. Sections were re-examined a nd referral data on location and clinical diagnosis were compared with histologi cal findings. Results: A total of 120 lesions were collected. Of these, 59 (49% ) consisted of prolapsed lacrimal gland. The remaining 61 (51%) lesions contain ed ectopic lacrimal gland tissue, either as part of a complex choristoma in 38 ( 32%) cases, or as solitary ectopic lacrimal gland tissue in 23 (19%) cases. Th e majority (97; 81%) of lesions had been located at the temporal epibulbar conj unctiva and included mainly prolapsed lacrimal gland and complex choristoma. The clinical referral diagnoses covered a wide spectrum of lesions. The most freque nt clinical diagnoses were non-specific tumour (35%), non-specific cyst (18% ) and dermoid (11%). Of the 61 lesions containing ectopic lacrimal gland tissue , only two had been preoperatively diagnosed as such and only two of the 59 lesi ons with prolapsed lacrimal gland had been correctly diagnosed. Conclusions: Pro lapsed palpebral lobe of the lacrimal gland was the most common lesion and, as e xpected, the prime location was the temporal conjunctiva. Despite this location, the referring clinical diagnosis was often wrong or non-specific. Surgeons see m to have been unaware of the various clinical manifestations of extrafossal gla ndular tissue, particularly when excising lesions in the upper temporal region o f the conjunctiva. Surgical intervention in this location may jeopardizethe excr etory ducts of the lacrimal gland and may consequently lead to dry eye and thus should be avoided when the typical clinica

关键词：病理学结果泪腺窝迷芽瘤颞侧球结膜睑部病理研究泪腺脱垂临床诊断特异性肿瘤皮样囊肿

神经内镜下经幕下小脑上入路切除松果体区肿瘤的临床效果

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中华神经外科杂志 2020年第5期36卷 491-493页

作者：贾艳飞贺振华杨虎杨强雒晓东王晓曦张新定潘亚文李强兰州大学第二医院神经外科 730000

2017年12月至2019年8月兰州大学第二医院神经外科采用单纯神经内镜下经幕下小脑上入路切除松果体区肿瘤5例,术后MRI提示肿瘤全部切除。术后行单纯放疗4例,放疗加化疗1例。病理学结果提示:生殖细胞瘤3例,畸胎瘤1例,混合型生殖细胞肿瘤1... 详细信息

2017年12月至2019年8月兰州大学第二医院神经外科采用单纯神经内镜下经幕下小脑上入路切除松果体区肿瘤5例,术后MRI提示肿瘤全部切除。术后行单纯放疗4例,放疗加化疗1例。病理学结果提示:生殖细胞瘤3例,畸胎瘤1例,混合型生殖细胞肿瘤1例。术后1例患者出现精神症状,2例患者出现双眼上视不能合并复视。随访0.2~1.8年,5例患者均可正常生活,无一例肿瘤复发。单纯神经内镜下经幕下小脑上入路适用于病变主体位于Galen静脉复合体以下的松果体区肿瘤,其安全性和有效性良好。

关键词：松果体区肿瘤生殖细胞肿瘤生殖细胞瘤病理学结果肿瘤复发精神症状神经外科畸胎瘤