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痤疮患者疾病特异性生活质量与焦虑、压抑相关

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 45-46页

作者： Yazici K. Baz K. Yazici A.E. 马慧群 Mersin Univ.Tip Fakultesi Hastanesi Psikiyatri AD Zeytinlibahce Cad. 33079 Mersin Turkey

Objective.We aimed to evaluate the relationships between acne severity, anxiety, depression and disease-specific quality of life in patients with acne.Method.A total of 61 patients with acne vulgaris and 38 healthy volunteers were included in the study.Acne severity was assessed by the Global Acne Grading System.All patients were asked to complete the Acne Quality of Life Scale (AQOL), Dermatology Life Quality Index (DLQI) and Hospital Anxiety and Depression Scale (HAD), and healthy controls to fill only the HAD.Results.The mean HAD anxiety subscale (HAD-A) and HAD depression subscale (HAD-D) scores of the patients were significantly higher than those of the controls.The rates of subjects at risk for anxiety (26.2%) and for depression (29.5%) were significantly higher in the patient group than in the control group (0%and 7.9%, respectively).We found no correlations between acne severity and scores of AQOL, DLQI, HAD-A and HAD-D.AQOL and DLQI scores were positively correlatedwith HAD-Aand HADD scores in the patient group.The patients at risk for anxiety had significantly higher scores on AQOL and DLQI compared to those who were not at risk.There were no statistically significant differences between the female and male patients with respect to AQOL, DLQI, HAD-A and HAD-D scores.Conclu-sion.(1) Irrespective of the degree of severity, patients with acne are at increased risk for anxiety and depression compared to the normal population.(2) Acne negatively affects quality of life, and the greater the impairment of quality of life due to acne, the greater the level of anxiety and depression.(3) A greater impairment of dermatologic quality of life seems to put the patient at an increased risk for anxiety disorder.

关键词：痤疮患者疾病特异性生活质量寻常痤疮危险率分级系统于非

原发性皮肤大B细胞淋巴瘤患者中与疾病特异性存活时间相关的bcl-6和MUM1/IRF4蛋白的表达:组织芯片研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 33-34页

作者： Sundram U. Kim Y. Mraz-Gernhard S. 李政霄 Dr.Stanford Univ. School of Medicine Department of Pathology Stanford CA United States

Background: Systemic B-cell lymphomas have been studied using microarrays, which has led to a better understanding of their molecular characteristics. Initial microarray studies of these lymphomas have implicated several genes as important predictors of outcome. In this study, we used a tissue micro-array (TMA) to characterize primary cutaneous large B-cell lymphomas (PCLBCL). Methods: We studied 14 patients for whom clinical follow up was available, including four patients whose lesions were limited to the leg on presentation. Immunohistochemical staining with CD20, CD44, CD21, CD5, CD10, bcl-2, bcl-6, Ki67, p53, and multiple myeloma 1 (MUM1) was examined. Results: Our results identify two subgroups of lymphomas. The first group showed staining with bcl-6 and had an overall survival of 176 months (P=0.003). The majority of this group was negative for MUM1. The second group lacked staining with bcl-6 and had an overall survival of 26 months, with a majority of these cases staining with MUM1. Three of four patients with PCLBCL of the leg showed no staining with bcl-6. Conclusions: Our study demonstrates the utility of TMAs in the analysis of PCLBCL and that expression of bcl-6 and MUM1 correlates with survival.

关键词：淋巴瘤患者 B细胞淋巴瘤 MUM1/IRF4 bcl-6 组织芯片疾病特异性存活时间多发性骨髓瘤生存时间分子学

国际全科前沿——初级保健中预防性干预提升老年人健康成果的作用和效益

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中国全科医学 2024年第21期27卷 M0003-M0003页

2024年2月BMJ刊发的“Preventive interventions to improve older people's health outcomes:systematic review and meta-analysis”通过回顾分析2009-2019年18项随机对照试验,探讨了初级保健中对老年人实施非疾病特异性预防性干预的有效性。研究指出,虽然这些干预措施对减少医疗资源利用的影响有限,但在提升老年人基本日常生活能力和自我健康评估方面表现出积极成效。同时研究强调,在出院患者护理环境改变后,对患者电话随访和上门家访以及对医疗专业人员进行教育是促进积极健康成果的关键策略。

关键词：初级保健医疗专业预防性干预日常生活能力护理环境疾病特异性老年人健康随机对照试验

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遗传性胆汁酸合成缺陷症胆汁酸谱研究进展

中华儿科杂志 2022年第8期60卷 843-847页

作者：郑祎于欣雨黄新文浙江大学医学院附属儿童医院遗传代谢科国家儿童健康与疾病临床医学研究中心国家儿童区域医疗中心杭州310052

胆汁酸在促进脂质、脂溶性维生素吸收和维持正常肠肝循环方面起重要作用。由胆固醇合成胆汁酸至少需要经过17种酶的催化反应,任何1种酶缺陷都会造成胆汁酸合成障碍,导致血浆和(或)尿液中疾病特异性胆汁酸中间产物的积累,引起脂溶性维生... 详细信息

胆汁酸在促进脂质、脂溶性维生素吸收和维持正常肠肝循环方面起重要作用。由胆固醇合成胆汁酸至少需要经过17种酶的催化反应,任何1种酶缺陷都会造成胆汁酸合成障碍,导致血浆和(或)尿液中疾病特异性胆汁酸中间产物的积累,引起脂溶性维生素吸收不良、胆汁淤积性肝病及神经系统病变等症状。通过串联质谱分析技术检测血浆、尿液中的胆汁酸谱是协助遗传性胆汁酸合成缺陷症诊断、判断疾病严重程度和预后的简便而有效的手段。

关键词：疾病严重程度神经系统病变肠肝循环脂溶性维生素酶缺陷疾病特异性缺陷症胆汁酸谱

用疾病相关死亡率作为临床研究结局的优势和局限性思考

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英国医学杂志中文版 2020年第5期23卷 277-280页

作者： Janus Christian Jakobsen Jørn Wetterslev Christian Glaud 张渊(译) Copenhagen Trial Unit Centre for Clinical Intervention ResearchRigshospitaletCopenhagen University HospitalCopenhagenDenmark 加拿大麦克马斯特大学

在临床随机试验和系统综述中,疾病相关死亡率(例如心血管死亡率或乳腺癌死亡率)常作为研究结局。使用疾病相关死亡率补充或替代全因死亡率的理由似乎是,疾病相关死亡率更易于检测干预的效果。从理论上讲,疾病相关死亡率是大多数干预措... 详细信息

在临床随机试验和系统综述中,疾病相关死亡率(例如心血管死亡率或乳腺癌死亡率)常作为研究结局。使用疾病相关死亡率补充或替代全因死亡率的理由似乎是,疾病相关死亡率更易于检测干预的效果。从理论上讲,疾病相关死亡率是大多数干预措施旨在影响的指标;与疾病相关的干预作用不会被实验组和对照组中发生的与疾病无关的事件(例如交通事故)"稀释"。如果发生与疾病或试验干预无关的事件,理论上,干预疗效的预计值实际上会受到稀释和影响。尽管使用疾病相关死亡率替代全因死亡率听起来很有吸引力,但本文中我们将思考其方法学的一些局限性。当死亡率是相关的结果时,建议根据效能将全因死亡率作为主要结果,将疾病特异性死亡率作为次要或探索性结果。

关键词：全因死亡率预计值疾病特异性干预措施系统综述干预疗效方法学疾病相关

晚期前列腺癌内分泌治疗预后模型构建及危险因素分析

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河南外科学杂志 2023年第4期29卷 58-61页

作者：梁桂森宋东奎郑州大学第一附属医院泌尿外科郑州450052

目的探讨影响晚期前列腺癌内分泌治疗患者预后的危险因素,并以此建立一个生存风险分层模型。方法本研究纳入2013-01—2020-12在郑州大学第一附属医院泌尿外科以内分泌治疗为主要治疗手段的157例IV期前列腺癌患者。收集患者的功能状态(... 详细信息

目的探讨影响晚期前列腺癌内分泌治疗患者预后的危险因素,并以此建立一个生存风险分层模型。方法本研究纳入2013-01—2020-12在郑州大学第一附属医院泌尿外科以内分泌治疗为主要治疗手段的157例IV期前列腺癌患者。收集患者的功能状态(PS)、血小板计数(PLT)、前列腺特异性抗原(PSA)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、Gleason评分(GS)、血红蛋白(Hb)、疾病程度(EOD)和腺癌分化高低等数据信息。使用Kaplan-Meier方法评估疾病特异性生存(DSS),确定与DSS相关的指标并使用Cox比例风险模型多因素分析得出独立的预后因素。计算DSS中独立预后因素的危险率(HR),根据HR将患者分为高风险、中风险、低风险3组(确定3组间DSS有统计学意义),以此建立了生存风险分层模型。结果单因素分析中,PS、PLT、PSA、ALP、LDH、GS评分,Hb、EOD和腺癌分化高低,是疾病特异性生存(DSS)的影响因素,差异有统计学意义(P<0.05)。在多变量Cox比例风险模型中,PS和PLT是独立的预后因素。根据危险率(HR)将患者分为3个危险组,3组间DSS率差异有统计学意义(P<0.05)。结论这些结果表明,PS和PLT是晚期前列腺癌内分泌治疗独立的预后因素,联合两个因素可以根据DSS风险对接受内分泌治疗的晚期前列腺癌患者进行分层并建立生存风险分层模型。

关键词：前列腺癌内分泌治疗疾病特异性预后

儿童反复腹痛多维度量方法的创建:在3个机构进行的基于人口的研究

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 58-60页

作者： Malaty H.M. Abudayyeh S. O'Malley K.J. 贺莉 Veterans Affairs Medical Center (111D) 2002 Holcombe BlvdHoustonTX 77030United States Dr.

Objective. Recurrent abdominal pain (RAP) is a common problem in children and adolescents. Evaluation and treatment of children with RAP continue to challenge physicians because of the lack of a psychometrically sound measure for RAP. A major obstacle to progress in research on RAP has been the lack of a biological marker for RAP and the lack of a reliable and valid clinical measure for RAP. The objectives of this study were (1) to develop and test a multidimensional measure for RAP (MM-RAP) in children to serve as a primary outcome measure for clinical trials,(2) to evaluate the reliability of the measure and compare its responses across different populations,and (3) to examine the reliabilities of the measure scales in relation to the demographic variables of the studied population. Methods. We conducted 3 cross-sectional studies. Two studies were clinic-based studies that enrolled children with RAP from 1 pediatric gastroenterology clinic and 6 primary care clinics. The third study was a community-based study in which children from 1 elementary and 2 middle schools were screened for frequent episodes of abdominal pain. The 3 studies were conducted in Houston,Texas. Inclusion criteria for the clinicbased studies were (1) age of 4 to 18 years; (2) abdominal pain that had persisted for 3 or more months; (3) abdominal pain that was moderate to severe and interfered with some or all regular activities; (4) abdominal pain that may or may not be accompanied by upper-gastrointestinal symptoms; and (5) children were accompanied by a parent or guardian who was capable of giving informed consent,and children over the age of 10 years were capable of giving informed assent. The community-based study used standardized questionnaires that were offered to 1080 children/parents from the 3 participating schools; 700 completed and returned the questionnaires (65% response rate). The questionnaire was designed to elicit data concerning the history of abdominal pain or discomfort. A total of 160 children met Apley’s criteria and w

关键词：儿童反复腹痛上消化道症状度量标准反复性腹痛疼痛强度失能因子分析横断面研究疾病特异性

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单克隆抗体用于疾病诊断

国外畜牧科技 1986年第4期 58-59页

作者：张振宇

用杂交瘤技术可对动物疾病进行更及时更精确的诊断,而且杂交瘤技术也是疫苗发展的基础。生产疾病特异性单克隆抗体新方法的第一

关键词：单克隆抗体杂交瘤技术疾病诊断动物疾病抗体分泌细胞疾病特异性免疫应答反应脾细胞骨髓瘤细胞杂交细胞

患丙型肝炎老干部未进行抗病毒治疗:对生活质量造成影响的生理和社会心理因素

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 48-49页

作者： Rowan P.J. Al-Jurdi R. Tavakoli-Tabasi S. H.B. El-Serag 陈瑜 Houston Veterans Affairs Medical Center (152) 2002 Holcombe Blvd. Houston TX 77030 United States Dr.

Background and Aims: Treatment-naive hepatitis C virus (HCV)infected patients report impaired health-related quality of life (HRQOL), although causes are unclear. Psychosocial factors may be major determinants of HRQOL. Methods: We administered a general (Short Form-36; SF-36) and a liver-specific (Chronic Liver Disease Questionnaire; CLDQ) HRQOL measure to 62 HCV-infected veterans being considered for antiviral therapy. Psychosocial assessment included the Structured Clinical Interview for DSM-IV Axis I Disorders/Non-Patient (SCID-VNP), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Abbreviated Cook-Medley (ACM) anger measure, and Medical Outcomes Study Social Support Measure (SSM). We examined the potential determinants of HRQOL, including psychosocial measures, demographic measures (age, sex, race/ethnicity), clinical measures (presence of cirrhosis, comorbid medical conditions), and viral data (quantitative PCR). Results: SF-36 scores were significantly lower in HCV-infected patients than published U.S. population norms but similar to those reported by previous studies of HCV infected samples. CLDQ scores were very similar to those reported by previous studies. Demographic, clinical, and viral indicators were not statistically associated with HRQOL, and neither was the presence of a substance abuse or psychotic disorder. Lower BDI-II and BAI scores were associated with better general and disease-specific HRQOL. Lower SSM scores were associated with lower scores on SF-36 but not CLDQ; however, this effect did not persist in multiple linear regression analyses. In these, BDI-II was the strongest independent predictor of both SF-36 and CLDQ. Conclusions: Psychosocial factors, especially depression, are strong indicators of impaired HRQOL for HCV-infected veterans not receiving antiviral therapy. Screening and treatment of psychosocial factors is recommended.

关键词：丙型肝炎抗病毒生活质量病毒学指标心理因素慢性肝病社会支持疾病特异性药物滥用医学成果