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经皮补充超低剂量雌二醇对骨质密度的影响:一项随机临床试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 44-45页

作者： Ettinger B. Ensrud K.E. Wallace R. 马锦琪 Dr.156 Lombard Street San Francisco CA 94111 United States

OBJECTIVE: Because small increments in levels of endogenous plasma estradiol are associated with higher postmenopausal bone mineral density, we investigated the safety and effectiveness in preventing bone loss of unopposed, very-low-dose transdermal estradiol for postmenopausal women. METHODS: This was a randomized, placebo-controlled, double-blind trial with 2-year follow-up at 9 United States clinical centers. The study population comprised 417 postmenopausal women, aged 60-80 years, with intact uterus and bone mineral density z scores of -2.0 or higher, who were randomly assigned to receive either unopposed transdermal estradiol at 0.014 mg/d (n = 208) or placebo (n = 209). All participants received calcium and vitamin D supplementation. Lumbar spine and total hip bone mineral density change was measured by dual-energy X-ray absorptiometry; endometrial hyperplasia incidence was assessed by endometrial biopsy. RESULTS: Median plasma estradiol level in the estradiol group increased from 4.8 pg/mL at baseline to 8.5 pg/mL at 1 year (P < .001 versus baseline) and to 8.6 pg/mL at 2 years (P < .001 versus baseline) and was unchanged in the placebo group. Lumbar spine bone mineral density increased 2.6%in the estradiol group and 0.6%in the placebo group (between-group difference 2.0%, P < .001). Mean total hip bone mineral density increased 0.4%in the estradiol group and decreased 0.8%in the placebo group (between-group difference 1.2%, P < .001). Osteocaicin levels and bone-specific alkaline phosphatase were lower in the estradiol group than the placebo group (P < .001 each). Endometrial hyperplasia developed in 1 woman in the estradiol group but in none of the placebo group (difference in 2-year rates 0.5%, 95%confidence interval 0-7.3%). CONCLUSION: Postmenopausal treatment with low-dose, unopposed estradiol increased bone mineral density and decreased markers of bone turnover without causing endometrial hyperplasia.

关键词：骨质密度随机临床试验骨密度骨转换率降钙素子宫内膜增生子宫内膜活检双盲试验无对水平比对

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硒与疾病

微量元素与健康研究 1989年第1期6卷 18-19页

作者：黄碧霞李小梁郭震娄宗盘毕敏明中国科学技术大学应用化学系安徽中医学院附属医院安徽医科大学第一附属医院

自从1973年发现 Se 是谷胱甘肽过氧化物酶的辅因子以来,对 Se 的研究日渐深入。研究表明,Se 具有清除自由基、清除脂质过氧化物的作用。临床观察发现,哮喘、冠心病、脑血管病、Wilson 氏病患者血清脂质过氧化物水平比对照健康人高。为... 详细信息

自从1973年发现 Se 是谷胱甘肽过氧化物酶的辅因子以来,对 Se 的研究日渐深入。研究表明,Se 具有清除自由基、清除脂质过氧化物的作用。临床观察发现,哮喘、冠心病、脑血管病、Wilson 氏病患者血清脂质过氧化物水平比对照健康人高。为了进一步研究上述疾病的发病机制,本文观察了这些疾病患者体内 Se 的水平。

关键词：脂质过氧化物水平比对血清脂质临床观察脑血管病辅因子发病机制谷胧甘肤肝微粒体总胆固醇

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血液检验对贫血疾病诊断的应用

实用医技杂志 2016年第10期23卷 1107-1108页

作者：丘衍博刘雄伟黄衍锋陈建霞广东省深圳市龙岗中心医院 518100

人体内血红细胞的数量减少,量值低至正常值后所呈现的临床症状,即为贫血。临床测定红细胞量的方法极为复杂,通常以血红蛋白浓度替代其量值。研究显示,若成年男性的血红蛋白低于130 g/L,非妊娠成年女性血红蛋白低于120 g/L,孕妇血红蛋白... 详细信息

人体内血红细胞的数量减少,量值低至正常值后所呈现的临床症状,即为贫血。临床测定红细胞量的方法极为复杂,通常以血红蛋白浓度替代其量值。研究显示,若成年男性的血红蛋白低于130 g/L,非妊娠成年女性血红蛋白低于120 g/L,孕妇血红蛋白低于110 g/L时,则表示存在贫血现象-（[1]）。贫血的类型具多样性,临床在诊断时常出现漏诊或误诊,故加强讨论贫血的诊断方法对鉴别贫血具积极意义。

关键词：血红细胞临床测定疾病诊断细胞量血液检测临床症状血液检验量值诊断方法水平比对

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孕妇血清免疫球蛋白变化的观察

中国医师进修杂志 1990年第4期13卷 49-,48页

作者：刘善英张萍朱瑞嫦李国帧李金英王秀英大连市第五人民医院妇产科大连市第五人民医院妇产科大连市第五人民医院检验科大连市女子自强学校

本文采用琼脂单相免疫扩散法对169例妊娠6～41周的孕妇血清免疫球蛋白进行测定,同时检查31例非孕妇女做为对照。目的是探讨孕妇免疫球蛋白的变化,现将测定结果报告如下:

关键词：血清免疫球蛋白免疫扩散法非孕妇女 IgG 水平比对晚孕期体液免疫血清样本检验方法

神经生长因子-酪氨酸激酶A途径参与人体体温和应激调节:对遗传性感觉异常和自发性Ⅳ型神经病变患者的研究

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 60-61页

作者： Loewenthal N. Levy J. Schreiber R. E. Hershkovitz 王经纬 Pediatric Department Soroka Medical Center POB 151 Beer Sheva 84101 Israel Dr.

Hereditary sensory and autonomie neuropathy type IV (HSAN IV) is caused by mu tations in the tyrosin kinase A (TrkA) gene, encoding for the high- affinity re ceptor of nerve growth factor (NGF). The NGF- TrkA system is expressed in many endocrine glands. We hypothesized that HSAN IV represents a natural model for im paired NGF effect on the neuroendocrine system in humans. We have documented the clinical outcome of 31 HSAN IV patients in a single medical center, and investi gated their basal endocrine system status. The endocrine system response to thir st was compared between six patients and six healthy children. High rates of mor tality (22% ) and severe morbidity (30% ) have been found in HSAN IV patients. Hypothermia was noted in 40% of the patients and unexplained fever was observ ed in 56% . Subnormal adrenal function was demonstrated in six (30% ) of the p atients studied. Furthermore, we found lower plasma norepinephrine (NE) levels i n six HSAN IV patients compared with a control group after the thirst test. Our findings emphasize the importance of NGF- TrkA pathway in the physiology of the neuroendocrine system and its response to stress. Inadequate response to stress might contribute to the observed significant mortality, morbidity, and temperat ure instability in HSAN IV patients.

关键词：感觉异常神经生长因子人体体温内分泌系统 TrkA 内分泌腺体水平比对高亲和力受体肾上腺功能低体温

IL-6和抗磷脂抗体与患有避孕药相关的血栓性疾病

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 50-51页

作者： Salobir B. abovi M. 张会孝 University Medical Centre Department of Vascular DiseasesZaka 7 1000 Ljubljana Slovenia Dr.

OBJECTIVE: The aim of this study was to explore the possible (joint) contrib ut ing role of interleukin-6 (IL-6) and antiphospholipid antibodies to the occurr ence of the venous thromboembolism in women using oral contraceptives. METHODS: Interleukin-6 and antiphospholipid antibodies (anti-β2-glycoprotein I antibo dy-immunoglobulin M [IgM], G [IgG], and A [IgA]; anticardiolipin-IgM and IgG; antiphospha-tidylserine-IgM and IgG) were measured in 30 women (median age 41, range 28-49 years) in the stable period (on average 3.5 years) after first ven ous thromboembolism. Sixteen patients used oral contraceptives during the episod e of venous thromboembolism (oral contraceptives group), whereas 14 patients did not (non-oral contraceptives group). Thirty-seven age-matched, healthy women served as controls RESULTS: Compared with controls, the oral contraceptives gro up had elevated IL-6 (median interquartile range 2.3 [1.1-4.3] versus 1.4 [0- 2.0] pg/mL, P < .05). The oral contracepti ves group had elevated anti-β2-glycoprotein I antibody-IgM in comparison wit h both the non-oral contraceptives group (median interquartile range 47.5 [2.0 -77.0] versus 29.50 [11.00-45.50] OD450,P < .06) and controls (47.5 [2.0-77.0 ] versus 17.5 [3.5-30.0] OD450,P < .001). Interleukin-6 level in the non-oral contraceptives group was related to obesity, whereas such a relation was not fo und in the oral contraceptives group, suggesting the presence of another factor (oral contraceptive use), which stimulates IL-6 production. Of particular inter est is our finding that elevated IL-6 levels correlated significantly positivel y with elevated anti-β2-glycoprotein I antibody-IgG in patients who were use rs of oral contraceptives (but not overweight, n = 10) (r = 0.56, P < .05). CONC LUSION: The results suggest a new hypothesis that, in susceptible women, use of oral contraceptives induces production of IL-6, which stimulates production of anti-β2-glycoprotein I. Thus, the prothrombotic profile is

关键词：血栓性疾病抗磷脂抗体静脉血栓蛋白抗体 IgG 水平比对四分位数磷脂酰丝氨酸于易凝血功能异常

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假性硬皮病伴发癌症

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 36-36页

作者： KikuchiK. Hoashi T. YazawaN. TamakiK. 冯义国 Department of Dermatology Graduate School of Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan Dr.

In the period 1994-2002, we saw 71 patients with sclerotic skin chnges; 66 were diagnosed with systemic sclerosis (SSc) while five (7% ) were diagnosed with pseudoscleroderma associated with various malignancies. The mean duration of disease in these five patients was significantly shorter than that of patients with SSc. The incidence of positive antinuclear antibodies, Raynaud’ s phenomenon or oesophageal involvement in patients with pseudoscleroderma was significantly lower than that in patients with SSc. The distributions of skin sclerosis varied in each case. Serum basic fibroblast growth factor (bFGF) levels in the five patients with pseudoscleroderma were very elevated compared with levels in controls. Elevated expression of bFGF was detected on fibroblasts of affected skin and in one lung-cancer tissue sample obtained by excision.

关键词：硬皮病皮肤硬化抗核抗体阳性水平比对雷诺现象组织切片

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葡萄植株整形对插条产量和质量的影响

国外农学(果树) 1986年第2期 18-18页

作者：刘伟芹

本文对Б×P×CO4砧木植株的下述整形效果进行了研究。头状整形(对照),短蔓整形,单臂和双臂整形及1.7～1.8米高干整形(新梢自由分布)。整形类型对砧木植株一年生新梢的发育有显著影响。单株成熟新梢的平均长度如下:对照为45米,短蔓扇形... 详细信息

本文对Б×P×CO4砧木植株的下述整形效果进行了研究。头状整形(对照),短蔓整形,单臂和双臂整形及1.7～1.8米高干整形(新梢自由分布)。整形类型对砧木植株一年生新梢的发育有显著影响。单株成熟新梢的平均长度如下:对照为45米,短蔓扇形为47.6米,单臂为41.6米,双臂为38.8米,高干为38.6米。高干整形的新梢成熟部分达到其总长度的80.7%,比其他整形的成熟度高11.6～16.0%。短蔓整形的插条数量最多。高干整形的插条成熟度指标较其他整形为优。于5月末和6月中喷布0.01%的赤霉酸溶液,对供试品种的母株和插条产量均有良好影响,能保证单株新梢总长增加19%,

关键词：葡萄植株新梢喷布赤霉酸成熟度整形效果单株水平比对生理活性物质生产数量

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瑞典志愿者口服霍乱菌苗5年后的免疫记忆

国外医学.预防.诊断.治疗用生物制品分册 1989年第2期 80-80页

作者：宋思安

本文报道对5年前用霍乱B亚单位-全菌体菌苗(B+WCV)口服免疫的瑞典志愿者,再用该菌苗加强免疫,检测其血清抗体滴度,以此间接说明肠道免疫记忆的存在,过去10年中未接种过霍乱菌苗的瑞典志愿者作为对照。结果表明,用该菌苗免疫者,其血清Ig... 详细信息

本文报道对5年前用霍乱B亚单位-全菌体菌苗(B+WCV)口服免疫的瑞典志愿者,再用该菌苗加强免疫,检测其血清抗体滴度,以此间接说明肠道免疫记忆的存在,过去10年中未接种过霍乱菌苗的瑞典志愿者作为对照。结果表明,用该菌苗免疫者,其血清IgG抗毒素滴度均有明显升高,但加强免疫组比对照组高10倍。免疫前加强免疫组与对照组IgA抗毒素水平无差异,免疫后加强免疫组100%、对照组80%志愿者IgA抗毒素水平

关键词：霍乱菌苗滴度血清抗体 IgG 亚单位接种者杀弧菌抗体水平比对时间比对