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青光眼和高眼压症患者使用拉坦前列素、曲沃前列素、比马前列素降低昼夜眼压的比较研究

世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 47-48页

作者： Orzalesi N. Rossetti L. Bottoli A. Fogagnolo P. 安胜(译) 不详 Department of Medicine Surgery and Odontoiatry University of Milan San Paolo Hospital Via di Rudin 8 20142 Milano Italy

Purpose: To compare 24-hour reduction in intraocular pressure (iop) by latanoprost 0.005% ,travoprost 0.004% ,and bimatoprost 0.03% in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH). Design: Randomized,double-masked,crossover study. Participants: Twenty-four patients with POAG and 20 with OH. Methods: Patients were treated with latanoprost,travoprost,and bimatoprost for 1 month. The treatment sequence was randomized,and washout lasted 30 days for each trial drug. Four 24-hour tonometric curves were recorded for each patient: 1 at baseline and 1 after each treatment period. Main Outcome Measures: Intraocular pressure was measured at 3,6,and 9 am; noon; 3,6,and 9 pm; and midnight by 2 treatment-masked well-trained evaluators using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slit lamp. Supine systemic blood pressure was recorded at the same times. A randomized-blocks analysis of variance was used to analyze data. Results: All 3 drugs were highly effective in reducing iop when compared to baseline. Mean iop reductions were similar after the 3 prostaglandin analogs,and none of the differences among treatments reached statistical significance. The drugs’ effect was significantly greater during the daytime (9 am-9 pm) than during the nighttime (midnight-6 am) with all prostaglandin analogs. In 7 of 44 patients (16% ),nocturnal iop was significantly higher than diurnal iop,both at baseline and under the 3 prostaglandin analogs. Conclusions: From a clinical point of view,the overall results seem to indicate that the 3 prostaglandin analogs are powerful agents in controlling round-the-clock iop in POAG and OH patients.

关键词：原发性开角型青光眼拉坦前列素昼夜iop 高眼压症患者持续给药测量曲线 POAG 坐位姿势测量眼压

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维普期刊数据库

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通过昼夜体位变化的再现研究睡眠中眼压峰值的增加

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 19-19页

作者： Hara T. Tsuru T. 王大江(译) 不详 Jichi Medical School Minamikawachimachi Tochigi 329- 0498 Japan

Objective:To characterize diurnal intraocular pressure (iop)-changes in primary open-angle glaucoma by reproducing iops based on patient posture. Methods: In 148 patients with untreated primary open-angle glaucoma who had iops recorded during clinic hours that were less than 21 mm Hg (average,14.8± 3.2 mm Hg),we measured iop by noncontact tonometry every 2 hours from 6 AM to midnight and every 3 hours from midnight to 6 AM with patients sitting and supine. The iop was reproduced by designating the sitting iop as measurements taken when the patient was awake and the supine iop as measurements taken when the patient was asleep for each individual. The reproduced diurnal iop was composed of 12 measurements that included 2 to 4 iop levels measured with the patients supine and the rest while they were sitting. Results: The peak of sitting diurnal iop (mean± SD) for 148 patients was 16.0± 2.7 mm Hg,which was significantly lower than the peak of supine iop (18.9± 3.9 mm Hg) or the reproduced iop (17.5± 3.6 mm Hg) (P iop at each measurement time peaked at 3 AM during sleep; with sitting diurnal iop or supine diurnal iop,the peak iops were at noon. Twenty-nine patients (20% ) with an iop less than 21mmHg during clinic hours had a reproduced iop of 21mmHg or greater while asleep,compared with only 5 patients (3% ) when the patients were sitting only. Conclusions: In patients with primary open-angle glaucoma and iops less than 21 mm Hg during clinic hours,20% of patients had a reproduced iop of 21 mm Hg or greater,compared with only 3% who had an iop of 21 mm Hg or greater while sitting. Intraocular pressures peaked in most patients during sleep.

关键词：眼压计测量昼夜iop 体位变化睡眠青光眼患者峰值仰卧位开角型原发性 lOP

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TWENTY-FOUR HOUR DIURNAL CURVE COMPARISON OF COMMERCIALLY AVAILABLE BIMATOPROST 0.03% VERSUS TIMOLOL MALEATE 0.5%/OORZOLAMIDE 2% FIXED COMBINATION

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国际眼科杂志 2003年第1期3卷 98-98页

作者： D.G.Day E.D.Sharpe C.J.Beischel J.N.Leech J.A.Stewart W.C.Stewart Omni Eye Services GAOphthalmology Consultants SCWest Ashley Medical Center SCPharmaceutical Re-search Network LLC SCPharmaceutical Re-search Network LLC SCPharmaceutical Re-search Network LLC SC and Carolina Eye Institute At The University of South Carolina School of Medicine SC USA

Purpose: To evaluate the efficacy and safety of bimatoprost 0.03 percent given every evening versus timolol maleate 0.5 per-cent/dorzolamide 2 percent fixed combination (TDFC) given twice daily in open-angle glaucoma and ocular hypertensive patients. Design: A single-masked, two center, crossover comparison with two eight-week treatment periods following a four-week medicine free run-in period. Diurnal curve intraoc-

关键词：青光眼 Bimatoprost 疗效比较马来酸噻吗络尔/多佐胺昼夜iop

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维普期刊数据库

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