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国际心血管病杂志 1998年第3期 172-173页

作者：胡桃红

左室重构是心肌梗塞(MI)的一个重要结局,它能引起进行性心功能减退及心衰。该研究通过测定AMI急性期(溶栓治疗后90～180分钟)的收缩末容积指数(ESVI),评价

关键词：前壁心梗死亡率患者左室造影溶栓治疗预测因子预测要因收缩末容积预测指标

超声心动图指导巨大左室患者CRT成功优化1例

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中国超声医学杂志 2016年第2期32卷 176-177页

作者：刘芳杨靖张萍北京清华长庚医院心脏内科

患者男,69岁。主因"发作性上腹部疼痛1个月"就诊于我院,诊断为"胆石症、急性胆管炎"拟行外科手术治疗。患者7年前因"扩张型心肌病,心功能Ⅲ级"于外院行心脏再同步化治疗(cardiac resynchronization therapy,CRT),2年前行CRT更换术。体... 详细信息

患者男,69岁。主因"发作性上腹部疼痛1个月"就诊于我院,诊断为"胆石症、急性胆管炎"拟行外科手术治疗。患者7年前因"扩张型心肌病,心功能Ⅲ级"于外院行心脏再同步化治疗(cardiac resynchronization therapy,CRT),2年前行CRT更换术。体格检查:血压110/70mm Hg,颈静脉无怒张,双肺呼吸音清,心界向左下扩大,心率60次/

关键词： CRT 左室射血分数超声心动图超声波诊断房室间期患者左室舒张末内径起搏器心室起搏血流速度时间积分右室起搏 LVEF 收缩末容积指导

硫氮()酮(Diltiazem)对冠心病左心室功能的作用

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国外医学.心血管疾病分册 1985年第6期 369-370页

作者：吕国庆

钙离子拮抗剂通过阻止钙离子慢通道内流而产生对心肌的负性肌力作用和扩张血管平滑肌的作用。本文旨在估价硫氮(?)酮在冠状动脉疾病中对左心室收缩性,心肌等容松弛及心室舒张等方面的作用。方法:15名平均年龄为51岁的男性冠心病患者,均... 详细信息

钙离子拮抗剂通过阻止钙离子慢通道内流而产生对心肌的负性肌力作用和扩张血管平滑肌的作用。本文旨在估价硫氮(?)酮在冠状动脉疾病中对左心室收缩性,心肌等容松弛及心室舒张等方面的作用。方法:15名平均年龄为51岁的男性冠心病患者,均有大于50%直径的冠状动脉狭窄,其中6例为单支病变,1例为双支病变,8例为三支病变。除

关键词：冠心病患者心肌早期充盈舒张期左心室 Diltiazem 收缩末容积负性肌力作用

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衰老对左心室收缩力的影响

国际老年医学杂志 1990年第1期 38-39页

作者：李强

衰老可引起衡量心室功能的参数发生变化。本文以左室力一长度关系为指标,研究左心室收缩力是否受衰老过程的影响。方法研究20例无心血管病史和体检、心电图、胸部x线、二维超声心动图证实心内结构正常及未服用药物的健康人。分为二组:A... 详细信息

衰老可引起衡量心室功能的参数发生变化。本文以左室力一长度关系为指标,研究左心室收缩力是否受衰老过程的影响。方法研究20例无心血管病史和体检、心电图、胸部x线、二维超声心动图证实心内结构正常及未服用药物的健康人。分为二组:A组10例年龄

关键词：收缩期收缩力左心室射血分数收缩末容积超声心动图超声波诊断

2型肌强直性肌营养不良累及心肌和骨骼肌的31P-MRS和MRI定量研究

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 48-49页

作者： Schneider-Gold C. Beer M. Kstler H. 袁海峰

In myotonic dystrophy type 2 (DM2/PROMM), cardiac muscle involvement is usuall y more benign than in DM1, but clinically severe cardiomyopathy has been reporte d in some patients. Using a novel method of magnetic resonance spectroscopy (MRS ), we examined the left ventricular myocardium and the left gastrocnemius muscle in 11 unselected DM2/ PROMM patients without overt cardiac disease. Data on car diac morphology and function were obtained by gradient echo two dimensional cin e magnetic resonance imaging (MRI); no significant differences were found betwee n DM2 patients and healthy controls, but using a median split approach older pat ients showed mildly increased left ventricular (LV) volumes, i.e., 59%increase of end systolic volume index (ESVI) and 35%increase of enddiastolic volume ind ex (EDVI), and an increase of LV mass (26%). On cardiac MRS, DM2/PROMM patients showed a reduction of phosphocreatine (PCr) and adenosine triphosphate (ATP) by 25 and 20%compared to matched healthy controls. No significant differences wer e found between younger and older patients. In skeletal muscle of the DM2 patien ts, no significant decrease of PCr and ATP concentrations was found. However, in older patients, who commonly show overt hip flexor muscle weakness, we observed reduced values for PCr and ATP. Our MRS and MRI findings reveal evidence for su bclinical cardiomyopathy in DM2/PROMM patients without overt heart disease. Futu re prospective studies are needed to clarify the risk of developing overt cardia c disease in DM2 and to define prognostic factors.

关键词：肌营养不良肌强直 MRI P-MRS 定量研究收缩末容积舒张末容积左心室质量梯度回波心室肌

实时三维超声和组织多普勒显像评价左室收缩同步性的相关性研究

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上海医学 2007年第S1期30卷 5-5页

作者：舒先红曾欣潘翠珍崔洁董丽莉葛均波陈灏珠复旦大学附属中山医院上海市心血管病研究所上海200032

目的比较实时三维超声心动图和组织多普勒显像在分析左室收缩同步性的临床价值。方法60例研究对象分为两组:A组为31例健康志愿者,B组为29例扩张性心肌病患者。对所有研究对象进行实时三维经胸超声心动图和组织多普勒检查,得到左室舒张... 详细信息

目的比较实时三维超声心动图和组织多普勒显像在分析左室收缩同步性的临床价值。方法60例研究对象分为两组:A组为31例健康志愿者,B组为29例扩张性心肌病患者。对所有研究对象进行实时三维经胸超声心动图和组织多普勒检查,得到左室舒张末容积(EDV)、收缩末容积(ESV)、左室射血分数(LVEF)、心电图Q波起始点距离16节段和12节段容积最小容积点时间间隔的标准差及其最大差(分别是Tmsv 16-SD,Tmsv12-SD;Tmsv-16-Dif,Tmsv-12-Dif)。应用该软件对组织多普勒显像进行定量评价,得到心电图Q波起始点到等容收缩波峰值、收缩波峰值、舒张早期及晚期波峰值、最大应变的标准差(分别是TIVC-SD,TS-SD,Te-SD,Ta-SD,Tε-SD)。结果B组的LVEF显著小于A组(P0．05)。结论实时三维超声心动图和组织多普勒均能够评价左室心肌收缩同步性,两种方法的评价结果具有一定的相关性。

关键词：左室收缩同步性实时三维超声组织多普勒显像收缩末容积多普勒检查左室心肌经胸超声心动图左室舒张末射血分数定量评价

慢性心力衰竭患者服用ghrelin对其左室功能、运动耐量和肌肉萎缩的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 43-43页

作者： Nagaya N. Moriya J. Yasumura Y. 杜媛 Dr.Department of Internal Medicine National Cardiovascular Center 5-7-1 Fujishirodai Suita Osaka 565-8565Japan

Background-Ghrelin is a novel growth hormone-releasing peptide that also induces vasodilation, inhibits sympathetic nerve activity, and stimulates feeding through growth hormone-independent mechanisms. We investigated the effects of ghrelin on left ventricular(LV)function, exercise capacity, and muscle wasting in patients with chronic heart failure(CHF). Methods and Results-Human synthetic ghrelin(2 μm/kg twice a day)was intravenously administered to 10 patients with CHF for 3 weeks. Echocardiography, cardiopulmonary exercise testing, dual x-ray absorptiometry, and blood sampling were performed before and after ghrelin therapy. A single administration of ghrelin elicited a marked increase in serum GH(25-fold). Three-week administration of ghrelin resulted in a significant decrease in plasma norepinephrine(1132±188 to 655±134 pg/mL; P< 0.001). Ghrelin increased LV ejection fraction(27±2%to 31±2%; P< 0.05)in association with an increase in LV mass and a decrease in LV end-systolic volume. Treatment with ghrelin increased peak workload and peak oxygen consumption during exercise. Ghrelin improved muscle wasting, as indicated by increases in muscle strength and lean body mass. These parameters remained unchanged in 8 patients with CHF who did not receive ghrelin therapy. Conclusions-These preliminary results suggest that repeated administration of ghrelin improves LV function, exercise capacity, and muscle wasting in patients with CHF.

关键词：慢性心力衰竭左室功能运动耐量肌肉萎缩 ghrelin 运动试验交感神经活动射血分数收缩末容积静脉途径

赖诺普利对慢性心力衰竭患者心室重塑和心功能的影响

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中国医学文摘（内科学） 2003年第6期 688-688页

作者：曾一凯

80例患者,随机分为对照组38例,治疗组42例。两组均采用综合疗法,治疗组加用赖诺普利5～10mg/d,维持6个月。结果:治疗组心功能较治前明显改善(P<0.001),治疗组与对照组比较左室射血分数上升(51.1±2.8)％和(34.2±2.6)％(P<0.001)、左室... 详细信息

80例患者,随机分为对照组38例,治疗组42例。两组均采用综合疗法,治疗组加用赖诺普利5～10mg/d,维持6个月。结果:治疗组心功能较治前明显改善(P收缩末容积下降(118±41.9)

关键词：慢性心力衰竭赖诺普利心功能心室重塑射血分数收缩末容积左室舒张末步行距离

直接血管成形术中行冠状动脉内血栓抽吸切除术对ST段抬高型前壁心肌梗死患者左室重构的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 47-47页

作者： De Luca L. Sardella G. Davidson C.J. 杜媛 Department of Cardiovascular and Respiratory Sciences La Sapienza University Policlinico Umberto I Viale del Policlinico 155 00100 Rome Italy Dr.

Objective: To evaluate prospectively the impact on left ventricular(LV) remodelling of an intracoronary aspiration thrombectomy device as adjunctive therapy in primary percutaneous coronary intervention(PCI) in patients with anterior ST elevation myocardial infarction(STEMI). Methods: 76 consecutive patients with anterior STEMI(65.3(11.2) years, 48 men) were randomly assigned to intracoronary thrombectomy and stent placement(n=38) or to conventional stenting(n=38) of the infarct related artery. Each patient underwent transthoracic echocardiography immediately after PCI and at six months. At the time of echocardiographic control, major adverse cardiovascular events(MACE) in terms of death, new onset of myocardial infarction, and hospitalisation for heart failure were also evaluated. Results: After a successful primary PCI, patients in the thrombectomy group achieved a higher rate of post-procedure myocardial blush grade 3(36.8%v 13.1%, p=0.03) and effective ST segment resolution at 90 minutes(81.6%v 55.3%, p=0.02). Six months after the index intervention, 19 patients(26.8%) developed LV dilatation, defined as an increase in end diastolic volume(EDV) ≥20%: 15 in the conventional group and four in the thrombectomy group(p=0.006). Accordingly, at six months patients treated conventionally had significantly higher end systolic volumes(82(7.7) ml v 75.3(4.9) ml, p< 0.0001) and EDV(152.5(18.1) ml v 138.1(10.7) ml, p< 0.0001) than patients treated with thrombectomy. No differences in cumulative MACE were observed(10.5%in the conventional group v 8.6%in the thrombectomy group, not significant). Conclusion: Compared with conventional stenting, adjunctive aspiration thrombectomy in successful primary PCI seems to be associated with a significantly lower incidence of LV remodelling at six months in patients with anterior STEMI.

关键词：前壁心肌梗死 ST段抬高左室重构血管成形术切除术梗死相关动脉经胸超声心动图收缩末容积舒

一项新的左室不同步指标在预测心脏再同步化治疗后心室重构逆转中的作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 48-48页

作者： Porciani M.C. Lilli A. MacIoce R. 巩雪 Department of Heart and Vessels University of Florence Viale Morgagni 85 Florence 50134 Italy

目的:大多数用于预测心脏再同步化治疗(CRT)后左室(LV)重构逆转的组织多普勒超声参数在射血期评估,反映的是LV不同步。目前一项新的负荷成像参数可反映主动脉瓣关闭之后12个LV节段收缩所耗费的总时间,本试验旨在评价这一参数的预测价值... 详细信息

目的:大多数用于预测心脏再同步化治疗(CRT)后左室(LV)重构逆转的组织多普勒超声参数在射血期评估,反映的是LV不同步。目前一项新的负荷成像参数可反映主动脉瓣关闭之后12个LV节段收缩所耗费的总时间,本试验旨在评价这一参数的预测价值。方法与结果:纳入59例按现行标准完成治疗的患者,在CRT治疗前和治疗后6个月对其进行研究。

关键词：心脏再同步化心室重构射血期预测价值超声参数组织多普勒后左室成像参数收缩末容积反应者