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Body awareness therapy: A new strategy for relief of symptoms in irritable bowel syndrome patients

World Journal of Gastroenterology 2007年第23期13卷 3206-3214页

作者： EM Eriksson IE Mller RH Sderberg HT Eriksson GK Kurlberg Departments of Surgery Sahlgrenska University Hospital/stra Gteborg Sweden Departments of Medicine Sahlgrenska University Hospital/stra Gteborg Sweden

AIM: To compare irritable bowel syndrome (IBS) pa- tients with apparently healthy persons and to evaluate body awareness therapy, which is a physiotherapeutic remedy focusing on normalising tensions in the body, for the treatment of IBS with the hypothesis that altered body tension is associated with the syndrome. METHODS: Twenty-one IBS patients received body awareness therapy two hours weekly for 24 wk. At base- line as well as after 12 and 24 wk, they underwent ex- aminations including resource oriented body examination in combination with body awareness scale evaluation and f illed in gastrointestinal and psychological symptom questionnaires. Saliva cortisol was analysed. A group of 21 apparently healthy persons underwent the same ex- aminations once. RESULTS: Compared to the apparently healthy group, IBS patients scored higher at baseline for gastrointestinal and psychological symptoms. They showed more often alterations in normal body tension patterns, as well as deviating cortisol slopes in saliva. After 24 wk of body awareness therapy, their gastrointestinal and psychologi- cal symptoms were reduced overall. Somatic symptoms decreased in parallel with depressive symptoms. Whole body pain score decreased, coping ability as well as bio- chemical stress markers improved. CONCLUSION: IBS patients scored higher for gastroin- testinal and psychological symptoms, and presented with altered biochemical stress markers. Their body tension deviated compared to healthy controls. Furthermore,body awareness therapy gave relief of both somatic com- plaints, psychological symptoms and normalised body tension. These findings indicate that distorted tension constitutes an important part of the symptoms in IBS.

关键词：急性肠综合症疼痛考的索物理疗法应激

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Expression of intestinal mucosa tight junctions claudin proteins and mRNA in patients with irritable bowel syndrome

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Journal of Medical Colleges of PLA(China) 2007年第3期22卷 153-159页

作者：孔武明龚均董蕾鲁晓岚徐俊荣 Department of Gastroenterology Second Affiliated Hospital of Medical CollegeXi'an Jiaotong University

Objective:To investigate the changes of intestinal mucosa tight junctions (TJs) claudin-1, -3,-4 proteins and mRNA changes in patients with irritable bowel syndrome (IBS) and to elucidate their possible roles in the changes of bowel evacuation habit and ***:Claudin-1,-3,-4 proteins and mRNA were evaluated in intestinal mucosa in control group,D-IBS (diarrhea IBS) group and C-IBS (constipation IBS) group with immunohistochemical assay and ***:It was observed that claudin-1,-3,-4 proteins were localized in the membranes of epithelial cells along the entire length of the plasma membrane including the apical end of the epithelial *** claudins were concentrated at the site of TJs ***-1,-3,-4 mRNA and claudin-1 protein in small intestinal mucosa and colonal mu- cous in D-IBS group were significantly downregulated (P＜0.05).Claudin-1,-3,-4 mRNA and proteins in small intestinal mucosa and colonal mucous in C-IBS group were significantly upregulated (P＜0.05). There was no significant difference in the expression of claudin-3 protein in both small intestinal mucosa and colonal mucous between D-IBS group and control group(P＞0.05).Similarly,no significantly differ- ent expression of claudin-4 protein in colonal mucous in D-IBS group was found compared with control group (P＞0.05).Otherwise,the expression of claudin-4 protein in small intestinal mucosa decreased in D-IBS group (P＜0.05).Conclusion:Claudin-1,-3,-4 may play a potential important role in the changes of bowel evacuation habit and formation in patients with *** is not due to the localization changes of claudin proteins in T J,but may be caused by the quantitative changes of the expression of TJ proteins and mRNA.

关键词：急性肠综合症肠黏膜蛋白质 mRNA

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