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基于公理化设计的微流体装置的稳健优化设计

基于公理化设计的微流体装置的稳健优化设计

作者：付丽伟南京理工大学

学位级别：硕士

公理化设计理论不仅提供了一种自顶向下的系统化的方法来指导设计活动,而且可以用来评价设计的优劣。由于其出现时间较短,虽发展迅速,但仍有一些尚未完善的部分极大地制约了它的应用。稳健设计作为一种已经被广泛应用的工程方法,在理论... 详细信息

公理化设计理论不仅提供了一种自顶向下的系统化的方法来指导设计活动,而且可以用来评价设计的优劣。由于其出现时间较短,虽发展迅速,但仍有一些尚未完善的部分极大地制约了它的应用。稳健设计作为一种已经被广泛应用的工程方法,在理论本质上是符合公理化设计理论中的两条设计公理的。详细地阐述了公理化设计理论的内容及应用范围,并在此基础上提出了以蒙特卡罗方法模拟积分的方法来计算设计的信息量,当设计参数个数较多时,此方法的效率较高。同时,该方法可以推广到功能需求和设计参数符合正态分布的设计,而多数制造系统的概率密度函数都属正态分布,因此大大扩展了信息公理的实用范围。不仅如此,该方法还可以计算设计参数个数大于功能需求个数的冗余设计的信息量,极大的方便了很多流体系统的信息量计算工作。总结和分析了对微流体装置工作过程产生影响的各项因素,利用COMSOL有限元软件对微流体装置工作过程进行了仿真,得到的仿真数据接近实验数据。在此基础上利用田口方法对其进行稳健设计,认为界面张力、分散相物质粘度以及集中流直径等因素对其生产微球的大小及均匀度具有较大的影响,并得出最佳参数组合。

关键词：公理化设计信息量稳健设计微流体装置试验设计 COMSOL

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微流体装置与系统研究

上海大学学报（自然科学版） 2003年第5期9卷 377-380页

作者：张国贤罗玉元上海大学机电工程与自动化学院上海200072

介绍了国内外微流体装置及系统的发展和应用,分析了近期有待解决的几个关键问题,指出该技术富于挑战性,同时具有广阔的应用前景.

关键词：微流体装置微电子机械系统微泵微阀

A novel in vitro angiogenesis model based on a microfluidic device

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Chinese Science Bulletin 2011年第31期56卷 3301-3309页

作者： DAI XiaoZhen CAI ShaoXi YE QunFang JIANG JiaHuan YAN XiaoQing XIONG Xin JIANG QiFeng WANG Albert Chih-Lueh TAN Yi Key Laboratory of Biorheological Science and Technology （Chongqing University） of Ministry of Education Bioengineering College Chongqing University Chongqing 400044 China Laboratory Research Center The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China Muscle and Motility Group Boston Biomedical Research Institute 64 Grove Street Watertown MA 02472 USA Chinese-American Research Institute for Diabetic Complications Wenzhou Medical College Chashan College Park Wenzhou 325035 China Pediatric Diabetes Research at KCHRI of the Department of Pediatrics University of Louisville Louisville KY 40202 USA

Angiogenesis is very important for many physiological and pathological processes. However, the molecular mechanisms of angiogenesis are unclear. To elucidate the molecular mechanisms of angiogenesis and to develop treatments for "angiogenesis-dependent" diseases, it is essential to establish a suitable in vitro angiogenesis model. In this study, we created a novel in vitro angiogenesis model based on a microfluidic device. Our model provides an in vivo-like microenvironment for endothelial cells (ECs) cultures and monitors the response of ECs to changes in their microenvironment in real time. To evaluate the potential of this microfluidic device for researching angiogenesis, the effects of pro-angiogenic factors on ECs proliferation, migration and tube-like structure formation were investigated. Our results showed the proliferation rate of ECs in 3D matrix was significantly promoted by the pro-angiogenic factors (with an increase of 59.12%). With the stimulation of pro-angiogenic factors gradients, ECs directionally migrated into the Matrigel from low concentrations to high concentrations and consequently formed multi-cell chords and tube-like structures. These results suggest that the device can provide a suitable platform for elucidating the mechanisms of angiogenesis and for screening pro-angiogenic or anti-angiogenic drugs for "angiogenesis-dependent" diseases.

关键词：抗血管生成微流体装置模型基体外小说内皮细胞增殖分子机制血管形成

基团贡献法估算离子液体的静态介电常数(英文)

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Chinese Journal of Chemical Engineering 2014年第1期22卷 79-88页

作者：周颖林真吴可君徐国华何潮洪 State Key Laboratory of Chemical Engineering Department of Chemical and Biological Engineering Zhejiang University

Static dielectric constant is a key parameter to estimate the electro-viscous effect which plays important roles in the flow and convective heat transfer of fluids with ions in microfluidic devices such as micro reactors and heat exchangers.A group contribution method based on 27 groups is developed for the correlation of static dielectric constant of ionic liquids in this *** ionic liquids considered include imidazolium,pyridinium,pyrrolidinium,alkylammonium,alkylsulfonium,morpholinium and piperidinium cations and various *** data collected cover the temperature ranges of 278.15-343.15 K and static dielectric constant ranges of *** results of the method show a satisfactory agreement with the literature data with an average absolute relative deviation of 7.41%,which is generally of the same order of the experimental data *** method proposed in this paper provides a simple but reliable approach for the prediction of static dielectric constant of ionic liquids at different temperatures.

关键词：静态介电常数离子液体基团贡献法温度范围微流体装置粘滞效应关键参数微反应器

伴随传质的液液体系微分散流型图的实验研究(英文)

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Chinese Journal of Chemical Engineering 2012年第1期20卷 18-26页

作者：邵华伟吕阳成王凯骆广生 State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

This paper presents the experimental results of liquid-liquid microflows in a coaxial microfluidic device with mass *** working systems were n-butanol + phosphoric acid(PA) + water,methyl isobutyl ketone(MIBK) + PA + water,30% kerosene in tri-n-butylphosphate(TBP) + PA + *** direction and intensity of mass transfer were adjusted by adding PA in one of two phases mutual saturated in *** PA transferred from the organic phase to the aqueous phase,tiny aqueous droplets may generate inside the organic phase by mass transfer inducement to form a new W/O/W flow pattern directly on some special *** the PA concentration was very high,violent Marangoni effect could be observed to throw part of organic phase out of droplets as *** interphase transfer of PA could expand the jetting flow region,in particular for systems with low or medium inter-facial tension and when the mass transfer direction was from the aqueous phase to the organic phase.

关键词：传热传质 Marangoni效应实验流模式地图甲基异丁基酮微流体装置有机相

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微纳电子技术 2013年第4期50卷 265-266页

微流体专家Dolomite加入LioniXB．V．微流体专家Dolomite宣布与LioniX达成合作共识，LioniX业务领域涵盖集成光学、光流体学和微流体以及表面功能化和IO传感系统。Dolo-mite与LioniX的合作项目包括微流体装置和系统的设计、开发和制造... 详细信息

微流体专家Dolomite加入LioniXB．V．微流体专家Dolomite宣布与LioniX达成合作共识，LioniX业务领域涵盖集成光学、光流体学和微流体以及表面功能化和IO传感系统。Dolo-mite与LioniX的合作项目包括微流体装置和系统的设计、开发和制造，此次合作充分利用双方优势拓展业务范围。两家公司间的合作协议规定了以下四个核心合作领域：①LioniXB．V．将成为Dolo-mite世界领先水平产品的分销商，销售的产品主要包括微流控芯片、泵浦、连接器、阀门和配件等。

关键词：微流体装置合作项目市场传感系统表面功能化微流控芯片集成光学合作协议

Nephrocyte-neurocyte interaction and cellular metabolic analysis on membrane-integrated microfluidic device

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Science China Chemistry 2016年第2期59卷 243-250页

作者： Qichen Zhuang Shiqi Wang Jie Zhang Ziyi He Haifang Li Yuan Ma Jin-Ming Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of Chemistry Tsinghua university Beijing 100084 China The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Tsinghua University Beijing 100084 China

Cell-cell interaction and cell metabolic analysis provide new opportunities for better understanding of critical biochemical processes. Advanced microfluidic technologies enable to create more realistic in vitro microenvironment by spatial and temporal control of cell growth and co-culture. In this work, we design a microfluidic device to achieve the co-culture of PC12 cells and 293 cells, and study in vitro cell-cell interaction via cell metabolic analysis by mass spectrometry. The membraneintegrated microfluidic device was firstly used for cell co-culture, and the cellular metabolite was further investigated by mass spectrometer(MS). Our results showed that the differentiation of PC12 cells could be successfully induced by m NGF and also greatly influenced by the microchannel treatment of fetal bovine serum(FBS) solution. The identification of cell morphology, microtubule-associated protein 2(MAP-2) expression and viability of differentiated PC12 cells were conducted before 293 cells being introduced into the top microfluidic channels and stimulated to secrete cell metabolism products. The developed microfluidic device is a potentially useful tool for high throughput of cell-cell interaction study.

关键词：微流体装置神经细胞相互作用代谢分析微流控 PC12细胞 293细胞集成

A new look on wetting models:continuum analysis

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Science China(Physics,Mechanics & Astronomy) 2012年第11期55卷 2158-2166页

作者： LIU JianLin XIA Re ZHOU XiaoHua School of Pipeline and Civil Engineering China University of PetroleumQingdao 266555China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Department of Mathematics and Physics Fourth Military Medical UniversityXi’an 710032China

In this study,we considered the wetting phenomenon on a general substrate from a new viewpoint of continuum *** analyses first show how the Wenzel and the Cassie models deviate the practical results in some special substrates,and then elucidate the mechanism of the triple contact line(TCL) *** upon variational theory of the total free functional dealing with the movable boundary condition,we show that the macroscopic contact angle(MCA) expression is the corresponding transversality *** manifests that the MCA depends only on the chemical and geometric property at the TCL,and is not affected by the gravity of the droplet and the contact area beneath the *** continuum model also shows the exploration of the pinning effect on a sharp wedge or the interface between two different *** investigation will help designing super-hydrophobic materials for novel micro-fluidic devices.

关键词：连续模型润湿现象连续分析连续介质力学动边界条件微流体装置变分原理几何性质

A novel heating area design of temperature-jump microfluidic chip for synchrotron radiation solution X-ray scattering

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Nuclear Science and Techniques 2016年第4期27卷 115-119页

作者： Yi-Wen Li Feng-Gang Bian Jie Wang Shanghai Institute of Applied Physics Chinese Academy of Sciences Zhangjiang Campus Shanghai 201204 China University of Chinese Academy of Sciences Beijing 100049 China

In this paper, we present a novel design scheme of temperature-jump(T-jump) area for microfluidic *** simulation and experimental research of thermal characteristics of the solution in microchannels is *** simulation of the temperature-jump microchannel is analyzed to study the heat transfer characteristics by comparing performance of three proposed *** of the power requirement is discussed in the dimensional design of microheater. Temperature-sensitive fluorescent dye is applied to investigate the temperature field of microchannel heated by a designed microheater. It is found that the T-jump microfluidic device can provide rapid heating for solutions with strong convection heat transfer ability.

关键词：微流控芯片温升设计温度场 X射线散射同步辐射溶液微流体装置跳变