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泰山医学院学报 2006年第8期27卷 724-726页

作者：蔡文杰辛培玲泉州市第一医院放射治疗科福建泉州362000

目的评价在晚期移行细胞癌病人应用阿霉素＋吉西他滨（AG）每2周一周期，共6周期，序贯异磷酰胺＋紫杉醇＋顺铂（ITP）每3周一周期，共4周期方案的耐受性及疗效。方法AG每2周为一周期，共6周期，序贯ITP每3周为一周期，共4周期。15例病... 详细信息

目的评价在晚期移行细胞癌病人应用阿霉素＋吉西他滨（AG）每2周一周期，共6周期，序贯异磷酰胺＋紫杉醇＋顺铂（ITP）每3周一周期，共4周期方案的耐受性及疗效。方法AG每2周为一周期，共6周期，序贯ITP每3周为一周期，共4周期。15例病人分别接受5种AG剂量水平的方案化疗，最高剂量是阿霉素50mg／m^2，吉西他滨2000mg／m^2；ITP方案的剂量为异磷酰胺1500mg／m^2第1～3天，紫杉醇135mg／m^2及顺铂70mg／m^2第1天。每个治疗周期间应用粒细胞集落刺激因子。结论AG方案隔周给药阿霉素50mg／m^2、吉西他滨2000mg/m^2是可行的。AG—ITP序贯化疗结束后9／14（64％）有效（3例CR；6例PR）。

关键词：泌尿系癌移行细胞癌序贯化疗阿霉素吉西他滨异磷酰胺紫杉醇顺铂

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腹主动脉旁淋巴结转移的子宫内膜癌患者术后化疗的有效性

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 33-33页

作者： Takeshima N. Umayahara K. Fujiwara K. 吕涛 Department of Gynecology Cancer Institute Hospital3-10-6 AriakeKoto-kuTokyo135-8550Japan

Objective:To examine the effectiveness of postoperative chemotherapy for para-aortic lymph node (PAN) metastasis in patients with endometrial cancer. Methods:Among 350 clinical stage I-II endometrial cancer patients who underwent systemic pelvic and para-aortic lymphadenectomy during the period 1995 through 2002,26 patients were identified with PAN metastasis. Of these patients,nine had only one positive PAN and 17 had two or more positive PANs (mean 4.9,range 1-22). All patients were treated postoperatively with a single chemotherapy regimen consisting of ifosfamide,epiadriamycin,and cisplatin scheduled for 5 cycles. Median (range) follow-up for surviving patients was 85 (38-119) months. Treatment outcome,including disease-free survival relative to the number of positive PANs,was investigated. Results:Among the 26 patients with PAN involvement,four developed recurrence. Three of the four patients had 10 or more positive PANs. Estimated 5-year disease-free survival rates were 89%for patients with one positive PAN,82%for those with two or more positive PANs,and 85%for all patients. No significant difference was identified between the first two groups (P = 0.6543). Conclusions:Postoperative chemotherapy can yield a favorable outcome in endometrial cancer patients with PAN metastasis,even those with multiple positive nodes.

关键词：无病生存率表柔比星异磷酰胺存活患者临床分期化疗药物淋巴结转移无显著性差异

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1例复发卵巢血管肉瘤治疗后妊娠的病例报道与文献回顾

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 43-43页

作者： Jha S. Chan K.K. Poole C.J. Rollason T.P. 李跃萍 123 Lodge Hill Road Selly Oak Birmingham B29 6NL United Kingdom

Background. Ovarian angiosarcomas are rare tumors which may to be distinguished from other unusual primary ovarian tumors such as clear cell carcinoma, yolk sac tumor and leiomyosarcoma on the basis of histological appearance and immunohistochemistry. Angiosarcomas of the ovary occur in all age groups but are more frequent in women of child bearing age (less than 40 years). Surgery and radiotherapy have been the traditional treatment modalities. Case. The case we present is the only reported long-term survivor of recurrent ovarian angiosarcoma. Her initial treatment was surgical, both at presentation and relapse but since she wished conservation of fertility, radical surgery and radiotherapy were avoided and she underwent further adjuvant chemotherapy with doxorubicin and ifosfamide. She remains in remission 6 years after treatment of recurrence of the primary tumor and has had a successful pregnancy following treatment. Conclusion. Adjuvant chemotherapy of ovarian angiosarcoma with a combination of doxorubicin and ifosfamide appears effective and should be considered in women at risk of relapse who wish to conserve fertility.

关键词：卵巢血管肉瘤文献回顾卵黄囊瘤异磷酰胺辅助性化疗透明细胞癌平滑肌肉瘤根治性手术联合放疗复发风险

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