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Vogt－小柳－原田氏综合征报告

山西医科大学学报 1994年第3期 309-309页

作者：赵彩霞太原重型机器厂职工医院内科

Ｖｏｇｔ－小柳－原田氏综合征报告赵彩霞（太原重型机器厂职工医院内科０３００２４）Ｖｏｇｔ－小柳－原田氏综合征（Ｖｏｇｔ－Ｋｏｙｏｎａｇｉ－Ｈｏｖａｄａｓｙｎｄｒｏｍｅ）亦葡萄膜－脑－脑膜炎综合征，临床上较少见，现报告... 详细信息

Ｖｏｇｔ－小柳－原田氏综合征报告赵彩霞（太原重型机器厂职工医院内科０３００２４）Ｖｏｇｔ－小柳－原田氏综合征（Ｖｏｇｔ－Ｋｏｙｏｎａｇｉ－Ｈｏｖａｄａｓｙｎｄｒｏｍｅ）亦葡萄膜－脑－脑膜炎综合征，临床上较少见，现报告１例。１病例患者，男，６９岁，主因...

关键词：田氏综合征综合病症 Vogt 小柳

光动力疗法治疗Vogt-小柳-原田病中心凹下脉络膜新生血管形成

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 41-41页

作者： Nowilaty S.R. Bouhaimed M. 刘瑛 Vitreoretinal Division Department of Ophthalmology King Khaled Eye Specialist Hospital PO Box 7191 Riyadh 11462 Saudi ArabiaDr.

Aim: To assess the effects of photodynamic therapy (PDT)with verteporfin in the treatment of subfoveal choroidal neovascularisation (CNV) secondary to Vogt-Koyanagi- Harada disease (VKH). Methods: Six eyes of six patients with VKH who developed subfoveal CNV underwent standard PDT. Repeated treatments were performed at 3 month intervals for persistent leakage. Charts and angiographic data were analysed retrospectively. Results: Age of patients ranged between 17 years and 27 years. Five CNV lesions were recent and classic (greatest lesion diameter was 1100-3100 μm). One CNV was chronic and partially scarred. Mean visual acuity (VA) at presentation was 20/200. Five patients had more than 1 year of follow up. In five eyes there was active inflammation and CNV. Of these eyes, the first three required one PDT each. The final CNV scar was smaller/stable with improvement of VA in two eyes. The third developed a larger CNV scar with loss of two lines of VA. Submacular fibrosis developed in all three. In the fourth eye, mild CNV leakage persisted after one PDT but hazy media precluded a second PDT. At 18 months the CNV scar and VA were stable. The fifth case, with mild inflammation, required three PDT. The CNV leakage became minimal, the lesion became smaller, and VA improved significantly. The sixth eye with CNV had no inflammation and needed two PDT sessions to halt the CNV leakage. The final lesion was smaller and vision was stable. There were no PDT related complications in our series. Conclusion: Photodynamic therapy with verteporfin appears to be a safe and viable treatment option for subfoveal CNV secondary to VKH. It offers a chance for stabilisation or even improvement of vision. Further study is warranted.

关键词：中心凹光动力疗法 Vogt 原田病小柳脉络膜新生血管

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Vogt-小柳-原田综合征1例报告

中国神经精神疾病杂志 1979年第5期 240-240页

作者：于同乐安徽省淮南市第一人民医院内科神经病组

Vogt-小柳-原田综合征多见于日本,国内报道不多,现将本院所见1例报告如下: 王××,男,11岁,学生。2个月前起病时自觉轻微发热、头痛、眩晕、耳鸣、听力减退、走路不稳(夜晚加重)。自服维生素A、D治疗1个月无效,且出现视物模糊,影响学习... 详细信息

Vogt-小柳-原田综合征多见于日本,国内报道不多,现将本院所见1例报告如下: 王××,男,11岁,学生。2个月前起病时自觉轻微发热、头痛、眩晕、耳鸣、听力减退、走路不稳(夜晚加重)。自服维生素A、D治疗1个月无效,且出现视物模糊,影响学习,乃于1978年7月22日来诊。既往史和家族史无特殊。

关键词：葡萄膜炎综合征色素膜炎葡萄膜疾病综合病症小柳玻璃体混浊 Vogt

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福格特一小柳一原田综合征一例

国际皮肤性病学杂志 2011年第2期37卷 70-70页

作者：曾敬思张艳丽方勇吴佑沛曾昭明华中科技大学同济医学院附属协和医院皮肤科武汉430022 武汉抗白癜风专科门诊部

患者男，58岁。于2009年1月初，出现头晕、头痛等类似感冒症状，并日渐感到双眼视物膜糊，两耳听力减退。自认为是闲年迈体衰所致，未加介意。1个月后，

关键词：原田综合征小柳 2009年感冒症状听力减退双眼视

vogt-小柳-原田综合征临床与脑梗塞(附5例报告)

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脑与神经疾病杂志 2000年第2期8卷 79-79页

作者：李英阎丽清赵承爱山西省介体市汾西矿务局职工总医院神经内科 031200 山西省介体市汾西矿务局职工总医院神经内科

ovgt-小柳-原田综合征(vogt-koy-anagi-harada)临床少见。但个别病例可致脑梗塞,应引起注意。现将笔者多年来经治(包括外院收治)5例报告如下。

关键词：脑梗塞综合征小柳脑梗综合病症 vogt 黑色素细胞

Vogt-小柳-原田病患者对黑素细胞特异性蛋白KU-MEL-1的频发免疫反应

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 26-26页

作者： Otani S. Sakurai T. Yamamoto K. Y. Kawakami 邢咏新 Division of Cellular Signaling Institute for Advanced Medical Research Keio University School of Medicine 35 Shinanomachi Shinjyukuku Tokyo 160-8582 JapanDr.

Aim: To isolate autoantigens possibly involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. Methods: Autoantigens recognised by immunoglobulinGantibodies (IgG Ab) in sera from VKH patients were isolated by screening the lambda phage cDNA libraries made from melanocytes and a highly pigmented melanoma cell line with the patients'sera. Presence of IgG specific for the autoantigens in sera from patients with various panuveitis and healthy individuals was evaluated. Relation between the specific IgG and various clinicopathological features was examined. Results: KU-MEL-1 was found to be one of the 81 isolated positive clones representing 35 distinct genes, which is a previously isolated melanoma antigen preferentially expressed in melanocytes. The IgG Ab specific for KU-MEL-1 was detected in sera from patients with VKH in significantly higher amounts than in sera from patients with Behcet's disease, sarcoidosis, and from healthy individuals. Positive serum KU-MEL-1 Ab was significantly associated with HLA-DRB10405 and male VKH patients. Conclusion: KU-MEL-1 was identified as a new autoantigen for VKH. The highly frequent induction of IgG Ab for KU-MEL-1 in HLADRB10405 positive VKH patients may suggest the possible involvement of KU-MEL-1 specific CD4+T cells in the pathogenesis of VKH, suggesting the possible use in the development of diagnostic and therapeutic treatments for VKH patients.

关键词：原田病小柳黑素细胞 KU-MEL-1 Vogt 特异性患者

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Vogt－小柳－原田综合征一例

临床神经病学杂志 1995年第2期 101-101页

作者：顾柏林王苑华浙江省肖山市人民医院丽水地区人民医院

Ｖｏｇｔ－小柳－原田综合征一例顾柏林，王苑华患者，男，３０岁，农民。因发热１０天伴精神异常３天，于１９９２年３月１８日入院。１０天前感头昏乏力，发热，双颞有阵发性抽痛。３天后来我院门诊，Ｔ３９．４℃，但血常规正常，脑... 详细信息

Ｖｏｇｔ－小柳－原田综合征一例顾柏林，王苑华患者，男，３０岁，农民。因发热１０天伴精神异常３天，于１９９２年３月１８日入院。１０天前感头昏乏力，发热，双颞有阵发性抽痛。３天后来我院门诊，Ｔ３９．４℃，但血常规正常，脑电图为临界状态，神经系统无异常发现...

关键词：综合征综合病症 Vogt 脑电图电诊断图阵发性小柳丽水地区葡萄膜炎色素膜炎葡萄膜疾病

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Vogt—小柳—原田氏综合征一例报告

山西医药杂志 1983年第3期 192-192页

作者：鞠富盛赵玉林省人民医院神经科省人民医院神经科

李××,男,58岁,住院号94713。因进行性视力损害伴间断发烧两个月,于1982年5月29日住我院。患者于1982年3月下旬开始觉双眼视物不清,前额憋胀、自觉发烧,未测体温,有时双耳似蝉呜。视物模糊日益加重,至5月16日对面的人分不清五官,伴头晕... 详细信息

李××,男,58岁,住院号94713。因进行性视力损害伴间断发烧两个月,于1982年5月29日住我院。患者于1982年3月下旬开始觉双眼视物不清,前额憋胀、自觉发烧,未测体温,有时双耳似蝉呜。视物模糊日益加重,至5月16日对面的人分不清五官,伴头晕。5月21日于外院就医,查视力左0.07,右0.03,诊断“视乳头水肿”,怀疑颅内占位性病变,似行脑同位素扫描和脑室造影术,因故

关键词：田氏小柳 Vogt 综合征综合病症

评价急性Vogt-小柳-原田病患者常规应用皮质激素对预后的影响

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 19-19页

作者： Read R.W. AccorintiM. 王海燕 University of Alabama at Birmingham BirminghamALUnited States Dr.

Purpose:To compare the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada ***:Retrospective comparative interventional case ***:settings:Nine international uveitis specialty *** population:Forty-eight patients presenting over a three-year period to a study center with acute Vogt-Koyanagi-Harada ***:Initial treatment with corticosteroid either orally(Oral only group) or intravenously followed by an oral taper(IV+ Oral group) .main outcome measures:Change in visual acuity with treatment;development of ocular complications,including visually significant cataract,choroidal neovascularization,subretinal fibrosis,fundus pigment migration,nummular hypopigmented lesions,and diffuse fundus depigmentation;use of immunosuppressive ***:The Oral only group comprised 15 patients(31%) and the IV+ Oral group 33 patients(69%) .Median follow-up was 15 *** was no difference in duration of follow-up between groups(P=.234) .There was no difference in the change in visual acuity between groups,adjusting for initial visual acuity(P=.402) .There were no differences in the rates of development of visually significant cataract,fundus pigmentary changes,or in the rate of use of subsequent immunosuppressive therapy between treatment *** patients developed choroidal neovascularization or subretinal fibrosis over the study ***:Route of administration of corticosteroid had no detectable effect on change in visual acuity nor on the development of visually significant complications over the study *** trials are necessary to address speed of resolution and definitively answer outcome questions.

关键词：原田病小柳 Vogt 皮质激素患者常规预后