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托吡酯预防成人偏头痛发作的临床研究

中国疼痛医学杂志 2008年第2期14卷 111-113页

作者：史树贵邵淑琴蔡昌启罗明奎第三军医大学西南医院神经内科第三军医大学数学教研室重庆400038

三项较大规模的随机双盲研究证明,托吡酯可以预防成人偏头痛的发作。与较经典的偏头痛预防性治疗药物相比,托吡酯对成人偏头痛的发作次数、头痛天数、头痛强度及头痛指数的降低不低于经典预防方法,如β受体拮抗剂普萘洛尔、三环类抗抑... 详细信息

三项较大规模的随机双盲研究证明,托吡酯可以预防成人偏头痛的发作。与较经典的偏头痛预防性治疗药物相比,托吡酯对成人偏头痛的发作次数、头痛天数、头痛强度及头痛指数的降低不低于经典预防方法,如β受体拮抗剂普萘洛尔、三环类抗抑郁药阿米替林、抗癫痫药丙戊酸等,且较上述治疗方法的副作用小。目前国内尚无托吡酯预防成人偏头痛发作的文献报道,由于国人在种族、发病年龄、体重等方面与西方人种有差异,因此托吡酯是否能够预防我国成人偏头痛发作尚不清楚。为此我们对托吡酯预防国人偏头痛发作的疗效进行了前瞻性阳性对照的开放性研究。[第一段]

关键词：头痛发作托吡酯预防性成人临床研究三环类抗抑郁药随机双盲研究 β受体拮抗剂

厄瑞奴单抗可明显减少阵发性偏头痛每月发作天数

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国际药学研究杂志 2016年第6期43卷 1139-1139页

作者：刘子侨

安进公司宣布首个治疗偏头痛Ⅲ期临床新药厄瑞奴单抗（erenumab）试验达到主终点。与安慰剂比较,较基线明显减少阵发性偏头痛每月发作的天数。该药靶向和阻断降钙素基因相关肽受体,此受体与偏头痛发作有关。ARISE研究是全球范围的Ⅲ期... 详细信息

安进公司宣布首个治疗偏头痛Ⅲ期临床新药厄瑞奴单抗（erenumab）试验达到主终点。与安慰剂比较,较基线明显减少阵发性偏头痛每月发作的天数。该药靶向和阻断降钙素基因相关肽受体,此受体与偏头痛发作有关。ARISE研究是全球范围的Ⅲ期临床试验,为多中心、随机、12周、双盲、安慰剂对照研究,评价该药对预防阵发性偏头痛的疗效和安全性。

关键词：头痛发作偏头痛阵发性单抗 Ⅲ期临床试验降钙素基因相关肽安慰剂对照数

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Fisher综合征伴偏头痛发作1例报告

中风与神经疾病杂志 2007年第5期24卷 626-626页

作者：申存周王淑荣哈尔滨医科大学第四附属医院神经内科黑龙江哈尔滨150001

Fisher综合征临床比较少见,现报告1例Fisher综合征伴偏头痛发作如下。1 临床资料患者,女,47岁,因“头痛、眩晕伴复视5d”入院。患者自诉于入院前5d无明显诱因突发头痛、眩晕伴复视,当时自觉恶心,未吐,无大汗。头痛以右额部为著,诉偶有... 详细信息

Fisher综合征临床比较少见,现报告1例Fisher综合征伴偏头痛发作如下。1 临床资料患者,女,47岁,因“头痛、眩晕伴复视5d”入院。患者自诉于入院前5d无明显诱因突发头痛、眩晕伴复视,当时自觉恶心,未吐,无大汗。头痛以右额部为著,诉偶有右眼球胀痛,病程中自觉忽冷忽热,未测体温;

关键词： Fisher综合征头痛发作临床比较临床资料眼球胀痛测体温复视眩晕

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安抚偏头痛治疗和预防发作并重

江苏卫生保健（今日保健） 2015年第3期 4-5页

作者：万琪江苏省人民医院神经内科

张老师今年38岁，她从16岁开始就患偏头痛。刚开始一年也就发作几次，后来慢慢转变为一个月发作1次，近三个月来几乎隔几天就发作1次。每次发作，都如噩梦般，头痛欲裂，并有恶心、呕吐，止痛片已经吃到5片也只能缓解几个小时。发作时... 详细信息

张老师今年38岁，她从16岁开始就患偏头痛。刚开始一年也就发作几次，后来慢慢转变为一个月发作1次，近三个月来几乎隔几天就发作1次。每次发作，都如噩梦般，头痛欲裂，并有恶心、呕吐，止痛片已经吃到5片也只能缓解几个小时。发作时吃不好睡不好，无法做任何事情，只得请假回家休息。这让张老师焦急不已，一是担心自己的病情，二是担心这样下去，无法完成教学任务，耽误了学生。

关键词：张老师头痛发作近三曲坦类药物氟桂利嗪非甾体抗炎药类药米曲急性发作这一天

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偏头痛发作时激光诱发电位的地形学和双极分析

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 23-24页

作者： De Tommaso M Guido M. Libro G. 王英鹏 Dept. Neurologic and Psychiat. Sci. University of Bari Bari Italy Dr.

Objective. - The aim of this study was to perform further evaluation of laser- evoked potentials (LEPs) during miraine attacks using multichannel recording and topographic analysis. Specifically, this study aimed to confirm the pattern previously observed in acute migraine, while also defining the components of LEPs that are mainly modified during headache, as well as the correlation between features of LEPs and clinical variables. In addition, we aimed to conduct a dipolar source analysis of the main LEP waves in migraine patients to check the variability in the source location of LEPs during acute migraine. Background. - An amplitude enhancement of LEPs was previously detected during migraine attack using a single scalp derivation on the vertex; hyperalgesia to heat stimuli was also detected for both the face and hand. Methods. - Eighteen patients suffering from migraine without aura were analyzed. The supraorbital zones and the dorsum of the hand were stimulated on both the symptomatic and nonsymptomatic sides in all patients. The LEPs were recorded via 25 scalp electrodes. Dipolar source analysis of the P2 components was performed using a spherical model in all patients and using a realistic Magnetic Resonance model in four patients. Results. - During attacks, the later waves, and particularly the P2 component, were significantly enhanced; the amplitude of the P2 component obtained during the attack by stimulation of the supraorbital zone on the side of the headache was significantly correlated with the intensity of pain and the frequency of headache. In our patients, the P2 wave was generated in the anterior cingulate cortex, with a shift toward its rostrocaudal portion, and was mainly devoted to elaboration of the emotive compound of pain during migraine attack. Conclusions. - Cortical activation by laser stimuli during migraine attack was confirmed. This effect was more pronounced in patients with a higher frequency of migraine attacks. This may be due to a lack of inhibitory control over the transmission

关键词：头痛发作诱发电位致偏痛觉过敏头皮电极无症状诱导法热刺激皮层区尾状核

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偏头痛发作中无症状的左心室功能不全

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 45-46页

作者： Vidalón M. 张慧(译) Avenida Mascote 679 Apto 21 Sao Paulo 04363000 Brazil 不详

Objective. -The aim of the present study was to evaluate cardiac performance of patients with migraine attacks during the overload produced by phenylephrine infusion. Background. -It is known that circulatory changes occur during migraine. However, the relationship between this finding and transient cardiac dysfunction is still unknown. Methods. -By means of two-dimensional direct M-mode echocardiography, we measured fractional shortening, ejection fraction, and mean velocity of circumferential fibers shortening in 18 patients with migraine and in 10 normal subjects as a control group. These measures were performed in two different periods: during attack-free intervals and during attacks. Pain intensity of typical migraine attack was evaluated on a 0 to 10 scale. Results. -Cardiac size and function were normal at rest in both groups. However, during migraine attacks, phenylephrine infusion provoked significant decrease in fractional shortening,EF, and mean velocity of circumferential fibers shortening, followed by concomitant increase of headache severity. On the other hand, during the attack-free interval and in the control group phenylephrine infusion did not show significant changes in cardiac function parameters. Conclusions. -Our data suggest that left ventricular dysfunction during the phenylephrine test could participate in the complex pathophysiological mechanism of migraine attacks.

关键词：头痛发作左心室功能不全无症状去氧肾上腺素偏头痛患者 M型超声心动图肌纤维收缩心脏表现

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A型肉毒毒素对预防偏头痛发作似无作用

基础医学与临床 2007年第10期27卷 1117-1117页

克罗地亚萨格勒布医科大学的Maja Relja博士及其同事在7月的《头痛》（Cephalalgia，2007；27：492-503．）上报道Ⅱ期试验的结果：使用A型肉毒毒素（BoNTA）多次治疗，对于预防偏头痛发作与安慰剂无显著差异。

关键词： A型肉毒毒素头痛发作预防医科大学克罗地亚 Ⅱ期试验安慰剂

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丛集性头痛与发作性偏头痛的鉴别诊断

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 18-19页

作者： Zidverc-Trajkovic J. Pavlovic A.M. Mijajlovic M. 郭俊 Institute of Neurology Dr Subotica 611000 Belgrade Serbia and Montenegro

The utility of the differences between cluster headache (CH) and paroxysmal he micrania (PH) is limited by the considerable overlap of their clinical character istics. We compared 54 patients with CH and eight patients with PH in terms of d emographic features, characteristics of headache attacks, associated autonomic f eatures, temporal forms of disorders, and response to verapamil. According to ou r results, clinical features that distinguished CH and PH patients were: maximal pain localization, ocular in CH patients and extra-ocular in PH group;mean att ack duration was longer and mean attack frequency was lower in CH patients in co mparison with PH patients. Conjuctival injection was the only autonomic sign see n more frequently in CH patients. There were more CH patients with episodic and more PH patients with unremitting form of the disorder in examined groups. Altho ugh statistical analysis pointed out a significant difference between these clin ical features, there was no clinical characteristic that exclusively belonged to one of these headache entities. Demographic characteristics (age,gender, social background), the other headache attack features(nocturnal attacks, interattack tenderness), the other autonomic signs, as well as the response to verapamil did not differ significantly between two groups.

关键词：丛集性头痛鉴别诊断头痛发作神经体征发作持续时间自主神经症状发作间期维拉帕米时间形态发病形式