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Possible therapeutic role of Ig E blockade in irritable bowel syndrome

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World Journal of Gastroenterology 2016年第43期22卷 9451-9456页

作者： Eli Magen Tinatin Chikovani Medicine C Department Allergy and Clinical Immunology Unit Barzilai Medical Center Ben Gurion University of Negev Department of Microbiology and Im-munology Tbilisi State Medical University

Omalizumab is a humanized monoclonal antibody that binds to the high-affinity type-I Ig E Fc receptors on mast cells(MCs) and basophils, inhibiting the Ig E immune pathway. Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder, and dysregulation of the immune system likely contributes to its etiology and/or symptomatology. Colonic biopsies from patients with IBS demonstrate considerable increase in the number of degranulating MCs releasing histamine in proximity to nerves, and this event may underlie the common IBS symptom of abdominal pain. Pharmacologic control of MC activation and mediator release is a current area of active interest in the field of IBS research. Recently, we and Pearson et al described 2 cases of patients with IBS with diarrhea(IBS-D) showing positive clinical response to omalizumab. In both cases, the female patients had severe, long-lasting IBS-D and achieved an almost complete resolution of IBS symptoms. Both patients were also able to discontinue all IBS medications after commencing the anti-Ig E therapy. For both patients, the omalizumab treatment showed a relatively rapid onset of action, resembling the efficacy observed in and previously reported for patients with chronic spontaneous urticaria. In this Editorial, we discuss the possible biological mechanisms that may underlie the clinical efficacy of omalizumab in IBS. We suggest that there is a need for a well-designed prospective study to investigate the therapeutic effects of anti-Ig E in IBS.

关键词： IgE Omalizumab 急躁的肠症候群反煽动性有腹泻的急躁的肠症候群

Antioxidant,anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl.&Cham

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1047-1053页

作者： Claudia V.Moreno-Quirós Alberto Sánchez-Medina Maribel Vázquez-Hernández Ana G.Hernández Reyes Rosa V.García-Rodríguez Unidad de Servicios de Apoyo en Resolución Analítica Universidad VeracruzanaXalapaVeracruzMexico

Objective: To evaluate the anti-inflammatory, analgesic, antioxidant and acute toxicity of extracts obtained from a successive extraction with solvents of ascending polarity[hexane, hex; chloroform, CHCl3 and ethanol(Et OH)] of Ternstroemia sylvatica Schltdl.& ***: The antioxidant potential was evaluated by 2,2 diphenyl-1-picrylhydrazyl, the ferric reducing/antioxidant power assays and by determining the total phenolic *** anti-inflammatory and antinociceptive effects were evaluated using the in vivo croton oil-induced ear edema, phorbol 12-myristate 13-acetate induced ear edema, carrageenaninduced paw edema, acetic acid-induced writhing and formalin murine models. The acute toxicity was tested using the Lorke's method in ***: The Et OH extract was the most active for the antioxidant potential tests diphenyl-1-picrylhydrazyl(68.70% inhibition), ferric reducing/antioxidant power[(2 431.30 ± 102.10) mmol Fe2+and total polyphenols content(215.80 ± 8.50) meq AG/g]. The anti-inflammatory activity was evaluated by topical application of croton oil(2 mg/ear dose) where the Et OH extract showed the strongest activity compared to the control group(45.13% inhibition), whereas in the phorbol 12-myristate 13-acetate model,at the same dose, the CHCl3 extract showed the highest inhibition(42.88%). In the carrageenan induced edema model, the Et OH extract showed a stronger inhibition compared to indomethacin(56.34% and 50.70% at doses of 250 and 500 mg/kg of extract, respectively) during the first hour. Similarly, the same extract showed the highest analgesic activity(30.60% inhibition) in the acetic acid contortion assay, and in the formalin test it showed a greater effect with respect to the control group in both ***: Our work confirms the value of Ternstroemia sylvatica as an important anti-inflammatory and analgesic plant, whose mechanism seems to be associated to its antioxidant effects, and supports its uses in the Mexican traditional

关键词： Ternstroemia sylvatica 反煽动性止痛药用的植物

Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis

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World Journal of Gastroenterology 2017年第20期23卷 3615-3623页

作者： Jun Li Shu Zhang Rui Zhou Jian Zhang Zong-Fang Li National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy the Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy Department of General Surgerythe Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine

Acute pancreatitis(AP)is one of the most common *** is associated with significant morbidity and mortality,but it lacks specific and effective *** Chinese medicine(TCM)is one of the most popular complementary and alternative medicine modalities worldwide for the treatment of *** current evidence from basic research and clinical studies has shown that TCM has good therapeutic effects on *** review summarizes the widely used formulas,single herbs and monomers that are used to treat AP and the potential underlying mechanisms of *** of the abundance,low cost,and safety of TCM as well as its ability to target various aspects of the pathogenesis,TCM provides potential clinical benefits and a new avenue with tremendous potential for the future treatment of AP.

关键词：尖锐胰腺炎繁体中文药其他的治疗胰保护反煽动性

Bilirubin in coronary artery disease:Cytotoxic or protective?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 469-476页

作者： Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule Department of Medicine Westchester Medical CenterNew York Medical College Department of Medicine Cleveland Clinic Department of Medicine Sinai Hospital of BaltimoreJohns Hopkins University Department of Medicine University of Minnesota Department of Medicine University of Pittsburgh Einstein Healthcare Network Government Medical College Division of Gastroenterology and Hepatobiliary Disease New York Medical College

Bilirubin has traditionally been considered a cytotoxic waste ***,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative *** properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative *** fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of *** this article,we review the current literature exploring the association between levels of bilirubin and risk of *** conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.

关键词： Bilirubin 细胞毒素保护抗氧化剂反煽动性反冠的动脉疾病类脂化合物 peroxidation 吉伯