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简论文艺和宗教对人的主体心性的反向作用

江西社会科学 1991年第5期11卷 87-90页

作者：谢珊珊

文艺和宗教是人类文化史上最古老的学科之一,它们既象一对孪生兄弟,有着共同的渊源、共同的特点,同时又互相排斥、相互对立,各自以独特的形式掌握世界,探索人生的目的和意义。文艺和宗教这种既互相融合、利用又相互排斥,对立的现象,在文... 详细信息

文艺和宗教是人类文化史上最古老的学科之一,它们既象一对孪生兄弟,有着共同的渊源、共同的特点,同时又互相排斥、相互对立,各自以独特的形式掌握世界,探索人生的目的和意义。文艺和宗教这种既互相融合、利用又相互排斥,对立的现象,在文艺,宗教发展史上写下了奇妙的一页。历史上的文艺宗教现象林林总总,纷繁复杂,它们之间的关系涉及到许多方面,要在短短几千字之内理清它们的关系,似乎不太可能。基于此。

关键词：宗教文艺主体心性反向作用掌握世界的方式宗数宗教情感感性直观直觉感知艺术情感

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论谣言对戊戌革新运动的反向作用

教学与管理 1988年第4期 26-29页

作者：杨军

谣言,在戊戌革新运动中起了不能低估的与历史发展相悖的反向作用。今天,探讨这个问题,从中引出教训,对于加强当前改革过程中的舆论宣传工作,有着重要的借鉴作用,同时也有利于消弭某些“小道消息”及其不良影响。

关键词：守旧派反向作用慈禧政治势力矫枉过正现象革新运动戊戌

帕金森病与重症肌无力——安坦在神经肌肉传递上的反向作用

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上海第二医科大学学报 1989年第1期 62-62页

作者：蔡海鸥

报道一例60岁的男性原发性帕金森病,病史5年,未作过任何治疗。后因病情加重,给予安坦4mg/d。3天后,加用左旋多巴(200mg/d)。用安坦一周后,患者出现肩、颈肌无力,睑下垂、复视。安坦增加到6mg/d,震颤改善,但乏力现象继续加重,并出现吞... 详细信息

报道一例60岁的男性原发性帕金森病,病史5年,未作过任何治疗。后因病情加重,给予安坦4mg/d。3天后,加用左旋多巴(200mg/d)。用安坦一周后,患者出现肩、颈肌无力,睑下垂、复视。安坦增加到6mg/d,震颤改善,但乏力现象继续加重,并出现吞咽困难。经静脉注射氯化腾喜龙,肌无力症状减轻。乙酰胆碱受体(AchR)抗体滴定率为17nmol/L(正

关键词：安坦帕金森病重症肌无力神经肌肉传递肌无力症状左旋多巴腾喜龙乙酰胆碱受体 AchR 反向作用

A DNA vaccine against extracellular domains 1-3 of flk-1 and its immune preventive and therapeutic effects against H22 tumor cell in vivo

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World Journal of Gastroenterology 2004年第14期10卷 2039-2044页

作者： FanLü Zhao-YinQin Wen-BinYang Yin-XinQi Yi-MinLi DepartmentofGeneralSurgery SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina DepartmentofGeneralSurgery SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina

AIM: To construct a DNA vaccine against extracellular domains 1-3 of fetal liver kinase-1(flk-1), and to investigate its preventive and therapeutic effect against H22 cell in vivo. METHODS: Flk-1 DNA vaccine was produced by cloning extracellular domains 1-3 of flk-1 and by inserting the cloned gene into pcDNA3.1(+). Fifteen mice were divided into 3 groups and inoculated by vaccine, plasmid and saline respectively to detect specific T lymphocyte response. Thirty Mice were equally divided into preventive group and therapeutic group. Preventive group was further divided into V,P,andS subgroups, namely immunized by vaccine,pcDNA3.1(+) and saline, respectively, and attacked by H22 cell. Therapeutical group was divided into 3 subgroups of V,P and S, and attacked by H22, then treated with vaccine, pcDNA3.1(+) and saline, respectively. The tumor size, tumor weight, mice survival time and tumor latency period were compared within these groups. Furthermore,intratumoral microvessel density (MVD) was assessed by immunohistochemistry. RESULTS: DNA vaccine pcDNA3.1(+)flk-1-domains 1-3 was successfully constructed and could raise specific CTL activity. In the preventive group and therapeutic group,tumor latency period and survival time were significantly longer in vaccine subgroup than that in P and S subgroups (P＜0.05);the tumor size, weight and MVD were significantly less in vaccine subgroup than that in P and S subgroups (P＜0.05). The survival time of therapeutic vaccine subgroup was significantly shorter than that of preventive vaccine subgroup (P＜0.05);the tumor size, and MVD of therapeutic vaccine subgroup were significantly greater than that of preventive vaccine subgroup (P＜0.05).CONCLUSION: DNA vaccine against flk-1 domains 1-3 can stimulate potent specific CTL activity; and has distinctive prophylactic effect on tumor H22, and also can inhibit the tumor growth in vivo. This vaccine may be used as an adjuvant therapy because it is less effective on detectable tumor.

关键词： DNA疫苗细胞外功能区1-3 flk-1 免疫学预防性治疗作用反向作用 H22肿瘤细胞

Multidrug resistance reversal in human gastric carcinoma cells by neferine

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World Journal of Gastroenterology 2004年第20期10卷 3062-3064页

作者： Jian-GuoCao xiao-QingTang Shu-HongShi InstituteofOncology NanhuaUniversityHengyang421001HunanProvinceChina DepartmentofPhysiology NanhuaUniversityHengyang421001HunanProvinceChina

AIIVI: To investigate the reversal effect of neferine on multidrug resistance in human gastric carcinoma cell line. METHODS: Cells of a human gastric cancer cells line, SGC7901, and its vincristine (VCR) -resistant variant, SGC7901/VCR, were cultivated with or without neferine and/or VCR. The cytotoxic effect of VCR was evaluated by the MTT assay. Cell apoptosis induced by VCR was determined by flow cytometry(FCM). The expression of P-glycoprotein (P-gp) and a multidrug-resistance-associated protein (MRP) in cells was examined by immunofluorescence and FCM. RESULTS: Neferine at the concentration from 2.5 μmol/L to 10 μmol/L had no cytotoxicity to SGC7901 cells, and its variant SGC7901/VCR cells. The ICso of VCR against SGC7901 and SGC7901/VCR cells was 0.059 μg/mL and 2.32 μg/mL, respectively, indicating that SGC7901/VCR cells were 39 times more resistant to VCR than its parent SGC7 901 cells. After treatment with neferine at concentrations of 2.5, 5 and 10 μmol/L, the IC50 of VCR to SGC7901/VCR cell line decreased to 0.340, 0.128 and 0.053 μg/mL, respectively,thus, increased the chemosensitivity by 6.8-, 18.1- and 43.8-fold, respectively. SGC7901/VCR cells were apoptosis resistant to VCR. Neferine (2.5, 5 and 10 μmol/L) promoted the VCR-induced apoptosis of SGC7901/VCR cells in a dosedependent manner. The expressions of P-gp and MRP were strongly positive in SGC7901/VCR cells, which were significantly down-regulated after treatment with neferine (10 μmol/L)for 24 h. CONCLUSION: Neferine reverses multidrug resistance of human gastric carcinoma SGC7901/VCR cells, which may be associated with the down-regulations of P-gp and MRP expression in SGC701/VCR cells.

关键词：多数药剂抵抗力反向作用胃癌癌细胞肿瘤荷花碱

Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resiatant human colon carcinoma LoVo/5-FU cells

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World Journal of Gastroenterology 2004年第13期10卷 1979-1983页

作者： Zhi-WeiYu PengZhao MingLiu Xin-ShuDong JiTao Xue-QinYao Xin-ttuaYin YuLi Song-BinFu DepartmentofAbdominalSurgery theThirdAffiliatedHospitalofHarbinMedicalUniversityHarbin150040HeilongjiangProvinceChina DepartmentofGeneralSurgery ThefifthHospitalofHarbinMedicalUniversityHarbin150040HeilongjiangProvinceChina DepartmentofGeneralSurgery NanfangHospitalGuangzhou510515GuangdongProvinceChina DepartmentofGeriatrics theSecondAffiliatedHospitalofHarbinMedicalUniversityHarbin150096HeilongjiangProvineceChina DepartmentofMolecularBiology HarbinMedicalUniversityHarbin150057HeilongjiangProvinceChina

AIM: To observe the reversal effects of wide-type p53 gene on multi-drug resistance to 5-FU (LOVO/5-FU).METHODS: After treatment with Ad-p53, LOVO/5-FU sensitivity to 5-Fu was investigated using tetrazolium dye assay. Multidrug resistance gene-1 (MDR1) gene expression was assayed by semi-quantitative reverse transcriptionpolymerase chain reaction and the expression of p53 protein was examined by Western ***: The reversal activity after treatment with wide type p53 gene was increased up to 4.982 fold at 48 h. The expression of MDR1 gene decreased significantly after treatment with wide-type p53 gene, and the expression of p53 protein lasted for about 5 d, with a peak at 48 h, and began to decrease at 72 ***: Wide-type p53 gene has a remarkable reversal activity for the high expression of MDR1 gene in colorectal cancers. The reversal effects seem to be in a time dependent manner. It might have good prospects in clinical application.

关键词：反向作用 5-氟抵抗力腺病毒调节作用基因表达野生型 p53基因多药炕药性结肠癌肿瘤 LoVo/5-FU

地基、基础与上部结构共同工作相互作用问题探讨

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农业科学研究 1993年第3期23卷 76-79页

作者：王伟

1 问题的提出传统的地基基础设计方法是把地基、基础与上部结构作为独立的结构单元分别设计计算。通常的方法是先把上部结构分离出来,然后根据已知的荷载用普通结构力学方法进行内力分析,并求出各支座反力,将其反向作用在基础上,再作... 详细信息

1 问题的提出传统的地基基础设计方法是把地基、基础与上部结构作为独立的结构单元分别设计计算。通常的方法是先把上部结构分离出来,然后根据已知的荷载用普通结构力学方法进行内力分析,并求出各支座反力,将其反向作用在基础上,再作简化计算。假定地基对基础反力是按直线分布的,此时,基础上全部作用力为已知,便可求出各基础各截面的内力和变位。进而,将地基对基础的反力反向作为地基的荷载,最后便可求出地基各点的变位。

关键词：上部结构地基基础结构力学方法支座反力反向作用内力分析附加应力不均匀沉降直线分布简化计算

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总结与简化物理规律数学表达式的方法

中学物理 2008年第3期26卷 62-64页

作者：阴瑞华河北省唐山师范学院物理系

物理规律是物理学理论体系中最核心的内容,只有掌握了物理规律,才能遵循这些规律去分析、处理千变万化的物理问题.因此,理解和掌握物理规律理所当然地也就成为学习物理的中心任务,更是物理教师教学中的重中之重.但是,在物理规律的教学中... 详细信息

物理规律是物理学理论体系中最核心的内容,只有掌握了物理规律,才能遵循这些规律去分析、处理千变万化的物理问题.因此,理解和掌握物理规律理所当然地也就成为学习物理的中心任务,更是物理教师教学中的重中之重.但是,在物理规律的教学中,经常遇到这样二个问题:一是如何总结得出物理规律的数学表达式:实际教学中,通过实验得出正比例或者反必例关系式,这是很容易的.但是。

关键词：物理规律物理教师物理学理论中心任务中学物理焦耳定律二次函数阿基米德定律牛顿第二定律反向作用

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混凝土刚架拱梁与索梁预应力计算方法分析

建筑结构 2017年第23期47卷 27-29页

作者：张小冬白福波袁振军哈尔滨工业大学建筑设计研究院哈尔滨150090

钢筋混凝土刚架拱梁与索梁结构由普通钢筋混凝土与预应力钢筋混凝土两种构件组成,将预应力作为等效荷载作用进行结构内力分析与构件截面设计时,需要计算主弯矩、次弯矩和综合弯矩。通过七个正截面内力计算简图推证:只需计算一个综合弯矩... 详细信息

钢筋混凝土刚架拱梁与索梁结构由普通钢筋混凝土与预应力钢筋混凝土两种构件组成,将预应力作为等效荷载作用进行结构内力分析与构件截面设计时,需要计算主弯矩、次弯矩和综合弯矩。通过七个正截面内力计算简图推证:只需计算一个综合弯矩,再计入预压轴力对截面的作用,即可建立适合预应力复杂结构在承载能力极限状态下的截面计算公式,及正常使用极限状态下的钢筋应力增量计算公式。因预应力作用与外荷载对结构构件作用的方向相反,使构件控制截面上的内力绝对值变小,使结构可以承担更大荷载。

关键词：刚架拱梁与索梁作用内力综合弯矩强度差反向作用