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卵巢肿瘤患者血清中TPS、CA125水平及其临床意义

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福建医药杂志 2007年第6期29卷 108-108,90页

作者：王小梅郑辉哲福建省级机关医院 350003 福建省肿瘤医院

卵巢恶性肿瘤是女性生殖系统三大恶性肿瘤之一.由于卵巢位于盆腔深部,不易扪及或查出,至今缺乏有效的早期诊断方法,其5年存活率仅为25%～30%[1].因此,早期诊断,早期治疗是提高卵巢癌生存率和降低死亡率的关键.组织多肽特异性抗原(tissue... 详细信息

卵巢恶性肿瘤是女性生殖系统三大恶性肿瘤之一.由于卵巢位于盆腔深部,不易扪及或查出,至今缺乏有效的早期诊断方法,其5年存活率仅为25%～30%[1].因此,早期诊断,早期治疗是提高卵巢癌生存率和降低死亡率的关键.组织多肽特异性抗原(tissue polypeptide specific antigen,TPS)是一种反映肿瘤细胞分裂和增殖活性的标志物,可用于卵巢癌的诊断.卵巢特异性抗原(carbohydrate antigen125,CA125)已广泛应用于卵巢癌的临床诊断及监测[2].我们研究了TPS对卵巢肿瘤的诊断价值及其与CA125的关系,现将结果报告如下.

关键词：卵巢肿瘤患者 CA125水平 TPS 临床意义组织多肽特异性抗原卵巢恶性肿瘤卵巢特异性抗原血清

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卵巢肿瘤患者焦虑抑郁情绪影响因素调查研究

中国医药指南 2012年第35期10卷 583-584页

作者：薛杰韬樊娟冼小燕舒欣广东省湛江市坡头区中国海洋石油南海西部医院妇产科广东湛江524057

目的研究调查卵巢肿瘤患者焦虑抑郁情绪的影响因素。方法对我院患有卵巢肿瘤的202例患者进行调查研究,主要采取对这202例患者发放焦虑抑郁量表的形式。结果对202例患者进行调查后发现,焦虑呈阳性的患者有45例(22.28%),抑郁呈阳性的患者... 详细信息

目的研究调查卵巢肿瘤患者焦虑抑郁情绪的影响因素。方法对我院患有卵巢肿瘤的202例患者进行调查研究,主要采取对这202例患者发放焦虑抑郁量表的形式。结果对202例患者进行调查后发现,焦虑呈阳性的患者有45例(22.28%),抑郁呈阳性的患者有53例(26.23%)。患者越了解自己的病情,或病情越严重,出现焦虑和抑郁的比例越高。且患者的文化程度越高,患者就越不容易出现焦虑。患者的抑郁、焦虑情绪还与患者的婚姻状况、家庭和谐程度有关,而抑郁与患者的文化程度等无明显关系。结论主要影响患者焦虑、抑郁的因素有患者的病情、对病情的了解情况、婚姻状态、家庭关系,患者的文化程度可影响患者的焦虑,对抑郁的情绪无明显的影响。

关键词：卵巢肿瘤患者焦虑抑郁影响因素调查研究

卵巢肿瘤患者血清CA125、CA199及其联检的临床意义

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放射免疫学杂志 2006年第1期19卷 58-58页

作者：王琳滕佩红姜丽华张乐研杨晓平解放军第107中心医院检验科 264002

本文通过测定卵巢肿瘤患者血清CA125、CA199及联检,探讨其在卵巢肿瘤鉴别中的应用价值.

关键词：血清CA125 卵巢肿瘤患者 CA199 临床意义联检

交界性或浸润性卵巢肿瘤患者保守治疗后接受辅助生殖技术的安全性研究(法国)

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 20-20页

作者： Fortin A. Hazout A. Thoury A. P. Madelenat 李跃萍 Service Gynécologie-Obstétrique MaternitéAline-de-CrépyYCHU Bichat-Claude-Bernard 46 rue Henri-Huchard 75018 Paris France

Objective. -Ovulation induction, the usual resort of Assisted Reproductive Technologies (ART), has been suspected of carrying a responsibility in the genesis of ovarian tumours. For patients with a borderline or invasive ovarian tumour, treated by conservative surgery and desiring to become pregnant, the problem is thus of a possible resort to the Assisted Reproductive Technologies. Patients and methods. -This is a multicenter, national and retrospective study. 40 operated patients between January 1971 and January 2001 have been included. 27 patients (67.5% ) had a borderline tumour, 10 (25% ) a non-epithelial tumour (germinal or stromal) and 3 (7.5% ) an epithelial invasive carcinoma. All these patients have benefited from a conservative surgical management of fertility. The Assisted Reproductive Technologies were simple stimulation for 5 women and IVF for the 35 others. The effectiveness and the risks of Assisted Reproductive Technologies have been estimated respectively by the number of pregnancies obtained and the recurrence rates. Results. -With a global follow-up of 372 months (January 1971: date of the primary surgical procedure -June 2002: closing of the study), 17 patients have obtained 17 pregnancies with the Assisted Reproductive Technologies, rate of 42.5% (17/40): 1 spontaneous abortion, 16 delivery with 23 children (triple pregnancies and 3 twin pregnancies). 3 patients treated for a borderline tumour have had a recurrence after induction of ovulation. Among the 40 patients, no one presented an evolved disease at the last news. The patients who had a recurrence had a delay to begin the Assisted Reproductive Technologies significantly lower than the patients who had no recurrence. Discussion and conclusion. -The assisted reproductive technologies for patients who had been treated for a borderline or invasive ovarian tumour, and who were infertile in spite of conservative management, have allowed 42.5% of these women to obtain a pregnancy and does not se

关键词：卵巢肿瘤患者交界性辅助生殖技术上皮性卵巢肿瘤浸润性卵巢癌体外受精妊娠数诱导排卵保守手术自发性流产

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18例妊娠合并卵巢肿瘤患者的围手术期护理

哈尔滨医药 2011年第1期31卷 80-80页

作者：冷晓红黑龙江省林甸县人民医院黑龙江林甸166330

妊娠合并卵巢肿瘤或急腹症时,常须通过手术进行治疗。为保证孕妇与胎儿的安全,手术治疗方案的选择及围手术期的护理尤为重要。妊娠合并附件肿物儿需要手术治疗者,占所有妊娠妇女的1‰。对有生育要求的妊娠合并卵巢肿瘤患者,适宜手术的... 详细信息

妊娠合并卵巢肿瘤或急腹症时,常须通过手术进行治疗。为保证孕妇与胎儿的安全,手术治疗方案的选择及围手术期的护理尤为重要。妊娠合并附件肿物儿需要手术治疗者,占所有妊娠妇女的1‰。对有生育要求的妊娠合并卵巢肿瘤患者,适宜手术的时间是14~18孕周。2008年1月至2008年12月我科共收治18例此类患者并行手术治疗,经术前、术后实施针对性的护理,取得了较好的效果,

关键词：围手术期护理卵巢肿瘤患者妊娠妇女治疗方案手术治疗附件肿物生育要求急腹症

恶性与良性卵巢肿瘤患者血清中O^6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)和谷胱甘肽S-转移酶(GST)活性的意义

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 28-28页

作者： Akc.ay T. Dinc.er Y. Alademir Z. 刘亦恒 Fahrettin Kerim Gokay Cad. 156/4 Kadikoy Istanbul Turkey

Objective: To demonstrate O6- methylguanine- DNA methyltransferase (MGMT) and glutathione S- transferase (GST) activities by analyzing the sera separately obtained from patients with malignant ovarian tumors, benign ovarian tumors, and healthy individuals. Study Design: Fourty- nine patients with ovarian cancer, nine patients with benign tumors, and 22 healthy women were included in this study. Blood samples were obtained from all the subjects in the malignant- tumor, benign- tumor, and control groups. Patients with malignant tumors underwent second and third phlebotomies one week following the surgery and after the chemotherapy regimen, respectively. MGMT, GST, and protein levels were measured for each serum sample. GST activity of the samples was measured by the method of Habig et al. using l- chloro- 2- 4 dinitrobenzene (CDNB) as substrate. MGMT activity was measured by the transfer of radio labelled methyl groups from a prepared MG- DNA substrate to the enzyme fraction of serum. Protein concentration was measured by biuret method. Results: Our work demonstrated that untreated patients with malignant ovarian tumors revealed significantly greater MGMT and GST activities in their sera than did both healthy individuals and patients with benign ovarian tumors, while no significant difference was found between the healthy group and the patients with benign ovarian tumors with respect to their sera MGMT and GST activities. GST activity following chemotherapy was significantly lower than the postoperative values preceding chemotherapy. A relationship between sera MGMT and GST activities, tumor histology and pathology was not found in this study. Conclusion: Our work suggests the fact that detection of sera MGMT and GST activities is important in diagnostic and therapeutic approaches during the course of ovacancer.

关键词： DNA甲基转移酶卵巢肿瘤患者 GST MGMT O^6 谷胱甘肽良性卵巢肿瘤鸟嘌呤恶性卵巢肿瘤良性肿瘤组

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卵巢上皮肿瘤患者的症状及收诊科室

世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 60-60页

作者： Paulsen T K.rn J Kj.rheim K 朱晓明

Objective: To study referral to hospital units and the clinical characteristic s of women with epithelial ovarian tumors in a prospective, population-based st udy. Methods: Clinical information on all women diagnosed with epithelial invasi ve (n=486) and borderline ovarian tumors (n=137) in Norway during 2002 was deriv ed from notifications to the Cancer Registry of Norway and medical, surgical and histopathological records. Results: Sixty-one percent of women with invasive o varian tumors were initially referred to gynecology units. The 38%of women refe rred to surgical and medical units were more likely to have symptoms as ‘bowel irregularity’, ‘pain outside the abdominal cavity’, ‘persisting fatigue’and ‘respiratory difficulties’. These women were older, had lower performance sta tus and had a delay in treatment of 20 and 24 days respectively compared to 11 a t gynecology units. Conclusion: Greater awareness of the symptoms of ovarian can cer might lead to earlier diagnosis and treatment and thus possibly improve surv ival.

关键词：卵巢上皮卵巢肿瘤患者肠紊乱侵袭性呼吸困难大样本研究

腹腔镜下诊断与治疗青春期卵巢肿瘤36例分析

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中华妇产科杂志 2006年第1期41卷 66-67页

作者：尹方李光仪王刚广东省佛山市第一人民医院妇产科 528000

青春期卵巢肿瘤并不多见,多因下腹隐痛或剧痛、月经异常而行腹部B超或MRI、CT等检查时得以发现和诊断.其治疗方法以手术切除肿瘤为首选.与开腹手术相比,腹腔镜手术具有术后恢复快、切口小、愈合好、住院时间短等优点,因而更易于为青春... 详细信息

青春期卵巢肿瘤并不多见,多因下腹隐痛或剧痛、月经异常而行腹部B超或MRI、CT等检查时得以发现和诊断.其治疗方法以手术切除肿瘤为首选.与开腹手术相比,腹腔镜手术具有术后恢复快、切口小、愈合好、住院时间短等优点,因而更易于为青春期女性患者所接受.本文对36例经腹腔镜探查证实并手术治疗的青春期卵巢肿瘤患者的临床资料进行分析,探讨腹腔镜技术对青春期卵巢肿瘤的诊断和治疗价值。

关键词：卵巢肿瘤患者治疗方法青春期诊断腹腔镜下腹腔镜手术腹腔镜探查腹腔镜技术下腹隐痛腹部B超

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妊娠合并卵巢恶性肿瘤的诊断及处理

中国实用妇科与产科杂志 2007年第10期23卷 746-747页

作者：刘辉彭芝兰四川大学华西第二医院妇产科四川成都610041

在妊娠合并妇科恶性肿瘤中,卵巢恶性肿瘤居第2位,据报道妊娠合并卵巢肿瘤的比例为0.19%,其中恶性肿瘤占0.93%～3.00%不等,而在非妊娠期卵巢肿瘤患者中,恶性肿瘤可高达18%～21%[1-3].

关键词：卵巢恶性肿瘤非妊娠期诊断卵巢肿瘤患者妇科恶性肿瘤标准治疗生理性变化妊娠期妇女