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功能材料信息 2010年第4期7卷 58-59页

作者：周洪英

据海外媒体报道，美国宾夕法尼亚大学的研究人员近日开发出一个纳米级的碳基平台，可用于电子探测单个dna（脱氧核糖核酸）分子。该技术有望实现高通量低成本的快速dna电子测序。相关研究成果发表于近期的《纳米快报》上。

关键词：单个dna分子电子探测纳米孔美国宾夕法尼亚大学设备石墨脱氧核糖核酸研究人员

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石墨烯纳米孔设备可探测单个dna分子

纳米科技 2010年第4期7卷 74-75页

美国宾夕法尼亚大学的研究人员近日开发出一个纳米级的碳基平台，可用于电子探测单个dna（脱氧核糖核酸）分子。该技术最终有望在快速dna电子测序方面发挥“用武之地”。相关研究论文发表于最新一期的《纳米快报》。

关键词：单个dna分子电子探测纳米孔美国宾夕法尼亚大学设备石墨脱氧核糖核酸研究人员

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石墨烯纳米孔设备可探测单个dna分子

大众科技 2010年第9期12卷 7-7页

据物理学家组织网报道，美国宾夕法尼亚大学的研究人员近期开发出一个纳米级的碳基平台，可用于电子探测单个dna（脱氧核糖核酸）分子。该技术最终有望在快速dna电子测序方面发挥“用武之地”。相关研究论文发表于最新一期的《纳米快报》。

关键词：单个dna分子电子探测纳米孔美国宾夕法尼亚大学设备石墨脱氧核糖核酸物理学家

石墨烯纳米孔设备可探测单个dna分子有望实现高通量低成本快速dna电子测序

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中国西部科技 2010年第19期9卷 72-72页

[科技日报]据物理学家组织网报道,美国宾夕法尼亚大学的研究人员近日开发出一个纳米级的碳基平台,可用于电子探测单个dna（脱氧核糖核酸）分子。该技术最终有望在快速dna电子测序方面发挥＂用武之地＂。相关研究论文发表于最新一期的《... 详细信息

[科技日报]据物理学家组织网报道,美国宾夕法尼亚大学的研究人员近日开发出一个纳米级的碳基平台,可用于电子探测单个dna（脱氧核糖核酸）分子。该技术最终有望在快速dna电子测序方面发挥＂用武之地＂。相关研究论文发表于最新一期的《纳米快报》。

关键词：单个dna分子电子探测纳米孔测序低成本高通量美国宾夕法尼亚大学设备

Damage of dna ends induced by mechanical force during AFM nano-manipulation

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Nuclear Science and Techniques 2013年第1期24卷 26-31页

作者： DUAN Na WANG Xinyan ZHANG Chen ZHANG Yi HU Jun Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

An experimental and statistical study was carried out to explore the effects of mechanical forces on the ends of linear double-stranded dna (dsdna) fragments. Mechanical force was applied onto individual dna molecules during atomic force microscope (AFM)-based picking-up manipulation. By comparing the PCR efficiency of two dna fragments with primers either at ends or at the inner regions, it was found that the ends of dna fragments were damaged during picking-up process.

关键词：机械力 AFM dna损伤纳米操纵单个dna分子 dna片段诱导原子力显微镜

Detection and analysis of dna recapture through a solid-state nanopore

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Chinese Science Bulletin 2014年第35期59卷 4953-4959页

作者： Ying Hu Zhi Zhou Xinyan Shan Xinghua Lu Institute of Physics Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter

Motion control of a single molecule through a solid-state nanopore offers a new perspective on detecting and analyzing single *** recapture of a single dna molecule reveals the dynamics in dna translocation through a nanopore and may significantly increase the signal-to-noise ratio for dna base ***,the transient current at the moment of voltage reversal prevents the observation of instantly recaptured molecules and invalidates the continuous dna ping-pong *** performed and analyzed the dna translocation and recapture experiment in a silicon nitride solid-state *** calculation of molecular motion clearly shows the recapture dynamics with different delay *** prohibited time when the data acquisition system is saturated by the transient current is derived by equivalent circuit analysis and finite element *** COMSOL simulation reveals that the membrane capacitance plays an important role in determining the electric field distribution during the charging *** a result of the transient charging process,a non-constant driving force pulls the dna back to nanopores faster than theoretically *** observed long time constant in the transient current trace is explained by the dielectric absorption of the membrane capacitor.

关键词：单个dna分子纳米孔固态检测瞬态电流数据采集系统生物分子运动控制

Real time observation of the photocleavage of single dna molecules

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Chinese Science Bulletin 2003年第7期48卷 673-675页

作者： LI Bin , HU Jun , WANG Ying, WU Shiying, HUANG Yibo & LI Minqian Shanghai Institute of Nuclear Research,Chinese Academy of Sciences, Shanghai 201800,China Shanghai Institute of Nuclear Research Chinese Academy of Sciences Shanghai 201800 China

A method for real time observation of photo-cleavage of stretched λdna at single molecular level by a fluorescent microscope coupled with CCD is developed. dna molecules stained with YOYO-1 are stretched by the mo-lecular combing technique and fixed on a modified slide. Then the process of photocleavage and relaxation of dna under radiation of blue light is observed. We speculate that the conformation change of stretched dna and the effect of water are likely to facilitate the effect of YOYO photocleav-age dna molecules. The photocleavage effect of YOYO for stretched dna may be useful to study dna elasticity, cancer research as well as the interaction between dna and dyes.

关键词：单个dna分子光致断裂原子力显微镜荧光显微镜实时观察生物大分子

Combined-dynamic mode "dip-pen" nanolithography and physically nanopatterning along single dna molecules

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Chinese Science Bulletin 2004年第7期49卷 665-667页

作者： LIBin WANGYing WUHaiping ZHANGYi ZHANGZhixiang ZHOUXingfei LIMinqian HUJun ShanghaiInstituteofAppliedPhysics ChineseAcademyofSciences.Shanghai201800China ShanghaiJiaotongUniversity Bio-XScienceResearchCenter.Shanghai200030China

Atomic force micriscope (AFM)-based dip-pen nanolithography (DPN) is an emerging approach for con-structing nanostructures on material surfaces such as gold, silicon and silicon oxide. Although DPN is a powerful tech-nique, it has not shown its ability of direct-writing and pat-terning of nanostructures on surfaces of soft materials, for example biomacromolecules. Direct depositing on soft sur-faces becomes possible with the introduction of a com-bined-dynamic mode DPN rather than mostly used contact mode DPN or tapping mode DPN. In this report, the com-bined dynamic mode DPN is used for direct depositing pro-tein ink on dna molecules at the nanometer scale.

关键词：原子力显微镜浸笔纳米光刻技术单个dna分子纳米结构材料表面结合动力模型纳米图案