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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 62-62页

作者： Fowler J.F. Ghosh A. Sung J. M.S. Duh 李政霄 Analysis Group Inc. 111 Huntington Ave Boston MA 02199 United States

Background: The impact of chronic hand dermatitis (ChHD) on patient- reported outcomes and economic costs has not been assessed in a US population. Objective: We sought to evaluate the quality of life, work productivity, activity impairment, and health care costs of patients with ChHD versus those without ChHD. Methods: A 13- item self- assessment questionnaire to identify ChHD was developed and validated. Skindex- 29 and Work Productivity and Activity Impairment questionnaires were used to assess quality of life and work productivity for ChHD. The survey was mailed to a random sample of 1380 members of a Massachusetts managed care organization (N=507, response rate = 36.74% ). Univariate and multivariate analyses were conducted to determine the incremental effect of ChHD on quality of life, work productivity, and activity impairment. Health insurance claims were used to assess medical costs. Results: Quality of life, along with work productivity and activity impairment, were significantly worse for patients with CHD than for those without ChHD; however, there was no significant difference in work time missed. After adjusting for significant covariates, a 25% cost increase in total medical costs was found attributable to ChHD, which translates to an incremental cost of ＄ 70 per patient per month. Limitations: Survey response rate is not high; the survey respondents may not be completely representative of the nonrespondents. The cost burden of ChHD is underestimated because of the omission of over- the- counter drug and indirect costs. The multivariate models had a low goodness of fit indicated by the low R2 statistics. Conclusions: ChHD has a significant detrimental effect on quality of life,work productivity, activity impairment, and heath care costs. More awareness and treatment of this condition are needed to improve patient outcomes and decrease health care cost.

关键词：生活质量应答者应答率保健组织马萨诸塞州非处方共变量时间消耗多变量分析间接费用

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一项基于连接设备用户的大型队列研究评估步行和血压之间的关系

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中华老年心脑血管病杂志 2016年第1期18卷 24-24页

目的：最近发现升高或降低的血压与主体的活动有关,这也代表一个方便的预防工具。然而,客观的纵向的研究数据对于提供量身定制的建议是必要的。本研究的目的是基于连接设备大样本用户,来评估步行和血压之间关系。设计和方法：应用横截... 详细信息

目的：最近发现升高或降低的血压与主体的活动有关,这也代表一个方便的预防工具。然而,客观的纵向的研究数据对于提供量身定制的建议是必要的。本研究的目的是基于连接设备大样本用户,来评估步行和血压之间关系。设计和方法：应用横截面研究和纵向多元线性回归,分析了来自19000例携带Withings脉冲活动追踪器和无线血压计的成年人数据。

关键词：连接设备共变量多元线性回归队列研究追踪器质量指数体质量研究人群公共卫生保健非药物性

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转移性结直肠癌患者化疗期间的睡眠质量与预后相关

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中华结直肠疾病电子杂志 2015年第4期4卷 20-页

近2/3癌症患者存在睡眠障碍,流行病学研究表明昼夜节律损坏是导致睡眠问题的潜在机制,目前缺乏睡眠问题对癌症患者临床结果影响的大数据。法国Innominato博士在近期的Sleep Medicine杂志上发表研究,评估化疗前和化疗中转移性结直肠癌患... 详细信息

近2/3癌症患者存在睡眠障碍,流行病学研究表明昼夜节律损坏是导致睡眠问题的潜在机制,目前缺乏睡眠问题对癌症患者临床结果影响的大数据。法国Innominato博士在近期的Sleep Medicine杂志上发表研究,评估化疗前和化疗中转移性结直肠癌患者主观睡眠不佳对预后的作用,结果表明睡眠质量与转移性结直肠癌的临床预后相关。共纳入361例未化疗的转移性结直肠癌患者进行EORTC QLQ-C30问卷调查,将睡眠主诉作为正常或时间依赖性共变量(TDC),采用Cox比例风险模型。

关键词：转移性结直肠癌睡眠质量共变量昼夜节律流行病学研究 EORTC 睡眠问题进展期结直肠癌潜在机制问卷调查

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急性冠状动脉综合征患者中输血与临床结局

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 5-5页

作者： Rao S.V. Jollis J.G. Harrington R.A. 任付先 Duke Clinical Research Institute 2400 Pratt St Durham NC 27715 United States Dr.

Context: It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associated with improved survival. Objective: To determine the association between blood transfusion and mortality among patients with acute coronary syndromes who develop bleeding, anemia, or both during their hospital course. Design, Setting, and Patients: We analyzed 24112 enrollees in 3 large international trials of patients with acute coronary syndromes (the GUSTO IIb, PURSUIT, and PARAGON B trials). Patients were grouped according to whether they received a blood transfusion during the hospitalization. The association between transfusion and outcome was assessed using Cox proportional hazards modeling that incorporated transfusion as a time-dependent covariate and the propensity to receive blood, and a landmark analysis. Main Outcome Measure:Thirtyday mortality. Results: Of the patients included, 2401(10.0%) underwent at least 1 blood transfusion during their hospitalization. Patients who underwent transfusion were older and had more comorbid illness at presentation and also had a significantly higher unadjusted rate of 30-day death (8.00%vs 3.08%; P < .001), myocardial infarction(MI) (25.16%vs 8.16%; P < .001), and death/MI(29.24%vs10.02%; P < .001) compared with patients who did not undergo transfusion. Using Cox proportional hazards modeling that incorporated transfusion as a timedependent covariate, transfusion was associated with an increased hazard for 30-day death (adjusted hazard ratio , 3.94; 95%confidence interval, 3.26-4.75) and 30-day death/MI(HR, 2.92; 95%CI, 2.55-3.35). In the landmark analysis that included procedures and bleeding events, transfusion was associated with a trend toward increased mortality. The predicted probability of 30-day death was higher with transfusion at nadir hematocrit values above 25%. Conclusions: Blood transfusion in the setting of acute coronary syndromes is associated with higher mortality, and this relationship persists

关键词：临床结局合并出血贫血患者共变量缺血性心脏病出血事件输血治疗临床试验资料试验结果研究指标

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补充铁剂对母乳喂养的足月低出生体重儿血液学的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 18-18页

作者： Aggarwal D. Sachdev H. P. S. Nagpal J. 贺莉 E-6/ 12 Vasant Vihar New Delhi-110 057 India Prof.

Aims: To determine the haematological effects of iron supplementation in predo minantly breast fed term low birth weight (LBW) infants. Methods: Seventy three healthy term LBW ( < 2500 g), predominantly breast fed infants aged 50-80 days were randomised into two groups to receive either iron (3 mg/kg/day) (iron suppl emented (IS) group; n = 37) or placebo drops (placebo (P) group; n = 36). Haemat ological parameters and anthropometrywere measured at baseline and repeated afte r four and eight weeks. Results: A total of 62 subjects (32 in the IS group and 30 in the P group) came for the first follow up and 26 (13 in the IS group and 1 3 in the P group) reported for the second visit. There were no significant diffe rences in serum ferritin and anthropometry. However, covariates (infant age, hae moglobin, and ferritin, and maternal haemoglobin) adjusted haemoglobin change wa s significantly higher in the IS group after fourweeks (4.6 g/l;95%CI 0.5 to 8.8) and eightweeks (8.6 g/l; 95%CI 1.8 to 15.4). Conclusions: Iron supplem entation in a therapeutic dose in term breast fed LBW infants results in a margi nal increase in haemoglobin. The functional benefit of this haemoglobin rise req uires further evaluation.

关键词：母乳喂养铁剂人体测量学安慰剂血清铁蛋白重复测量共变量补充治疗周和

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