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世界核心医学期刊文摘(神经病学分册) 2006年第2期 14-15页

作者： Stoeck K. Bodemer M. Ciesielczyk B. I.Zerr 郭俊 Department of Neurology Georg-August University Robert-Koch-Str 40 37075 G ttingen Germany.Dr

Background: In neurodegenerative diseases, increasing attention has been focus ed on inflammatory mediators such as pro-inflammatory and anti-inflammatory cy tokines and their potential influence in the process of neurodegeneration. In pr ion diseases, much data has been gained on the cell culture and animal disease m odels level, but only limited information is available on humans affected by Cre utzfeldt-Jakob disease (CJD). Objective: To obtain data on anti-inflammatory c ytokines interleukin 4 and interleukin 10 in the cerebrospinal fluid of patients with CJD, patients with other dementia, and nondemented neurological patients a nd controls. Design: Cerebrospinal fluid samples were collected from CJD patient s and control subjects, and concentrations of the anti-inflammatory cytokines i nterleukin 4 and interleukin 10 were determined using an enzyme-linked immunoso rbent assay. Patients: Cerebrospinal fluid samples from 61 patients were analyze d. The group was composed of patients with CJD (n=20), patients with other forms of dementia (n=10), patients with motoneuron disease (n=6), patients with normal pressure hydrocephalus (n=5), and control subjects (n=20). Results: Interleukin 10 levels were significantly elevated in the cerebr ospinal fluid of CJD patients (median, 9.8 pg/mL). The elevation was significant to other dementia (median, 7.9 pg/mL, P < .05), motoneuron disease (median, 7.9 pg/mL, P < .05), normal pressure hydrocephalus (median, 7.0 pg/mL, P < .05), an d controls (median, 1.3 pg/mL, P < .001). Levels of interleukin 4 were significa ntly elevated in cerebrospinal fluid of patients with CJD (median, 26.4 pg/mL) c ompared with control subjects (median, 6.2 pg/mL, P < .001) and patients with a motoneuron disease (median, 10.5 pg/mL, P < .001). Conclusions: Elevated levels of the anti-inflammatory cytokines interleukin 4 and interleukin 10 in cerebros pinal fluid of patients with CJD are new findings. The data of the present study provide a clue towa

关键词：克罗伊茨 IL-4 脑脊液患者 CJD 费尔特雅各布

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变异型克罗伊茨费尔特-雅各布病的危险因素:一项病例对照研究

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 10-11页

作者： Ward H.J.T. Everington D. Cousens S.N. 江山 National CJD Surveillance Unit University of Edinburgh Western General Hospital Crewe Road EdinburghEH4 2XU United KingdomDr

Objective: To investigate the potential risk factors for variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom. Methods: Definite and probable vCJD cases (n = 136) were residing in Great Britain at disease onset, and were referred between May 1995 and November 2003. Control subjects (n = 922) were recruited between 2002 and 2003, from 100 randomly selected geographical clusters sampled to represent the geographical distribution of vCJD. Results: Reported frequent consumption of beef and beef products thought likely to contain mechanically recovered or head meat, or both, including burgers and meat pies, was associated with increased risk for vCJD, as was reported frequent chicken consumption. Surgical operations were generally similarly reported for cases and control subjects, with the exception of a small group of minor operations, possibly attributable to underreporting in control subjects. Cases and control subjects had similar reported occupational histories and exposure to animals. Interpretation: These findings are consistent with dietary exposure to contaminated beef products being the main route of infection of vCJD, but recall bias cannot be excluded. There was no convincing evidence of increased risk through medical, surgical, or occupational exposure or exposure to animals.

关键词：克罗伊茨费尔特变异型雅各布

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与硬脑膜移植有关的克罗伊茨费尔特——雅各布病1979年1月～1996年5月,日本

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疾病监测 1998年第6期 41-42页

与硬脑膜移植有关的克罗伊茨费尔特—雅各布病１９７９年１月～１９９６年５月，日本１９９７年，日本克罗伊茨费尔特—雅各布病（ＣＪＤ）民间观察组向文厚省报告了其对全日１９９６份神经学、精神病学及神经病理学机构通信问卷调查的... 详细信息

与硬脑膜移植有关的克罗伊茨费尔特—雅各布病１９７９年１月～１９９６年５月，日本１９９７年，日本克罗伊茨费尔特—雅各布病（ＣＪＤ）民间观察组向文厚省报告了其对全日１９９６份神经学、精神病学及神经病理学机构通信问卷调查的结果。此报告涉及１９７９年１月至１...

关键词：硬脑膜病人移植物克罗伊茨费尔特雅各布日本

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WHO有关牛海绵状脑病和克罗伊茨弗尔特──雅各布病新变种出现的公共卫生问题的专家咨询会议

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疾病监测 1996年第7期11卷 269-270页

作者：赵惠敏

ＷＨＯ有关牛海绵状脑病和克罗伊茨弗尔特──雅各布病新变种出现的公共卫生问题的专家咨询会议１９９６年４月２－３日，在日内瓦ＷＨＯ组织的一次专家咨询组会议上，国际专家组复审了１９９６年３月２０日英国官方报告的有关牛海绵状... 详细信息

ＷＨＯ有关牛海绵状脑病和克罗伊茨弗尔特──雅各布病新变种出现的公共卫生问题的专家咨询会议１９９６年４月２－３日，在日内瓦ＷＨＯ组织的一次专家咨询组会议上，国际专家组复审了１９９６年３月２０日英国官方报告的有关牛海绵状脑病（ＢＳＥ）和克罗伊茨弗尔特──...

关键词：克罗伊茨 WHO 公共卫生问题牛海绵状脑病专家咨询弗尔会议雅各布新变种

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美国克罗伊茨弗尔特—雅各布病监测

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疾病监测 1997年第4期 38-39页

美国克罗伊茨弗尔特—雅各布病监测人克罗伊茨弗尔特－雅各布病（ＣＪＤ）和牛海绵状脑病（ＢＳＥ）被分类为可传染的海绵状脑病，是亚急性脑退化病。ＢＳＥ是１９８６年在英国首次被确定的，当地有１５５０００多头牛被感染，当时扩大... 详细信息

美国克罗伊茨弗尔特—雅各布病监测人克罗伊茨弗尔特－雅各布病（ＣＪＤ）和牛海绵状脑病（ＢＳＥ）被分类为可传染的海绵状脑病，是亚急性脑退化病。ＢＳＥ是１９８６年在英国首次被确定的，当地有１５５０００多头牛被感染，当时扩大传播主要是由于用污染的牛肉和骨作小...

关键词：克罗伊茨海绵状脑病弗尔美国美利坚合众国北美洲雅各布

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变异型克罗伊茨费尔特-雅各布病患者的CSF磷酸-tau蛋白浓度升高:诊断和病理学意义

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 49-50页

作者： Goodall C.A. Head M.W. Everington D. A.J.E. Green 陈晨 National CJD Surveillance Unit Western General Hospital Crewe Road Edinburgh EH4 2XU United Kingdom.Dr

Objective: To investigate whether phosphorylated tau protein (tau-pT181) is increased in variant Creutzfeldt-Jakob disease (vCJD) and if the tau-pT181/tau protein ratio is useful for distinguishing between patients with and without CJD. Methods: CSF tau protein and tau-pT181 were measured in 50 patients with sporadic CJD (sCJD), 51 patients with vCJD, 46 sCJD controls, and 37 vCJD controls, using Innotest hTau and Innotest P-Thr181, Innogenetics. Results: Concentrations of CSF tau protein were increased in sCJD (5120 v 367 pg/ml in controls, p < 0.001) and vCJD (952 v 106 pg/ml, p < 0.001); tau-pT181 was also raised in sCJD (61 v 35 pg/ml in controls, p = 0.002) and vCJD (114 v 33 pg/ml, p < 0.001). Median concentrations of tau-pT181 were higher in vCJD than in sCJD (p < 0.001). The tau-pT181/tau protein ratio was lower than in controls in both sCJD (12 v 128 (p < 0.001)) and vCJD (119 v 279 (p < 0.001)). Mean tau-pT181/tau protein ratio was 10-fold higher in vCJD than in sCJD. Raised CSF tau protein had the highest efficiency for distinguishing sCJD and vCJD from controls. Conclusions: CSF tau-pT181 concentrations are raised in vCJD and are higher than in CJD. Measurement of CSF tau-pT181/tau protein ratio does not improve the diagnostic efficiency of CSF tau protein alone for either vCJD or sCJD. The higher concentration of CSF tau-pT181 found in vCJD suggests that unexplained pathogenic factors influence the phosphorylation of tau protein in vCJD patients.

关键词：克罗伊茨 tau 蛋白浓度患者 CSF 费尔特变异型雅各布

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MM2皮质型散发性克罗伊茨费尔特-雅各布病的临床特征和诊断

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 11-11页

作者： Krasnianski A. Meissner B. Schulz- Schaeffer W. I. Zerr 郭俊 Department of Neurology Georg- August University Robert- Koch Str 40 D- 37075 G ttingen Germany Dr.

Objective: To describe clinical features and diagnostic tests of the MM2 cortical subtype in sporadic Creutzfeldt- Jakob disease. Methods: Clinical symptoms, magnetic resonance imaging studies, electroencephalograms, and cerebrospinal fluid markers were studied in 12 patients with genetically and neuropathologically verified sporadic Creutzfeldt- Jakob disease. Histological findings were semi- quantitatively evaluated. Results: Compared with classical sporadic Creutzfeldt- Jakob disease, the disease duration was prolonged (median, 14 months). All patients had dementia and early and prominent neuropsychological signs such as spatial disorientation, aphasia, or apraxia. Alzheimer disease was the most frequent initial diagnosis (33% ). Increased S100B protein in the cerebrospinal fluid was found in 100% ; the 14- 3- 3 protein test was positive in 91% . Electroencephalograms revealed periodic sharp wave complexes in 42% . T2- weighted magnetic resonance imaging showed basal ganglia hyperintensities in only 1 patient, and cortical hyperintensities were not necessarily present. Severe cortical damage was the most prominent histological feature. Conclusions: The S100B (100% ) and 14- 3- 3 (91% ) protein investigations were the most sensitive diagnostic tests. Prolonged disease duration, dementia as the only typical Creutzfeldt- Jakob disease symptom for a longer time, and low sensitivity of magnetic resonance imaging studies and electroencephalograms make the diagnosis in the MM2 cortical subtype difficult. Therefore, detailed clinical investigation is especially important in this sporadic Creutzfeldt- Jakob disease subtype. We suggest that rapidly progressive dementia with early and prominent neuropsychological deficits in older patients should lead to suspicion of the MM2 cortical subtype even if other neurological deficits are absent. At least some cases of MM2 cortical sporadic Creutzfeldt- Jakob disease may be misdiagnosed as rapidly progressive Alzheimer disease.

关键词：克罗伊茨 MM2 散发性费尔特雅各布皮质临床特征

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印染 2013年第3期 56-58页

行业动态中国"生态赤字"经济战略转型刻不容缓近日来,我国大部分地区遭受雾霾天气,空气污染严重,自然生态被破坏,给中国"高污染、高能耗、高排放"的经济发展模式敲响警钟,"生态赤字"倒逼经济战略转型已刻不容缓。世界自然基金会发布的2... 详细信息

行业动态中国"生态赤字"经济战略转型刻不容缓近日来,我国大部分地区遭受雾霾天气,空气污染严重,自然生态被破坏,给中国"高污染、高能耗、高排放"的经济发展模式敲响警钟,"生态赤字"倒逼经济战略转型已刻不容缓。世界自然基金会发布的2010年《全球生态足迹报告》表明,在过去几十年间,中国经济快速增长,而工业化过程日益增长的资源能源需求,导致中国已经消耗的资源超过自身生态系统所能提供资源的两倍以上,中国正背负着越来越沉重的"生态赤字"。