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Antioxidant effect of a novel synthetic hydrogen sulfide releasing Danshensu derivative and its clinical implications

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中国药理学与毒理学杂志 2018年第4期32卷 273-274页

作者： Jin-song BIAN Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore 117600 PR Singapore

Oxidative stress induces apoptosis of many cells and arrest of their *** Danshensu(DSS) and hydrogen sulfide(H_2S) produce significant antioxidant effect in various *** this study,we synthesized SDSS,a new H_2S-releasing compound derived from DSS,and studied its antioxidant effect in an H_2O_2-induced MC3T3-E1 osteoblastic cell injury *** first characterized the H_2S releasing property of SDSS in both in vivo and in vitro *** chromatogram showed that intravenous injection of SDSS in adult rats released ADT-OH,a well proved H_2S sustained-release moiety,within several minutes in the rat *** an H_2S selective fluorescent probe,we further confirmed that SDSS released H_2S in MC3T3-E1 osteoblastic *** studies revealed that SDSS had no significant toxic effect but produced protective effects against H_2O_2-induced MC3T3-E1 cell *** also reversed the arrest of cell differentiation caused by H_2O_2 *** was caused by the stimulatory effect of SDSS on bone sialo protein,runt-related transcription factor-2,collagen expression,alkaline phosphatase activity,and bone nodule *** studies revealed that SDSS reversed the reduced superoxide dismutase activity and glutathione content,and the increased ROS production in H_2O_2 treated *** addition,SDSS significantly attenuated H_2O_2-induced activation of p38-,ERK1/2-,and *** also stimulated phosphatidylinositol 3-kinase/Akt signaling *** of this pathway attenuated the cytoprotective effect of *** also observed the effect of SDSS on aspirin-induced gastric injury and found that SDSS protected against aspirin-induced gastric *** conclusion,SDSS protects cells against H_2O_2-induced apoptosis by suppressing oxidative stress.

关键词：细胞凋亡丹神素治疗方法临床分析

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