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Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis

World Journal of Gastroenterology 2006年第47期12卷 7666-7670页

作者： Hidehiro Sawa Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Makoto Shinzeki Takahiro Nakajima Yoshikazu Kuroda Department of Gastroenterological Surgery Kobe University Graduate School of Medical Sciences Kobe 650-0017 Japan Department of Surgery Kinki University School of Medicine Osaka-sayama 589-8511 Japan

AIM: To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental se-vere acute pancreatitis (SAP).METHODS: SAP was induced by creating closed duode-nal loop in C3H/HeN mice. SAP was induced immediately after intraperitoneal injection of anti-HMGB1 neutralizing antibody (200 μg). Severity of pancreatitis, organ injury (liver, kidney and lung), and bacterial translocation to pancreas was examined 12 h after induction of SAP.RESULTS: Anti-HMGB1 neutralizing antibody significant-ly improved the elevation of the serum amylase level and the histological alterations of pancreas and lung in SAP. Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and cre-atinine in SAP. However, anti-HMGB1 antibody worsened the bacterial translocation to pancreas.CONCLUSION: Blockade of HMGB1 attenuated the development of SAP and associated organ dysfunction, suggesting that HMGB1 may act as a key mediator for inflammatory response and organ injury in SAP.

关键词：急性胰腺炎十二指肠细菌易位丙胺酸

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Effect of dipeptide of glutamine and alanine on severe traumatic brain injury

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Chinese Journal of Traumatology 2007年第3期10卷 145-149页

作者：杨德林徐俊法 Department of Neurosurgery Huashan HospitalFudan University Department of Neurosurgery People's Hospital in Pudong New Area

Objective:To determine the effect of dipeptide of glutamine and alanine on patients with severe traumatic brain injury. Methods:A total of 46 patients(31 males and 15 females,aged 7-68 years,(47±9.6)years on average) with severe traumatic brain injury were randomized into two groups.Group G(n=23)and Group C(n=23). The patients in Group G received nutritional remedy with the dipeptide of glutamine and aianine,whereas the patients in Group C received routine nutritional therapy only.GCS changes,the length of stay in the neurosurgical intensive care unit(NICU),the mortality,the count of lymphocytes,related complications including lung infection and hemorrhage of alimentary tracts,etc,were examined and recorded. Results:The fatality rate and the length of stay in NICU in Group G was lower than these in Group C (P0.05). The patients with lung infection and alimentary tract hemorrhage in Group G were less than those in Group C (P<0.05).The count of lymphocytes in Group G was more than that in Group C(P<0.05),but no difference was found in other nutritional data. Conclusions:Dipeptide of glutamine and alanine can increase the resisting stress and anti-infection ability of patients with severe traumatic brain injury,which can also lower the mortality and shorten the NICU stay.

关键词：谷氨酸盐丙胺酸二肽重症创伤性脑损伤营养疗法

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干杯伴侣

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中国对外贸易 1995年第5期 29-29页

酒是一种历史悠久、流传最广的饮料,可以佐餐、提神、助兴。然而过量的饮酒也会产生副作用。

关键词：味之素维生素C 历史悠久谷氨酸胺贸易商行健康食品代谢速度胃粘膜丙胺酸合作生产

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Response of Alanine Dosemeter to Heavy Ions

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2003年第1期 76-76页

作者： LiWenjian SuXu YangYingjie YuanJianlei DangBingrong WangXiao MaQiufeng ZhouLibin HaoJifang MaoShuhong 不详 NationalInstituteforRadiologicalProtection ChineseCenterforDiseaseControlandPrevention.

The amino acid L-α-alanine has been investigated for use as a radiation detector in low and high LET radiation fields[1]. The radiatioa detector is cheap and easy to handle. The radiation inducing free radicals are stable at normal laboratory conditions for doses below 10^4 Gy over a long period of time, which makes the detector useful for intercomparison and documentation purposes. The dosimetric features of alanine-based electron spin resonance (ESR) detectors in high energy electron beams used in radiotherapy were considered[2]. The 5 mm long alanine detectors were found to be the most suitable for carrying out in vivo dosimetry on patients undergoing electron beam radiotherapy. However, data concerning dosimetry of the alanine dosemeter to heavy charged particles are lacking, especially in China.

关键词：丙胺酸药物剂量重离子氨基酸放射性探测

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