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青海医药杂志 1992年第1期22卷 12-13页

作者：杨于恒徐明珍青海省人民医院妇科

1987年6月至1990年6月用溴隐停单用或与克罗米酚等联用,治疗排卵障碍性不孕48例。其中无排卵症38例,黄体功能不良10例。22例高泌乳素血症,26例血泌乳素正常。治疗结果:无排卵症排卵率68.42％,黄体不良好转率40％,妊娠率31.25％。其中高... 详细信息

1987年6月至1990年6月用溴隐停单用或与克罗米酚等联用,治疗排卵障碍性不孕48例。其中无排卵症38例,黄体功能不良10例。22例高泌乳素血症,26例血泌乳素正常。治疗结果:无排卵症排卵率68.42％,黄体不良好转率40％,妊娠率31.25％。其中高泌乳素血症排卵率77.78％,黄体功能好转率50％,妊娠率64.29％,正泌乳素血症排卵率60％,黄体功能好转率33.33％,妊娠率30％。

关键词：排卵障碍高泌乳素血症克罗米酚排卵率黄体功能不良垂体微腺瘤药物治疗子宫内膜活检不孕因素不孕症门诊

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不明原因习惯性流产者使用丈夫单核细胞进行免疫治疗前后,细胞内细胞因子检测TH1和TH2细胞的改变

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 17-18页

作者： Yokoo T. Takakuwa K Ooki I. 朱磊 Department of Obstetrics and Gynecology Niigata University School of Medicine 1- 757 Asahimachi-dori Niigata Japan Dr.

Objective: To elucidate the possible mechanisms of immunotherapy for unexplained recurrent aborters using their husband’s mononuclear cells. Design: Prospective clinical study. Setting: Institutional practice at the Outpatient Clinic for Infertility, Niigata University Medical Hospital. Patient(s): Fifty-two unexplained recurrent aborters were chosen as an experimental group. Intervention(s): Each patient was injected with her husband’s mononuclear cells as immunotherapy. Peripheral blood was obtained from the patients. Main Outcome Measure(s): The percentage of CD4-positive cells, TH1 cells, TH2 cells, and the TH1/TH2 ratio were analyzed in the patients before and after immunotherapy. The same analyses were performed in the successful and the unsuccessful group. Result(s): To date, 42 of the 52 patients have become newly pregnant. Of the 42, 34 patients have already delivered (successful group) and 3 are now pregnant, while the remaining 8 cases experienced repeated abortion (unsuccessful group). The percentage of TH2 cells significantly increased in the total patient population, while the TH1/TH2 ratio significantly decreased in the total patient population and in the successful group. Conclusion(s): These findings suggest that immunotherapy with the husband’s mononuclear cells for unexplained recurrent abortion induces a dominant state of TH2 cells in the patients.

关键词：习惯性流产 TH1 TH2 免疫治疗继续妊娠不孕症门诊大学医院

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克罗米芬抵抗的多囊卵巢综合征患者体外受精时,超声下彻底的卵母细胞回收与卵巢楔形切除结果相似

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 8-8页

作者： Branigan E.F. Estes A. Walker K. Rothgeb J. 朱磊 Bellingham IVF and Infertility Center Bellingham WA Dr.

Objective: The purpose of this study was to compare the effectiveness of a thorough sonographic oocyte retrieval to a routine in vitro fertilization retrieval to induce ovulation, pregnancy, and endocrine changes in patients with polycystic ovarian syndrome in their post-in vitro fertilization cycles. Study design: Sixty-four patients from a tertiary infertility clinic, with clomiphene citrate-resistant polycystic ovarian syndrome and who were undergoing in vitro fertilization, were assigned randomly into 2 groups. Group 1 (n = 34) had a thorough (every possible follicle punctured) sonographic oocyte retrieval, and group 2 (n = 30) had a routine (only follicles that were likely to contain oocytes) in vitro fertilization retrieval. These patients who did not conceive in their in vitro fertilization cycle were monitored with ultrasound scanning for evidence of ovulation, pregnancy, before and after day 3 gonadotropin,and steroid hormone levels. Analysis of variance and the Student t test were used for statistical significance. Results: Ovulation rates of 53% (18/34) and cumulative pregnancy rate of 44% (8/18) were observed in group 1, with no ovulations in group 2. Significant decreases in luteinizing hormone/FSH ratio (4.1 to 1.7) and testosterone (1.2 to 0.7 ng/mL) occurred after treatment in the thorough sonographic oocyte retrieval group, with no change after routine in vitro fertilization. Operating time was increased signifi cantly in the thorough sonographic oocyte retrieval group (45 vs 24 minutes) in group 2. Conclusion: Thorough sonographic oocyte retrieval during in vitro fertilization cycle can produce significant improvements in the endocrinologic abnormalities, ovulation, and pregnancies that are comparable with ovarian wedge resection in patients with clomiphene citrate-resistant polycystic ovarian syndrome.

关键词：多囊卵巢综合征体外受精克罗米芬卵母细胞楔形切除促性腺激素内分泌紊乱诱发排卵不孕症门诊

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