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Silencing gamma-aminobutyric acid A receptor alpha 1 subunit expression and outward potassium current in developing cortical neurons

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Neural Regeneration Research 2011年第18期6卷 1404-1409页

作者： Tao Bo Jiang Li Jian Li Xingfang Li Kaihui Xing Department of Pediatrics Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

We used RNA interference （RNAi） to disrupt synthesis of the cortical neuronal y-aminobutyric acid A receptor （GABAAR） al in rats during development, and measured outward K＋ currents during neuronal electrical activity using whole-cell patch-clamp techniques. Three pairs of small interfering RNA （siRNA） for GABAAR al subunit were designed using OligoEngine RNAi software. This siRNA was found to effectively inhibited GABAAR al mRNA expression in cortical neuronal culture in vitro, but did not significantly affect neuronal survival. Outward K^currents were decreased, indicating that GABAAR al subunits in developing neurons participate in neuronal function by regulating outward K＋ current.

关键词： γ-aminobutyric acid a receptor al subunit neuron development outward potassium current

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Effects of gamma-aminobutyric acid receptors on muscarinic receptor-mediated free calcium ion levels in the facial nucleus following facial nerve injury

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Neural Regeneration Research 2011年第11期6卷 855-859页

作者： Guangfeng Jiang Dawei Sun Rui Zhou Fugao Zhu Yanqing Wang Xiuming Wan Banghua Liu Department of Otolaryngology & Head and Neck Surgery Affiliated Hospital of Medical School Qingdao University Qingdao 266003 Shandong Province China School of Public Health Shandong University Jinan 250012 Shandong Province China Department of Scientific Teaching Affiliated Hospital of Medical School Qingdao University Qingdao 266003 Shandong Province China Department of Otolaryngology & Head and Neck Surgery Union Hospital of Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

Muscarinic receptors and nicotine receptors can increase free calcium ion levels in the facial nucleus via different channels following facial nerve injury. In addition, γ-aminobutyric acid A （GABAA） receptors have been shown to negatively regulate free calcium ion levels in the facial nucleus by inhibiting nicotine receptors. The present study investigated the influence of GABAA, γ-aminobutyric acid B （GABAB） and C （GABAc） receptors on muscarinic receptors in rats with facial nerve injury by confocal laser microscopy. GABAA and GABAB receptors exhibited significant dose-dependent inhibitory effects on increased muscarinic receptor-mediated free calcium ion levels following facial nerve injury. Results showed that GABAA and GABAB receptors negatively regulate muscarinic receptor effects and interplay with cholinergic receptors to regulate free calcium ion levels for facial neural regeneration.

关键词： injury of facial nerve γ-aminobutyric acid a receptor γ-aminobutyric acid B receptor muscarinic receptor facial nucleus calcium ion peripheral nerve injury neural regeneration

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