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2004 National Meeting on Pharmacology of Young Pharmacologists

作者： Jie LIU Wei MO Zhao-Qian LIU Zhi-Rong TAN Xiao-Ping CHEN Lian-Sheng WANG Gan ZHOU Hong-Hao ZHOU Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China

AIMS: To determine whether Gly389 polymorphism of β

关键词： β1-adrenergic receptor genetic polymorphism sensitivity

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Clinical evaluation of valsartan and metoprolol tartrate in treatment of diabetic nephropathy with positive β1-adrenergic and anti-angiotensin Ⅱ type 1 receptor antibody

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Chinese Medical Journal 2012年第19期125卷 3543-3547页

作者： ZHAO Lin-shuang BAI Wei-wei XIANG Guang-da YUE Ling SUN Hui-ling Department of Endocrinology Wuhan General Hospital of People's Liberation Army Guangzhou Military Area CommandWuhanHubei 430070China

Background Studies have confirmed that angiotensin II receptor blocker （ARB） and angiotensin converting enzyme inhibitors （ACEI） in the treatment of diabetic nephropathy （DN） has special advantages. We observed the effects of valsartan and metoprolol tartrate hydrchloride in treatment of DN patients with positive β1-adrenergic and anti-angiotensin II type 1 （AT1） receptor antibody. Methods The epitopes of the second extracellular loop of β1 receptor （197-222） and AT1 receptor （165-191）, were synthesized and used respectively to screen serum autoantibodies from patients with DN （n=371, group A）, diabetes mellitus （DM） without renal failure （n=107, group B） and healthy blood donors （n=47, control, group C） by enzyme-linked immunosorbent assay （ELISA）. Metoprolol tartrate 25-50 mg, three times per day, valsartan 160 mg, once a day, aspirin 100 rag, once a day, and nitrendipine 10-20 mg, three times per day, were given to DN patients with positive or negative autoantibodies. The cystatin C level and 24-hour urinary protein were measured before and after treatment. Results In DN patients, the positive rate of the autoantibodies against β1 receptors and AT1 receptor was 47.7% and 51.5%, respectively, which were significantly higher than those in DM patients and healthy controls （all P 〈0.01）. Patients with anormalous cystatin C had higher positive rates of the autoantibodies than patients with normal cystatin C. Valsartan and metoprolol tartrate reduced proteinuria significantly （P 〈0.01） in DN patients with positive autoantibodies. Conclusions The findings suggest that these autoantibodies against β1 and ATl-receptor may play important roles in the pathogenesis of DN. Valsartan and metoDrolol tartrate are effective and safe in the treatment of DN.

关键词： diabetic nephropathy β1-adrenergic receptor anti-angiotensin H type 1 receptor valsartan metoprolol tartrate

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The novel C-terminal Chromogranin A-derived serpinin and pyroglutaminated serpinin act as cardiacβ-adrenergic agonists

The novel C-terminal Chromogranin A-derived serpinin and pyr...

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第十六届嗜铬细胞国际学术会议

作者： Bruno Tota Stefano Gentile Teresa Pasqua Hisatsugu Koshimizu Niamh X Cawley Maria Carmela Cerra Y Peng Loh Tommaso Angelone Department of Cell Biology University of Calabria Section of Cellular Neurobiology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of HealthBethesda Department of Pharmaco-Biology University of Calabria

＜正＞Very recently,Koshimizu et al.（2011） showed that three forms of serpinin peptides,serpinin （AIa26Leu）,pyroglutaminated（pGIu）-serpinin（pGlu23Leu） and serpinin-Arg-Arg-Gly （Ala29Gly） are derived from cleavage at pairs of basic residues in the highly conserved C terminus of Chromogranin A（CgA）.Serpinin induces PN-1 expression in（neuro）endocrine

关键词： Serpinin heart β1-adrenergic receptor inotropism lusitropism

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