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β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 505-510页

作者： Xiao-jing ZHAO Zhuo PEN Ping LI Er-xiu CHEN Jian LIU Yan-xia GAO Yun-xia REN Li-jun LI Department of Emergency Medicine the Second Affiliated Hospital of Medical CollegeXi'an Jiaotong University Mechanical Energy and Experimental Center of Medical CollegeXi'an Jiaotong University

Objective:We investigated the influence of β-receptor blocker metoprolol on return of spontaneous circulation(ROSC) during cardiopulmonary resuscitation(CPR) in rats with induced myocardial infarction(MI).Methods:Male Sprague-Dawley rats were randomly divided into three groups:the sham-operated group,the MI group without metoprolol,which was fed the vehicle,and the MI+metoprolol group receiving intragastric *** group was further divided randomly into three subgroups,depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac ***:The ROSC rate was significantly decreased in the low dose subgroup of MI group,unchanged in the medium dose subgroup of MI group,and significantly decreased in the high dose subgroup of MI group,compared with the same dose subgroup of sham-operated ***+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup,and a higher ROSC rate than MI group in the high dose *** was no difference in blood K+ values of successful rats between MI group and MI+metoprolol *** rats with successful CPR had lower blood K+ values than rats with unsuccessful CPR in each of the three treatment ***:Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during *** increasing high blood K+ value would attenuate the rate of a successful CPR.

关键词： β-receptor blocker Cardiopulmonary resuscitation Return of spontaneous circulation Epinephrine Chemical examination

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