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Journal of Pharmaceutical Analysis 2022年第2期12卷 293-300页

作者： Xue Xiao Kaili He Ya-Jun Hou Zhangmin Xiang Yunyun Yang Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology Guangdong Provincial Engineering Research Center for Ambient Mass SpectrometryInstitute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou510070China

A rapid and sensitive method for analyzing trace b-blockers in complex biological samples,which involved magnetic solid-phase extraction(MSPE)coupled with Fourier transform ion cyclotron resonance mass spectrometry(FTICR-MS),was *** nanosilver-functionalized magnetic nanoparticles with an interlayer of poly(3,4-dihydroxyphenylalanine)(polyDOPA@Ag-MNPs)were synthesized and used as MSPE adsorbents to extract trace b-blockers from biological *** extraction,the analytes loaded on the polyDOPA@Ag-MNPs were desorbed using an organic solvent and analyzed by *** method was rapid and sensitive,with a total detection procedure of less than 10 min as well as limits of detection and quantification in the ranges of 3.5-6.8 pg/mL and 11.7-22.8 pg/mL,*** accuracy of the method was also desirable,with recoveries ranging from 80.9%to 91.0%following the detection of analytes in human blood *** the experimental results demonstrated that the developed MSPE-FTICR-MS method was suitable for the rapid and sensitive analysis of trace b-blockers in complex biological samples.

关键词： β-blockers Magnetic solid-phase extraction Nanosilver-functionalized magnetic nanoparticles Poly(3,4-dihydroxyphenylalanine) Fourier transform ion cyclotron resonance mass spectrometry

Determination of 23 β_2-agonists and 5 β-blockers in animal muscle by high performance liquid chromatography-linear ion trap mass spectrometry

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Science China Chemistry 2010年第4期53卷 832-840页

作者： WU YongNing1,2, MIAO Hong1, FAN Sai1,2 & ZHAO YunFeng1,2 1 Institute of Nutrition and Food Safety, Chinese Centre for Disease Control and Prevention, Beijing 100021, China 2 College of Veterinary Medicine, China Agricultural University, Beijing 100193, China 1. Institute of Nutrition and Food Safety Chinese Centre for Disease Control and Prevention Beijing 100021 China2. College of Veterinary Medicine China Agricultural University Beijing 100193 China

A high performance liquid chromatography-linear ion trap mass spectrometry method using isotope dilution technique has been developed for the simultaneous determination of 23 β2-agonists and 5 β-blockers in animal muscle tissues. Pork and chicken muscle samples were acid hydrolyzed and extracted with 5% trichloracetic acid in water, and then cleaned up using MCX solid phase extraction (SPE) cartridge. Methanol and 0.1% formic acid were used as mobile phases for gradient elution. A Waters AtlantisT3 column was used for separation. ESI positive ion scan mode was used with selective reaction monitoring. 9 β2-Agonists labeled by the deuterium isotope were used as internal standards for quantification. The linear ranges of 23 β2-agonists and 5 β-blockers were 5-200 μg/L, the coefficient of correlation was not less than 0.995, and the limit of detection for each compound in the muscle tissue was below 0.2 μg/kg. The recoveries of each compound in the spiked samples at three levels 5, 10, 20 μg/kg were in the range of 47.3%-123.7%, and the relative standard deviations were in the range of 3.2%-25.7%. The developed method is sensitive and specific for the determination of β2-agonists and β-blockers in pork and chicken muscle samples.

关键词： β2-agonists β-blockers muscle determination HPLC-ITMS

Beneficial effects of switching from β-blockers to nebivolol on the erectile function of hypertensive patients

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Asian Journal of Andrology 2006年第2期8卷 177-182页

作者： MichaelDoumas AlexandrosTsakiris StellaDouma Alkiviadis Grigorakis AngelosPapadopoulos AthinaHounta SotiriosTsiodras Dimitrios Dirnitriou Helen Giamarellou Hypertension Outpatient Clinic Fourth Department of Internal Medicine Urologic Outpatient Clinic Second Department of UrologyUniversityof AthensAttikon HospitalAthens 12461Greece

Aim： To investigate the effect of substituting β-blockers with nebivolol on the erectile function of patients suffering from essential hypertension. Methods： Forty-four young and middle-aged men （31-65 years） with essential hypertension visited our outpatient clinic and took β-blocker treatment （atenolol, metoprolol or bisoprolol） for more than 6 months. All the patients completed a questionnaire regarding erectile function （International Index for Erectile Function）. Patients were then switched to an equipotent dose of nebivolol for 3 months and, at the end of this time period, filled out the same questionnaire. Results： Twenty-nine out of the 44 （65.9%） patients who took p-blockers （atenolol, metoprolol or bisoprolol） had exhibited erectile dysfunction （ED）. Their systolic and diastolic blood pressure did not change significantly with the treatment switch. In 20 out of these 29 （69%） patients, a significant improvement in the erectile function score was exhibited after 3 months of nebivolol administration, and in 11 of these 20 patients, erectile function was normalized. Conclusion： Nebivolol seems to have a beneficial effect on ED （possibly due to increased nitric oxide availability）; however, further prospective, randomized, placebo-controlled studies are needed to confirm the beneficial effects of nebivolol. （Asian J Androl 2006 Mar; 8： 177-182）

关键词： erectile dysfunction essential hypertension β-blockers nebivolol

The study of diuretics and β-blockers by gradient high-performance liquid chromatography

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The study of diuretics and β-blockers by gradient high-perf...

All CABG Patients Who Have No Contraindications: Do They Get Perioperative Beta blockers?

中国化学会第十四届有机分析及生物分析学术研讨会

作者： XIAO Hui TONG Ping ZHANG Lan~* CHEN Guo-nan (Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety,The Sport Science Research Center,Fuzhou University,Fuzhou 350002)

An accurate,sensitive and fast reversed-phase high-performance liquid chromatography (RP-HPLC) as an analytical method for the quantitative analysis of ten drugs in human urine was developed and *** objects of analysis were 10 drugs belonging to two different groups, diuretics (amiloride (AM),triamterene (TA),hydrochlorothiazide (HC),chlortalidone (CT), metolazone (MT),indapamide (IN)) and β-blockers (carteolol,esmolol,propranolol and carve- dilol).It involved liquid-liquid extraction procedures followed by liquid chromatography coupled to variable-wave UV *** separation of analyzed compounds was conducted by means of a 5 μm Eclipse XDB-C analytical column (150 mm×4.6 mm,i.d.) with 5μm Eclipse XDB-C pre- column (4 mm×4 mm,i.d.) with gradient *** drugs were determined within 15 *** mobile phase was comprised of various proportions of acetonitrile and phosphate buffer pH *** linearities were obtained in the range of 0.04～30 μg/mL with the correlation coeffi- cients (r)≥0.9985 for 10 *** of detection (LODs) for the compounds ranged from 0.020 to 0.030 μg/mL at S/N of *** RSDs (n=5) of the method was 0.050%～0.57% for migration times and 0.76～8.0% for peak heights,*** minimum required perfor- mance limit (MRPL),established by world anti-doping agency (WADA),was attained to the 10 compounds in this study.

关键词： Diuretics β-blockers HPLC Urine

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International Journal of Clinical Medicine 2019年第9期10卷 421-427页

作者： Mohammad Miah Mauin Uddin Syed Al Nahian Khalid Zahir Mostafa Mehanna Ahmed Ashoub Cardiac Surgery Queen Elizabeth Hospital Birmingham UK Cardiothoracic Surgery New Cross Hospital Wolverhampton UK Cardiothoracic Surgery Liverpool Heart and Chest Hospital Liverpool UK Cardiothoracic Anaesthesia and Critical Care New Cross Hospital Wolverhampton UK

New-onset postoperative atrial fibrillation (POAF) following Coronary artery bypass graft (CABG) surgery has been described in up to 15% to 40% of patients in the initial postoperative period. POAF is related with higher mortality, increased hospital resource utilization, postoperative extra ITU hours and hospital days, consequently increasing hospital-related budgets. Beta blocker administration decreases the rate of POAF from 30% - 40% to 12% - 16% after CABG. According to the EACTS (European Association of Cardiothoracic Surgery) guideline December 2006, β-blockers should routinely be used as the first choice for the prophylaxis of atrial fibrillation (AF) in all patients undergoing cardiac surgery, if not contraindicated (IB). To compare the contemporary practice with the recommended standard retrospective data of consecutive 400 patients treated with isolated CABG between July 2015 and June 2017 were collected. Those patients who received β-blockers on the day of surgery or the following morning (Continued and Restarted on 1st POD) met the standard guidelines. Thus, according to the data (12% + 20%) 32% of the patients met the standard. To compare the rate of Postoperative Atrial fibrillation, we divided the patients into two groups. Group A, who followed the guideline (128 patients) and Group B, who resumed β-blockers 48 hours onwards (272 Patients). In group A, only 8 patients developed postoperative AF whereas in group B 88 patients developed postoperative AF which is also statistically significant (P β-blockers use at perioperative period.

关键词： CABG-Coronary Artery Bypass Graft β-blockers AF-Atrial Fibrillation POAF-Postoperative Atrial Fibrillation

Simultaneous enantioseparation and simulation studies of atenolol,metoprolol and propranolol on Chiralpak^■IG column using supercritical fluid chromatography

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Journal of Pharmaceutical Analysis 2021年第6期11卷 746-756页

作者： Pranav A.Pandya Priyanka A.Shah Pranav S.Shrivastav Department of Chemistry School of SciencesGujarat UniversityAhmedabad380009India

Enantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(SFC).The effect of organic modifiers(methanol,isopropanol and their mixture),column temperature and back pressure on chiral separation ofβ-blockers was *** chromatographic separation with respect to resolution,retention,and analysis time was achieved using a mixture of CO_(2) and 0.1%isopropyl amine in isopropanol:methanol(50:50,V/V),in 75:25(V/V)*** the optimized conditions,the resolution factors(Rs)and separation factors(a)were greater than3.0 and 1.5,***,with increase in temperature(25-45℃)and pressure(100-150 bars)there was corresponding decrease in retention factors(k),a and ***,a reverse trend(a and Rs)was observed for atenolol with increase in *** thermodynamic data from van’t Hoff plots revealed that the enantioseparation was enthalpy driven for metoprolol and propranolol while entropy driven for *** understand the mechanism of chiral recognition and the elution behavior of the enantiomers,molecular docking studies were *** binding energies obtained from simulation studies were in good agreement with the elution order found experimentally and also with the free energy *** method was validated in the concentration range of 0.5-10μg/m L for all the *** limit of detection and limit of quantitation ranged from 0.126 to 0.137μg/m L and 0.376-0.414μg/m L,*** method was used successfully to analyze these drugs in pharmaceutical preparations.

关键词： Enantioseparation Supercritical fluid chromatography β-blockers Chiralpak^(■)IG column Molecular docking Binding energy

Effect of β-blocker therapy in diabetic patients with stable coronary heart disease: a meta-analysis

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Journal of Geriatric Cardiology 2019年第3期16卷 291-297页

作者： Aaqib H Malik Suchith Shetty Kausik Kar Ramzi El Accaoui Department of Medicine Westchester Medical Center and New York Medical CollegeValhallaNYUSA Division of Cardiology Department of MedicineUniversity of Iowa Health CareCarver College of MedicineIowaUSA

Background β-blocker (BB) therapy is a cornerstone for the treatment of coronary heart disease (CHD).The evidence of the benefit from long-term BB therapy in diabetic patients with stable CHD is *** meta-analysis summarizes the evidence relating to the BB therapy in diabetic patients with stable *** A meta-analysis was performed according to PRISMA and MOOSE guidelines for reporting of systematic reviews of observational ***,Embase,and Cochrane central were searched and two authors independently screened studies for *** quality of studies was assessed with the Newcastle Ottawa *** primary outcome of interest was all-cause mortality,cardiovascular (CV) mortality and major adverse cardiovascular events (MACE) in diabetic patients with and without BB therapy.A generic inverse variance model was used to pool odds ratio or hazards ratio from included studies to calculate the overall effect *** significance threshold was set at P-value < *** was assessed by *** Four non-randomized studies with 9515 participants were selected for the *** studies were post-hoc analyses of randomized controlled trials,and one article was an analysis of a nationally representative *** a fixed effects model,BB therapy in diabetic patients with stable CHD was found to be associated with increased risk of CV mortality,and MACE (27% and 32% respectively;P-value < 0.05) and was not associated with a reduction in all-cause mortality (HR 1.12;95% CI: 0.94–1.33;P-value = 0.22).Conclusion BB therapy in diabetic patients with stable CHD appears to be linked to higher *** randomized trials are needed in this population to confirm these findings.

关键词： β-blockers Cardiovascular mortality Diabetes MACE

Primary prevention of bleeding from esophageal varices in patients with liver cirrhosis

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World Journal of Hepatology 2014年第6期6卷 363-369页

作者： Christos Triantos Maria Kalafateli Department of Gastroenterology University Hospital of Patras

Variceal bleeding is a life threatening situation with mortality rates of at least 20%. Prophylactic treatment with non-selective beta blockers(NSBBs) is recommended for patients with small varices that have not bled but with increased risk for bleeding. The recommended treatment strategies on primary prevention of variceal bleeding in patients with medium and largesized varices are NSBBs or endoscopic band ligation. Nitrates, shunt surgery and sclerotherapy are not recommended in this setting. In this review, the most recent data on prevention of esophageal variceal bleeding are presented. Available data derived from randomized-controlled trials suggest both treatment strategies, and according to Baveno V consensus in portal hypertension "the choice of treatment should be based on local resources and expertise, patient preference and characteristics, side-effects and contra-indications".

关键词： Cirrhosis Portal hypertension Esophageal varices Primary prevention β-blockers Endoscopic band ligation

Pharmacological strategies in extracorporeal membrane oxygenation weaning failure: a call to action

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Emergency and Critical Care Medicine 2023年第2期3卷 43-45页

作者： Francisco J.González-Ruiz Francisco M.Baranda-Tovar Luis A.Baeza-Herrera JoséD.Utrilla-Álvarez Ricardo E.Quirázco-Cordova Gustavo Rojas-Velasco Department of Cardiovascular Critical Care National Institute of Cardiology“Dr.Ignacio Chávez”Mexico CityMexico National Institute of Cardiology.Juan Badiano 1 Belisario Dominguez Secc 16Tlalpan14080Mexico CityMexico

Extracorporeal membrane oxygenation has emerged as a viable alternative for stabilizing and improving critically ill patients in acute cardiovascular ***,the weaning stage has been associated with a high morbidity and mortality *** makes searching for strategies that reduce failure in this final process *** a new approach must be tried and included in our protocols,seeking the patient’s well-being at all *** this article,the authors discuss their point of view regarding potential pharmacological alternatives and the mechanism of action involved,which could decrease the mortality associated with this therapeutic.

关键词： β-blockers Extracorporeal membrane oxygenation Inodilators Mechanical circulatory support Pharmacological strategies

Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis

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World Journal of Gastroenterology 2010年第47期16卷 5982-5992页

作者： Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc Department of Hepato-gastroenterology B Saint Eloi Hospital University Hospital of Montpellier Department of Statistics University Hospital of Nimes Department of Hepato-gastroenterology University Hospital of Angers

AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif *** outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding.

关键词： Oesophageal varices Portal hypertension Cirrhosis Secondary prevention β-blockers Banding ligation