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Chemoselective Catalytic Hydrogenation of α,β-unsaturated ketones and α,β-unsaturated Carboxylic Esters

Chemical Research in Chinese Universities 1998年第2期14卷 17-22页

作者： ZHANG Jing-wen ZHAO Jian-zhang ZHANG Xiao-long JIANG Yu-lin MA Xiu-li SUN Yun-xiu JIANG Wen-pu LI Yao-xian XU Zhi-luo Department of Chemistry Jilin UniversityChangchun130023

The effect of catalysts P-2 00-Ni(Nickel boride) and P-2 00-Ni-M(M: Co, Fe, Cu, Sn), prepared by adopting a modified recipe, on the chemoselective hydrogenation of carbon carbon double bonds in α,β- unsaturated ketones, and the activity of catalysts P-1.80-Ni, P-2 00-Ni or P-1.80(2 00) -Ni-M(M: Pd, Co, Cu) in the selective hydrogenation of carbon carbon double bonds in α,β-unsaturated carboxylic esters, were investigated systematically. According to the experimental results, the selectivities of these catalysts toward the hydrogenation of the carbon carbon double bonds of α,β-unsaturated keones or α,β-unsaturated carboxylic esters are 96%—100% or 100%, respectively.

关键词： α β-unsaturated ketone Nickel boride α β-unsaturated carboxylic ester

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Catalytic conjugate addition of indole toα,β-unsaturated ketones by Co(ClO_4)-2·6H_2O/bis-Schiff base complexes

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Chinese Chemical Letters 2012年第5期23卷 525-528页

作者： Yong Hai Hui Chun Mei Chen Zheng Feng Xie Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education and Xinjiang Uyghur Autonomous RegionCollege of Chemistry and Chemical EngineeringXinjiang UniversityUrumqi 830046China

Co（ClO_4））_2·6H_2O/bis-Schiff base complexes promoted the conjugate addition of indole toα,β-unsaturated ketones under mild conditions,giving the corresponding addition products with high *** the complex has bee... 详细信息

关键词： Conjugate addition Indole α β-unsaturated ketone Schiff base

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Visible-Light-Induced[4+1]Cyclization-Aromatization of Acylsilanes andα,β-unsaturated ketones

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CCS Chemistry 2023年第2期5卷 325-333页

作者： Zhihong Zhu Weilu Zhang Yizhi Zhang Shanshan Liu Xiao Shen Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds and MaterialsMinistry of EducationWuhan UniversityWuhan 430072

Herein we report the first[4+1]cyclization-aromatization reaction of acylsilanes andα,β-unsaturated *** unprecedented visible-light-induced reaction proceeded through mild conditions without addition of any catalyst or additive,affording a variety of furans with broad substrate scope and good functional-group *** synthetic utility of the method was demonstrated by various downstream transformations of the otherwise difficult-to-access sulfone-containing silyl *** mechanism study reveals that 1,4-diketones are not likely to be the intermediates of the reaction.

关键词： acylsilane α β-unsaturated ketone carbene photo chemistry cyclization-aromatization furan

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Synthesis and biological evaluation of α,β-unsaturated carbonyl compounds targeting the NLRP3 inflammasome

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Journal of Chinese Pharmaceutical Sciences 2018年第5期27卷 295-306页

作者： Qiuyun Kong Nan Hang Chao Zhang Shuchun Li Zhongjun Li Yang Sun Xiangbao Meng State Key Laboratory of Natural and Biomimetic Drugs ＂ Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing 100191 China State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China

A series of α,β-unsaturated ketone derivatives were synthesized, and their anti-inflammatory activity toward NLRP3 inflammasome was evaluated in vitro. Several compounds were identified as anti-inflammatory agents, among which compound A21 exhibited potent anti-inflammatory activity in a dose-dependent manner with an IC50）of 0.95 μM. Moreover, a preliminary structure-activity relationship was also summarized.

关键词： α β-unsaturated ketone NLRP3 IL-1β Anti-inflammatory

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