检索结果-南通市图书馆

检索条件"主题词=β-N-acetyl-D-hexosaminidase"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine

Glycoside hydrolase family 18 and 20 enzymes are novel targe...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2...

作者： Yanwei duan Tian Liu Yong Zhou Tongyi dou Qing Yang State Key Laboratory of Fine Chemical Engineering School of Life Science and Biotechnology and School of SoftwareDalian University of Technology School of Life Science and Medicine Dalian University of Technology Institute of Plant Protection Chinese Academy of Agricultural Sciences

Berberine is a traditional medicine that has multiple medicinal and agricultural ***,little is known about whether berberine can be a bioactive molecule toward carbohydrate-active enzymes,which play numerous vital roles in the life *** this study,berberine and its analogs were discovered to be competitive inhibitors of glycoside hydrolase family 20 β-n-acetyl-d-hexosaminidase(GH20 Hex) and GH18 chitinase from both humans and the insect pest Ostrinia *** and its analog SYSU-1 inhibit insect GH20 Hex from ***(Of Hex1),with Ki values of 12 and 8.5 μM,***-crystallization of berberine and its analog SYSU-1 in complex with Of Hex1 revealed that the positively charged conjugate plane of berberine forms π-π stacking interactions with Trp,which are vital to its inhibitory ***,the 1,3-dioxole group of berberine binds an unexplored pocket formed by Trp,Trp and Val,which also contributes to its inhibitory *** was also found to be an inhibitor of human GH20 Hex(Hs HexB),human GH18 chitinase(Hs Cht and AMCase) and insect GH18 chitinase(Of ChtI).Besides GH18 and GH20 enzymes,berberine was shown to weakly inhibit human GH84 O-GlcnAcase(Hs OGA) and Saccharomyces cerevisiae GH63 α-Glucosidase I(Sc Glu I).By analyzing the published crystal structures,berberine was revealed to bind with its targets in an identical mechanism,namely via π-π stacking and electrostatic interactions with the aromatic and acidic residues in the binding *** paper reports new molecular targets of berberine and may provide a berberine-based scaffold for developing multi-target drugs.

关键词： berberine glycoside hydrolase β-n-acetyl-d-hexosaminidase chitinase inhibitor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：