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Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes

World Journal of Gastroenterology 2014年第27期20卷 9128-9137页

作者： Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi Department of Medical Microbiology and Immunology University of Szeged Department of Molecular and Cell Biology Boston University Henry M. Goldman School of Dental Medicine First Department of Internal Medicine University of Szeged

AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.

关键词： α-defensins HNP1-3 β-defensin 1 Diabetes Copy number polymorphism Single nucleotide polymorphism

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Concentrations of α-and β-defensins in gastric juice of patients with various gastroduodenal diseases

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World Journal of Gastroenterology 2005年第1期11卷 99-103页

作者： YoshitoNishi HajimeIsomoto HiroshiMukae HiroshiIshimoto Chun-YangWen AkihiroWada KenOhnita YoheiMizuta IkuoMurata ToshiyaHirayama MasamitsuNakazato ShigeruKohno SecondDepartmentofInternalMedicine NagasakiUniversitySchoolofMedicineSakamoto1-7-1NagasakiJapan DepartmentofMolecularPathology AtomicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineSakamoto12-4NagasakiJapan DepartmentofBacteriology InstituteofTropicalMedicineNagasakiUnive~itySchoolofMedicineSakamoto12-4NagasakiJapan ThirdDepartmentofInternalMedicine MiyazakiMedicalCollegeKiyotakeMiyazakiJapan

AIM: To determine the concentration of α-and β-defensins in gastric juice of patients with various gastroduodenal diseases. METHODS: Concentrations of human neutrophil peptides (HNPs) 1-3, the major forms of α-defensins, and human β-defensin (HBD)-1and HBD-2were measured by radioimmunoassay in plasma and gastric juice of 84 subjects, consisting of 54 Helicobacter pylori-infected and 30 uninfected subjects. They included 33 patients with chronic gastritis (CG), 12 with gastric ulcer (GU), 11 with duodenal ulcer (DU), 11 with benign gastric polyp (BGP) and 16 with normal mucosa (N group) on upper endoscopy. Plasma pepsinogen Ⅰ and Ⅱ levels, biomarkers for gastric mucosal inflammation and atrophy, were also measured. RESULTS: Gastric juice HNPs 1-3 levels in patients with CG, GU and BGP were significantly higher than those in patients with DU and N. Gastric juice HBD-2 concentrations in patients with CG and GU were significantly higher than those in the N group, but were significantly lower in DU patients than in GU patients. Gastric juice HBD-1 levels and plasma levels of these peptides were similar in the patient groups. Concentrations of gastric juice HNPs 1-3 and HBD-2 of in H pylori-infected patients were significantly different from those in uninfected subjects. HNPs 1-3 concentrations in gastric juice correlated negatively with plasma pepsinogen I levels and Ⅰ/Ⅱ ratios. HBD-2 levels in gastric juice correlated positively and negatively with plasma pepsinogen Ⅱ concentrations and Ⅰ/Ⅱratios, respectively. CONCLUSION: HNPs 1-3 and HBD-2 levels in gastric juice are diverse among various gastrointestinal diseases, reflecting the inflammatory and atrophic events of the background gastric mucosa affected by H pylori.

关键词： Helicobacter pylori infection Gastroduodenal diseases α-defensins β-defensin

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