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Oil Crop Science 2022年第2期7卷 63-70页

作者： Huihui Liu Ling Han Xiaoyang Xia Xia Xiang Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Oil Crops and Lipids Process Technology National&Local Joint Engineering LaboratoryKey Laboratory of Oilseeds ProcessingMinistry of Agriculture and Rural AffairsHubei Key Laboratory of Lipid Chemistry and NutritionWuhan430062Hubei ProvinceChina

Aluminum has been associated with neurodegenerative ***(α-linolenic acid),an essential dietary component for human health,possesses prominent biological ***,we aim to explore the neuroprotective effects of ALA on aluminum toxicity and reveal the underlying *** show that aluminum chloride(denoted as Al)enabled cell viability decline and apoptosis with oxidative stress and mitochondrial damage in differentiated rat pheochromocytoma cells(PC12)for 24 h *** with Al(10 mmol/L)treatment alone,ALA(50μmol/L)pretreatment for 24 h significantly enhanced cell viability by 28.40%,and hindered cell apoptosis by 12.35%,together with recovering redox state balance and alleviating mitochondrial *** was measured that ALA treatment upregulated Bcl-2 expression and down-regulated Bax level,accompanied with an expression decline of caspase-3 and ***,ALA pretreatment was proved to increase protein kinase A(PKA)expression and to promote phosphorylation of cAMP response element-binding protein(p-CREB),resulting in elevation on the level of brain-derived neurotrophic factor(BDNF).The above results showed that ALA attenuated Al toxicity in PC12 cells by mediating the PKA-CREBBDNF signaling pathway.

关键词： Aluminium toxicity α-linolenic acid PC12 cells Oxidative stress PKA-CREB-BDNF

Biotechnology ofα-linolenic acid in oilseed rape(Brassica napus)using FAD2 and FAD3 from chia(Salvia hispanica)

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Journal of Integrative Agriculture 2023年第12期22卷 3810-3815页

作者： XUE Yu-fei Inkabanga Tseke ALAIN YIN Neng-wen JIANG Jia-yi ZHAO Yan-ping LU Kun LI Jia-na DING Yan-song ZHANG Shi-qing CHAI You-rong Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City and Southwest University/Chongqing Key Laboratory of Crop Quality Improvement/College of Agronomy and Biotechnology Southwest UniversityChongqing 400715P.R.China Engineering Research Center of South Upland Agriculture Ministry of Education/Academy of Agricultural SciencesSouthwest UniversityChongqing 400715P.R.China Faculty of Agricultural Sciences National Pedagogic University(UPN)Kinshasa 8815D.R.Congo

α-linolenic acid(ALA,18:3Δ9,12,15)is an essential fatty acid for humans since it is the precursor for the biosynthesis of omega-3 long-chain polyunsaturated fatty acids(LC-PUFA).Modern people generally suffer from deficiency of ALA because most staple food oils are low or lack ALA *** enrichment of ALA in staple oil crops is a promising ***(Salvia hispanica)has the highest ALA content in its seed oil among known oil *** this study,the FAD2 and FAD3 genes from chia were engineered into a staple oil crop,oilseed rape(Brassica napus),via Agrobaterium tumefaciens-mediated transformation of their LP4-2A fusion gene construct driven by the seed-specific promoter P_(NapA).In seeds of T0,T1,and T2 lines,the average ALA contents were 20.86,23.54,and 24.92%,respectively,which were 2.21,2.68,and 3.03 folds of the non-transformed controls(9.42,8.78,and 8.22%),*** highest seed ALA levels of T0,T1,and T2 plants were 38.41,35.98,and 39.19%respectively,which were 4.10-4.77 folds of the respective ***-pathway enzyme genes(BnACCD,BnFATA,BnSAD,BnSCD,BnDGAT1,BnDGAT2,and BnDGAT3)and positive regulatory genes(BnWRI1,BnLEC1,BnL1L,BnLEC2,BnABI3,BnbZIP67,and BnMYB96)were all significantly *** contrast,BnTT1,BnTT2,BnTT8,BnTT16,BnTTG1,and BnTTG2,encoding negative oil accumulation regulators but positive secondary metabolism regulators,were all significantly *** means the foreign ShFAD2-ShFAD3 fusion gene,directly and indirectly,remodeled both positive and negative loci of the whole FA-related network in transgenic *** seeds.

关键词： biotechnology α-linolenic acid oilseed rape(Brassica napus) FAD2 FAD3 chia(Salvia hispanica)

Formulation ofα-linolenic acid microemulsion free of co-surfactant

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Chinese Chemical Letters 2010年第1期21卷 105-108页

作者： Feng Liu Zheng Wu Wang School of Chemical and Material Engineering Jiangnan University Wuxi 214036 China School of Agriculture and Biology Shanghai Jiaotong University Shanghai 200240 China

A novel class of α-linolenic acid-in-water microemulsion free of co-surfactant was investigated as potential food delivery systems. Rough demarcation within the transparent region was deduced from the results of conductivity and polarizing optical microscopy. The microemulsion mean hydrodynamic diameter and characterization were determined by dynamic light scattering and negative-staining TEM. The location of ALA molecules in the microemulsion formulations was determined by 1 H NMR spectroscopy.

关键词： Microemulsion α-linolenic acid Particle diameter ~1H NMR

A dose-response meta-analysis of α-linolenic acid and linoleic acid consumption and prostate cancer

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A dose-response meta-analysis of α-linolenic acid and linol...

Preliminary Research on the Effect of linolenic acid on Human Oocyte Maturation

产业竞争力与创新驱动——2014年山东省科协学术年会

作者： Lomg Zhai Yili Wu Dongfeng Zhang Department of epidemiology and health statistics Qingdao University Medical college

Background:Epidemiological studies evaluating the association of a-linolenic acid（ALA） and linoleic acid（LA） with prostate cancer（PCa） risk have produced inconsistent ***:Pertinent studies were identified by a search of MEDLINE and *** or random effect pooled measure was selected on the basis of homogeneity test among ***-response relationship was assessed by generalized least-squares trend estimation analysis and restricted cubic ***:Overall,15 studies with 276748 participants for ALA and 11 studies including 222840 participants for LA were *** overall combined relative risk（95% confidence interval） of PCa for the highest *** category of ALA and LA intake was 1.043（0.863-1.262） and 0.921（0.819-1.034）,*** stratified analysis by study design,the association of dietary ALA intake with PCa was significant among cohort studies with relative risk being 0.886（0.805-0.974）.Within prospective studies linear doseresponse relationship was found,and the risk of PCa decreased by 5.8%（RR=0.942,95% CI=0.901-0.985,P=0.01） for every 1.0 g/d increment in ALA ***:Results from prospective studies provide evidence of a protective effect of dietary ALA consumption on *** intake is not significantly associated with PCa *** studies,particularly prospective studies,are needed.

关键词： α-linolenic acid Linoleic acid Prostate cancer Dose-response meta-analysis

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Reproductive and Developmental Medicine 2019年第1期3卷 42-48页

作者： Ji-Jun Hu Jia-Xin Li Xing-Ling Wang Yi-Chun Guan Li-Jun Sun Reproductive Medical Center The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanChina Medical College of Pingdingshan University Pingdingshan 467000HenanChina

Objective:To investigate the effects of exogenousα-linolenic acid(ALA)on in vitro maturation(IVM)and developmental competence of human ***:Experiment 1 examined the effects of ALA at different concentrations(0[control],10,50,100,and 200μmol/L)in the IVM medium on oocyte *** with 50μmol/L ALA significantly accelerated oocyte maturation(P<0.05)and resulted in significantly higher mitochondrial DNA(mtDNA)copy number compared to the ***,50μmol/L ALA was selected for combination with follicular fluid(FF)to investigate oocyte developmental *** of the matured oocyte was analyzed by real-time polymerase chain *** 2 investigated the effects of FF with optimal ALA concentration(Group A:ALA+FF+IVM medium)or without ALA(Group B:FF+IVM medium)on oocyte maturation,fertilization,2 pronuclear cleavage,and embryo and blastocyst ***(MDA)content and superoxide dismutase(SOD)activity were measured for maturation medium from Group A,Group B,and Group C(control group,IVM medium only).Results:Treatment with 50μmol/L ALA obviously accelerated oocyte maturation(P<0.05)and resulted in significantly higher mtDNA copy number(P<0.05)in the matured oocytes compared to the control(0μmol/L ALA).Supplementation of 50μmol/L ALA and FF(Group A)obviously increased the total maturation rate than FF-treated group(Group B)which has higher(P<0.05)total maturation rate than that of Group ***,no significant differences were observed in fertilization,embryo availability,and blastocyst production among Group A,B,and *** with 50μmol/L ALA decreased the level of MDA(P<0.05),but had no effect on the activity of SOD in the IVM ***:Our results suggested that the treatment with 50μmol/L ALA during IVM improves maturation in human *** is also likely to improve embryo availability and blastocyst *** might be associated with the alteration of mtDNA replication(increased mtDNA copy n

关键词： Human Oocyte In vitro Maturation Mitochondrial DNA Oxidative Stress α-linolenic acid

Feeding Calcium Salts of Linseed Oil on Metabolic Status and Reproductive Traits in Grazing Dairy Cows

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Open Journal of Animal Sciences 2024年第3期14卷 219-233页

作者： Jesica Daniela Iorio Yaliska Moreno González Maria Florencia Olmeda Dino Curletto Daniel Edgardo Scandolo Martin Guillermo Maciel Rafael Alejandro Palladino Mauricio Javier Giuliodori Eloy Eduardo Salado School of Agriculture of the University of Buenos Aires (FAUBA) Buenos Aires Argentina Faculty of Agricultural Sciences National University of Lomas de Zamora (UNLZ) Lomas de Zamora Argentina Rafaela Agricultural Experiment Station National Institute of Agricultural Technology (INTA) Rafaela Argentina Faculty of Veterinary Science La Plata National University (FCV) La Plata Argentina

This experiment aimed to evaluate the effect of calcium salts of linseed oil (rich in alpha-linolenic acid (ALA, C18:3n-3) on metabolic and reproductive traits in high-producing dairy cows under grazing. Thirty-six Holstein dairy cows were randomly assigned, in a complete block design, to receive ALA supplementation (0.85 kg∙day−1 of calcium salts of linseed oil) or to remain as untreated control (CON). The concentrate was formulated to offer the same amount of energy across treatments (CON cows received an extra kg of corn to compensate for the higher energy density of ALA treatment). A PMR + Alfalfa pasture was offered to all cows at the same time. A fixed time artiﬁcial insemination (FTAI) at 80 DIM, preceded by a Presynch plus Ovsynch protocol was implemented for the first service and later, on return to estrus, heat detection and artiﬁcial insemination (AI) were performed. Pregnancy diagnosis was checked at 30, 42, 60, and 90 d after AI. Blood and milk samples were taken biweekly. Treatment affected plasma cholesterol concentration (160.36 vs. 186.70 mg∙dl−1, p = 0.03, for ALA and CON, respectively) and on size of corpus luteum (CL, 17.6 vs. 13.7 mm, p = 0.02, for ALA and CON, respectively). Supplementation tended (p = 0.136) to increase conception rate by 200 DIM (81.69% vs. 55.43% in ALA and CON cows, respectively). However, treatment had no effect (p > 0.05) on body weight (BW), body condition score (BCS), and circulating levels of beta-hydroxybutyrate (BHBA), glucose, insulin, growth hormone (GH) and insulin-like growth factor (IGF-I). Our results suggest that supplementation with calcium salts of linseed oil could enhance ovarian function without affecting energy metabolism in early lactation dairy cows.

关键词： α-linolenic acid Supplementation Reproduction Grazing Dairy Cows

The Role of Jasmonates as Antibulbing Substances in the Bulb Formation of Onion

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Agricultural Biotechnology 2024年第1期13卷 1-4,8页

作者： Noboru Takada Atsushi Saito Yuuki Matsuzuka Tatsushi Mochiduki Eriko Wakita Meng WANG Yasunori Koda Faculty of Agriculture and Life Science Hirosaki University3Bunkyo-choHirosaki 036-8561Japan The United Graduate School of Agricultural Science Iwate UniversityMoriokaIwate 020-8550Japan National Institute of Vegitable and Tea Science National Agriculture and Food Research Organization360 KusawaAnoTsu 514-2392Japan Research Faculty of Agriculture Hokkaido UniversityKita-9 Nishi-9Kita-kuSapporo 060-8589Japan

Onion plants form spherical bulbs under long-day *** regulating bulb formation remain *** the course of chemical studies on the bulb formation,α-linolenic acid was isolated from onion extracts as an antibulbing substance,the amount of which was synchronized with the bulb *** allene oxide synthase inhibitor canceled the antibulbing activity ofα-linolenic acid,it was disclosed that jasmonic acid concerns this ***-activity-relationship study revealed that its(3R,7S)stereochemistry is necessary for showing its antibulbing *** is concluded that(3R,7S)-jasmonate derived fromα-linolenic acid actually participates in the regulation of bulb formation.

关键词： Onion(Allim cepa L.cv.Higuma) Isolation Bulb formation Antibulbing substance α-linolenic acid Methyl jasmonate

Fatty acid analysis in the seeds of 50 Paeonia ostii individuals from the same population

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Journal of Integrative Agriculture 2018年第8期17卷 1758-1767页

作者： WEI Xiao-bao XUE Jing-qi WANG Shun-li XUE Yu-qian LIN Huan SHAO Xing-feng XU Dong-hui ZHANG Xiu-xin Key Laboratory of Biology and Genetic Improvement of Horticultural Crops Ministry of Agriculture/Institute of Vegetables and FlowersChinese Academy of Agricultural Sciences Department of Food Science and Engineering Ningbo University

Tree peony seeds are rich in α-linolenic acid(ALA), and the peony seed oil is now being produced in China. Paeonia ostii is the most widely used tree peony species for oil extraction, which is commercially called Fengdan and treated as a single cultivar. Here, 50 P. ostii individuals from the same population in northern China were randomly selected for fatty acids(FAs) analysis. Thirteen FAs were isolated, and the most abundant five were palmitic acid(5.31–6.99%), stearic acid(1.22–2.76%), oleic acid(18.78–28.15%), linoleic acid(11.86–26.10%), and ALA(41.11–57.51%). There were significant individual differences of plants in FA quality and quantity and the linoleic acid content in Plant No. 48 even exceeded the scope of 1–99%. Further statistical analysis indicated that most of the individual FAs, saturated FAs, unsaturated FAs, and total FAs levels showed significant positive correlations to each other, whereas the seed yield per plant was independent and not correlated to the factors mentioned above. Ward’s hierarchical clustering results grouped the 50 plants into four clusters based on FA contents and seed yield, and the seven plants in Cluster IV were identified as good candidates for oil production. Our results confirmed that the individual differences did occur in P. ostii and Fengdan cannot be simply treated as one uniform cultivar. Also, these results may help simplify the selection of plants for oil peony breeding and accelerate the development of the oil peony industry.

关键词： Paeonia ostii seed oil fatty acids α-linolenic acid individual difference

Feeding Calcium Salts of Linseed Oil on Productive Performance and Milk Fatty acid Profile in Grazing Dairy Cows

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Open Journal of Animal Sciences 2020年第4期10卷 761-781页

作者： Yaliska Moreno González Jesica Iorio María Florencia Olmeda Dino Curletto Daniel Scandolo Martín Guillermo Maciel Alejandra Cuatrin Rafael Alejandro Palladino Carolina Pérez Eloy Eduardo Salado Faculty of Agriculture University of Buenos Aires Buenos Aires Argentina Faculty of Agricultural Science National University of Lomas de Zamora Buenos Aires Argentina INTA (National Institute of Experimental Agriculture) Research Station Rafaela Rafaela Santa Fe Argentina CONICET (National Research Council of Argentina) Buenos Aires Argentina INTA (National Institute of Experimental Agriculture) Food Technology Institute Castelar Buenos Aires Argentina

The objective of this study was to determine the effect of supplying calcium salts of linseed oil (Ca-FA) rich in omega-3 (α-linolenic acid) on the production and chemical composition of milk and its nutraceutical value in dairy cows in early lactation. The trial lasted 12 weeks (2 weeks for adaptation to lipids and 10 weeks of data collection). A total of 36 Holstein dairy cows with 58.0 ± 17.0 days in milk (DIM), 594.1 ± 92.4 kg BW, 2.6 ± 1.5 parity and 38.9 ± 9.3 kg milk day-1 were used in a randomized complete block design. The treatments were: 1) Omega-3 (O3): 5.2 kg DM day-1 of concentrate including 0.7 kg DM of Ca-FA + 13.5 kg DM day-1 of partial mixed ration (PMR) + 12 kg DM day-1 of alfalfa pasture (Medicago sativa) and 2) Control (C): diet similar to O3 but lipid supplementation was replaced by cracked corn grain so that the diets were isoenergetic. No treatment effect was detected (P > 0.05) for any milk production and composition variables, except for urea in milk that was slightly higher in O3 (P = 0.02). The treatment × week interaction was significant (P ·day-1 and 3.86% vs. 3.23% for fat yield and content, respectively). Total DMI and PMR were similar (P > 0.05) between treatments. Concentrate intake was higher (P < 0.01) in C compared with O3. Pasture DMI tended (P = 0.06) to be greater for cows that

关键词： Dairy Cow Calcium Salts of Linseed Oil α-linolenic acid Nutraceutical Value

The effects of total dietary C18 PUFA on growth performance and fillet fatty acid composition of rainbow trout(Oncorhynchus mykiss) and subsequent fatty acid wash-out using a finishing period

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The effects of total dietary C18 PUFA on growth performance ...