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Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875

Chinese Journal of Natural Medicines 2021年第9期19卷 700-705页

作者： ZOU Jian ZHANG Shuai ZHAO Huan WANG Yong-Heng ZHOU Zheng-Qun CHEN Guo-Dong HU Dan LI Ning YAO Xin-Sheng GAO Hao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents ofTCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China

Biotransformation ofα-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7 S,8 S,7’S,8’R)iso-magnosalicin(1 a)/(-)(7 R,8 R,7’R,8’S)iso-magnosalicin(1 b)and(+)(7 R,8 R,7’S,8’R)magnosalicin(2 a)/(-)(7 S,8 S,7’R,8’S)magnosalicin(2 b),and four known metabolites,(±)acoraminol A(3),(±)acoraminol B(4),asaraldehyde(5),and 2,4,5-trimethoxybenzoic acid(6).Their structures,including absolute configurations,were determined by extensive analysis of NMR spectra,X-ray crystallography,and quantum chemical ECD calculations.The cytotoxic activity and Aβ_(42)aggregation inhibitory activity of all the compounds were evaluated.Compound 2 displayed significant anti-Aβ_(42)aggregation activity with an inhibitory rate of 60.81%(the positive control EGCG:69.17%).In addition the biotransformation pathway ofα-asarone by Alternaria longipes CGMCC 3.2875 was proposed.

关键词： Biotransformation α-asarone Alternaria longipes CGMCC 3.2875 Anti-Aβ_(42)aggregation activity

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Effects of acrous gramineus and its component, alpha-asarone, on apoptosis of hippocampal neurons after seizure in immature rats

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Neural Regeneration Research 2008年第1期3卷 19-24页

作者： Libin Yang Shulei Li Yanzhi Huang Jianmin Liang Yuhong Wang Department of Pediatrics the First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Histology and Embryology Norman Bethune Medical School Jilin University Changchun 130021 Jilin Province China Department of Internal Medicine Children Hospital of Changchun City Changchun 130061 Jilin Province China Department of Neurology the First Clinical Hospital affiliated to Harbin Medicine University Harbin 150001 Heilongjiang Province China

BACKGROUND： α-asarone and acrous gramineus have been shown to play a necessary function in enhancing the reactivity and convulsant threshold to electric stimulation of immature rats. They have also been shown to effectively suppress epileptic seizures induced by pentylenetetrazol in young rats. However, the mechanisms for these roles have been still unclear. OBJECTIVE： To observe the effects in immature rats of acrous gramineus and α -asarone on apoptosis of hippocampal neurons after epileptic seizure at the protein level, and to analyze the mechanism for these effects. DESIGN： A randomized controlled animal experiment. SETTINGS： Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, Norman Bethune Medical School of Jilin University; Department of Internal Medicine, Children＇s Hospital of Changchun City; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University. MATERIALS： Fifty 3-week old Wistar rats, 34-40 g, irrespective of gender, were provided by Gaoxin Research Center of Medical Animal Experiment, Changchun. The animals were treated according to the animal ethical standards. The following chemicals were used for this study： acrous gramineus powders or infusion （Batch No, 0307113, Tianjiang Medicine Company Limited, Jiangyin）, α-asarone tablets （Batch No. 030219, Tianwei Pharmaceutical Factory, Shenyang）, and phenobarbital sodium tablets （Batch No. 020608, Xinya Medicine Company Limited, Shanghai）. The animals were divided into five groups randomly. First, ten rats were chosen as the normal controls. The remaining rats were treated with i.p. injections of pentylenetetrazol to stimulate an epileptic model. METHODS： The experiments were performed at the Neurological Laboratory of the First Hospital of Jilin University between October and December 2004. The rats were treated with i.p. injections of pentylenetetrazol （60 mg/kg） to establish an epileptic model. According to Racine＇ s standard, animals that reached stage 4 and 5 were cho

关键词： epilepsy immature rats acrous gramineus α-asarone hippocampus apoptosis

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Effect of α-asarone on ethanol-induced learning and memory impairment in mice and its underlying mechanism

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中国药理学与毒理学杂志 2019年第10期 852-852页

作者： XU Fei-fei LI Qin-qing ZHANG Qi LI Xiao-qing GUO Mei-tong ZHANG Yi-ming WANG Zi-lin WANG Jie ZHAO Jia-qi TIAN Ya-juan ZHANG Zhao CHU Shi-feng HE Wen-bin Shanxi University of Chinese Medicine Shanxi Key Laboratory of Chinese Medicine Encephalopathy Chinese Academy of Medical Sciences Peking Union Medical College

OBJECTIVE To investigate the effect ofα-asarone on ethanol-impaired cognitive ability and explore the underlying mechanism in mice. METHODS A mouse model of impaired learning and memory was created by ethanol(2.0 g · kg;, ig). α-asarone(7.5, 15 and 30 mg·kg;, ip) was delivered 10 min prior to ethanol administration. After 40 min, the locomotor activity of mice with learning and memory impairment was evaluated by the open field test and the behavioral effect of α-asarone was evaluated using the novel object recognition test.Glutamate（Glu） and γ-aminobutyric acid（GABA） levels in the hippocampus were determined by ELISA, and the proteins expression levels of hippocampal α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid（AMPA） receptor（Glu R2）, N-methyl-D-aspartic acid（NMDA）receptor（NMDAR2 B）, synaptophysin I（SYNΙ）, glutamate transporter type 1（GLT-1） and calcium/calmodulindependent protein kinaseⅡ（Ca MKⅡ） were detected by Western blotting. RESULTS There was no significant difference in the horizontal or vertical locomotor activity between the ethanol and normal groups or the 7.5, 15 and 30 mg·kg;α-asarone groups[F（5, 48）=0.6536, P>0.05; F（5, 49）=1.995, P>0.05]. The recognition index in the ethanol group was significantly decreased as compared with that in the normal group[F（5, 46） =6.739, Pα-asarone groups as compared with that in the ethanol group（Pα-asarone group（P>0.05）. The hippocampal Glu: GABA ratio in mice was significantly elevated in the ethanol group as compared with that in the normal group（33.42±0.8972 vs 30.79±0.2102, Pα-asarone groups（31.99±0.4986 vs. 33.42±0.8972; 30.97±0.1757 vs. 33.42±0.8972; 30.83 0.1723 vs. 33.42±0.8972, Pα-asarone groups（P<0.05）, with the exception of GluR2, NMDAR2B

关键词： learning and memory impairment α-asarone ethanol glutamate GABA excitotoxicity

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