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Chinese Journal of Chemistry 2014年第3期32卷 241-247页

作者： Yehui Chen Liwen Yang Nianfa Yang Zhusheng Yang Jin Zhang Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education College of ChemistryXiangtan UniversityXiangtanHunan 411105China

(−)-Menthyl(S)-6'-acrylyl-2'-methyloxy-1,1'-binaphthalene-2-carboxylate(3)was synthesized and anionically polymerized using n-BuLi as an initiator in *** monomer 3 was levorotatory and had an[α]_(D)^(25)value of−72.4,but its corresponding polymer poly-3 was dextrorotatory and showed an[α]_(D)^(25)value of+***-3 was confirmed to exist in the form of one-handed helical structure in solution by means of comparing the specific optical rotation and the CD spectra with that of 3 and the model compounds such as(−)-menthyl(S)-6'-propionyl-2'-methyloxy-1,1'-binaphthalene-2-carboxylate 2b and(−)-menthyl(S)-6'-heptanoyl-2'-methyloxy-1,1'-binaphthalene-2-carboxylate *** conclusion was also confirmed by the fact that the g-value of poly-3 is about 11 times of that of monomer 3.

关键词： chiral α,β-unsaturated ketone synthesis anionic polymerization helical polymer

3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors

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Acta Pharmaceutica Sinica B 2017年第4期7卷 479-484页

作者： Hasnah Osman Nor Hashima Idris Ezatul Ezleen Kamarulzaman Habibah A.Wahab Mohd.Zaheen Hassan School of Chemical Sciences Universiti Sains Malaysia School of Pharmaceutical Sciences Universiti Sains Malaysia

Dengue is a severe mosquito-borne viral infection causing half a million deaths annually. Dengue virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active sites. Results were validated through an in vitro DENV2 NS2B/NS3 protease assay using a fluorogenic Boc-Gly-Arg-Arg-AMC substrate. Nitro derivatives of 3,5-bis(arylidene)-4-piperidones (4e and 4j) emerged as promising lead molecules for novel protease inhibitors with an IC50 of 15.22 and 16.23 µmol/L, respectively, compared to the standard, panduratin A, having IC50 of 57.28 µmol/L.

关键词： Dengue virus NS2B/NS3 protease Piperidone α,β-unsaturated ketone Protease inhibitors

Synthesis of α,β-unsaturated ketones using Potassium fluoridealumina Catalyst by Microwave Irradiation

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Chinese Chemical Letters 1998年第6期9卷 521-522页

作者： Xiao Hui ZHANG Da Bin GAO Ming GUO Shan Zhen YAN(Department of Chendstry and Chemical Engineering, Dalian University, Dalian 116622) Department of Chemistry Dalian University Dalian 116622 China

Microwave irradiation can accelerate the rate of the synthetic reaction of α,β-unsaturated ketones by using KF-Al2O3 as catalyst. The rate enhancement of the reaction is 360-860 fold.

关键词： Microwave irradiation α,β-unsaturated ketone KF-Al_2O_3

Narasaka reaction:Desilylative acylation of 1-alkenylsilanes with acid anhydrides

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Chinese Chemical Letters 2021年第9期32卷 2751-2755页

作者： Wei Xiao Jie Wu School of Pharmaceutical and Materials Engineering&Institute for Advanced Studies Taizhou UniversityTaizhou 318000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Recent advances in the desilylative acylation of 1-alkenylsilanes with acid anhydrides under transition metal catalysis are *** catalytic desilylative acylation of 1-alkenylsilanes provides an efficient route toα,β-unsaturated ketones by using rhodium or iridium as the ***,various one pot sequence reactions have been developed,which can synthesizeα,β-unsaturated ketones from simple starting materials in an economic ***,this approach is applied to the asymmetric synthesis of atropisomers possessing silanol groups with excellent enantioselectivity.

关键词： Acid anhydride 1-Alkenylsilane Desilylative acylation Transition metal catalysis α,β-unsaturated ketone

A Facile Method for the Epoxidation of Cyclic Enone Catalyzed by tert-BuNH2 with 30% Hydrogen Peroxide as Oxidant

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Chinese Journal of Chemistry 2006年第10期24卷 1480-1482页

作者：欧阳小月江焕峰黄精美 Department of Chemistry University of Science and Technology of China Hefei Anhui 230026 China College of Chemistry South China University of Technology Guangzhou Guangdong 510640 China

It was found that tert-BuNH2 is an efficient catalyst for epoxidation of α,β-unsaturated ketones with 30% H2O2 under mild conditions. For most of the cyclic unsaturated ketones used, moderate to excellent yields （4... 详细信息

关键词： epoxidation hydrogen peroxide amine catalysis α,β-unsaturated ketone

Mn（lll）-Mediated Chlorination of Conjugated ketones

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Chinese Journal of Chemistry 2011年第10期29卷 2097-2100页

作者：刘兴超王璐邹建平 Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou Jiangsu 215123 China Testing and Analysis Center of Suzhou University Suzhou Jiangsu 215123 China

Mn（III）-Cl formed by the reaction of Mn（OAc）3 and hydrochloric acid in situ, reacted with α,β-unsaturated ketones readily to afford α,β-dichloroketones in good yields under mild conditions. The products are ke... 详细信息

关键词： chlorination Mn(OAc)3 α,β-unsaturated ketone

Efficient synthesis of terminal α,β-unsaturated ketones as the intermediates of the proteasome epoxyketone inhibitors via Weinreb amide

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Journal of Chinese Pharmaceutical Sciences 2009年第1期18卷 33-36页

作者：吕杨邹晓民牟科傅翌秋马超周博徐萍北京大学药学院药物化学系北京100191

Peptidyl epoxyketones were potential antitumor agents due to their 20S proteasome inhibitory activities. Based on their structures and special inhibitory mechanism, a series of compounds were designed by linking the epoxyketone moiety （the Cterminal pharmacophore） and the peptide backbones. To make these compounds, we used a novel method to prepare the terminal α,β-unsaturated ketone, the crucial intermediate, from Weinreb amide with satisfactory yield （62%-65%）.

关键词： Epoxyketone Synthesis α,β-unsaturated ketone Weinreb amide

Synthesis of Novel Naphthalimide-based Enone Triazole

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Synthesis of Novel Naphthalimide-based Enone Triazole