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Precipitation behavior of P550 steel for non-magnetic drill collars during isothermal aging at 650–900℃

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Journal of Iron and Steel research(International) 2022年第4期29卷 636-646页

作者： Li-wei Xu Huai-bei Zheng Hua-bing Li Zhou-hua Jiang Shu-cai Zhang Jiang-tao Yu Hao Feng Yue Lin School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114002LiaoningChina

Precipitation behavior of P550 steel for non-magnetic drill collars was investigated by microstructure characterization as well as thermodynamic calculation.The results demonstrate that the main precipitate formed at 650–900℃was cellular Cr_(2)N,and its precipitation depended heavily on the aging temperature.The most sensitive precipitation temperature of cellular Cr_(2)N was 750℃.At 750℃,the cellular Cr_(2)N exhibited fast-slow precipitation kinetics with the aging time prolonging.The initial precipitation of cellular Cr_(2)N was governed by the short-range intergranular diffusion of Cr.During long-term aging,its growth was controlled by the long-range bulk diffusion of Cr.In addition,cellular Cr_(2)N induced the precipitation of r phase ahead of the cell after long period of aging.Increasing the nitrogen content resulted in the increment of both the nucleation site and the driving force for the cellular Cr_(2)N,which jointly promoted its precipitation.

关键词： P550 steel Non-magnetic drill collar Precipitation behavior Cellular Cr_(2)N r Phase Nitrogen

GAPIT Version 3: Boosting Power and Accuracy for Genomic Association and Prediction

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 629-640页

作者： Jiabo Wang Zhiwu Zhang Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic resource reservation and Utilization Sichuan Province and Ministry of EducationSouthwest Minzu UniversityChengdu 610041China Department of Crop and Soil Sciences Washington State UniversityPullmanWA 99164USA

Genome-wide association study(GWAS)and genomic prediction/selection(GP/GS)are the two essential enterprises in genomic research.Due to the great magnitude and complexity of genomic and phenotypic data,analytical methods and their associated software packages are frequently advanced.GAPIT is a widely-used genomic association and prediction integrated tool as an r package.The first version was released to the public in 2012 with the implementation of the general linear model(GLM),mixed linear model(MLM),compressed MLM(CMLM),and genomic best linear unbiased prediction(g BLUP).The second version was released in 2016 with several new implementations,including enriched CMLM(ECMLM)and settlement of MLMs under progressively exclusive relationship(SUPEr).All the GWAS methods are based on the single-locus test.For the first time,in the current release of GAPIT,version 3 implemented three multi-locus test methods,including multiple loci mixed model(MLMM),fixed and random model circulating probability unification(Farm CPU),and Bayesian-information and linkage-disequilibrium iteratively nested keyway(BLINK).Additionally,two GP/GS methods were implemented based on CMLM(named compressed BLUP;c BLUP)and SUPEr(named SUPEr BLUP;s BLUP).These new implementations not only boost statistical power for GWAS and prediction accuracy for GP/GS,but also improve computing speed and increase the capacity to analyze big genomic data.Here,we document the current upgrade of GAPIT by describing the selection of the recently developed methods,their implementations,and potential impact.All documents,including source code,user manual,demo data,and tutorials,are freely available at the GAPIT website(http://***/GAPIT).

关键词： GWAS Genomic selection Software r GAPIT

mrMLM v4.0.2: An r Platform for Multi-locus Genome-wide Association Studies

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 481-487页

作者： Ya-Wen Zhang Cox Lwaka Tamba Yang-Jun Wen Pei Li Wen-Long ren Yuan-Li Ni Jun Gao Yuan-Ming Zhang Crop Information Center College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Mathematics Egerton UniversityEgerton 536-20115Kenya State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China Department of Epidemiology and Medical Statistics School of Public HealthNantong UniversityNantong 226019China College of Informatics Huazhong Agricultural UniversityWuhan 430070China

Previous studies have reported that some important loci are missed in single-locus genome-wide association studies(GWAS),especially because of the large phenotypic error in field experiments.To solve this issue,multi-locus GWAS methods have been recommended.However,only a few software packages for multi-locus GWAS are available.Therefore,we developed an r software named mr MLM v4.0.2.This software integrates mr MLM,FASTmr MLM,FASTmr EMMA,p LArm EB,p KWm EB,and ISIS EM-BLASSO methods developed by our lab.There are four components in mr MLM v4.0.2,including dataset input,parameter setting,software running,and result output.The fread function in data.table is used to quickly read datasets,especially big datasets,and the do Parallel package is used to conduct parallel computation using multiple CPUs.In addition,the graphical user interface software mr MLM.GUI v4.0.2,built upon Shiny,is also available.To confirm the correctness of the aforementioned programs,all the methods in mr MLM v4.0.2 and three widely-used methods were used to analyze real and simulated datasets.The results confirm the superior performance of mr MLM v4.0.2 to other methods currently available.False positive rates are effectively controlled,albeit with a less stringent significance threshold.mr MLM v4.0.2 is publicly available at Bio Code(https://***/biocode/tools/BT007077)or r(https://***/web/packages/mr MLM.GUI/index.html)as an open-source software.

关键词： Genome-wide association study Linear mixed model mrMLM Multi-locus genetic model r

不同沉水植物净水能力与植株体细菌群落组成相关性

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环境科学 2019年第11期40卷 4962-4970页

作者：李琳岳春雷张华李贺鹏杨乐王珺浙江农林大学林业与生物技术学院临安311300 浙江省林业科学研究院杭州310000

选取苦草(Vallisneria natans)、密刺苦草(Vallisneria denseserrulata)、黑藻(Hydrilla verticillata)、伊乐藻(Elodea canadensis)、金鱼藻(Ceratophyllum demersum)、竹叶眼子菜(Potamogeton malaianus)、篦齿眼子菜(Potamogeton pectinatus)和微齿眼子菜(Potamogeton maackianus)这8种亚热带地区常见的沉水植物为研究对象,在室内静水条件下对其氮、磷吸收和水质净化能力进行对比试验,并结合16S r rNA基因测序对沉水植物关联细菌群落组成进行测定,研究沉水植物对水体的净化能力与植株体菌群之间的相关性.结果表明,8种沉水植物对水体中的氮磷的去除主要通过植物增效作用,植物吸收富集作用去除率较低.其中密刺苦草对水体中TN、TP的去除率最高,达到了91.58%和96.81%.伊乐藻、金鱼藻对水中氮磷自身吸收能力高于其他组,密刺苦草和苦草的植物增效的净化能力最强.经分析,8种沉水植物对水体中氮磷的净化能力较强可能是因为植物关联的细菌大多具有降解作用.根瘤菌目(rhizobiales)、伯克霍尔德氏菌目(Burkholderiales)、黄杆菌目(Flavobacteriales)、产碱杆菌科(Alcaligenaceae)、贪铜菌属(Cupriavidus)和芽孢杆菌属(Bacillales)的细菌可能是引起密刺苦草增效的净化能力较强的优势菌群,异常球菌纲(Deinococci)、丛毛单胞菌科(Comamonadaceae)、腐螺旋菌科(Saprospiraceae)和生丝微菌属(Hyphomicrobium)的细菌可能是引起苦草增效的净化能力较强的优势菌群.

关键词：沉水植物净化能力 16S r rNA基因测序降解作用优势菌群

金融发展、研发投入与绿色全要素生产率——基于不同维度金融发展的视角

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华东理工大学学报（社会科学版） 2022年第6期37卷 127-145页

作者：张莹莹东北财经大学金融学院辽宁大连116000

本文基于中国2011—2019年30个省份的面板数据,采用SBM-GML方法测算了各省份的绿色全要素生产率,在金融规模、金融效率和金融结构等三个维度下,运用中介效应模型分析金融发展对绿色全要素生产率的传导机制。本文运用主成分分析法对金融... 详细信息

本文基于中国2011—2019年30个省份的面板数据,采用SBM-GML方法测算了各省份的绿色全要素生产率,在金融规模、金融效率和金融结构等三个维度下,运用中介效应模型分析金融发展对绿色全要素生产率的传导机制。本文运用主成分分析法对金融发展水平进行了细分,进一步探讨在不同金融发展水平下,r&D投入的中介效应是否存在异质性。研究发现:金融发展在规模维度和结构维度上促进了绿色全要素生产率增长,但是在金融欠发达地区,金融发展只在结构维度上促进了绿色全要素生产率增长。r&D投入发挥了中介效应,在金融发达地区,r&D投入虽然没有增强金融规模和金融结构对绿色全要素生产率的促进作用,但是减弱了金融效率对绿色全要素生产率的抑制作用;在金融欠发达地区,r&D投入减弱了金融规模和金融效率对绿色全要素生产率的抑制作用。笔者建议从金融规模和金融效率入手,改善各地金融发展对绿色全要素生产率的抑制作用,发挥好r&D投入的中介效应,制定差异化的金融政策,提高中国金融发展的整体水平,促进绿色全要素生产率增长。

关键词：金融发展绿色全要素生产率 r &D 投入中介效应模型

CANON在SBAF中的快速启动及其微生物特征

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环境科学 2017年第1期38卷 253-259页

作者：刘竹寒岳秀于广平金腊华唐嘉丽吉世明暨南大学环境学院广州510632 广州中国科学院沈阳自动化研究所分所广州511458

启动周期长是单级全程自养脱氮工艺(CANON)的主要制约因素之一.本文研究了基于淹没式生物滤池(SBAF)的CANON工艺的快速启动方法.首先,以城镇污水处理厂二沉池中普通活性污泥为种泥,在(30±2)℃、不添加有机碳源,控制DO(阶段Ⅰ:0.3~0.5 m... 详细信息

启动周期长是单级全程自养脱氮工艺(CANON)的主要制约因素之一.本文研究了基于淹没式生物滤池(SBAF)的CANON工艺的快速启动方法.首先,以城镇污水处理厂二沉池中普通活性污泥为种泥,在(30±2)℃、不添加有机碳源,控制DO(阶段Ⅰ:0.3~0.5 mg·L^(-1),阶段Ⅱ~Ⅳ:0.1~0.2 mg·L^(-1))的实验条件下,经过48 d对污泥微生物的驯化,成功启动了CANON工艺,氨氮(NH+4-N)和总氮(TN)最大去除率分别达到99.9%和86.5%.其次,采用16S r DNA宏基因组高通量测序技术研究了体系内微生物种群结构特性.测序结果显示体系内两个优势微生物菌门是Proteobacteria(变形菌门)和Planctomycetes(浮霉菌门),平均分别占比26.6%和17.8%,主要脱氮微生物是β-Proteobacteria中的Nitrosomonas和Brocadiae中的Candidatus brocadia.通过以上实验分析得出:采用SBAF启动CANON技术,具有可实现体系快速启动、生物高效脱氮、过程稳定运行等特性.

关键词：淹没式生物滤池单级自养脱氮氨氮 16S r DNA宏基因组测序生物群落结构

Human antigen r mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer

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World Journal of Gastroenterology 2019年第2期25卷 205-219页

作者： Ausra Lukosiute-Urboniene Aldona Jasukaitiene Giedre Silkuniene Vidmantas Barauskas Antanas Gulbinas Zilvinas Dambrauskas Institute for Digestive System research Lithuanian University of Health Sciences Department of Pediatric Surgery Lithuanian University of Health Sciences Department of Surgery Lithuanian University ofHealth Sciences

AIM To determine the association of human antigen r(Hur) and inhibitors of apoptosis proteins(IAP1, IAP2) and prognosis in pancreatic cancer.METHODS Protein and mrNA expression levels of IAP1, IAP2 and Hur in pancreatic ductal adenocarcinoma(PDAC) were compared with normal pancreatic tissue. The correlations among IAP1/IAP2 and Hur as well as their respective correlations with clinicopathological parameters were analyzed. The Kaplan-Meier method and log-rank tests were used for survival analysis. Immunoprecipitation assay was performed to demonstrate Hur binding to IAP1, IAP2 mrNA. PANC1 cells were transfected with either anti-Hur sirNA or control sirNA for 72 h and quantitative reverse transcription polymerase chain reaction(rT-PCr), western blot analysis was carried out.rESULTS rT-PCr analysis revealed that Hur, IAP1, IAP2 mrNA expression were accordingly 3.3-fold, 5.5-fold and 8.4 higher in the PDAC when compared to normal pancreas(P ression of IAP1 was positively strongly correlated with Hur expression(P r = 0.783). Western blot analysis confirmed rTPCr results. High IAP1 expression, tumor resection status, T stage, lymph-node metastases, tumor differentiation grade, perineural and lymphatic invasion were identified as significant factors for shorter survival in PDAC patients(P r was mainly expressed in the ductal cancer cell's nucleus and less so in cytoplasm. rNA immunoprecipitation analysis confirmed IAP1 and IAP2 post-transcriptional regulation by Hur protein. Following siHur transfection, IAP1 mrNA and protein levels were decreased, however IAP2 expression levels were increased.CONCLUSION Hur mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer. Further studies are needed to assess the underlying mechanisms.

关键词： Pancreatic cancer Inhibitors of apoptosis proteins Human antigen r Posttranscriptional regulation

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5-HTr异源二聚体功能研究进展

中国药理学通报 2023年 1201-1205页

作者：高欢谭博杜广营苏瑞斌军事科学院军事医学研究院毒物药物研究所抗毒药物与毒理学国家重点实验室烟台大学药学院

血清素2A受体(5-HT2Ar)作为致幻剂、抗抑郁药、抗焦虑药和非典型抗精神病药物等许多精神活性药物的作用靶点，受到人们的广泛关注。5-HT2Ar属于G蛋白偶联受体(GPCrs)，与mGlur2、D2r和CB1r等多种GPCrs形成异源二聚体。二聚体中的mGlur2... 详细信息

血清素2A受体(5-HT2Ar)作为致幻剂、抗抑郁药、抗焦虑药和非典型抗精神病药物等许多精神活性药物的作用靶点，受到人们的广泛关注。5-HT2Ar属于G蛋白偶联受体(GPCrs)，与mGlur2、D2r和CB1r等多种GPCrs形成异源二聚体。二聚体中的mGlur2、D2r与CB1r影响5-HT2Ar偶联的信号通路和诱导的动物行为，并且3种受体分别被敲除后，致幻性5-HT2Ar激动剂诱导产生的甩头反应次数明显降低。基于5-HT2Ar/mGlur2、5-HT2Ar/D2r和5-HT2Ar/CB1r异源二聚体的重要性，该文将3种受体与5-HT2Ar形成异源二聚体的发现与功能进行详细综述，为探寻以5-HT2Ar为靶点的精神活性药物作用机制提供参考。

关键词： 5-HT r mGlur D2r CB r 异源二聚体甩头反应

突发危机事件下中国股市行业板块间多尺度相依结构及动态演化研究——以新冠肺炎疫情为分析背景

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工业技术经济 2023年第5期42卷 70-79页

作者：于金明金秀刘月立东北大学工商管理学院沈阳110169

近年来,频繁爆发的危机事件对中国经济和金融市场造成了严重的负面冲击。在此背景下,本文将变分模态分解和r Vine Copula结合,以新冠肺炎疫情为分析背景,研究突发危机事件下中国股市行业板块间相依结构及其动态演化,并进一步从短期和长... 详细信息

近年来,频繁爆发的危机事件对中国经济和金融市场造成了严重的负面冲击。在此背景下,本文将变分模态分解和r Vine Copula结合,以新冠肺炎疫情为分析背景,研究突发危机事件下中国股市行业板块间相依结构及其动态演化,并进一步从短期和长期两个方面,探讨相依结构的异质特征。研究发现:(1)行业间相依结构的关键节点及行业间关联方式随疫情的发展而发生变化,在长期和短期尺度下,行业间相依结构具有异质性特征;(2)疫情冲击导致相依结构中关联行业间相关系数提高,引起跨行业风险传染,长期传染效应强于短期传染效应;(3)疫情冲击在短期内引起各行业间发生风险传染,但长期来看,存在“风险隔离行业”。研究结果可以为投资者决策、行业部门风险监测预警、监管者防范和化解系统性风险提供重要依据。

关键词：突发危机事件新冠肺炎疫情多尺度相依结构变分模态分解 r Vine Copula