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Coronary heart disease： incidence, risk factors and interventions in Jiaozhou of Shandong province

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Chinese Medical Journal 2014年第12期127卷 2275-2278页

作者： Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin Department of Cardiology Affiliated Cardiovascular Hospital of Qingdao UniversityQingdaoShandong 266071China Department of Cardiology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266042China Department of Cardiology Jiaozhou Peoples HospitalQingdaoShandong 266300China Department of Cardiology Jiaozhou Puji Central Health InstituteQingdaoShandong 266326China

Background Coronary heart disease (CHD) is the most common type of heart disease and cause of heart attacks.This study investigated the epidemiological characteristics of CHD and its risk factors in Jiaozhou,Shandong province,to ultimately find a way of reducing the prevalence of cardiovascular disease,and to provide a theoretical basis for establishing a cardiovascular disease management path under the regional medical collaborative mechanism.Methods A questionnaire survey was performed including 1 952 people aged 35 years or older who were questioned by means of stratified,cluster,proportional sampling to investigate the prevalence of CHD and its risk factors.The data were inputted into SPSS11.0 statistical software for processing and analysis.We advised the local medical institutions to establish health files for the residents with CHD and risk factors.They were followed up regularly.Their risk factors and life-style were monitored,and advice was given as to proper medications.Green channels were established,and the patients were transmitted in a timely manner to superior hospitals for better treatment if the necessary treatments were not available in the local hospitals.The control of risk factors was observed after the follow-up for half a year.Results In Jiaozhou,the rates of coronary artery disease,hypertension,diabetes,hyperlipidemia and overweight were 8.15%,28.54%,11.43%,35.46%,and 18.70% respectively.The rates of hypertension,diabetes,hyperlipidemia and overweight were higher than the data published in "The report of Chinese cardiovascular disease 2012"; which are 24%,9.7%,18.6%,and 9.7%,respectively.The control of risk factors improved significantly after the guidance of the residents lifestyle and medication for six months.Conclusions The high prevalence of coronary artery disease in Jiaozhou is closely related to age,gender,diet structure,family history of cardiovascular disease,hypertension,diabetes,hyperlipidemia,overweight,and unhealthy lifestyle.Under the regional medical coordination mechanism,

关键词：冠状动脉疾病危险因素心脏疾病发病率山东省干预措施胶州市心血管疾病

First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease： results of the first in man FIREHAWK trial

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Chinese Medical Journal 2012年第6期125卷 970-976页

作者： QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin Department of Cardiology Cardiovascular Institute and Fu Wai Hospital Chinese Academy Of Medical Sciences and Peking Union Medical College Beijing 100037 China Catheterization Laboratory Cardiovascular Institute and Fu Wai Hospital Chinese Academy Of Medical Sciences and Peking Union Medical College Beijing 100037 China Yale University School of Medicine New Haven CT USA Cardiovascular Research Foundation New York NY USA Columbia University Medical Center New York NY USA

Background Durable polymers used for first-generation drug-eluting stents (DES) potentially contribute to persistent inflammation and late DES thrombosis. We report the first in human experience with the rapamycin-eluting biodegradable polymer coated cobalt-chromium FIREHAWK stent with abluminal groove. Methods A total of 21 patients with stable or unstable angina, or prior myocardial infarction, with single de novo native coronary stenoses <30 mm in length in vessel sizes ranging from 2.25 to 4.0 mm were enrolled. The primary endpoint was major adverse cardiac events (MACE) at 30 days defined as the composite of cardiac death, myocardial infarction (Q and non-Q), or ischemia-driven target lesion revascularization. Secondary endpoints include device, lesion, and clinical success rates, 4-month in-stent late lumen loss by quantitative coronary angiography (QCA), proportion of uncovered or malapposed stent struts by optical coherence tomograpphy (OCT) at 4 months, and MACE at 4, 12, 24 and 36-month follow-up. Results Device success was 95.7%, lesion and clinical success was 100.0%. There were no MACE events at 30 days. One patient died of non-cardiac hemorrhagic stroke 5 days after index procedure. At 4 months, in-stent late loss was (0.13±0.18) mm, and complete strut coverage was 96.2% by OCT with 0.1% strut malapposition. At 4-month follow-up there was no additional MACE events, and a single target vessel (non-target lesion) revascularization. Conclusions The FIREHAWK abluminal groove biodegradable polymer rapamycin-eluting stent demonstrated feasibility, safety and efficacy in this first in human experience. OCT findings indicated excellent stent strut coverage 4 months after implantation. Larger studies are required to confirm whether the early FIREHAWK stent results translate into longer term restenosis and thrombosis benefits.

关键词：可生物降解聚合物雷帕霉素冠状动脉疾病支架洗脱 MACE 审判男子

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冠状动脉CT血流储备分数研究新进展

中华内科杂志 2023年第11期62卷 1364-1368页

作者：张闰秋张龙江南京大学医学院附属金陵医院、东部战区总医院放射诊断科南京210002

冠状动脉CT血流储备分数(CT-FFR)是一种基于冠状动脉CT血管成像(CCTA)的影像数据模拟计算血流储备分数(FFR)的无创新技术,能同时提供病变的解剖学与功能性缺血信息,且与有创FFR有高度的一致性,为冠心病的临床管理提供了创新的工具,是近... 详细信息

冠状动脉CT血流储备分数(CT-FFR)是一种基于冠状动脉CT血管成像(CCTA)的影像数据模拟计算血流储备分数(FFR)的无创新技术,能同时提供病变的解剖学与功能性缺血信息,且与有创FFR有高度的一致性,为冠心病的临床管理提供了创新的工具,是近些年冠心病无创影像学研究的热点领域。本文综述了CT-FFR最新的研究进展。

关键词：血流储备分数冠状动脉疾病 CT血管成像

Association of chronic obstructive pulmonary disease with coronary artery disease

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Chinese Medical Journal 2013年第17期126卷 3205-3208页

作者： LIANG Bin-miao XU Zhi-bo YI Qun OU Xue-mei FENG Yu-lin Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Respiratory Medicine No. 2 People's Hospital of Chengdu Chengdu Sichuan 610017 China

Background The relationship between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) remains largely unknown. This study aimed to explore the association of COPD with CAD, especially with multi- vessel disease (VD). Methods The data of 354 patients who underwent multi-detector computed tomography (MDCT) for suspected CAD were analyzed. Luminal narrowing was defined as at least one lesion 50% or greater stenosis. The analysis of serum biochemistry profile and spirometrywere performed on all eligible patients, and the diagnosis of COPD was defined as the criteria of Global Initiative for Chronic Obstructive Lung Disease. Results Patients with CAD had a significantly higher complication of COPD than those without CAD (11.8% vs. 3.7%, P <0.001). Comparing with patients without COPD, those with COPD were more likely to have multi-VD, proportion of smoking and high C-reactive protein (CRP) (P <0.001). Multivariate Logistic regression analysis revealed that the multi-VD was significantly correlated with COPD (P=-0.012) and CRP (P=0.015). Conclusions There was a high complication of COPD in patients with CAD, and COPD may be a critical risk factor for CAD, especially for multi-VD. CAD and COPD were closely associated and the interplay of systemic inflammation might in part explain the relationship between them.

关键词：慢性阻塞性肺疾病冠状动脉疾病慢性阻塞性肺病 Logistic回归分析协会计算机断层扫描 C-反应蛋白 CAD

Heart rate distribution and predictors of resting heart rate after initiation of beta-blocker treatment in patients with coronary artery disease： REsults of Sympathetic Evaluation And Research of China （RESEARCH） study

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Chinese Medical Journal 2013年第18期126卷 3460-3463页

作者： ZHAO Ying-xin LI Yue-ping GAO Fei MA Han-ying WANG Zhi-jian HAN Hong-ya SHEN Hua ZHOU Yu-jie Department of Cardiology Anzhen Hospital Capital Medical University Beijing 100029 China

Background The importance of heart rate as secondary prevention strategies for patients with coronary artery disease (CAD) is emphasized by multiple guidelines. However, limited information is available on the heart rate distribution and the change patterns of resting heart rate when initiating beta-blocker therapy among Chinese patients with CAD. Methods The REsults of Sympathetic Evaluation And Research of China (RESEARCH) study is a multi-centre, prospective, observational study involving 147 centers in 23 cities across China. All eligible beta-blocker naive patients were prescribed with metroprolol succinate. Initial dosage and target heart rate were selected at the discretion of their physicians in charge according to their usual institutional practice. The heart rate distribution and the change patterns of resting heart rate after initiation of beta-blocker therapy were observed. Results The majority of patients (63.6%) were prescribed with 47.5mg metroprolol succinate. At baseline, there were only 17.4% of patients whose heart rate was less than 70 beats per minute, and the proportion reached 42.5% and 79.1%, one month and two months after initiation of beta-blockers, respectively. Multivariate linear regression analysis showed that baseline heart rate (B=0.900, SE=0.006, t=141.787, P<0.0001) and the dosage (B=-0.007, SE=0.002, t=-3.242, P=0.001) were independent predictors of resting heart rate 2months after beta-blocker therapy. Conclusions Resting heart rate is not optimally controlled in a broadly representative cohort of Chinese outpatients with CAD even after initiation ofβ-blocker therapy, and baseline heart rate and the dosage of beta-blocker are both independent predictors of resting heart rate afterβ-blocker therapy.

关键词： β-受体阻滞剂冠状动脉疾病速率分布预测因子交感神经心脏患者治疗

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冠状动脉起源异常行外科去顶手术1例

中华心血管病杂志 2022年第6期50卷 603-605页

作者：徐文杰徐承义韩啸王炜宋丹武汉亚洲心脏病医院心内科武汉430021

患者中年女性,有高血压等冠心病危险因素,临床表现为典型劳力性胸痛症状且逐渐加重,行冠状动脉造影发现左主干起源异常及开口狭窄可能,同时可见右冠状动脉至左冠状动脉侧支循环,因导管无法与左主干血管腔同轴,无法明确左主干开口狭窄情... 详细信息

患者中年女性,有高血压等冠心病危险因素,临床表现为典型劳力性胸痛症状且逐渐加重,行冠状动脉造影发现左主干起源异常及开口狭窄可能,同时可见右冠状动脉至左冠状动脉侧支循环,因导管无法与左主干血管腔同轴,无法明确左主干开口狭窄情况,结合病史特点及侧支循环等情况认为该患者存在冠状动脉严重狭窄的可能性极大,故术中行血管内超声检查明确左主干开口存在严重狭窄,最终行外科手术治疗。患者左主干开口起源异常并重度狭窄为冠状动脉起源异常的高危类型,容易漏诊且猝死率极高,需尽早发现、尽早治疗。

关键词：冠状动脉疾病左主干去顶手术

微RNA与冠状动脉疾病研究的文献计量学评价

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中国医药导报 2024年第2期21卷 25-30页

作者：李敏赵小晗刘敏马晓娟中国中医科学院西苑医院心血管科北京100091 北京中医药大学研究生院北京100029

目的基于CiteSpace和VOSviewer探讨微RNA(miRNA)与冠状动脉疾病(CAD)研究的热点与趋势。方法通过检索WebofScience核心合集数据库和中国知网、万方数据知识服务平台、维普网,获取2010年1月至2023年6月有关miRNA与CAD研究的相关文献,利用... 详细信息

目的基于CiteSpace和VOSviewer探讨微RNA(miRNA)与冠状动脉疾病(CAD)研究的热点与趋势。方法通过检索WebofScience核心合集数据库和中国知网、万方数据知识服务平台、维普网,获取2010年1月至2023年6月有关miRNA与CAD研究的相关文献,利用CiteSpace6.2.R2、VOSviewer1.6.19绘制作者、关键词共现、突现、时间线图谱。结果共纳入英文文献1733条,中文文献748条。中国是最高产的国家,中山大学是领先的研究机构,王阶发表论文最多。冠心病、动脉粥样硬化是主要关键词。结论验证不同miRNA亚型对CAD的调控作用及其机制为主要热点,未来的研究将致力于促进miRNA在CAD早期诊断、治疗及预后中的临床应用。

关键词：微RNA 冠状动脉疾病 CiteSpace VOSviewer

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冠状动脉疾病绿色介入治疗的研究进展

心电与循环 2018年第1期37卷 44-47页

作者：姜文兵朱宁杨向军浙江省温州市人民医院心内科 325000 苏州大学苏州大学附属第一医院心内科

冠状动脉疾病是指冠状动脉粥样硬化致使管腔发生堵塞以及冠状动脉发生功能性改变。其为导致患者心绞痛、心肌梗死、心力衰竭甚至猝死的根本原因。介入治疗是目前公认的冠状动脉疾病的有效方法。虽然不断发展的介入技术和器械在冠状动脉... 详细信息

冠状动脉疾病是指冠状动脉粥样硬化致使管腔发生堵塞以及冠状动脉发生功能性改变。其为导致患者心绞痛、心肌梗死、心力衰竭甚至猝死的根本原因。介入治疗是目前公认的冠状动脉疾病的有效方法。虽然不断发展的介入技术和器械在冠状动脉疾病的治疗中展现了良好的效果,能够给患者带来长期无冠状动脉事件生存的临床获益,但是支架内再狭窄仍然是阻碍冠状动脉疾病治疗进展的主要原因,还需进一步改进介入手段或器械。近年来随着可吸收药物洗脱支架(BVS)以及药物涂层球囊(DCB)的出现,再狭窄的问题又有了新的解决方案。

关键词：冠状动脉疾病可吸收药物洗脱支架药物涂层球囊

IQon光谱CT多参数定量检查在冠状动脉疾病临床鉴别诊断中的应用价值分析

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黑龙江医药 2024年第1期37卷 192-195页

作者：龚伟琴林端福建中医药大学附属人民医院医学影像科福建福州350004

目的:探讨IQon光谱CT多参数定量检查在冠状动脉疾病临床鉴别诊断中的应用价值。方法:选择我院收治的86例冠状动脉疾病患者与同期体检86名健康人员分别纳入观察组与对照组。对两组研究对象均进行IQon光谱CT多参数定量检查。比较两组光谱C... 详细信息

目的:探讨IQon光谱CT多参数定量检查在冠状动脉疾病临床鉴别诊断中的应用价值。方法:选择我院收治的86例冠状动脉疾病患者与同期体检86名健康人员分别纳入观察组与对照组。对两组研究对象均进行IQon光谱CT多参数定量检查。比较两组光谱CT多参数定量检查结果,并根据检查结果绘制ROC曲线,分析碘密度图、常规图像、能谱曲线斜率、有效原子序数图诊断冠心病的最佳截断值与AUC,比较各项目单独检测与联合检测诊断冠心病的效能。结果:观察组碘密度图、常规图、有效原子序数图检查结果均低于对照组,能谱曲线斜率检查结果高于对照组(P冠状动脉疾病临床鉴别诊断中的应用效果较好,多参数联合检测可为冠状动脉疾病临床诊断提供充足数据参考,帮助医师准确诊断疾病,对后续治疗方案的制定与改善也具有重要意义。

关键词： IQon光谱CT 多参数定量检查冠状动脉疾病鉴别诊断