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Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration research 2025年第8期20卷 2319-2320页

作者： Kiyoung Kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Cotton Leaf Diseases Recognition Using Deep Learning and Genetic Algorithm

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Computers, Materials & Continua 2021年第12期69卷 2917-2932页

作者： Muhammad Rizwan Latif Muhamamd Attique Khan Muhammad Younus Javed Haris Masood Usman Tariq Yunyoung Nam Seifedine Kadry Department of Computer Science HITEC University TaxilaTaxilaPakistan Wah Engineering College University of WahWah Cantt47080Pakistan College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea Faculty of Applied Computing and Technology Noroff University CollegeKristiansandNorway

Globally,Pakistan ranks 4th in cotton production,6th as an importer of raw cotton,and 3rd in cotton *** 10%of GDP and 55%of the country’s foreign exchange earnings depend on cotton *** 1.5 million people in Pakistan are engaged in the cotton value ***,several diseases such as Mildew,Leaf Spot,and Soreshine affect cotton *** diagnosis is not a good solution due to several factors such as high cost and unavailability of an ***,it is essential to develop an automated technique that can accurately detect and recognize these diseases at their early *** this study,a new technique is proposed using deep learning architecture with serially fused features and the best feature *** proposed architecture consists of the following steps:(a)a self-collected dataset of cotton diseases is prepared and labeled by an expert;(b)data augmentation is performed on the collected dataset to increase the number of images for better training at the earlier step;(c)a pre-trained deep learning model named ResNet101 is employed and trained through a transfer learning approach;(d)features are computed from the third and fourth last layers and serially combined into one matrix;(e)a genetic algorithm is applied to the combined matrix to select the best points for further *** final recognition,a Cubic SVM approach was utilized and validated on a prepared *** the newly prepared dataset,the highest achieved accuracy was 98.8%using Cubic SVM,which shows the perfection of the proposed framework..

关键词： Plants diseases data augmentation deep learning features fusion features selection

Classification of Retroviruses Based on Genomic Data Using RVGC

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Computers, Materials & Continua 2021年第12期69卷 3829-3844页

作者： Khalid Mahmood Aamir Muhammad Bilal Muhammad Ramzan Muhammad Attique Khan Yunyoung Nam Seifedine Kadry Department of CS&IT University of SargodhaSargodha40100Pakistan Department of CS&IT University of MianwaliMianwali42200Pakistan School of Systems and Technology University of Management and TechnologyLahore54782Pakistan Department of Computer Science HITEC University TaxilaTaxilaPakistan Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea Faculty of Applied Computing and Technology Noroff University CollegeKristiansandNorway

Retroviruses are a large group of infectious agents with similar virion structures and replication ***,cancer,neurologic disorders,and other clinical conditions can all be fatal due to retrovirus *** of retroviruses by genome sequence is a biological problem that benefits from computational *** National Center for Biotechnology Information(NCBI)promotes science and health by making biomedical and genomic data available to the *** research aims to classify the different types of rotavirus genome sequences available at the ***,nucleotide pattern occurrences are counted in the given genome sequences at the preprocessing *** on some significant results,the number of features used for classification is reduced to *** classification shall be carried out in two *** first phase of classification shall select only two *** data in the first phase is transferred to the next phase,where the final decision is taken with the remaining three *** data sets of animals and human retroviruses are selected;the training data set is used to minimize the classifier’s number and training;the validation data set is used to validate the *** performance of the classifier is analyzed using the test data ***,we use decision tree,naive Bayes,knearest neighbors,and vector support machines to compare *** results show that the proposed approach performs better than the existing methods for the retrovirus’s imbalanced genome-sequence dataset.

关键词： Retroviruses machine learning bioinformatics classification

Network Analysis for Projects with High Risk Levels in Uncertain Environments

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Computers, Materials & Continua 2022年第1期70卷 1281-1296页

作者： Mohamed Abdel-Basset Asmaa Atef Mohamed Abouhawwash Yunyoung Nam Nabil M.AbdelAziz Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast Lansing48824MIUSA Department of Computer Science and Engineering Soonchunhyang UniversityAsan31538Korea

The critical path method is one of the oldest and most important techniques used for planning and scheduling *** main objective of project management science is to determine the critical path through a network representation of *** critical path through a network can be determined by many algorithms and is useful for managing,monitoring,and controlling the time and cost of an entire *** essential problem in this case is that activity durations are uncertain;time presents considerable uncertainty because the time of an activity is not always easily or accurately *** issue increases the need to use neutrosophic theory to solve the critical path ***-world problems are characterized by a lack of precision,consistency,and *** concept of neutrosophic sets has been introduced as a generalization of fuzzy,intuitionistic fuzzy,and crisp sets to overcome the ambiguity surrounding real-world ***-,falsity-,and indeterminacy-membership functions are used to express neutrosophic *** study was performed to examine a neutrosophic event-oriented algorithm for determining the critical path in activity-on-arc *** activity time estimates are presented as trapezoidal neutrosophic numbers,and score and accuracy functions are used to obtain a crisp model of the *** appropriate numerical example is then used to explain the proposed method.

关键词： Project management project life cycle project planning project scheduling CPM neutrosophic set theory trapezoidal neutrosophic number

Fruits and Vegetable Diseases Recognition Using Convolutional Neural Networks

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Computers, Materials & Continua 2022年第1期70卷 619-635页

作者： Javaria Amin Muhammad Almas Anjum Muhammad Sharif Seifedine Kadry Yunyoung Nam university of Wah WahCanttPakistan National university of Technology(NUTECH) IJP RoadIslamabadPakistan COMSATS university Islamabad Wah CampusPakistan Faculty of Applied Computing and Technology Noroff University CollegeKristiansandNorway Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

As they have nutritional,therapeutic,so values,plants were regarded as important and they’re the main source of humankind’s energy *** pathogens will affect its leaves at a certain time during crop cultivation,leading to substantial harm to crop productivity&economic selling *** the agriculture industry,the identification of fungal diseases plays a vital ***,it requires immense labor,greater planning time,and extensive knowledge of plant *** approaches are developed and tested by different researchers to classify plant disease identification,and that in many cases they have also had important results several ***,the proposed study presents a new framework for the recognition of fruits and vegetable *** work comprises of the two phases wherein the phase-I improved localization model is presented that comprises of the two different types of the deep learning models such asYouOnly Look Once(YOLO)v2 and Open Exchange Neural(ONNX)*** localizationmodel is constructed by the combination of the deep features that are extracted from the ONNX model and features learning has been done through the convolutional-05 layer and transferred as input to the YOLOv2 *** localized images passed as input to classify the different types of plant *** classification model is constructed by ensembling the deep features learning,where features are extracted dimension of 1×1000 from pre-trained Efficientnetb0 model and supplied to next 07 layers of the convolutional neural network such as 01 features input,01 ReLU,01 Batch-normalization,02 *** proposed model classifies the plant input images into associated labels with approximately 95%prediction scores that are far better as compared to current published work in this domain.

关键词： Efficientnetb0 open exchange neural network features learning softmax YOLOv2

The likelihood of having a serum PSA level of ≥ 2.5 or ≥ 4.0 ng ml^-1 according to obesity in a screened Korean population

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Asian Journal of Andrology 2013年第6期15卷 770-772,I0007页

作者： Won Jae Yang Department of Urology Soonchunhyang University College of Medicine Seoul 140-743 South Korea

This study aimed to determine if lower serum total prostate-specific antigen （PSA） levels in obese Korean men affect prostate cancer （PCa） screening, as an increased body mass index （BMI） is inversely associated with the PSA level. Between March 2007 and December 2012, 22 208 native Korean men who were eligible to receive a serum PSA test were recruited. Logistic regression was used to estimate the odds of an ＇abnormal＇ PSA （ ≥ 2.5 or/〉 4.0 ng ml^- 1） in these men （age： 45-75 years, PSA 〈 10 ng ml^-1） based on BMI, which was categorized as normal （BMI 〈25 kg m^-2） and obese （BMI i〉 25 kg m-2）. In all, 20 509 men （92.3%） were included in the study after applying the inclusion criteria. After controlling for age, there was a statistically significant trend towards a lower likelihood of having a serum PSA level ≥ 2.5 ng ml^-1 with an increased BMI, with obese men having an 18% lower likelihood （odds ratio： 0.823, 95% confidence interval： 0.743-0.912; P〈0.001） compared to men with a normal BMI. Obese men were approximately 82% as likely to have a PSA level ≥ 2.5 ng ml^-2 as men with a normal BMI. These results might affect PCa screening using serum total PSA. Further studies are needed to better define these results in clinical biopsy practice.

关键词： obesity prostate cancer (PCa) prostate-specific antigen (PSA) screening

Measles outbreaks in the Kyeongin area of the Republic of Korea,2013-2014:A single-center experience in a country of measles elimination

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 67-72页

作者： Sun Hyoung Park Dong Hun Lee Jang Yong Jin Young-Lim Shin Meeyong Shin Sung Shin Kim Won Suk Suh Jae Ock Park Yong Hee Hong Department of Pediatrics College of MedicineSoonchunhyang UniversityBucheon HospitalBucheonRepublic of Korea

Objective: To identify the source of infection and determine the clinical features and laboratory finding of measles infection,Methods: In 27 measles patients,except for 3 adult patients,the rest of 24 pediatric measles cases were analyzed with regard to age,sex,immunization status,transmission routes and molecular genotyping of measles virus,Eighteen measles patients who admitted in isolation ward were set apart to investigate clinical findings and its correlation with laboratory characteristics,Retrospective analysis of cases was conducted in this study,Results: Of the 24 pediatric patients,23(95.8%) had not received any measles-containing vaccine(MCV),Sixteen of the patients(66.7%) were aged <12 months,The suspicious index case of a girl aged 34 months was not vaccinated with MCV1 and got measles after a trip to Philippines,and molecular genotype was revealed as B3,Measles outbreaks in the community such as a restaurant were followed by this one imported case,According to analysis of 18 patients admitted in isolation ward,the median level of C-reactive protein(CRP) was 0.38 mg/d L and that of lactate dehydrogenase(LDH) was 1 200 IU/L,All of the 18 patients had LDH levels above the normal range,Age correlated with CRP(ρ = 0.528,P = 0.024) and LDH(ρ = 0.501,P = 0.034),The duration of fever was correlated with the duration of fever before rash(ρ = 0.898,P < 0.01),The duration of hospitalization was correlated with CRP(ρ = 0.586,P = 0.011),The white blood cell counts were correlated with the levels of LDH(ρ = 0.505,P = 0.033),aspartate aminotransferase(ρ = 0.507,P = 0.032),and alanine aminotransferase(ρ = 0.481,P = 0.043),Conclusions: Early weaning of maternally derived measles antibodies therefore vaccination of MCV1 at a young age from 9 months to 12 months should be considered in situations of early exposure,Furthermore there is a call for consideration of scheduling an earlier age for the first dose of MMR vaccine in Europe,It is necessary for Korea to investigat

关键词： Measles Disease outbreaks Pediatrics

Ampullary neuroendocrine tumor diagnosed by endoscopic papillectomy in previously confirmed ampullary adenoma

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World Journal of Gastroenterology 2016年第13期22卷 3687-3692页

作者： Seoung Ho Lee Tae Hoon Lee Si-Hyong Jang Chi Young Choi Won Myung Lee Ji Hey Min Hyun Deuk Cho Sang-Heum Park Division of Gastroenterology Department of Internal Medicine Soonchunhyang University College of Medicine Cheonan Hospital Department of Pathology Soonchunhyang University College of Medicine Cheonan Hospital

Ampullary adenoma is a common indication for endoscopic papillectomy. Ampullary neuroendocrine tumor(NET) is a rare disease for which complete surgical resection is the treatment of choice. However, because of the morbidity and mortality associated with surgical resection, endoscopic papillectomy is increasingly used in selected cases of low grade, with no metastasis and no invasion of the pancreatic or bile duct. Also, confirmed and complete endoscopic resection of ampullary NET accompanied by adenoma has not been reported to date. We report herein a rare case of an ampullary NET accompanied with adenoma, which was successfully and completely resected via endoscopic papillectomy. Prior to papillectomy, this case was diagnosed as an ampullary adenoma.

关键词： Ampulla of Vater Neuroendocrine tumor Adenoma Papillectomy

Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5334-5340页

作者： Jina Yun Sang W Lee Sung H Lim Se H Kim Chan K Kim Seong K Park Department of Internal Medicine Division of Hematology-OncologySoonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea Department of Urology and Internal Medicine Soonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Choriocarcinoma is an infrequent entity and the most aggressive subtype of germcell *** of early metastatic spread and rapid disease progression,choriocarcinoma patients display poor *** etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA-CO)regimen is widely used to treat gestational trophoblastic tumors in females,its role in treating male choriocarcinoma is seldom *** SUMMARY A 32-year-old man was diagnosed with burned-out primary germ cell tumors(GCT)with retroperitoneum,liver and lung *** of the liver revealed pure *** patient received bleomycin,etoposide,and cisplatin *** two cycles of treatment,response evaluation revealed the mixed ***-CO regimen was used in the second-line *** eight cycles,the patient showed a potentially resectable state and thus,all residual masses were surgically *** patient was completely cured,and 10 years later,he is leading a healthy life without *** This paper is the first case of high-risk nonseminomatous GCT in a male patient to be successfully treated with the EMA-CO *** EMA-CO regimen can be used actively in patients with high-risk nonseminomatous GCT.

关键词： Antineoplastic combined chemotherapy protocols Choriocarcinoma Testicular neoplasms Cyclophosphamide Methotrexate Case report