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Acta Pharmaceutica Sinica B 2024年第2期14卷 517-532页

作者： Shuang Xiang Xiaoyun Lu International Cooperative laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE) Guangdong Provincial Key Laboratory of New Drug Design and EvaluationGuangzhou City Key Laboratory of Precision Chemical Drug DevelopmentSchool of PharmacyJinan UniversityGuangzhou 510632China

Neurotrophic receptor kinase(NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors,and tropomyosin receptor kinase(TRK) has been considered as an attractive therapeutic target for "pan-cancer" harboring these ***,two generations TRK inhibitors have been *** representative second-generation inhibitors selitrectinib and repotrectinib were designed to overcome clinic acquired resistance of the first-generation inhibitors larotrectinib or entrectinib resulted from solvent-front and gatekeeper on-target ***,xDFG(TRKAG667C/A/S,homologous TRKCG696C/A/S) and some double mutations still confer resistance to selitrectinib and repotrectinib,and overcoming these resistances represents a major unmet clinical *** this review,we summarize the acquired resistance mechanism of the first-and second-generation TRK inhibitors,and firstly put forward the emerging selective type Ⅱ TRK inhibitors to overcome xDFG mutations mediated ***,we concluded our perspectives on new challenges and future directions in this field.

关键词： NTRK fusions TRK kinase Clinical resistance xDFG mutations Selective type II inhibitors

3D printed silicon-based micro-lattices with ultrahigh areal/gravimetric capacities and robust structural stability for lithium-ion batteries

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Nano Research 2024年第4期17卷 2693-2703页

作者： Jie Fu Dong Wang Yan Li Xianzheng Liu Rui Zhang Zhiyuan Liu Pengdong Liu Lijuan Zhang Xuefei Li Guangwu Wen School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China Shandong Si-Nano Materials Technology Co. Ltd.Zibo 255000China

Nanostructured silicon anodes have shown extraordinary lithium storage properties for lithium-ion batteries(LIBs)but are usually achieved at low areal loadings(<1.5 mg·cm^(-2))with low areal *** sound electrochemical performance at high loading requires proportionally higher ion/electron currents and robust structural stability in the thicker ***,we report a three-dimensional(3D)printed silicon-graphene-carbon nanotube(3D-Si/G/C)electrode for simultaneously achieving ultrahigh areal/gravimetric capacities at high mass *** periodically arranged vertical channels and hierarchically porous filaments facilitate sufficient electrolyte infiltration and rapid ion diffusion,and the carbonaceous network provides excellent electron transport properties and mechanical integrity,thus endowing the printed 3D-Si/G/C electrode with fast electrochemical reaction kinetics and reversibility at high mass ***,the 3D-Si/G/C with high areal mass loading of 12.9 mg·cm^(-2) exhibits excellent areal capacity of 12.8 mAh·cm^(-2) and specific capacity of 1007 mAh·g^(-1),***-situ optical microscope and ex-situ scanning electron microscope(SEM)confirm that the hierarchically porous filaments with interconnected carbon skeletons effectively suppress the volume change of silicon and maintain stable micro-lattice architecture.A 3D printed 3D-Si/G/C-1||3D-LiFePO_(4)/G full cell holds excellent cyclic stability(capacity retention rate of 78%after 50 cycles)with an initial Coulombic efficiency(ICE)of 96%.This work validates the feasibility of 3D printing on constructing high mass loading silicon anode for practical high energy-density LIBs.

关键词： silicon anode areal capacity three-dimensional(3D)printing lithium-ion batteries

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi Huang Xiao-Xiao Liu Lan-Wei Li Guang-Ming Huang Zhao-Xia Huang Jin-Ping Qu national Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Unveiling the surface-interface properties of perovskite crystals and pivotal regulation strategies

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Nano Research 2024年第5期17卷 3950-3981页

作者： Qin Li Ziyu Wang Junjie Ma Mengqi Han Peng Gao Meng Cai Yiqiang Zhang Yanlin Song Shou Peng Henan Institute of Advanced Technology College of ChemistryZhengzhou UniversityZhengzhou 450001China key laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China China national Building Material Group Co. Ltd.Beijing 100036China State key laboratory of Advanced Technology for Float Glass Beijing 100036China

Metal-halide perovskite solar cells have garnered significant research attention in the last decade due to their exceptional photovoltaic performance and potential for *** achieving remarkable power conversion efficiency of up to 26.1%,a substantial discrepancy persists when compared to the theoretical Shockley-Queisser(SQ)*** of the most serious challenges facing perovskite solar cells is the energy loss incurred during photovoltaic conversion,which affects the SQ limits and stability of the *** significant than the energy loss occurring in the bulk phase of the perovskite is the energy loss occurring at the ***,we provide a systematic overview of the physical and chemical properties of the ***,we delve into the underlying mechanism causing the energy deficit and structural degradation at the surface-interface,aiming to enhance the understanding of carrier transport processes and structural chemical ***,we systematically summarized the primary modulating pathways,including surface reconstruction,dimensional construction,and electric-field ***,we propose directions for future research to advance the efficiency of perovskite solar cells towards the radiative limit and their widespread commercial application.

关键词： perovskite solar cells surface-interface treatment defect modification dimensional design energy regulation heterojunction and homojunction

Multichannel microneedle dry electrode patches for minimally invasive transdermal recording of electrophysiological signals

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Microsystems & Nanoengineering 2024年第3期10卷 119-136页

作者： Zhengjie Liu Xingyuan Xu Shuang Huang Xinshuo Huang Zhibo Liu Chuanjie Yao Mengyi He Jiayi Chen Hui-jiuan Chen Jing Liu Xi Xie State key laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhouChina School of Biomedical Engineering Sun Yat-Sen UniversityGuangzhouChina The First Affiliated Hospital of Sun Yat-Sen University GuangzhouChina

The collection of multiple-channel electrophysiological signals enables a comprehensive understanding of the spatial distribution and temporal features of electrophysiological *** approach can help to distinguish the traits and patterns of different ailments to enhance diagnostic *** array electrodes,which can penetrate skin without pain,can lessen the impedance between the electrodes and skin;however,current microneedle methods are limited to single channels and cannot achieve multichannel collection in small ***,a multichannel(32 channels)microneedle dry electrode patch device was developed via a dimensionality reduction fabrication and integration approach and supported by a self-developed circuit system to record weak electrophysiological signals,including electroencephalography(EEG),electrocardiogram(ECG),and electromyography(EMG)*** microneedles reduced the electrode–skin contact impedance by penetrating the nonconducting stratum corneum in a painless *** multichannel microneedle array(MMA)enabled painless transdermal recording of multichannel electrophysiological signals from the subcutaneous space,with high temporal and spatial resolution,reaching the level of a single microneedle in terms of signal *** MMA demonstrated the detection of the spatial distribution of ECG,EMG and EEG signals in live rabbit models,and the microneedle electrode(MNE)achieved better signal quality in the transcutaneous detection of EEG signals than did the conventional flat dry electrode *** work offers a promising opportunity to develop advanced tools for neural interface technology and electrophysiological recording.

关键词： needle rabbit electrode

Design of AI-Enhanced and Hardware-Supported Multimodal E-Skin for Environmental Object Recognition and Wireless Toxic Gas Alarm

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Nano-Micro Letters 2024年第12期16卷 1-22页

作者： Jianye Li Hao Wang Yibing Luo Zijing Zhou He Zhang Huizhi Chen Kai Tao Chuan Liu Lingxing Zeng Fengwei Huo Jin Wu State key laboratory of Optoelectronic Materials and Technologies and the Guangdong Province key laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Ministry of Education key laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063People’s Republic of China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005People’s Republic of China key laboratory of Flexible Electronics(KLOFE) School of Flexible Electronics(Future Technologies)Nanjing Tech University30 South Puzhu RoadNanjing 211816People’s Republic of China State key laboratory of Transducer Technology Shanghai 200050People’s Republic of China Guangdong Provincial key laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing Guangzhou 510641People’s Republic of China State key laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China Guangdong Provincial key laboratory of Research and Development of Natural Drugs and School of Pharmacy Guangdong Medical UniversityDongguan 523808People’s Republic of China The First Dongguan Affiliated Hospital Guangdong Medical UniversityDongguan 523808People’s Republic of China Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Environment and ResourcesFujian Normal UniversityFuzhou 350007People’s Republic of China

Post-earthquake rescue missions are full of challenges due to the unstable structure of ruins and successive *** of the current rescue robots lack the ability to interact with environments,leading to low rescue *** multimodal electronic skin(e-skin)proposed not only reproduces the pressure,temperature,and humidity sensing capabilities of natural skin but also develops sensing functions beyond it—perceiving object proximity and NO2 *** multilayer stacked structure based on Ecoflex and organohydrogel endows the e-skin with mechanical properties similar to natural *** robots integrated with multimodal e-skin and artificial intelligence(AI)algorithms show strong environmental perception capabilities and can accurately distinguish objects and identify human limbs through grasping,laying the foundation for automated post-earthquake ***,the combination of e-skin and NO2 wireless alarm circuits allows robots to sense toxic gases in the environment in real time,thereby adopting appropriate measures to protect trapped people from the toxic *** e-skin powered by AI algorithms and hardware circuits exhibits powerful environmental perception and information processing capabilities,which,as an interface for interaction with the physical world,dramatically expands intelligent robots’application scenarios.

关键词： Stretchable hydrogel sensors Multimodal e-skin Artificial intelligence Post-earthquake rescue Wireless toxic gas alarm

Interface Engineering on Constructing Physical and Chemical Stable Solid-State Electrolyte Toward Practical Lithium Batteries

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Energy & Environmental Materials 2024年第4期7卷 28-47页

作者： Honggang He Litong Wang Malek Al-Abbasi Chunyan Cao Heng Li Zhu Xu Shi Chen Wei Zhang Ruiqing Li Yuekun Lai Yuxin Tang Mingzheng Ge School of Textile and Clothing Nantong University School of Science Qingdao University of Technology Department of Biomedical Sciences City University of Hong Kong Institute of Applied Physics and Materials Engineering University of Macau College of Chemical Engineering Fuzhou University

Solid-state lithium batteries (SSLBs) with high safety have emerged to meet the increasing energy density demands of electric vehicles,hybrid electric vehicles,and portable electronic ***,the dendrite formation,high interfacial resistance,and deleterious interfacial reactions caused by solid-solid contact between electrode and electrolyte have hindered the commercialization of SSLBs.

关键词： dendrite formation high energy density interface instability interfacial resistance solid-state electrolyte

Constraints of palaeoenvironment on organic matter of Benxi Formation shale and discussion on enrichment mechanism under different facies

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Frontiers of Earth Science 2024年第1期18卷 148-171页

作者： Qianyang HE Delu LI Qiang SUN Jianwen GAO Haibin LI Xinhu LI Xiaochen ZHAO Shaofei WANG Gaozhe JI College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Shaanxi Provincial key laboratory of Geological Support for Coal Green Exploitation Xi’an University of Science and TechnologyXi’an 710054China Geological Research Institute for Coal Green Mining Xi’an University of Science and TechnologyXi’an 710054China Research Institute of Exploration and Development PetroChina Changqing Oilfield CompanyXi’an 710018China School of Civil Engineering and Architecture Shaanxi University of TechnologyHanzhong 723001China

As a hydrocarbon-rich sedimentary basin in China,the Ordos Basin has enormous potential for shale gas *** shale of the Upper Carboniferous Benxi Formation is rich in organic matter,however,its palaeoenvironment and organic matter enrichment mode are yet to be *** this study,the geochemical characteristics of the shale of the Benxi Formation in the east-central part of the Ordos Basin were analyzed to investigate its *** the same time,the organic matter enrichment modes in different sedimentary facies were compared and *** results indicate that:1)the shale of the Benxi Formation was mainly deposited on the continental margin and strong terrestrial clastic input;2)the deposition period of the Benxi Formation shale had a hot and humid climate with high palaeoproductivity and local volcanic hydrothermal fluid,and a high sedimentation rate with the strong stagnant *** bottom water was in dysoxic conditions and a semi-saline deposition environment;3)multiple factors,such as palaeoproductivity,volcanic hydrothermal,redox conditions,and palaeosalinity interact to influence the enrichment of shale organic matter in Benxi Formation;4)the organic matter enrichment modes of continental,marine-continental transitional,and marine shales can be classified into three types:“production mode”,“hybrid mode of preservation and production”,and“preservation mode”,*** study provides a reference for the organic matter enrichment mode,shale gas formation conditions,and core area evaluation in these marine-continental transitional shales,and also offers new guidance for exploration ideas for shale gas in different sedimentary facies.

关键词： Benxi Formation shale palaeoenvironment organic matter enrichment facies

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian Chen Yijuan Han Zhenhui Zhong Guodong Lu Yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State key laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

A novel method for modeling the phase change of iron ore particles in the cohesive zone of a blast furnace

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Particuology 2024年第3期86卷 252-261页

作者： Dianyu E Yingming Wen Jiayun Dan Youyuan Jiang Guangchao Wei Jiaxin Cui Jiangxi Provincial key laboratory for Simulation and Modelling of Particulate Systems Jiangxi University of Science and TechnologyNanchang330013China International Institute for Innovation Jiangxi University of Science and TechnologyNanchang330013China Ironmaking Plant Xiangtan Iron and Steel Corporation of Hunan HualingXiangtan411101China Schoolof Transportation and Vehicle Enginering Shandong University of TechnologyZibo255000China

Cohesive zone plays a vital role in the stable operation of a blast furnace(BF),yet the complex phase change process of iron ore particles in this zone is still not well *** this study,a novel one-dimensional(1D)unsteady phase change model was developed to elucidate the heat transfer and melting mechanisms of iron ore *** model validation,the effects of several key operating parameters(e.g.,particle diameter,gas velocity,initial temperature)on the phase change behavior of iron ore particles were analyzed,and the joint effect of multiple parameters was *** results show that larger-sized iron ore particles possess lower specific surface areas,which in turn reduces their convective heat absorption ***,the distance from the solid-liquid phase interface to the particle surface increases,thereby slowing down the movement of the phase interface and pro-longing the melting duration of the *** the gas velocity and the initial temperature does not have a significant impact on reducing the duration of the complete melting *** the specified conditions,it is observed that increasing the gas velocity by 3-fold and 9-fold results in a reduction of the melting duration by 2.4%and 8.3%,*** the initial temperature of iron ore particles results in a decrease in the core-to-surface temperature difference,a slower heating rate,and a shorter duration to achieve *** the factors affecting the melting process,the particle diameter is found to be the most significant in terms of the liquid phase precipitation,mushy zone thickness,and core-to-surface temperature difference of iron ore particles.

关键词： Blast furnace Iron ore melting Cohesive zone Heat transfer Phase change