检索结果-南通市图书馆

Frontiers of Chemical Science and Engineering 2018年第1期12卷 162-173页

作者： Muhammad I. Asghar Sakari Lepikko Janne Patakangas Janne Halme Peter D. Lund New Energy Technologies Group Department of Applied Physics Aalto University P.O. BOX 15100 FI-00076 Aalto Finland

A comparative analysis of perovskite structured cathode materials, La0.65Sr0.35Mn03 （LSM）, La0.8Sr0.2CoO3 （LSC）, La0.6Sr0.4FeO3 （LSF） and La0.6Sr0.4Co0.2Fe0.803 （LSCF）, was performed for a ceramic-carbonate nanocomposite fuel cell using composite electrolyte consisting of Gd0.1Ce0.9O1.95 （GDC） and a eutectic mixture of Na2CO3 and Li2CO3. The compatibility of these nanocomposite electrode powder materials was investigated under air, CO2 and air/CO2 atmospheres at 550 ℃. Microscopy measurements together with energy dispersive X-ray spectroscopy （EDS） elementary analysis revealed few spots with higher counts of manganese relative to lanthanum and strontium under pure CO2 atmosphere. Furthermore, electrochemical impedance （EIS） analysis showed that LSC had the lowest resistance to oxygen reduction reaction （ORR）（14.12 Ω·cm^2） followed by LSF （15.23 Ω·cm^2）, LSCF （19.38Ω·cm^2） and LSM （〉 300 Ω·cm^2）. In addition, low frequency EIS measurements （down to 50 gHz） revealed two additional semi-circles at frequencies around 1 Hz. These semicircles can yield additional information about electrochemical reactions in the device. Finally, a fuel cell was fabricated using GDC/NLC nanocomposite electrolyte and its composite with NiO and LSCF as anode and cathode, respectively. The cell produced an excellent power density of 1.06 W/cm^2 at 550 ℃ under fuel cell conditions.

关键词： electrode fuel cell low-temperature nano- composite perovskite

Effect of high negative incidence on the performance of a centrifugal compressor stage with conventional vaned diffusers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2011年第2期20卷 97-105页

作者： Ahti Jaatinen Aki Grnman Teemu Turunen-Saaresti Jari Backman Lappeenranta University of Technology

Three vaned diffusers, designed to have high negative incidence (-8°) at the design operating point, are studied experimentally. The overall performance (efficiency and pressure ratio) are measured at three rotational speeds, and flow angles before and after the diffuser are measured at the design rotational speed and with three mass flow rates. The results are compared to corresponding results of the original vaneless diffuser design. Attention is paid to the performance at lower mass flows than the design mass flow. The results show that it is possible to improve the performance at mass flows lower than the design mass flow with a vaned diffuser designed with high negative incidence. However, with the vaned diffusers, the compressor still stalls at higher mass flow rates than with the vaneless one. The flow angle distributions after the diffuser are more uniform with the vaned diffusers.

关键词： centrifugal compressor vaned diffuser efficiency performance flow field

Climate-driven synchrony in seed production of masting deciduous and conifer tree species

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2018年第2期11卷 180-188页

作者： Juan Gallego Zamorano Tatu Hokkanen Aleksi Lehikoinen The Helsinki Lab of Ornithology Finnish Museum of Natural HistoryHelsinki UniversityPO Box 1700014 HelsinkiFinland Natural Resources Institute finland PO Box 1801301 VantaaFinland

Aims Understanding fluctuations in plant reproductive investment can constitute a key challenge in ecology,conservation and *** events of trees(*** intermittent and synchronous production of abundant seeding material)is an extreme example of such *** objective was to establish the degree of spa-tial and temporal synchrony in common four masting tree species in boreal finland and account for potential causal drivers of these *** We investigated the spatial intraspecific and temporal interspe-cific fluctuations in annual seed production of four tree species in finland,silver birch Betula pendula Roth,downy birch Betula pubescens Ehrh.,Norway spruce Picea abies(L.)*** row-anberry Sorbus aucuparia *** also tested to see whether varia-tions in seed production were linked to annual weather *** abundance data were derived from tens of stands per spe-cies across large spatial scales within finland during 1979 to 2014(for rowanberries only 1986 to 2014).Important Findings All species showed spatial synchrony in seed production at scales up to 1000 *** estimates of seed production were strongly correlated between *** and summer temperatures explained most variation in crop sizes of tree species with 0-to 2-year time lags,whereas rainfall had relatively little *** weather during flowering(May temperature)in the flower-ing year(Year t)and 2 years before(t−2)were correlated with seed ***,high May temperatures during the previous year(t−1)adversely affected seed *** tempera-tures in Year t−1 was positively correlated with seed production,likely because this parameter enhances the development of flower primordials,but the effect was negative with a time lag of 2 *** negative feedback in temperature coefficients is also likely due to patterns of resource allocation,as abundant flowering and seed production in these species is thought to reduce the sub

关键词： climate change forest masting spatio-temporal synchrony

A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2015年第5期8卷 1505-1521页

作者： Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia Tomas Ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University ofHelsinki FI-00014 Helsinki Finland Laboratory of Industrial Physics Departmen t of Physics and Astronomy University of Turku FI-20014 Turku Finland INEB - Instituto de Engenharia Biomedica NewTherapies Group Universidade do Porto Rua do Campo Alegre 823 4150-180 Porto Portuga ICBAS - Instituto Ciencias Biomedicas Abel Salazar University of Porto Rua de Jorge Viterbo Ferreira 4050-313 Porto Portugal Faculty of Pharmacy University of Coimbra 3000-548 Coimbra Portugal IINFACTS - Instituto de Investigacao e Formacao Avancada em Ciencias e Tecnologias da Saude Instituto Superior de Ciencias da Saude-Norte Department of Pharmaceutical Sciences CESPU Rua Central de Gandra 4585-116 Gandra Portugal

Combination therapy via nanoparticulate systems has already been proposed as a synergistic approach for cancer treatment. Herein, undecylenic acid modified thermally hydrocarbonized porous silicon nanoparticles （UnTHCPSi NPs） loaded with sorafenib and surface-biofunctionalized with anti-CD326 antibody （Ab） were developed for cancer chemo-immunotherapy in MCF-7 and MDA-MB-231 breast cancer cells. The cytocompatibility study showed no significant toxicity for the bare and antibody-conjugated UnTHCPSi （Un-Ab） NPs at concentrations lower than 200 μg·mL^-1. Compared to the bare UnTHCPSi, Un-Ab NPs loaded with sorafenib reduced the premature drug release in plasma, increasing the probability of proper drug targeting. In addition, high cellular interaction and subsequent internalization of the Un-Ab NPs into the cells expressing CD326 antigen demonstrated the possibility of improving antigen-mediated endocytosis via CD326 targeting. While an in vitro antitumor study revealed a higher inhibitory effect of the sorafenib-loaded Un-Ab NPs compared to the drug-loaded UnTHCPSi NPs in the CD326 positive MCF-7 cells, there was no difference in the anti-proliferation impact of both the abovementioned NPs in the CD326 negative MDA-MB-231 cells, suggesting CD326 as an appropriate receptor for Ab-mediated drug delivery. It was also shown that the anti-CD326 Ab can act as an immunotherapeutic agent by inducing antibody dependent cellular cytotoxicity and enhancing the interaction of effector immune and cancer cells for subsequent phagocytosis and cytokine secretion. Hence, the developed nanovectors can be applied for simultaneous tumor-selective drug targeting and immunotherapy.

关键词： CD326 antibody porous silicon nanopartides chemo-immunotherapy breast cancer drug targeting

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第5期23卷 471-507页

作者： Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos Department of Biomedical Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic *** addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in *** this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer ***,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles ***,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this *** review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer.

关键词： Phototherapy Cancer Nanoparticles Therapeutic effect Clinical potential

Two decades of fire activity over the PEEX domain:a look from space,with contribution from models and ground-based measurements

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Earth Data 2024年第2期8卷 350-396页

作者： Larisa Sogacheva Timo H.Virtanen Anu-Maija Sundström Pekka Kolmonen Mikhail Sofiev Hanna K.Lappalainen Antti Arola Finnish Meteorological Institute Climate Research ProgrammeHelsinkiFinland Finnish Meteorological Institute Space and Earth Observation CentreHelsinkiFinland Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland

It has been suggested that forest fires will become more frequent/intense with changing climate,which would increase aerosol/gas emissions into the atmosphere.A better under-standing of the relations between meteorological conditions,fires,and fire emissions will help estimate the climate response via forest *** this study,we use ERA5 meteor-ological products,including temperature,precipitation,and soil moisture,to explain the frequency of forest fires and the amount of radiant energy released per time unit by burning vegetation(fire radiative power,FRP).We explore the relation-ships between satellite-retrieved fire products and aerosol properties(aerosol optical depth,AOD),carbon monoxide(CO),formaldehyde(HCHO),and nitrogen dioxide(NO_(2))con-centrations over the PEEX domain,which covers different vegetation zones(***/grasslands,forest,arctic tun-dra)of Pan-Eurasia and *** analyse the concentrations of black carbon and absorbing organic carbon using groundbased AErosol RObotic *** analysis covers the months of May to August from 2002 to *** show posi-tive temperature trends in the Northern zone(>65°N)in June and August(1.56°C and 0.64°C,respectively);all statistically significant trends for precipitation and soil moisture are *** can explain increased fire activity in Siberia over the recent years(2019-2022).Over the whole PEEX domain,FC and FRP trends remain insignificant or negative;a decrease in AOD may address those negative *** show that intrasummer variations exist for cropland/grassland fires,which occur most often in May and August,while Siberian forest fires occur more often in July and *** show that CO concentration has been gradually decreasing in the last two decades in May and *** trends are negative in May,June,and over summer for all regions,in July in Europe,China,the Southern zone(<55°N),and the PEEX *** trends are not significant in all ***_(2)trends are positive in May and

关键词： PEEX wild fires satellite trend enhancement ratios

Detection of Anthropogenic CO_(2) Emission Signatures with TanSat CO_(2) and with Copernicus Sentinel-5 Precursor(S5P)NO_(2) Measurements:First Results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第1期40卷 1-5页

作者： Dongxu YANG Janne HAKKARAINEN Yi LIU Iolanda IALONGO Zhaonan CAI Johanna TAMMINEN Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Finnish Meteorological Institute Helsinki FI-00560Finland

China’s first carbon dioxide(CO_(2))measurement satellite mission,TanSat,was launched in December *** paper introduces the first attempt to detect anthropogenic CO_(2) emission signatures using CO_(2) observations from TanSat and NO_(2) measurements from the TROPOspheric Monitoring Instrument(TROPOMI)onboard the Copernicus Sentinel-5 Precursor(S5P)*** focus our analysis on two selected cases in Tangshan,China and Tokyo,*** found that the TanSat XCO_(2) measurements have the capability to capture the anthropogenic variations in the plume and have spatial patterns similar to that of the TROPOMI NO_(2) *** linear fit between TanSat XCO_(2) and TROPOMI NO_(2) indicates the CO_(2)-to-NO_(2) ratio of 0.8×10^(-16) ppm(molec cm^(-2))^(-1) in Tangshan and 2.3×10^(-16) ppm(molec cm^(-2))^(-1) in *** results align with the CO_(2)-to-NOx emission ratios obtained from the EDGAR v6 emission inventory.

关键词： TanSat CO_(2) Remote sensing city carbon emission climate change

Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第3期7卷 299-315页

作者： Joao P.Martins Patrícia Figueiredo Shiqi Wang Erika Espo Elena Celi Beatriz Martins Marianna Kemell Karina Moslova Ermei Makil Jarno Salonen Mauri A.Kostiainen Christian Celia Vincenzo Cerullo Tapani Viitala Bruno Sarmento Jouni Hirvonen Helder A.Santos Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Department of Pharmacy University of Chieti-Pescara“G d’Annunzio”I-66100ChietiItaly Drug Research Program Division of Pharmaceutical BiosciencesFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Department of Chemistry University of HelsinkiFI-00014HelsinkiFinland Department of Physics and Astronomy University of TurkuFI-20014TurkuFinland Biohybrid Materials Department of Bioproducts and BiosystemsAalto UniversityFI-00076AaltoFinland i3S-Instituto de Investigaçao e Inovaçao em Saúde University of Porto4200-135PortoPortugal INEB-Instituto de Engenharia Biomedica University of Porto4200-135PortoPortugal CESPU-Instituto de Investigaçao e Formaçao Avançada em Ciencias e Tecnologias da Saúde 4585-116GandraPortugal Helsinki Institute of Life Science(HiLIFE) University of HelsinkiFI-00014HelsinkiFinland

Oral insulin delivery could change the life of millions of diabetic patients as an effective,safe,easy-to-use,and affordable alternative to insulin injections,known by an inherently thwarted patient ***,we designed a multistage nanoparticle(NP)system capable of circumventing the biological barriers that lead to poor drug absorption and bioavailability after oral *** nanosystem consists of an insulin-loaded porous silicon NP encapsulated into a pH-responsive lignin matrix,and surface-functionalized with the Fc fragment of immunoglobulin G,which acts as a targeting ligand for the neonatal Fc receptor(FcRn).The developed NPs presented small size(211±1 nm)and narrow size *** NPs remained intact in stomach and intestinal pH conditions,releasing the drug exclusively at pH 7.4,which mimics blood *** formulation showed to be highly cytocompatible,and surface plasmon resonance studies demonstrated that FcRn-targeted NPs present higher capacity to interact and being internalized by the Caco-2 cells,which express FcRn,as demonstrated by Western ***,in vitro permeability studies showed that Fc-functionalized NPs induced an increase in the amount of insulin that permeated across a Caco-2/HT29-MTX co-culture model,showing apparent permeability coefficients(Papp)of 2.37×10􀀀6 cm/s,over the 1.66×10􀀀6 cm/s observed for their non-functionalized ***,these results demonstrate the potential of these NPs for oral delivery of anti-diabetic drugs.

关键词： Nanoparticles Porous silicon Lignin FcRn Insulin Oral drug delivery

Reliability of R2R-printed, flexible electrodes for e-clothing applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Flexible Electronics 2020年第1期4卷 117-125页

作者： Rafal Sliz Olli-Heikki Huttunen Elina Jansson Juhani Kemppainen Jyrki Schroderus Marika Kurkinen Tapio Fabritius OPEM Unit University of OuluErkki Koiso-Kanttilankatu 390570OuluFinland VTT Technical Research Center of finland Kaitoväylä190570OuluFinland Polar Electro Oy Professorintie 590440KempeleFinland

Conformable electrodes are essential for the development of flexible electronics or functional clothing,regardless of their *** reliable ability to transfer electric signals or serve as sensing elements in various conditions is vital for the advancement of wearables that will enhance our everyday *** this research,we concentrate our efforts on the understanding of the influence of elongation and washing on roll-to-roll printed conductive electrodes of various shapes and materials.A large sample set provides data on the breaking mechanisms and how these affect the electrical properties of the *** addition,the physicochemical analysis offers insights into the electrodes’and materials’behavior in extreme conditions during elongation and washing *** achieved results indicate auspicious nanoparticle shapes and sizes as well as evidence regarding micro-scale breaking mechanisms responsible for electrodes *** of commercially available materials and roll-to-roll printing techniques allow the seamless application of achieved results and the creation of more reliable,flexible electronic devices.

关键词： breaking Reliability extreme

InAs nanowire superconducting tunnel junctions： Quasiparticle spectroscopy, thermometry, and nanorefrigeration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2017年第10期10卷 3468-3475页

作者： Jaakko Mastomaki Stefano Roddaro Mirko Rocci Valentina Zannier Daniele Ercolani Lucia Sorba Ilari J. Maasilta Nadia Ligato Antonio Fornieri Elia Strambini Francesco Giazotto NEST Scuola Normale Superiore and Istituto Nanoscienze-CNR Piazza S. Silvestro 12 I-55127 Pisa Italy Nanoscience Center Department of Physics University of Jyvaskyla 40014 Jyvaskyla Finland

We demonstrate an original method based on controlled oxidation for creating high-quality tunnel junctions between superconducting A1 reservoirs and InAs semiconductor nanowires （NWs）. We show clean tunnel characteristics with a current suppression by 〉4 orders of magnitude for a junction bias well below the A1 gap of △0≈ 200 μeV. The experimental data agree well with the Bardeen- Cooper-Schrieffer theoretical expectations for a superconducting tunnel junction. The studied devices employ small-scale tunnel contacts functioning as thermometers as well as larger electrodes that provide proof-of-principle active cooling of the electron distribution in the NWs. A peak refrigeration of approximately δT = 10 mK is achieved at a bath temperature of Tbath≈ 250-350 mK for our prototype devices. This method introduces important perspectives for the investigation of the thermoelectric effects in semiconductor nanostructures and for nanoscale refrigeration.

关键词： InAs nanowire superconducting tunnel junction thermometry nanorefrigeration