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Silicon-based FMCW signal generators:A review

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Journal of Semiconductors 2020年第11期41卷 5-12页

作者： Wei Deng Haikun Jia Baoyong Chi Institute of Microelectronics Tsinghua UniversityBeijing 100084China research Institute of Tsinghua University in Shenzhen Shenzhen 518057China

FMCW radars with high resolution necessities the generation of highly linear,low phase noise,and low spur chirp signals with large bandwidth and a short modulation *** paper reviews recent research progress on silicon-based FMCW signal generators,identifies advances in architecture,fundamental design,performance analysis,and applications of the FMCW synthesizer.

关键词： slicon FMCW PLLs radars wireless two-point modulation fast chirp digital pre-distortion

A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging

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Science china Chemistry 2020年第6期63卷 766-770页

作者： Jiacheng Lin Qianqian Li Xiaodong Zeng Ziyang Chen Qihang Ding Yang Li Hui Zhou Xianli Meng Deliang Chen Zixin Deng Xuechuan Hong Yuling Xiao State Key Laboratory of Virology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE)School of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineSichuan 611137China Department of Chemistry University of CambridgeCambridge CB21EWUK Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry Chemistry and Chemical Engineering CollegeGannan Normal UniversityJiangxi 341000China

Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and *** in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three ***,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of *** the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.

关键词： NIR-II orthotopic osteosarcoma imaging

Rapid fabrication of terahertz lens via three-dimensional printing technology

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Chinese Optics Letters 2015年第13期13卷 74-77页

作者：张忠琪魏旭立刘昌明王可嘉刘劲松杨振刚 wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology School of Optical and Electronic information Huazhong University of Science and Technology

We design a plano-convex lens working in the terahertz（THz） frequency range and fabricate it using threedimensional（3D） printing technology. A 3D field scanner is used to measure its focal properties, and the results agree well with the numerical simulations. The refractive index and absorption coefficient measurements via THz time-domain spectroscopy（THz-TDS） reveal that the lens material is highly transparent at THz frequencies. It is expected that this inexpensive and rapid 3D printing technology holds promise for making various THz optical elements.

关键词： Laser pulses Printing Refractive index Spectroscopy Terahertz spectroscopy

Macrophage involvement in the pathological evolution of ulcerative colitis-associated colon cancer and progress of related traditional Chinese medicine drug interventions

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Traditional Medicine research 2023年第8期8卷 37-52页

作者： Jun-Yu Ke Jin-Bin Song Long Li Zhen-Fan He Zhuo-Jian Huang Zheng-Lin Liu Gui-Rong Chen Su-Ru Wen Heng-Li Zhou Hui-Lin Ma Qun Du Yong-Qiang Wu Yan-Wu Li Xin-Lin Chen School of basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Surgery Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou 525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405China

Intestinal macrophages are essential players in intestinal inflammation and intestinal immune *** macrophages have the ability to polarize into two distinct phenotypes based on various environmental *** phenotypes include the typically activated pro-inflammatory M1 phenotype and the alternatively activated anti-inflammatory M2 *** normal circumstances,intestinal macrophages prevent inflammatory damage to the ***,when genetic and environmental factors influence the polarization of intestinal macrophages,it can lead to an imbalance in M1/M2 macrophage activation and subsequently an imbalance in the control of intestinal *** transforms physiological inflammation into pathological intestinal *** patients with ulcerative colitis-associated cancer(UC-CRC),intestinal inflammatory disorders are closely associated with intestinal M1/M2 macrophage polarization ***,restoring the polarization equilibrium of M1/M2 macrophages might be an evidence of traditional Chinese medicine in the treatment of UC-CRC,the pivotal role o effective measure to prevent and treat *** paper aims to examine the clinicalf macrophage polarization in UC-CRC pathogenesis,and the potential mechanisms of traditional Chinese medicine in regulating macrophage polarization to treat *** goal is to provide novel insights into the clinical practice,basic research,and drug development of UC-CRC.

关键词： ulcerative colitis ulcerative colitis-associated cancer macrophage polarization herbal compound herbal monomer signaling pathway

Theranostic Gold Nanoclusters for NIR-II Imaging and Photodynamic Therapy

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Chemical research in Chinese Universities 2021年第4期37卷 934-942页

作者： TANG Lin ZENG Xiaodong ZHOU Hui GUI Conghao LUO Qiulin ZHOU Wenyi WU Jing LI Qianqian LI Yang XIAO Yuling State Key Laboratory of Virology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of EductionHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsSchool of Pharmaceutical SciencesWuhan UniversityWuhan430071P.R.China Shenzhen Institute of wuhan University Shenzhen518057P.R.China

Fluorescence imaging in the second near-infrared window(NIR-II,1000―1700 nm)has demonstrated tremendous promise for biomedical applications,with its extraordinarily high resolution and deep tissue *** gold nanoclusters(AuNCs)have shown unique features for NIR-II imaging,such as photostability and biocompatibility,as compared to organic NIR-II molecules or other inorganic NIR-II ***,we report the first-in-class protein-capped ultrasmall AuNCs(BSA-AuNCs,BSA=bovine serum albumin)for simultaneous NIR-II imaging and photodynamic *** BSA-AuNCs show a uniform size,high quantum yield and excellent photostability,display a high accumulation and long retention in 4T1 tumor,and are used for clear imaging of blood vessels and lymph ***,laser irradiation of these AuNCs can rapidly trigger ROS generation,leading to effective inhibition of tumor cell growth in vitro and in *** study demonstrates the feasibility of a protein-capped ultrasmall AuNCs platform for theranostic applications by combining NIR-II imaging and photodynamic cancer therapy.

关键词： Gold nanocluster Protein capping Bioimaging Second near-infrared window Photodynamic therapy Theranostics

Differentially Private Top-k Items Based on Least Mean Square——Take E-Commerce Platforms for Example

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wuhan University Journal of Natural Sciences 2019年第2期24卷 98-106页

作者： CAO Mengyue WU Fusheng NI Mingtao XIONG Xingxing LIU Shubo WANG Jun Department of Foreign Languages Yangtze University College of Arts and Sciences Guizhou Key Laboratory of Economics System Simulation Guizhou University of Finance and Economics School of Cyber Science and Engineering Wuhan University School of Computer Science Leshan Normal University School of Computer Wuhan University College of Computer South-Central University for Nationalities

User preference data broadly collected from e-commerce platforms have benefits to improve the user’s experience of individual purchasing recommendation by data mining and analyzing,which may bring users the risk of privacy *** this paper,we explore the problem of differential private top-k items based on least mean ***,we consider the balance between utility and privacy level of released data and improve the precision of top-k based on *** show that our algorithm can achieve differential privacy over streaming data collected and published periodically by server *** evaluate our algorithm with three real datasets,and the experimental results show that the precision of our method reaches 85%with strong privacy protection,which outperforms the Kalman filter-based existing methods.

关键词： top-k differential privacy least mean square streaming data

Recent developments and perspectives of advanced high-strength medium Mn steel:from material design to failure mechanisms

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Materials Futures 2022年第3期1卷 9-33页

作者： Chengpeng Huang Chen Hu Yuxuan Liu Zhiyuan Liang Mingxin Huang Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongPeople’s Republic of China Shenzhen Institute of research and Innovation The University of Hong KongShenzhenPeople’s Republic of China Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China

Advanced high-strength steels are key structural materials for the development of next-generation energy-efficient and environmentally friendly *** Mn steel,as one of the latest generation advanced high-strength steels,has attracted tremendous attentions over the past decade due to its excellent mechanical ***,the state-of-the-art developments of medium Mn steel are systematically reviewed with focus on the following crucial aspects:(a)the alloy design strategies;(b)the thermomechanical processing routes for the optimizations of microstructure and mechanical properties;(c)the fracture mechanisms and toughening strategies;(d)the hydrogen embrittlement mechanisms and improvement strategies.

关键词： medium Mn steel alloy design mechanical property fracture mechanism hydrogen embrittlement

Performance Analysis for Multimedia Communication Systems with a Multilayer Queuing Network Model

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china Communications 2018年第8期15卷 67-76页

作者： Xuehua Tang Zhongyuan Wang Xiaojun Li Zhen Han Zheng He Youming Fu School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China research Institute of wuhan University in Shenzhen Shenzhen 518000China School of Computer Science Wuhan UniversityWuhan 430072China State Grid Economic and Technological research Institute CO. LTDBeijing 102209China

Software performance evaluation in multimedia communication systems is typically formulated into a multi-layered client-server queuing network(MLCSQN) problem. However, the existing analytical methods to MLCSQN model cannot provide satisfactory solution in terms of accuracy, convergence and consideration of interlocking effects. To this end, this paper proposes a heuristic solving method for MLCSQN model to boost the performance prediction of distributed multimedia software systems. The core concept of this method is referred to as the basic model, which can be further decomposed into two sub-models: client sub-model and server sub-model. The client sub-model calculates think time for server sub-model, and the server sub-model calculates waiting time for client sub-model. Using a breadthfirst traversal from leaf nodes to the root node and vice versa, the basic model is then adapted to MLCSQN, with net sub-models iteratively resolved. Similarly, the interlocking problem is effectively addressed with the help of the basic model. This analytical solver enjoys advantages of fast convergence, independence on specific average value analysis(MVA) methods and eliminating interlocking *** experimental results on accuracy and computation efficiency verify its superiority over anchors.

关键词：排队网络模型通讯系统多媒体性能分析计算效率软件系统服务者性能评估

Polyoxometalate-Derived Ir/WO_(x)/rGO Nanocomposites for Enhanced Electrocatalytic Water Splitting

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Energy & Environmental Materials 2021年第4期4卷 681-686页

作者： Bo Huang Yuntian Ma Zhelun Xiong Zicheng Xiao Pingfan Wu Peng Jiang Minghui Liang CAS Center for Excellence in Nanoscience CAS Key Laboratory of Nanosystem and Hierarchical FabricationCAS Key Lab Standardization&Measurement NanotechnologyNational Center for Nanoscience and TechnologyBeijing 100190China Institute of POM-based Materials Hubei University of TechnologyWuhan 430068China University of Chinese Academy of Sciences Beijing 100049China

Iridium(Ir)-based nanomaterials are promising electrocatalysts for water splitting,and to alleviate their costs as well as improve the performances are always important ***(POMs)composed of abundant metal,oxygen,and heteroatoms are nanoclusters with defined *** from the inherent advantages of POMs,highly dispersive and"unprotected"Ir nanoparticles originating from Ir-based colloid solution were successfully anchored on POM-derived WO_(3)/rGO nanocomposites for the first ***,the obtained hybrid material Ir/WO_(x)/rGO delivered improved electrocatalytic performance for water splitting,which is attributed to the addition of only quite small amount of POM *** work is also the first proof that POM can be employed as precursor to construct metal oxides to support Ir catalysts,providing a new vision for the design of advanced multi-metal electrocatalysts.

关键词： polyoxometalates iridium electrocatalyst water splitting