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Enhancement of critical-sized bone defect regeneration by magnesium oxide-reinforced 3D scaffold with improved osteogenic and angiogenic properties

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Journal of Materials Science & Technology 2023年第4期135卷 186-198页

作者： Bo Chen Zhengjie Lin Qimanguli Saiding Yongcan Huang Yi Sun Xinyun Zhai Ziyu Ning Hai Liang Wei Qiao Binsheng Yu Kelvin W.K.Yeung Jie Shen Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China D Printing Clinical Translational and Regenerative Medicine Center Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518067China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518036China Department of Orthopaedics and Traumatology the University of Hong KongChina Hong Kong Special Administrative RegionChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma the University of Hong Kong Shenzhen HospitalShenzhen 518053China School of Materials Science and Engineering Nankai UniversityTianjin 300071China Department of Pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Stomatology Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518067China applied Oral Sciences and Community Dental Care Faculty of Dentistrythe University of Hong KongChina Hong Kong Special Administrative RegionChina china Orthopaedic Regenerative Medicine Group(CORMed) Hangzhou 310000China

The healing of critical-sized bone defects(CSD)remains a challenge in orthopedic *** recent years,scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional(3D)printing technology have lighted up the treatment of the CSD due to the elaborate microenvironments and support they may ***,we established a magnesium oxide-reinforced 3D-printed biocompos-ite scaffold to investigate the effect of magnesium-enriched 3D microenvironment on CSD *** composite was prepared using a biodegradable polymer matrix,polycaprolactone(PCL),and the disper-sion phase,magnesium oxide(MgO).With the appropriate surface treatment by saline coupling agent,the MgO dispersed homogeneously in the polymer matrix,leading to enhanced mechanical performance and steady release of magnesium ion(Mg^(2+))for superior cytocompatibility,higher cell viability,advanced osteogenic differentiation,and cell mineralization capabilities in comparison with the pure *** in-vivo femoral implantation and critical-sized cranial bone defect studies demonstrated the importance of the 3D magnesium microenvironment,as a scaffold that released appropriate Mg^(2+) exhibited remarkably increased bone volume,enhanced angiogenesis,and almost recovered CSD after 8-week ***,this study suggests that the magnesium-enriched 3D scaffold is a potential candidate for the treatment of CSD in a cell-free therapeutic approach.

关键词： 3D printing Magnesium Critical-sized defect Bone regeneration Angiogenesis Scaffold

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Superconductivity in CuIr_(2-x)Al_(x)Te_(4) telluride chalcogenides

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Chinese Physics B 2022年第3期31卷 538-544页

作者： Dong Yan Lingyong Zeng Yijie Zeng Yishi Lin Junjie Yin Meng Wang Yihua Wang Daoxin Yao Huixia Luo School of Materials Science and Engineering State Key Laboratory of Optoelectronic Materials and TechnologiesKey aboratory of Polymer Composite&Functional MaterialsGuangzhou Key Laboratory of Flexible Electronic Materials and Wearable DevicesSun Yat Sen UniversiyGuangzhou 510275China Center for Neuron Science and Technology School of PhysicsSun Ya-Sen UniversityGuangzhou 510275China State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Shanghai research Center for Quantum Sciences Shanghai 201315China Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chenistry and Materials ScienceAnhui Normal UniversityWuhu 241002China College of Science Hangzhou Dianzi UniversityHangzhou 310018China

The relationship between charge-density-wave(CDW) and superconductivity(SC), two vital physical phases in condensed matter physics, has always been the focus of scientists’ research over the past decades. Motivated by this research hotspot, we systematically studied the physical properties of the layered telluride chalcogenide superconductors CuIr_(2-x)Al_(x)Te_(4)(0 ≤x≤ 0.2). Through the resistance and magnetization measurements, we found that the CDW order was destroyed by a small amount of Al doping. Meanwhile, the superconducting transition temperature(T_(c)) kept changing with the change of doping amount and rose towards the maximum value of 2.75 K when x = 0.075. The value of normalized specific heat jump(△C/γT_(c)) for the highest T_(c) sample CuIr_(2-x)Al_(x)Te_(4)was 1.53, which was larger than the BCS value of 1.43 and showed the bulk superconducting nature. In order to clearly show the relationship between SC and CDW states,we propose a phase diagram of T_(c) vs. doping content.

关键词： layered telluride chalcogenide superconductivity charge-density-wave CuIr_(2-x)Al_(x)Te_(4)

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Small-Molecule Fluorophores for Near-Infrared IIb Imaging and ImageGuided Therapy of Vascular Diseases

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CCS Chemistry 2022年第12期4卷 3735-3750页

作者： Yang Li Hua Zhu Xiaobo Wang Yan Cui Lijuan Gu Xiaowen Hou Mengting Guan Junzhu Wu Yuling Xiao Xiaoxing Xiong Xianli Meng Xuechuan Hong Department of Neurosurgery Renmin Hospital of Wuhan UniversityState Key Laboratory of VirologyWuhan University School of Pharmaceutical SciencesWuhan 430060 State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137 College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionInnovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLhasa 850000 Center for Experimental basic Medical Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE)Hubei Provincial Key Laboratory of Developmentally Originated DiseaseHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan 430071 Shenzhen Institute of wuhan University Shenzhen 518057

Accurate and dynamic visualization of vascular diseases can contribute to restraining further deterioration from diseases in a timely ***,visualization is still unable to precisely determine whether and to what extent blood vessels or brain tissues are ***,we report novel benzobis(1,2,5-thiadiazole)-based second near-infrared region(NIR-II)fluorophores HY1-HY4 with highly twisted structures(55°at the S_(0) state),extremely strong aggregation-induced emission(AIE)characteristics(I/I_(0)>13),and remarkably high fluorescence quantum yields(QYs)(up to 14.45%)in the NIR-II region(>1000 nm)and∼0.27%in the nearinfrared IIb window(NIR-IIb,>1500 nm)in aqueous *** NIR-IIb AIE HY4 dots,high-resolution NIR-IIb fluorescence imaging of revascularization and thrombolysis,and real-time feedback of the therapeutic efficacy of Chinese medicine Dengzhan Xixin injection(DXI)on ischemic stroke,were achieved for the first *** addition,results showed that DXI conferred neuroprotection against cerebral ischemia injury mediated via the angiogenesis *** attractive results provide a new perspective for designing ultrabright NIR-IIb probes for vascular-related phenomena,disease assessment,and precise intraoperative imageguided therapy with a deeper tissue penetration depth and higher resolution.

关键词： aggregation-induced emission NIR-IIb imaging(1500-1700 nm) vascular diseases ischemic stroke image-guided therapy

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Acetylcholinesterase inhibitors and antioxidants mining from marine fungi:bioassays,bioactivity coupled LC-MS/MS analyses and molecular networking

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Marine Life Science & Technology 2020年第4期2卷 386-397页

作者： Yingying Nie Wencong Yang Yayue Liu Jingming Yang Xiaoling Lei William HGerwick Yi Zhang Center for Marine Drugs research and Development Shenzhen Institute of Guangdong Ocean UniversityShenzhen 518000China College of Food Science and Technology Key Laboratory of Guangdong Province Aquatic Products Processing and SafetyGuangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of Marine FoodKey Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education InstitutionZhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain HealthResearch Institute for Marine Drugs and NutritionGuangdong Ocean UniversityZhanjiang 52408&China Center for Marine Biotechnology and Biomedicine Scripps Institution of OceanographyUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Marine fungi are potentially important resources for bioactive lead compounds for discovering new drugs for diseases such as Alzheimer's *** this paper,the combined bioassay model of acetylcholinesterase(AChE)inhibition,1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging,and Artemi ci larval lethality was used to evaluate the activity and toxicity of 35 n narine fun gal strains from seas around *** bioactive constitue nfs were revealed by thin layer chromatography(TLC)autography,bioactivity coupled LC-MS/MS and Global Natural Products Social Molecular Networking(GNPS).The results show that the extracts of five strains exhibited higher AChE inhibition ratios than the positive control compound,'tacrine;for which the ratio was 89.8%at 200 pig/*** strains displayed both AChE inhibition(inhibition ratios>20%at 200 pg/ml)and DPPH scavenging activity(scavenging ratios>30%at 200 pg/ml)together with low Artemia larval toxicity(lethal rates<12%).TLC autography showed that the fractioned extracts of four strains contained highly diverse and different bioactive constituents,includi ng strains Talaromyces sp.C2\-\,Aspergillus ter re us C23-3,Trichoderma harzianum DLEN2008005,and Penicillium corylophilum *** the most potent sample F-l 1-1-b(derived from Aspergillus tern us C23-3),five AChE inhibitors and seven antioxida nts were recognized as bioactive molecules by AChE coupled ultrafiltration followed by LC-MS/MS,and LC-MS/MS coupled with DPPH ***,with the aid of GNPS,the AChE inhibitors were plausibly annotated as territrem analogues including territrems A-C/D,arisugacin A and an unknown compound 4,and the seven antioxidants were assigned as butyrolactone *** E,a phenolic derivative and possibly unknown compounds 8-10 and 12.

关键词： Acetylcholinesterase inhibition Antioxida Marine fungi LC-MS/MS Molecular networking

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Copy number variation profile-based genomic typing of premenstrual dysphoric disorder in Chinese

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Journal of Genetics and Genomics 2021年第12期48卷 1070-1080页

作者： Hong Xue Zhenggang Wu Xi Long Ata Ullah Si Chen Wai-Kin Mat Peng Sun Ming-Zhou Gao Jie-Qiong Wang Hai-Jun Wang Xia Li Wen-Jun Sun Ming-Qi Qiao Shandong University of Traditional Chinese Medicine JinanShandong 250355China Division of Life Science and applied Genomics Center Hong Kong University of Science and TechnologyHong KongChina School of basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsu 210009China HKUST Shenzhen research Institute NanshanShenzhen 518057China Guangzhou HKUST Fok Ying Tung research Institute Science and Technology BuildingNansha Information Technology ParkNanshaGuangzhou 511458China

Premenstrual dysphoric disorder(PMDD) affects nearly 5% of women of reproductive age. Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its effective treatment. In the present study, analysis of genomic sequencing-based copy number variations(CNVs) called from 100 kb white blood cell DNA sequence windows by means of semisupervized clustering led to the segregation of patient genomes into the D and V groups, which correlated with the depression and invasion clinical types,respectively, with 89.0% consistency. Application of diagnostic CNV features selected using the correlation-based machine learning method enabled the classification of the CNVs obtained into the D group, V group, total patient group, and control group with an average accuracy of 83.0%. The power of the diagnostic CNV features was 0.98 on average, suggesting that these CNV features could be used for the molecular diagnosis of the major clinical types of PMDD. This demonstrated concordance between the CNV profiles and clinical types of PMDD supported the validity of symptom-based diagnosis of PMDD for differentiating between its two major clinical types, as well as the predominantly genetic nature of PMDD with a host of overlaps between multiple susceptibility genes/pathways and the diagnostic CNV features as indicators of involvement in PMDD etiology.

关键词： Clinical subtyping Genomic sequencing Machine learning Recurrent copy number variation Replication phase Semisupervized

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Nip promotes autophagy through facilitating the interaction of Rab7 and FYCO1

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1559-1572页

作者： Wenchang Xiao Danna Yeerken Jia Li Zhangfu Li Lanfang Jiang Dan Li Ming Fu Liying Ma Yongmei Song Weimin Zhang Qimin Zhan State Key Laboratory of Molecular Oncology National Cancer center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and Technology(HUST)WuhanChina Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijingChina Department of Hepato-Pancreato-Biliary Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenChina research Unit of Molecular Cancer research Chinese Academy of Medical SciencesBeijingChina Institute of Cancer research Shenzhen Bay LaboratoryShenzhenChina

Autophagy is the main degradation pathway to eliminate long-lived and aggregated proteins,aged or malfunctioning organelles,which is essential for the intracellular homeostasis and prevention of malignant *** the processes of autophagosome biogenesis have been well illuminated,the mechanism of autophagosome transport remains largely *** this study,we demonstrated that the ninein-like protein(Nip),a well-characterized centrosomal associated protein,was able to modulate autophagosome transport and facilitate *** autophagy,Nip colocalized with autophagosomes and physically interacted with autophagosome marker LC3,autophagosome sorting protein Rab7 and its downstream effector ***,Nip enhanced the interaction between Rab7 and FYC01,thus accelerated autophagic flux and the formation of ***,compared to the wild-type mice,NLP deficient mice treated with chemical agent DMBA were prone to increased incidence of hepatomegaly and liver cancer,which were tight associated with the hepatic autophagic *** together,our findings provide a new insight for the first time that the well-known centrosomal protein Nip is also a new regulator of autophagy,which promotes the interaction of Rab7 and FYC01 and facilitates the formation of autophagolysosome.

关键词： prevention DMBA interaction

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Macrophage involvement in the pathological evolution of ulcerative colitis-associated colon cancer and progress of related traditional Chinese medicine drug interventions

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Traditional Medicine research 2023年第8期8卷 37-52页

作者： Jun-Yu Ke Jin-Bin Song Long Li Zhen-Fan He Zhuo-Jian Huang Zheng-Lin Liu Gui-Rong Chen Su-Ru Wen Heng-Li Zhou Hui-Lin Ma Qun Du Yong-Qiang Wu Yan-Wu Li Xin-Lin Chen School of basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Surgery Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou 525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405China

Intestinal macrophages are essential players in intestinal inflammation and intestinal immune *** macrophages have the ability to polarize into two distinct phenotypes based on various environmental *** phenotypes include the typically activated pro-inflammatory M1 phenotype and the alternatively activated anti-inflammatory M2 *** normal circumstances,intestinal macrophages prevent inflammatory damage to the ***,when genetic and environmental factors influence the polarization of intestinal macrophages,it can lead to an imbalance in M1/M2 macrophage activation and subsequently an imbalance in the control of intestinal *** transforms physiological inflammation into pathological intestinal *** patients with ulcerative colitis-associated cancer(UC-CRC),intestinal inflammatory disorders are closely associated with intestinal M1/M2 macrophage polarization ***,restoring the polarization equilibrium of M1/M2 macrophages might be an evidence of traditional Chinese medicine in the treatment of UC-CRC,the pivotal role o effective measure to prevent and treat *** paper aims to examine the clinicalf macrophage polarization in UC-CRC pathogenesis,and the potential mechanisms of traditional Chinese medicine in regulating macrophage polarization to treat *** goal is to provide novel insights into the clinical practice,basic research,and drug development of UC-CRC.

关键词： ulcerative colitis ulcerative colitis-associated cancer macrophage polarization herbal compound herbal monomer signaling pathway

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Recent developments and perspectives of advanced high-strength medium Mn steel:from material design to failure mechanisms

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Materials Futures 2022年第3期1卷 9-33页

作者： Chengpeng Huang Chen Hu Yuxuan Liu Zhiyuan Liang Mingxin Huang Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongPeople’s Republic of China Shenzhen Institute of research and Innovation The University of Hong KongShenzhenPeople’s Republic of China Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China

Advanced high-strength steels are key structural materials for the development of next-generation energy-efficient and environmentally friendly *** Mn steel,as one of the latest generation advanced high-strength steels,has attracted tremendous attentions over the past decade due to its excellent mechanical ***,the state-of-the-art developments of medium Mn steel are systematically reviewed with focus on the following crucial aspects:(a)the alloy design strategies;(b)the thermomechanical processing routes for the optimizations of microstructure and mechanical properties;(c)the fracture mechanisms and toughening strategies;(d)the hydrogen embrittlement mechanisms and improvement strategies.

关键词： medium Mn steel alloy design mechanical property fracture mechanism hydrogen embrittlement

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High‑Quality Epitaxial N Doped Graphene on SiC with Tunable Interfacial Interactions via Electron/Ion Bridges for Stable Lithium‑Ion Storage

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纳微快报:英文版 2023年第11期15卷 185-204页

作者： Changlong Sun Xin Xu Cenlin Gui Fuzhou Chen Yian Wang Shengzhou Chen Minhua Shao Jiahai Wang School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006People’s Republic of China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongPeople’s Republic of China

Tailoring the interfacial interaction in SiCbased anode materials is crucial to the accomplishment of higher energy capacities and longer cycle lives for lithium-ion *** this paper,atomic-scale tunable interfacial interaction is achieved by epitaxial growth of high-quality N doped graphene(NG)on SiC(NG@SiC).This well-designed NG@SiC heterojunction demonstrates an intrinsic electric field with intensive interfacial interaction,making it an ideal prototype to thoroughly understand the configurations of electron/ion bridges and the mechanisms of interatomic electron *** density functional theory(DFT)analysis and electrochemical kinetic analysis reveal that these intriguing electron/ion bridges can control and tailor the interfacial interaction via the interfacial coupled chemical bonds,enhancing the interfacial charge transfer kinetics and preventing pulverization/*** a proof-of-concept study,this well-designed NG@SiC anode shows good reversible capacity(1197.5 mAh g^(−1)after 200 cycles at 0.1 A g^(−1))and cycling durability with 76.6%capacity retention at 447.8 mAh g^(−1)after 1000 cycles at 10.0 A g^(−1).As expected,the lithium-ion full cell(LiFePO_(4)/C//NG@SiC)shows superior rate capability and cycling *** interfacial interaction tailoring strategy via epitaxial growth method provides new opportunities for traditional SiC-based anodes to achieve high-performance lithium-ion storage and beyond.

关键词： SiC Heterojunction Interfacial engineering Lithium-ion battery DFT calculation

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A Networked Embedded Real-time Controller for Complex Control Systems

A Networked Embedded Real-time Controller for Complex Contro...

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2011 Chinese Control and Decision Conference（CCDC）

作者： Zheng Fang is with the Northeastern University,Shenyang,china.He is now with the Key Laboratory of Integrated Automation of Process Industry.Yanhua Fu

The complexity of real-world industrial control systems is growing rapidly due to expanding requirements on the system *** this trend continues,the old control system is becoming less and less *** solve this problem,in this paper,we develop a networked embedded real-time controller on which various control applications such as modeling,parameter identification,simulation and real-time control can be easily implemented to meet the ever-expanding requirements of complex industrial control *** embedded controller is built based on dual-core architecture （ARM plus DSP） to achieve high computational performance.A unified software development environment for complex control method is also developed to reduce the development time and ***,a complex control algorithm is implemented for a practical plant,which demonstrates the capabilities and the performances of the embedded *** controller can be widely used for educational,academic and industrial applications.

关键词： Embedded controller RTAI-Linux ARM DSP Matlab/Simulink/RTW

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