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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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Impurity modes in two-dimensional strongly coupled complex plasma crystals

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Plasma Science and Technology 2024年第8期26卷 1-7页

作者：吴诗杰徐韵乔冼顺宇何向磊杨肖易 School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Physics Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Complex plasma fluctuation processes have been extensively studied in many aspects,especially lattice waves in strongly coupled plasma crystals,which are of great significance for understanding fundamental physical phenomena.A challenge of experimental investigations in two-dimensional strongly coupled complex plasma crystals is to keep the main body and foreign particles of different masses on the same horizontal *** solve the problem,we have proposed a potential well formed by two negatively biased grids to bind the negatively charged particles in a two-dimensional(2D)plane,thus achieving a 2D plasma crystal in the microgravity *** study of such phenomena in complex plasma crystals under microgravity environment then becomes *** this paper,we focus on the continuum spectrum,including both phonon and optic branches of the impurity mode in a 2D system in microgravity *** results show the dispersion relation of the longitudinal and transverse impurity oscillation modes and their *** the macroscopic visibility of complex mesoscopic particle lattices,theoretical and experimental studies on this kind of complex plasma systems will help us further understand the physical nature of a wide range of condensed matters.

关键词： microgravity environment complex plasma lattice dispersion relation

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一个耦合KdV系统的孤子解（英文）

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应用数学 2025年第1期 211-216页

作者：曹锡芳吴怡恒陆奕徐文静夏雨彤扬州大学数学科学学院

本文利用贝克隆变换构造一个耦合KdV系统的孤子解.该系统是王灯山教授于2010年提出的.本文首先把著名的有关KdV方程的贝克隆变换推广到该系统,然后从平凡种子解出发构造该系统的孤子解;同时本文给出一个非线性叠加公式,并由此生成该系... 详细信息

本文利用贝克隆变换构造一个耦合KdV系统的孤子解.该系统是王灯山教授于2010年提出的.本文首先把著名的有关KdV方程的贝克隆变换推广到该系统,然后从平凡种子解出发构造该系统的孤子解;同时本文给出一个非线性叠加公式,并由此生成该系统的多孤子解.

关键词： KdV方程耦合KdV系统贝克隆变换孤子解

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In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light

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Journal of Environmental Sciences 2020年第1期32卷 149-162页

作者： Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He Department of Materials Science and Engineering Zhejiang Normal UniversityJinhua 321004China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 *** as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible *** best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,*** g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced *** indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only ***,the capability for absorbing visible light was improved measurably,which was beneficial to the MO *** top of that,a strong interaction between g-C3N4 and Bi4O5I2 was *** interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge ***,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than ***,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species.

关键词： g-C3N4 Bi4O5I2 Methyl Orange degradation Heterojunction Visible light

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Chitosan/Sodium Alginate Multilayer pH-Sensitive Films Based on Layer-by-Layer Self-Assembly for Intelligent Packaging

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Journal of Renewable Materials 2024年第2期12卷 215-233页

作者： Mingxuan He Yahui Zheng Jiaming Shen Jiawei Shi Yongzheng Zhang Yinghong Xiao Jianfei Che Key Laboratory of Soft Chemistry and FunctionalMaterials Nanjing University of Science and TechnologyNanjing210094China Collaborative innovation Center of Biomedical Functional Materials Nanjing Normal UniversityNanjing210046China

The abuse of plastic food packaging has brought about severe white pollution issues around the *** green and sustainable biomass packaging is an effective way to solve this ***,a chitosan/sodium alginate-based multilayer film is fabricated via a layer-by-layer(LBL)self-assembly *** the help of superior interaction between the layers,the multilayer film possesses excellent mechanical properties(with a tensile strength of 50 MPa).Besides,the film displays outstanding water retention property(blocking moisture of 97.56%)and ultraviolet blocking *** is introduced into the film to detect the food quality since it is one natural plant polyphenol that is sensitive to the pH changes ranging from 1 to 13 in food when spoilage *** is noted that the film is also bacteriostatic which is desired for food *** study describes a simple technique for the development of advanced multifunctional and fully biodegradable food packaging film and it is a sustainable alternative to plastic packaging.

关键词： Chitosan alginate layer-by-layer self-assembly pH-sensitive multilayer films

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Spatio-Temporal Wind Speed Prediction Based on Variational Mode Decomposition

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Computer Systems Science & Engineering 2022年第11期43卷 719-735页

作者： Yingnan Zhao Guanlan Ji Fei Chen Peiyuan Ji Yi Cao School of Computer and Science Nanjing University of Information Science and TechnologyNanjing210044China Department of Electrical and Computer Engineering University of WindsorWindsorN9B 3P4Canada

Improving short-term wind speed prediction accuracy and stability remains a challenge for wind forecasting *** paper proposes a new variational mode decomposition(VMD)-attention-based spatio-temporal network(VASTN)method that takes advantage of both temporal and spatial correlations of wind ***,VASTN is a hybrid wind speed prediction model that combines VMD,squeeze-and-excitation network(SENet),and attention mechanism(AM)-based bidirectional long short-term memory(BiLSTM).VASTN initially employs VMD to decompose the wind speed matrix into a series of intrinsic mode functions(IMF).Then,to extract the spatial features at the bottom of the model,each IMF employs an improved convolutional neural network algorithm based on channel AM,also known as ***,it combines BiLSTM and AM at the top layer to extract aggregated spatial features and capture temporal ***,VASTN accumulates the predictions of each IMF to obtain the predicted wind *** method employs VMD to reduce the randomness and instability of the original data before employing AM to improve prediction accuracy through mapping weight and parameter *** results on real-world data demonstrate VASTN’s superiority over previous related algorithms.

关键词： Short-term wind speed prediction variational mode decomposition attention mechanism SENet BiLSTM

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Regularized dynamic mode decomposition algorithm for time sequence predictions

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Theoretical & Applied Mechanics Letters 2024年第5期14卷 395-401页

作者： Xiaoyang Xie Shaoqiang Tang Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China

Dynamic mode decomposition(DMD) aims at extracting intrinsic mechanisms in a time sequence via linear recurrence relation of its observables, thereby predicting later terms in the sequence. Stability is a major concern in DMD predictions. We adopt a regularized form and propose a Regularized DMD(Re DMD) algorithm to determine the regularization parameter. This leverages stability and accuracy. Numerical tests for Burgers' equation demonstrate that Re DMD effectively stabilizes the DMD prediction while maintaining accuracy. Comparisons are made with the truncated DMD algorithm.

关键词： Dynamic mode decomposition Reduced order modelling Stability Regularization

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science china Chemistry 2025年第1期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen Jia-Liang Wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC *** integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA *** enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing

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An Active Flexure Compensation Method for LAMOST spectrograph based on BP-Neural Network

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Research in Astronomy and Astrophysics 2020年第3期20卷 42-49页

作者： Shuo Huang Hua Zou Tian-Jiao Liu Shi-Yu Zhao Hang Zhang College of Science Hohai UniversityNanjing 211100China

The Large sky Area Multi-Object fiber Spectroscopic Telescope(LAMOST)is a Chinese national scientific research facility operated by National Astronomical Observatories,Chinese Academy of Sciences(NAOC).The LAMOST survey for the Milky Way Galaxy and extra-galactic objects has been carried out for several *** accuracies in measuring radial velocity are expected to be 5 km s-1 for the low resolution spectroscopic survey(R=1800),and 1 km s-1 for the medium resolution *** stability of spectrograph is the main factor affecting the accuracies in measuring radial velocity,so an Active Flexure Compensation Method(AFCM)based on Back Propagation Neural Network(BPNN)is proposed in this *** utilizes a deep BP(4-layer,5-layer etc.)model of thermal-induced flexure to periodically predict and apply flexure corrections by commanding the corresponding tilt and tip motions to the *** spectrograph camera system is adjusted so that the positions of these spots match those in a reference *** simulated calibration of this compensation method analytically illustrates its performance on LAMOST spectrograph.

关键词： instrumentation:spectrographs methods:data analysis techniques:imaging spectroscopy telescopes

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