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Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform

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BMEMat(BioMedical Engineering Materials) 2023年第3期1卷 153-168页

作者： Ping Li Chao Wang Jiaoyan Qiu Fangteng Song Yuzhen Huang Yunhong Zhang Kai Zhang Hao Ji Yuanhua Sang Jonny JBlaker Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdaoChina state key Laboratory of Crystal Materials Shandong UniversityJinanChina Department of Materials and Henry Royce Institute The University of ManchesterManchesterUK Department of Biomaterials Institute of Clinical DentistryUniversity of OsloOsloNorway state key Laboratory of Microbial Technology and Microbial Technology Institute Shandong UniversityQingdaoChina

Zinc oxide nanorods have been extensively studied for the specific killing of breast cancer(BC)cells,and their killing mechanism and anticancer effects have been initially ***,systematic studies at the singlecell level are still necessary to explore cellular functions in *** this work,a hydrothermal method was used to synthesize zinc oxide nanorod arrays(ZnO NRs).Their effect on BC cells was demonstrated at single-cell resolution for the first time through microfluidic chips and a single-cell analysis *** inhibitory effects of ZnO NRs were ***,ZnO NRs suppressed cell proliferation and migration ***,Interferon-γ,Tumor Necrosis Factor-α,and Granzyme B in BC cells turned out to be antitumor instead of tumorigenic under ZnO NRs ***,ZnO NRs inhibition altered cellular functions and thus weakened intercellular and intercluster *** importantly,MDA-MB-231 cells(strongly metastatic)showed much greater resistance to ZnO NRs than MCF-7 cells(nonmetastatic).The experiments complemented the findings at the single-cell level and provided a more comprehensive consideration of the potential risks and applications of ZnO NRs in breast cancer therapy,which is of great importance for biomedical research on nanomaterials.

关键词： breast cancer cell heterogeneity microfluidic chips single cell ZnO NRs

Solving the Feature Diversity Problem Based on Multi-Model Scheme

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Journal on Artificial Intelligence 2021年第4期3卷 135-143页

作者： Guanghao Jin Na Zhao Chunmei Pei Hengguang Li Qingzeng Song Jing Yu School of Telecommunication Engineering Beijing PolytechnicBeijing100176China Department of Mathematics Wayne State UniversityDetroitMI48202USA School of Computer Science and Technology Tiangong UniversityTianjin300387China

Generally,the performance of deep learning models is related to the captured features of training *** the training samples belong to different domains,the diverse features may increase the difficulty of training high performance *** this paper,we built a new framework that generates multiple models on the organized samples to increase the accuracy of ***,our framework selects some existing models and trains each of them on organized training sets to get multiple trained ***,we select some of them based on a validation ***,we use some fusion method on the outputs of the selected models to get more accurate *** experimental results show that our framework achieved higher accuracy than the existing *** framework can be an option for the deep learning system to increase the classification accuracy.

关键词： Deep learning classification distribution of labels probability of labels

二茂铁功能化石墨烯氧化物的制备、表征及对高氯酸铵热分解的催化性能(英文)

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材料科学与工程学报 2013年第3期31卷 323-330页

作者：周磊王立俞豪杰高敬民丁文兵高浩其浙江大学化学工程与生物工程学系化学工程国家重点实验室浙江杭州310027 宁波工程学院浙江宁波315011

本文通过一种新的合成路线合成了二茂铁功能化的氧化石墨烯(GO-EDA-Fc)。利用傅里叶变换红外光谱和扫描电子显微镜对其结构和形貌进行了表征。通过热重分析(TGA)研究了其对高氯酸铵(AP)热分解的催化性能,结果表明,氧化石墨烯和二茂铁表... 详细信息

本文通过一种新的合成路线合成了二茂铁功能化的氧化石墨烯(GO-EDA-Fc)。利用傅里叶变换红外光谱和扫描电子显微镜对其结构和形貌进行了表征。通过热重分析(TGA)研究了其对高氯酸铵(AP)热分解的催化性能,结果表明,氧化石墨烯和二茂铁表现出很好的协同催化效果,对AP热分解具有高的催化活性。催化效果随着GO-EDA-Fc加入量的增加而增强,当加入4wt%的GO-EDA-Fc时,AP的高温分解峰的峰值温度下降了60℃,低温分解峰的峰值也有降低。文中还对催化机制进行了研究。

关键词：燃速促进剂石墨烯二茂铁高氯酸铵

Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions

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Bisphenol A modulates colorectal cancer protein profile and ...

第八次全国土壤生物与生物化学学术研讨会暨第三次全国土壤健康学术研讨会

作者： Zhuo-Jia Chen Xiang-Ling Yang Hao Liu Wei Wei Kun-Shui Zhang Hong-Bin Huang John P.Giesy Huan-Liang Liu Jun Du Hong-Sheng Wang Department of Pharmacy Sun Yat-sen University Cancer Center Guangdong Institute of Gastroenterology and the Sixth Affiliated Hospital Cancer research Institute and Cancer Hospital Guangzhou Medical University Department of Microbial and Biochemical Pharmacy School of Pharmaceutical SciencesSun Yat-sen University Department of Pharmacy Sun Yat-sen Memorial Hospital of Sun Yat-sen University Department of Veterinary Biomedical Sciences & Toxicological Center University of Saskatchewan

More and more evidences indicate that endocrine disruptor chemicals(EDCs) such as bisphenol A(BPA) can act as carcinogens and enhance susceptibility to *** the gut is in direct contact with orally ingested BPA,effects on occurrence and development of colorectal cancer remains an unexplored *** cancer SW480 cells treated with nanomolar(10 M) or greater(10 M)concentrations of BPA were compared with responses of a control *** study revealed that more than 56 proteins are modulated following exposure to BPA,which are relevant to structure,motility and proliferation of cells,production of ATP,oxidative stress,and protein *** studies revealed that BPA increased migration and invasion and triggered transformations from epithelial to mesenchymal transitions(EMT) of colorectal cancer cells,which was characterized by acquiring mesenchymal spindle-like morphology and increasing the expression of N-cadherin with a concomitant decrease of ***,BPA treatment increased the expression of transcription factor ***,signal AKT/GSK-3β mediated stabilization of Snail is involved during BPA-induced EMT of colon cancer *** study first demonstrated that the xenoestrogen BPA at nanomolar and greater concentrations modulates the protein profiles and promote the metastasis of colorectal cancer cells via induction of EMT.

关键词： Colon cancer BPA EMT Proteomic Tumorigenesis Migration

Time-varying formation pursuit based cooperative guidance for multiple missiles to intercept a maneuvering target

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Time-varying formation pursuit based cooperative guidance fo...

第37届中国控制会议

作者： Qilun Zhao Xiwang Dong Xun Song Zhang Ren Beijing Institute of Electronic System Engineering School of Automation Science and Electronic Engineering Science and Technology on Aircraft Control LaboratoryBeihang University

Time-varying formation pursuit based cooperative（TFPBC） guidance for multiple missiles to intercept a maneuvering target is investigated. In TFPBC guidance, multiple missiles are not only expected to intercept the target simultaneously but also need to form a desired time-varying formation configuration during the engagement. The motivation for TFPBC guidance is to create a favorable relative geometry for multiple missiles, which may enclose a maneuvering target and then improve the hit performance. Multiple missiles are classified into leader missile and follower missiles. TFPBC guidance law for the leader missile and follower missiles is constructed, respectively. An approach with four steps to determine the parameters in the TFPBC guidance law is given. The convergence of the designed TFPBC guidance law is proved. A numerical example for multiple missiles to intercept a maneuvering target is provided.

关键词： Missile guidance law cooperative guidance salvo attack time-varying formation maneuvering target

Time-varying formation tracking for UGV swarm systems with switching directed topologies

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Time-varying formation tracking for UGV swarm systems with s...

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作者： Chuang Lu Zhenmin Wang Xiwang Dong Qingdong Li Zhang Ren School of Automation Science and Electrical Engineering Science and Technology on Aircraft Control LaboratoryBeihang University

Time-varying formation tracking problems for unmanned ground vehicle（UGV） swarm systems with switching directed topologies are investigated, where the follower UGVs form a predefined time-varying formation while tracking the leader UGV. A consensus based protocol is constructed using local neighboring information and an algorithm consisting of three steps is also proposed to design the protocol. Sufficient conditions for the UGV swarm systems to achieve the time-varying formation tracking with switching directed topologies under the designed protocol are presented using the piecewise Lyapunov ***, based on a Ultra-Wind Band（UWB） based indoor navigation system, an experimental platform consisting of four omni-directional UGVs is introduced. Finally, both simulation and experimental examples are presented to demonstrate the effectiveness of the theoretical results.

关键词： Formation tracking control unmanned ground vehicle(UGV) swarm system switching directed topology

结合支持向量机和分子对接的方法虚拟筛选IMP-1型金属-β-内酰胺酶抑制剂

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结合支持向量机和分子对接的方法虚拟筛选IMP-1型金属-β-内酰胺...

2012年中国药学大会暨第十二届中国药师周

作者：陈姣郑珩姚文兵中国药科大学 School of Life Science and Technology China Pharmaceutical University

目的:金属-β-内酰胺酶能够广泛水解β-内酰胺类抗生素,目前临床上尚无针对其有效的抑制剂。因此,近年来金属-β-内酰胺酶抑制剂的开发受到重视。方法 :本论文结合支持向量机（SVM）和对接的方法虚拟筛选IMP-1型金属-β-内酰胺酶抑制剂... 详细信息

目的:金属-β-内酰胺酶能够广泛水解β-内酰胺类抗生素,目前临床上尚无针对其有效的抑制剂。因此,近年来金属-β-内酰胺酶抑制剂的开发受到重视。方法 :本论文结合支持向量机（SVM）和对接的方法虚拟筛选IMP-1型金属-β-内酰胺酶抑制剂。在SVM建模中,采用逐步筛选描述符（SDS）的方法实现描述符的自动筛选。这种结合SVM和对接的筛选方法极大的提高了命中率和筛选速度,节省了计算资源。结果 :用建好的模型虚拟筛选组合化合物数据库,命中25个化合物,购买8个用来做体外活性测试。其中有4个化合物对IMP-1的抑制活性值IC50在微摩尔级水平。这4个活性化合物中,有两个化合物具有全新的骨架结构,可进一步改造优化。结论 :结合SVM和对接方法进行虚拟筛选可用于高效开发金属-β-内酰胺酶抑制剂。

关键词： IMP-1型金属β-内酰胺酶抑制剂支持向量机对接虚拟筛选

制备具有优异弯曲性能的轻质3D互穿NiTi@Mg复合材料(英文)

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Transactions of Nonferrous Metals Society of China 2023年

作者：刘玉敬刘小春李坤茂吴翔周圣丰李卫张文财长沙理工大学材料科学与工程学院金属研究所暨南大学先进耐磨蚀及功能材料研究院重庆大学机械传动国家重点实验室暨南大学附属第一医院骨科

采用增材制造(AM)与熔渗技术相结合，开发了一种新型高强轻质互穿相复合材料NiTi@Mg，并对NiTi@Mg复合材料的界面结合、弯曲和循环强化性能进行研究。结果表明，AM-NiTi支架与Mg熔渗制备了具有冶金结合界面的互穿相NiTi@Mg复合材料。与N... 详细信息

采用增材制造(AM)与熔渗技术相结合，开发了一种新型高强轻质互穿相复合材料NiTi@Mg，并对NiTi@Mg复合材料的界面结合、弯曲和循环强化性能进行研究。结果表明，AM-NiTi支架与Mg熔渗制备了具有冶金结合界面的互穿相NiTi@Mg复合材料。与NiTi支架相比，NiTi@Mg互穿相复合材料的弯曲强度提高2.5倍，压缩强度提高1.7倍。在弯曲过程中，观察到大量位错堆积在界面处的软Mg区域。此外，有限元模型(FEM)显示，弯曲过程中裂纹萌生的应力集中区位于NiTi与Mg的界面处。NiTi@Mg复合材料的强化机制归因于Mg的孪生强化和异质结构强化。

关键词：金属复合材料 NiTi@Mg 弯曲性能有限元模拟强化机制

Distributed Extended Kalman-consensus Filtering Algorithm Based on Sensor Network for Nonlinear System

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Distributed Extended Kalman-consensus Filtering Algorithm Ba...

第37届中国控制会议

作者： Zheng Zhang Xiwang Dong Qingke Tan Yuan Liang Qingdong Li Zhang Ren School of Automation Science and Electrical Engineering Science and Technology on Aircraft Control LaboratoryBeihang University

Distributed state estimation（DSE） in collaborative tracking realm has received considerable attention in recent *** centralized filtering algorithms have encountered a series of problems, such as the poor robustness and the high communication overhead. To deal with these problems, this paper studies the distributed state estimation algorithm over mobile sensor networks. The focus is on developing a consensus-based distributed filtering algorithm, which named extended Kalmanconsensus filter（EKCF） algorithm. The EKCF algorithm is consist of two stages. During the first stage, each sensor uses local information to obtain the state estimation based on extended Kalman filtering algorithm. In the second stage, each sensor communicates with its neighbors by performing the consensus algorithm. The sufficient conditions and the detailed proof for the boundedness of the EKCF is proposed. Simulation results of the formation tracking model verifies the effectiveness of EKCF algorithm is proposed in this paper.

关键词： state estimation Extended Kalman-consensus filter Sensor network Formation tracking model