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Heterogeneous body compositions and all-cause mortality in acute coronary syndrome patients:a ten-year retrospective cohort study

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Journal of Geriatric Cardiology 2024年第5期21卷 534-541页

作者： Guang-Zhi LIAO Lin BAI Yu-Yang YE Xue-Feng CHEN Xin-Ru HU Yong PENG Department of Cardiology West China HospitalSichuan UniversityChengduSichuanChina

BACKGROUND The association of different body components,including lean mass and body fat,with the risk of death in acute coronary syndrome(ACS)patients are *** We enrolled adults diagnosed with ACS at our center between January 2011 and December 2012 and obtained fol-low-up outcomes via telephone *** used restricted cubic splines(RCS)with the Cox proportional hazards model to analyze the associations between body mass index(BMI),predicted lean mass index(LMI),predicted body fat percentage(BF),and the value of LMI/BF with 10-year *** also examined the secondary outcome of death during *** During the maximum 10-year follow-up of 1398 patients,331 deaths(23.6%)occurred,and a U-shaped relationship was found between BMI and death risk(P_(nonlinearity)=0.03).After adjusting for age and history of diabetes,the overweight group(24≤BMI<28 kg/m^(2))had the lowest mortality(HR=0.53,95%CI:0.29-0.99).Predicted LMI and LMI/BF had an inverse linear relationship with a 10-year death risk(P_(nonlinearity)=0.24 and P_(nonlinearity)=0.38,respectively),while an increase in BF was associ-ated with increased mortality(P_(nonlinearity)=0.64).During hospitalization,31 deaths(2.2%)were recorded,and the associations of the indicators with in-hospital mortality were consistent with the long-term outcome *** Our study provides new insight into the“obesity paradox”in ACS patients,highlighting the importance of considering body composition *** LMI and BF may serve as useful tools for assessing nutritional status and predicting the prognosis of ACS,based on their linear associations with all-cause mortality.

关键词： patients mortality coronary

Bispecific antibody drug conjugates:Making 1+1>2

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1965-1986页

作者： Yilin Gu Zhijia Wang Yuxi Wang Targeted Tracer research and Development Laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-Related Molecular NetworkNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610212China

Bispecific antibody‒drug conjugates(BsADCs)represent an innovative therapeutic category amalgamating the merits of antibody‒drug conjugates(ADCs)and bispecific antibodies(BsAbs).Positioned as the next-generation ADC approach,BsADCs hold promise for ameliorating extant clinical challenges associated with ADCs,particularly pertaining to issues such as poor internalization,off-target toxicity,and drug ***,ten BsADCs are undergoing clinical trials,and initial findings underscore the imperative for ongoing *** review initially delves into specific design considerations for BsADCs,encompassing target selection,antibody formats,and the linker–payload *** sections delineate the extant progress and challenges encountered by BsADCs,illustrated through pertinent case *** amalgamation of BsAbs with ADCs offers a prospective solution to prevailing clinical limitations of ***,the symbiotic interplay among BsAb,linker,and payload necessitates further optimizations and coordination beyond a simplistic“1+1”to effectively surmount the extant challenges facing the BsADC domain.

关键词： Bispecific antibody drug conjugates Antibody drug conjugates Bispecific antibody Targeted therapy Safety HER2 EGFR

Characterization of Fe-containing particles in Chengdu,southwest china,using single-particle aerosol mass spectrometry

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Journal of Environmental sciences 2024年第2期136卷 110-120页

作者： Renjiang He Junke Zhang Luyao Chen Wei Zhang Yingwei Xi School of Public Health Southwest Medical UniversityLuzhou 646000China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China sichuan Environmental Monitoring Center Chengdu 610074China

Single-particle aerosol mass spectrometry was used to study the characteristics of Fecontaining particles during winter in Chengdu,southwest *** mass concentrations of PM_(2.5)and PM_(10)during the study period were 64±38 and 89±49μg/m~3,respectively,and NO_(2)and particulate matter were high compared with most other regions of *** Fecontaining particles were divided into seven categories with different mass spectra,sources and aging *** highest contribution was from Fe mixed with carbonaceous components(Fe-C,23.1%)*** was more mixed with sulfate than nitrate and therefore the contribution of Fe mixed with sulfate(Fe-S,20.7%)particles was higher than that of Fe mixed with nitrate(Fe-N,12.5%)*** contributions from Fe-containing particles related to primary combustion were high in the small particle size range,whereas aged Fecontaining particles and dust-related particles were mostly found in the coarse particle size *** air masses mainly originated from the west and east of Chengdu,and the corresponding PM_(2.5)concentrations were 79±36 and 55±36μg/m~3,*** west and east air masses showed stronger contributions of Fe-containing particles related to biomass burning(Fe-B)and fossil fuel combustion(Fe-C and Fe-S)particles,*** southwest area contributed the most Fe-containing *** assessments of the effects of Fe-containing particles during heavy pollution period should pay more attention to Fe-C and Fe-S ***-reduction of Fe-containing particles should consider both local emissions and short-distance transmission from the surrounding areas.

关键词： Fe-containing particles Particle composition Potential source areas Evolution Chengdu

Tribological Behaviors of Electroless Nickel-Boron Coating on Titanium Alloy Surface

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 309-320页

作者： Yao Jia Jianping Lai Jiaxin Yu Huimin Qi Yafeng Zhang Hongtu He Key Laboratory of Testing Technology for Manufacturing Process in Ministry of Education State Key Laboratory of Environment-Friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China

Titanium alloys are excellent structural materials in engineering fields,but their poor tribological properties limit their further *** plating is an effective method to enhance the tribological performance of alloys,but it is difficult to efficiently apply to titanium alloys,due to titanium alloy’s strong chemical *** this work,the electroless Nickel-Boron(Ni-B)coating was successfully deposited on the surface of titanium alloy(Ti-6AL-4V)via a new pre-treatment ***,linearly reciprocating sliding wear tests were performed to evaluate the tribological behaviors of titanium alloy and its electroless Ni-B *** was found that the Ni-B coatings can decrease the wear rate of the titanium alloy from 19.89×10^(−3)mm^(3)to 0.41×10^(−3)mm^(3),which attributes to the much higher hardness of Ni-B *** heat treatment,the hardness of Ni-B coating further increases corresponding to coating crystallization and hard phase ***,heat treatment does not improve the tribological performance of Ni-B coating,due to the fact that higher brittleness and more severe oxidative wear exacerbate the damage of heat-treated ***,the Ni-B coatings heat-treated both in air and nitrogen almost present the same tribological *** finding of this work on electroless coating would further extend the practical applications of titanium alloys in the engineering fields.

关键词： Electroless coating Titanium alloy Tribology Wear Heat treatment Nanoindentation

A novel semi-dominant allele of the transmembrane NAC transcription factor ZmNTL2 reduces the size of multiple maize organs

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The Crop Journal 2024年第3期12卷 676-687页

作者： Chuan Li Yun Bai Yuwei Hou Siyu Wang Yue Xin Tao Yu Jing Wang Xiaowei Liu Hongyang Yi Chao Xia Hai Lan Moju Cao State Key Laboratory of Crop Gene Exploration and Utilization in Southwest china Maize Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina Jilin Engineering research Center for Crop Biotechnology Breeding College of Plant ScienceJilin UniversityChangchun 130012JilinChina

Maize plant architecture influences planting density and,in turn,grain *** of the plant architecture-related traits can be described as organ *** describe a miniature maize mutant,Tiny plant 4(Tip4),which exhibits reduced size of multiple organs and exhibits a semi-dominant monofactorial inheritance *** cloning confirmed that a 4-bp deletion in the NAC TF with transmembrane motif 1-Like(NTL)gene ZmNTL2,denoted as ZmNTL2^(Δ),confers the Tip4 ***-PCR showed that ZmNTL2 was expressed in all tested ***2 functions as a transcriptional activator and is located in both the nucleus and *** mutation does not affect the mRNA abundance of ZmNTL2 locus,but it does result in the loss of transmembrane domain and confines the ZmNTL2^(Δ)protein to the *** out ZmNTL2 has no effect on maize organ size development,indicating that the 4-bp deletion might be a gain-of-function mutation in organ size *** transcriptome sequencing with cytokinin and auxin content determination suggests that the decreased organ size may be possibly mediated by changes in hormone homeostasis.

关键词： Organ size c-ray mutagenesis Membrane-bound NAC TF Hormone homeostasis Maize

Dual carbon goal and agriculture in china:Exploring key factors influencing farmers’behavior in adopting low carbon technologies

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Journal of Integrative Agriculture 2024年第9期23卷 3215-3233页

作者： Jinpeng Zou Lulin Shen Fang Wang Hong Tang Ziyang Zhou College of Management Sichuan Agricultural UniversityChengdu 611130China

Identifying the factors influencing farmers’adoption of low-carbon technologies(FA)and understanding their impacts are essential for shaping effective agricultural policies amied at emission reduction and carbon sequestration in *** study employs a meta-analysis of 122 empirical studies,delves into 23 driving factors affecting FA and addresses the inconsistencies present in the existing *** systematically examine the effect size,source of heterogeneity,and time-accumulation effect of the driving factors on *** find that significant heterogeneity in the factors influencing FA,except for farming experience,sources of heterogeneity from the survey zone,methodology model,technological attributes,report source,financial support,and the sampling ***,age,farming experience,and adoption cost negatively correlate with *** contrast,educational level,health status,technical training,economic and welfare cognition,land contract,soil quality,terrain,information accessibility,demonstration,government promotion,government regulation,government support,agricultural cooperatives member,peer effect,and agricultural income ratio demonstrate a positive ***,demonstration and age show a particularly strong ***,the effect of demonstration,age,economic and welfare cognition,farming experience,land contract,soil quality,information accessibility,government promotion,and support,as well as agricultural cooperative membership and peer effects on FA,are generally stable but exhibit varying degrees of attenuation over *** effect of village cadre,family income,farm scale,gender,health status,technical training,and off-farm work on FA show notable temporal shifts and maintain a weak correlation with *** study contributes to shaping china’s current low-carbon agriculture policies across various *** encourages policymakers to comprehensively consider the stability of key factors,other potential factors,technologic

关键词： farmers influencing factors low-carbon technology adoption meta-analysis

Application of wastewater-based epidemiological monitoring of COVID-19 for disease surveillance in the city

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Frontiers of Environmental science & Engineering 2024年第8期18卷 81-87页

作者： Heng Chen Zhenhua Chen Liwen Hu Fengzhu Tang Dan Kuang Jiayi Han Yao Wang Xiao Zhang Yue Cheng Jiantong Meng Rong Lu Lan Zhang Chengdu Workstation for Emerging Infectious Disease Control and Prevention Chinese Academy of Medical SciencesChengdu 610047China Chengdu Center for Disease Control and Prevention Chengdu 610047China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Beijing 100050China National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100050China

Wastewater-based surveillance serves as a supplementary approach to clinical surveillance of COVID-19 during the *** study aimed to track the prevalence of the disease and the viral genetic variability through wastewater-based surveillance in the post-epidemic *** January to December 2023,samples were collected from the influent lines of two wastewater treatment plants(WWTPs),concentrated using PEG8000,and subjected to detection of the target genes ORF 1ab and N of SARS-CoV-2 via reverse transcriptional quantitative PCR(RT-qPCR).For next-generation sequencing(NGS),high-quality samples from both wastewater and clinical patients were *** analysis were performed using R software to evaluate the correlation between the SARSCoV-2 RNA concentrations in wastewater and positive rate of reported cases,indicating a positive *** diversity patterns of SARS-CoV-2 in wastewater resembled those in the patient source based on Principal Coordinates Analysis(PCoA)with three clusters for different *** rise of RNA concentration in wastewater indicates the growth of cases and the emergence of new variants,serving as an early warning of potential viral mutations,disease outbreaks even possible ***,the genomic surveillance of wastewater could help identify new variants that may not be captured through population monitoring,especially when sample sizes are ***,surveillance of SARS-CoV-2 in municipal wastewater has emerged as a reliable,earlywarning monitoring system for COVID-19 in the post-epidemic era.

关键词： Wastewater-based epidemiology Monitoring COVID-19 Post-epidemic era

Transfer relation between subgrade frost heave and slab track deformation and vehicle dynamic response in seasonally frozen ground

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2024年第2期25卷 130-146页

作者： Juanjuan REN Junhong DU Kaiyao ZHANG Bin YAN Jincheng TIAN MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Central South UniversityChangsha410075China Airport Planning and Design Institute POWERCHINA Kunming Engineering Corporation LimitedKunming650051China

Subgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track-subgrade frost heave and develop a dynamic model of vehicle-track-subgrade frost heave;(2)explore the transfer relation between subgrade frost heave and track structure deformation;(3)examine the characteristics of interlayer debonding;(4)study the influence of subgrade frost heave on the dynamic response of vehicles in high-speed railways in seasonally frozen regions.A Fourier series was used to fit the frost heave waveform and simulate the behavior of subgrade uneven frost heave using data collected *** results show:(i)The position of frost heave significantly affects the transfer of deformation to a slab *** largest deformation of the track slab,with the amplitude transfer ratio reaching 20%,was recorded when the frost heave occurred near the joint of the base plate.(ii)At the same frost heave amplitude,long-wave frost heave causes smaller deformation and debonding of the track structure than short-wave frost *** the wavelength range of 10-30 m,the main frequency of the acceleration spectral density was concentrated between 3.5 and 3.7 Hz,with larger frost heave wavelengths producing smaller superposition on the vertical acceleration of the vehicle.(ii)The maximum wheel-rail force occurs when the front bogie passes the frost heave peak,with greater frost heave amplitudes producing greater wheel-rail *** these results,we conclude there is a clear need to control the frost heave deformation of the track to reduce the dynamic response of the vehicle and in turn improve train operatSubgrade frost heave in seasonally frozen ground can greatly influence the safety and smooth running of high-speed trains and the service performance of track *** this study,we used a static model to:(1)investigate track`-subgr

关键词： Slab track Subgrade frost heave Transfer relation Vehicle-track-subgrade coupling Dynamic response

Radiation build-up and dissipation in Raman random fiber laser

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science china(Information sciences) 2024年第1期67卷 254-260页

作者： Shengtao LIN Zinan WANG Jiaojiao ZHANG Pan WANG Han WU Yifei QI Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China College of Electronics and Information Engineering Sichuan University

Raman random fiber laser(RRFL) is a complex physical system that arises from the distributed Raman amplification and the intrinsic stochasticity of fiber *** analysis of the underlying lightwave kinetics at steady state has been the focus of considerable ***,the transient state,such as the RRFL build-up and dissipation,is particularly important for revealing the lightwave interaction ***,we investigate for the first time the RRFL dynamics at the transient state and track the RRFL temporal and spectral evolution theoretically and ***,with the contribution of random distributed feedback,RRFL build-up exhibits continuous Verhulst logistic growth curves without cavity-related features,which is significantly different from the step-like growth curve of conventional fiber ***,the radiation build-up duration is inversely related to the pump power,and the spectral evolution of the RRFL undergoes two phases,i.e.,from spectral density increase to spectral *** the steady state to the pump switch-off state,the RRFL output power dissipates immediately,and the remaining Stokes lightwave from the Rayleigh scattering will gradually disappear after one round *** work provides new insights into the transient dynamic features of the RRFL.

关键词： random fiber laser stimulated Raman scattering transient phenomenon nonlinear optics łinebreak biological growth dynamics