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The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development

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JOURNAL OF MOLECULAR CELL BIOLOGY 2024年第1期16卷 mjad083页

作者： Song, Xiaozhen Hu, Ruixing Chen, Yi Xiao, Man Zhang, Hong Wu, Shengnan Lu, Qing shanghai jiao tong Univ Shanghai Childrens Hosp Sch Med Mol Diagnost Lab Shanghai 200040 Peoples R China shanghai jiao tong Univ BioX Inst Key Lab Genet Dev & Neuropsychiat Disorders Minist Educ Shanghai 200030 Peoples R China shanghai jiao tong Univ Ruijin Hosp Shanghai Inst Hematol Lab Dev & DisSch Med Shanghai 200025 Peoples R China shanghai jiao tong Univ Ruijin Hosp Shanghai Inst Hematol State Key Lab Med GenomSch Med Shanghai 200025 Peoples R China

TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways, contributing to immune responses, tumor progression, and embryonic development. Somatic mutations within the coiled-coil (CC) domain and WD40 repeat domain of TRAF7 could cause brain tumors, while germline pathogenic mutations contribute to severe developmental abnormalities. However, the precise molecular mechanism underlying TRAF7 involvement in embryonic development remains unclear. In this study, we employed zebrafish as an in vivo model system. TRAF7 knock down caused defects in zebrafish embryonic development. We determined the crystal structure of TRAF7 CC domain at 3.3 & Aring; resolution and found that the CC region trimerization was essential for TRAF7 functionality during zebrafish embryonic development. Additionally, disease-causing mutations in TRAF7 CC region could impair the trimer formation, consequently impacting early embryonic development of zebrafish. Therefore, our study sheds light on the molecular mechanism of TRAF7 CC trimer formation and its pivotal role in embryonic development.

关键词： TRAF7 coiled-coil domain crystal structure trimerization embryonic development FAMILY

Complex transmission matrix retrieval for a highly scattering medium via regional phase differentiation

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Photonics Research 2024年第5期12卷 876-883页

作者： QIAOZHI HE RONGJUN SHAO YUAN Qu LINXIAN LIU CHUNXU DING JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

Accurately measuring the complex transmission matrix(CTM) of the scattering medium(SM) holds critical significance for applications in anti-scattering optical imaging, phototherapy, and optical neural networks. Noninterferometric approaches, utilizing phase retrieval algorithms, can robustly extract the CTM from the speckle patterns formed by multiple probing fields traversing the SM. However, in cases where an amplitude-type spatial light modulator is employed for probing field modulation, the absence of phase control frequently results in the convergence towards a local optimum, undermining the measurement accuracy. Here, we propose a high-accuracy CTM retrieval(CTMR) approach based on regional phase differentiation(RPD). It incorporates a sequence of additional phase masks into the probing fields, imposing a priori constraints on the phase retrieval algorithms. By distinguishing the variance of speckle patterns produced by different phase masks, the RPD-CTMR can effectively direct the algorithm towards a solution that closely approximates the CTM of the SM. We built a prototype of a digital micromirror device modulated RPD-CTMR. By accurately measuring the CTM of diffusers, we achieved an enhancement in the peak-to-background ratio of anti-scattering focusing by a factor of 3.6, alongside a reduction in the bit error rate of anti-scattering image transmission by a factor of 24. Our proposed approach aims to facilitate precise modulation of scattered optical fields, thereby fostering advancements in diverse fields including high-resolution microscopy, biomedical optical imaging, and optical communications.

关键词： matrix phase holds

Social Network Analysis of COVID-19 Research and the Changing International Collaboration Structure

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Journal of shanghai jiaotong university(Science) 2024年第1期29卷 150-160页

作者：秦野陈蓉蓉 shanghai Discipline Assessment Center Ofice of Strategic PlanningShanghai Jiao Tong UniversityShanghai 200240China Network and Information Center Shanghai Jiao Tong UniversityShanghai 200240China

Research in Information Science and interdisciplinary areas suggested the formation of a growing network of international research *** massive transmission of COVID-19 worldwide especially after the identification of the Omicron variant could fundamentally alter the factors shaping the network's *** study employs network analysis methods to analyze the structure of the COVID-19 research collaboration from 2020 to 2022,using two major academic publication databases and the VOSviewer software.A novel temporal view is added by examining the dynamic changes of the network,and a fractional counting method is adopted as methodological improvements to previous *** reveals that the COVID-19 research network structure has undergone substantial changes over time,as collaborating countries and regions form and re-form new *** in the network can be partly explained by key developments in the pandemic and other social-political *** as one of the largest pivots in the network formed a relatively distinct cluster,with potential to develop a larger Asia-Pacific collaboration cluster based on its research impact.

关键词： COVID-19 international research collaboration network analysis high interdisciplinary research

Digital twin modeling and controlling of optical power evolution enabling autonomous-driving optical networks:a Bayesian approach

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Advanced Photonics 2024年第2期6卷 69-80页

作者： Xiaomin Liu Yihao Zhang Yuli Chen Yichen Liu Meng Cai Qizhi Qiu Mengfan Fu Lilin Yi Weisheng Hu Qunbi Zhuge shanghai jiao tong university State Key Laboratory of Advanced Optical Communication Systems and NetworksDepartment of Electronic EngineeringShanghaiChina

Optical networks are evolving toward ultrawide bandwidth and autonomous *** this scenario,it is crucial to accurately model and control optical power evolutions(OPEs)through optical amplifiers(OAs),as they directly affect the signal-to-noise ratio and fiber ***,a fundamental contradiction arises between the complex physical phenomena in optical transmission and the required precision in network *** theoretical methods underperform due to ideal assumptions,while data-driven approaches entail exorbitant costs associated with acquiring massive amounts of data to achieve the desired level of *** this work,we propose a Bayesian inference framework(BIF)to construct the digital twin of OAs and control OPE in a data-efficient *** the informative data are collected to balance the exploration and exploitation of the data space,thus enabling efficient autonomous-driving optical networks(ADONs).Simulations and experiments demonstrate that the BIF can reduce the data size for modeling erbium-doped fiber amplifiers by 80%and Raman amplifiers by 60%.Within 30 iterations,the optimal controlling performance can be achieved to realize target signal/gain profiles in links with different types of *** results show that the BIF paves the way to accurately model and control OPE for future ADONs.

关键词： optical fiber communications digital twin Bayesian inference optical amplifiers autonomous-driving optical networks

Numerical Investigation on Dynamic Response Characteristics of Fluid-Structure Interaction of Gas-Liquid Two-Phase Flow in Horizontal Pipe

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Journal of shanghai jiaotong university(Science) 2024年第2期29卷 237-244页

作者：王志伟何炎平李铭志仇明黄超刘亚东王梓 State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean&Civil EngineeringInstitute of Marine EquipmentShanghai Jiao Tong UniversityShanghai 200240China COSCO Shipping(Qidong)Offshore Co.Ltd. Qidong 226200JiangsuChina

Fluid-structure interaction(FSI)of gas-liquid two-phase fow in the horizontal pipe is investigated numerically in the present *** volume of fluid model and standard k-e turbulence model are integrated to simulate the typical gas-liquid two-phase fow ***,validation of the numerical model is conducted and the typical fow patterns are consistent with the Baker ***,the FSI framework is established to investigate the dynamic responses of the interaction between the horizontal pipe and gas-liquid two-phase *** results show that the dynamic response under stratified fow condition is relatively flat and the maximum pipe deformation and equivalent stress are 1.8 mm and 7.5 MPa ***,the dynamic responses induced by slug fow,wave fow and annular fow show obvious periodic ***,the dynamic response characteristics under slug flow condition are maximum;the maximum pipe deformation and equivalent stress can reach 4mm and 17.5 MPa,*** principal direction of total deformation is different under various flow ***,the periodic equivalent stress will form the cyclic impact on the pipe wall and affect the fatigue life of the horizontal *** present study may serve as a reference for FSI simulation under gas-liquid two-phase transport conditions.

关键词： gas-liquid two-phase flow volume of fluid model fluid-structure interaction(FSI) dynamic response characteristics

Ga(X)N/Si nanoarchitecture:An emerging semiconductor platform for sunlight-powered water splitting toward hydrogen

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Frontiers in Energy 2024年第1期18卷 56-79页

作者： Yixin LI Sharif Md.SADAF Baowen ZHOU Key Laboratory for Power Machinery and Engineering of the Ministry of Education Research Center for Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Centre Energie Matériaux et TélécommunicationsInstitut National de la Recherche Scientifique(INRS)-Universitédu Québec1650 Boulevard Lionel-BouletVarennesQuébec J3X1S2Canada

Sunlight-powered water splitting presents a promising strategy for converting intermittent and virtually unlimited solar energy into energy-dense and storable green *** the pioneering discovery by Honda and Fujishima,considerable efforts have been made in this research *** various materials developed,Ga(X)N/Si(X=In,Ge,Mg,etc.)nanoarchitecture has emerged as a disruptive semiconductor platform to split water toward hydrogen by *** paper introduces the characteristics,properties,and growth/synthesis/fabrication methods of Ga(X)N/Si nanoarchitecture,primarily focusing on explaining the suitability as an ideal platform for sunlight-powered water splitting toward green hydrogen *** addition,it exclusively summarizes the recent progress and development of Ga(X)N/Si nanoarchitecture for photocatalytic and photoelectrochemical water ***,it describes the challenges and prospects of artificial photosynthesis integrated device and system using Ga(X)N/Si nanoarchitectures for solar water splitting toward hydrogen.

关键词： Ga(X)N/Si nanoarchitecture artificial photosynthesis water splitting solar toward hydrogen

Hypermethylation of the ALOX12 and CBS promoters in osteoporosis:Potential biomarkers for early diagnosis

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Genes & Diseases 2024年第1期11卷 30-33页

作者： Shang Guo Yue Wu Weekai Chia Peichun Hsu Hongwei Wang Yunliang Wang Biao Zhong Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200023China Institute of Translational Medicine Shanghai General HospitalShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025China The university of Chicago Department of MedicineChicagoIL 60637USA Department of Neurology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China

As a bone-confined chronic degenerative disorder,the progression of osteoporosis is characterized by abnormal crosstalk between osteoblasts and osteoclasts,leading to an imbalance of bone remodeling in adults.1 Several studies reported that arachidonic acid ester 12 lipoxygenase(ALOX12)acts as a regulator in bone genesis by participating in the activation of the peroxisome proliferatoractivated receptor(PPARG)pathway through its reaction product.

关键词： osteoporosis diagnosis remodeling

Full-polarization angular spectrum modeling of scattered light modulation

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Photonics Research 2024年第3期12卷 485-490页

作者： RONGJUN SHAO CHUNXU DING YUAN QU LINXIAN LIU QIAOZHI HE YUEJUN WU JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

The exact physical modeling for scattered light modulation is critical in phototherapy,biomedical imaging,and free-space optical *** particular,the angular spectrum modeling of scattered light has attracted considerable attention,but the existing angular spectrum models neglect the polarization of photons,degrading their ***,we propose a full-polarization angular spectrum model(fpASM)to take the polarization into *** model involves a combination of the optical field changes and free-space angular spectrum diffraction,and enables an investigation of the influence of polarization-related factors on the performance of scattered light *** establishing the relationship between various model parameters and macroscopic scattering properties,our model can effectively characterize various depolarization *** a demonstration,we apply the model in the time-reversal data transmission and anti-scattering light *** method allows the analysis of various depolarization scattering events and benefits applications related to scattered light modulation.

关键词： scattered angular spectrum

High-performance Bi_(2)S_(3)/ZnO photoanode enabled by interfacial engineering with oxyanion for efficient photoelectrochemical water oxidation

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Nano Research 2024年第7期17卷 5996-6005页

作者： Ying-Chu Chen Hsiang-Yu Jui Yichen Feng Yun-Hsiang Lu Yu-Kuei Hsu Department of Chemical Engineering&Biotechnology "National Taipei University of Technology"No.1Sec.3Zhong-Xiao E.Rd.Da'an Dist.Taipei City 10608TaiwanChina Department of Opto-Electronic Engineering "National Dong Hwa University"No.1Sec.2Da Hsueh RoadShoufengHualien 97401TaiwanChina China-UK Low Carbon College Shanghai Jiao Tong UniversityNo.3Yinlian RoadLingangShanghai 201306China

In the present contribution,we demonstrate that the sluggish kinetics of oxygen evolution reaction(OER)over the bismuth sulfide(Bi_(2)S_(3))photoanode,which severely restricts its photoelectrochemical activity,is markedly accelerated by employing a sulfatecontaining ***-principle calculation points to the spontaneous adsorption of sulfate(SO_(4)^(2−))on Bi_(2)S_(3)and its capacity of stabilizing the OER intermediates through hydrogen bonding,which is further reinforced by increasing the local density of states near the Fermi level of Bi_(2)S_(3).Meanwhile,the electron transfer is also promoted to synergistically render the ratedetermining step(from O*to OOH*)of OER over Bi_(2)S_(3)kinetically *** but not least,benefitting from such enhanced OER activity and efficient charge separation resulted from depositing Bi_(2)S_(3)on the zinc oxide nanorods(ZnO NRs),forming a core–shell heterojunction,its photocurrent density achieves 8.61 mA·cm^(−2)at 1.23 VRHE,far surpassing those reported for additional Bi_(2)S_(3)-based and several state-of-the-art photoanodes in the literature and further exceeding their theoretical *** great promise of the Bi_(2)S_(3)/ZnO NRs is in view of such outperformance,the superior Faradaic yield of oxygen of more than~80%and the outstanding half-cell applied bias photon-to-current efficiency of~1%well corroborated.

关键词： photoelectrochemical water oxidation oxyanion adsorption electronic structure regulation oxygen evolution reaction(OER)intermediates stabilization Bi_(2)S_(3)