检索结果-南通市图书馆

维普期刊数据库

Metarelation2vec:A Metapath-Free Scalable Representation Learning Model for Heterogeneous Networks

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第2期29卷 553-575页

作者： Lei Chen Yuan Li Yong Lei Xingye Deng School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China

Metapaths with specific complex semantics are critical to learning diverse semantic and structural information of heterogeneous networks(HNs)for most of the existing representation learning ***,any metapaths consisting of multiple,simple metarelations must be driven by domain *** sensitive,expensive,and limited metapaths severely reduce the flexibility and scalability of the existing models.A metapath-free,scalable representation learning model,called Metarelation2vec,is proposed for HNs with biased joint learning of all metarelations in a bid to address this ***,a metarelation-aware,biased walk strategy is first designed to obtain better training samples by using autogenerating cooperation probabilities for all metarelations rather than using expert-given ***,grouped nodes by the type,a common and shallow skip-gram model is used to separately learn structural proximity for each node ***,grouped links by the type,a novel and shallow model is used to separately learn the semantic proximity for each link ***,supervised by the cooperation probabilities of all meta-words,the biased training samples are thrown into the shallow models to jointly learn the structural and semantic information in the HNs,ensuring the accuracy and scalability of the *** experimental results on three tasks and four open datasets demonstrate the advantages of our proposed model.

关键词： metarelation random walk heterogeneous network metapath representation learning

Effects of extracellular vesicle-derived noncoding RNAs on pre-metastatic niche and tumor progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 176-188页

作者： Zhuang Chen Qiming Wang Jinbo Liu Wenkang Wang Weitang Yuan Yang Liu Zhenqiang Sun Chengzeng Wang department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan 450001China department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450008China department of Breast Surgery The First Affliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China department of Radiotherapy Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450008China The First Affiliated Hospital of Zhengzhou University ZhengzhouHenan 450052China

A pre-metastatic niche(PMN)is a protective microenvironment that facilitates the colonization of disseminating tumor cells in future metastatic *** vesicles(EVs)play a role in intercellular communication by delivering cargoes,such as noncoding RNAs(ncRNAs).The pivotal role of extracellular vesicle-derived noncoding RNAs(EV-ncRNAs)in the PMN has attracted increasing *** this review,we summarized the effects of EV-ncRNAs on the PMN in terms of immunosuppression,vascular permeability and angiogenesis,inflammation,metabolic reprogramming,and fibroblast *** particular,we provided a comprehensive overview of the effects of EV-ncRNAs on the PMN in different ***,we discussed the promising clinical applications of EV-ncRNAs,including their potential as diagnostic and prognostic markers and therapeutic targets.

关键词： Biomarker Extracellular vesicles Noncoding RNAs

Multi-level temporal feature fusion with feature exchange strategy for multiple object tracking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2024年第8期20卷 505-512页

作者： GE Yisu YE Wenjie ZHANG Guodao LIN Mengying College of Computer Science and Artificial Intelligence Wenzhou University School of Computer Science and Technology Zhejiang Normal University department of Digital Media Technology Hangzhou Dianzi University College of Intelligent Manufacturing Wenzhou Polytechnic

With the deepening of neural network research, object detection has been developed rapidly in recent years, and video object detection methods have gradually attracted the attention of scholars, especially frameworks including multiple object tracking and detection. Most current works prefer to build the paradigm for multiple object tracking and detection by multi-task learning. Different with others, a multi-level temporal feature fusion structure is proposed in this paper to improve the performance of framework by utilizing the constraint of video temporal consistency. For training the temporal network end-to-end, a feature exchange training strategy is put forward for training the temporal feature fusion structure efficiently. The proposed method is tested on several acknowledged benchmarks, and encouraging results are obtained compared with the famous joint detection and tracking framework. The ablation experiment answers the problem of a good position for temporal feature fusion.

关键词： A

FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 264-274页

作者： Wei Shen Modan Yang Hao Chen Chiy He Huigang Li Xinyu Yang Jianyong Zhuo Zuyuan Lin Zhihang Hu Di Lu Xiao Xu Zhejiang University School of Medicine HangzhouZhejiang 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou HangzhouZhejiang 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhouZhejiang 310003China National Center for Healthcare Quality Management in Liver Transplant HangzhouZhejiang 310003China

Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum *** exact interplay between stress and liver diseases remains *** plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver *** the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain *** recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much ***21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to ***,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal *** review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

关键词： Autophagy Fibroblast growth factor 21 Liver diseases mTOR Stress

Design of graph computing accelerator based on reconfigurable PE array

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2024年

作者： Deng Junyong Jia Yanting Zhang Baoxiang Kang Yuchun Lu Songtao School of Electronic Engineering Xi’an University of Posts and Telecommunications

Due to the diversity of graph computing applications， the power-law distribution of graph data， and the high memory access-to-computation ratio， traditional architectures face significant challenges in terms of poor flexibility， imbalanced workload distribution， and inefficient memory access when executing graph computing tasks. Graph computing accelerator， GraphApp， based on a reconfigurable processing element (PE) array is proposed to address the aforementioned challenges. GraphApp utilizes 16 reconfigurable PEs for parallel computation and employs tiled data. By reasonably dividing the data into tiles， it achieves load balancing and enhances the overall efficiency of parallel computation. Additionally， it preprocesses graph data using the compressed sparse columns independently (CSCI) data compression format to alleviate the issue of low memory access efficiency caused by the high memory access-to-computation ratio. Lastly， GraphApp is evaluated using triangle counting (TC) and depth-first search (DFS) algorithms. Performance analysis is conducted by measuring the execution time of these algorithms in GraphApp against existing typical graph frameworks， Ligra， and GraphBIG， using six datasets from the stanford network analysis project (SNAP) database. The results show that GraphApp achieves a maximum performance improvement of 30.86% compared to Ligra and 20.43% compared to GraphBIG when processing the same datasets.

关键词：

Attention-Based Residual Dense Shrinkage Network for ECG Denoising

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2809-2824页

作者： Dengyong Zhang Minzhi Yuan Feng Li Lebing Zhang Yanqiang Sun Yiming Ling Hunan provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and TechnologyChangsha410114China School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China School of Computer and Artificial Intelligence Huaihua UniversityHuaihua418000China School of Computer National University of Defense TechnologyChangsha410073China New Energy Centralized Control Center CHN Energy Hunan Power New Energy Co.Ltd.Changsha410000China

Electrocardiogram(ECG)signal is one of the noninvasive physiological measurement techniques commonly usedin cardiac ***,in real scenarios,the ECGsignal is susceptible to various noise erosion,which affectsthe subsequent pathological ***,the effective removal of the noise from ECG signals has becomea top priority in cardiac diagnostic *** at the problem of incomplete signal shape retention andlow signal-to-noise ratio(SNR)after denoising,a novel ECG denoising network,named attention-based residualdense shrinkage network(ARDSN),is proposed in this ***,the shallow ECG characteristics are extractedby a shallow feature extraction network(SFEN).Then,the residual dense shrinkage attention block(RDSAB)isused for adaptive noise ***,feature fusion representation(FFR)is performed on the hierarchicalfeatures extracted by a series of RDSABs to reconstruct the de-noised ECG *** on the MIT-BIHarrhythmia database and MIT-BIH noise stress test database indicate that the proposed scheme can effectively resistthe interference of different sources of noise on the ECG signal.

关键词： Electrocardiogram signal denoising signal-to-noise ratio attention-based residual dense shrinkage network MIT-BIH

Simultaneous measurement of temperature and liquid refractive index based on fiber open Fabry-Pérot cavity and Bragg grating

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2024年第8期20卷 477-482页

作者： LIU Qinpeng WANG Danyang LI Xingrui GAO Hong YU Dakuang College of Science Xi'an Shiyou University

A temperature and refractive index sensor based on fiber Bragg grating(FBG) end surface cascade open Fabry-Pérot(FP) cavity has been designed and demonstrated experimentally. The open FP cavity has been fabricated on the end face of an FBG by dislocation fusion in this work, the open FP cavity could be used for refractive index sensing, and the temperature is measured by the FBG. The working principle of the sensor and the method of improving the sensitivity are analyzed by theoretical simulation. The refractive index sensitivity of the sensor is 1 108.4 nm/RIU, while the maximum fluctuation of the sensor stability experiment detection is 0.005 nm. The results show that it has satisfactory characteristics. The sensor is a compact all-fiber structure, so it has potential applications in the field of temperature refractive index sensing, such as biomedical and capacitor electrolyte detection.

关键词： A

同方期刊数据库

Manipulation of Na3V2（PO4）2F3 via aluminum doping to alter local electron states toward an advanced cathode for sodiumion batteries（英文）

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4253-4262页

作者： Shi-Min Wang Jin-Qi Li Li Xu Meng-Jiao Sun Wen-Jin Huang Qing Liu Fu-Tong Ren Yong-Jiang Sun Ling-Yan Duan Hang Ma Hong Guo International Joint research Center for Advanced Energy Materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-Carbon Technologies School of Materials and Energy Yunnan University College of Environmental and Chemical Engineering Metallurgy College R & D Center Yunnan Yuntianhua Co. Ltd International Joint research Center for Advanced Energy Materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-Carbon Technologies School of Materials and EnergySouthwest United Graduate School Yunnan University

With its unique 3D skeleton structure and exceptional cyclic stability,the Na+superionic conducto（NASICON）-type Na3V2（PO4）2F3（NVPF） has been con sidered as a competitive cathode material for advanced Na ion ***,the release of fluorine during th heat treatment leads to the formation of an additional phas Na3V2（PO4）3（NVP）,which results in a low-voltage plateau and compromises the energy ***,we modulat the local electronic states of the V site by aluminum sub stitution to strengthen the stability of *** results confirm that the aluminum introduction not only changes the loca electron states of V sites,significantly reducing the for mation of NVP by-product from 6.71 wt% to 1.01 wt% but also effectively reduces the band gap,improving th electronic conductivity of *** optimized Na3V1.9Al0.1（PO4）2F3exhibits higher energy density of 340 Wh·kg-1and excellent rate performance of 106.7 mAh·g-1at 10C compared with the pristine cathode.

关键词： Cathode Doping Electrochemistry NASICON Sodium-ion energy storage batteries

Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia YAO Xiaohu ZHOU Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue Key Laboratory of Bioresource research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin