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Quantum simulation and quantum computation of noisy-intermediate scale

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Chinese Physics B 2022年第10期31卷 1-7页

作者： Kai Xu Heng Fan Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Beijing Academy of Quantum Information Sciences Beijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

In the past years, great progresses have been made on quantum computation and quantum simulation. Increasing the number of qubits in the quantum processors is expected to be one of the main motivations in the next years, while noises in manipulation of quantum states may still be inevitable even the precision will improve. For research in this direction, it is necessary to review the available results about noisy multiqubit quantum computation and quantum simulation. The review focuses on multiqubit state generations, quantum computational advantage, and simulating physics of quantum many-body systems. Perspectives of near term noisy intermediate-quantum processors will be discussed.

关键词： quantum computation quantum simulation many-body physics quantum supremacy noisy intermediate-scale quantum technologies

Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins

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Chinese Physics B 2021年第3期30卷 1-8页

作者： Shouqin Lu Qihan Ding Mingkun Zhang Mian Long Center of Biomechanics and Bioengineering Key Laboratory of Microgravity(National Microgravity Laboratory)Beijing Key Laboratory of Engineered Construction and Mechanobiologyand CAS Center for Excellence in Complex System MechanicsInstitute of MechanicsChinese Academy of Sciences(CAS)Beijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China Chongqing Engineering Research Center of High-Resolution and 3D Dynamic Imaging Technology Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China

Molecular dynamics simulation(MDS)is a powerful technology for investigating evolution dynamics of target proteins,and it is used widely in various fields from materials to *** mini-review introduced the principles,main preforming procedures,and advances of MDS,as well as its applications on the studies of conformational and allosteric dynamics of proteins especially on that of the mechanosensitive *** perspectives were also *** review could provide clues in understanding the potentiality of MD simulations in structure–function relationship investigation of biological proteins.

关键词： molecular dynamics simulations mechanosensitive protein allosteric dynamics integrin

基于新型多间隙谐振腔的W波段高次模式扩展互作用速调管设计

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红外与毫米波学报 2023年第4期42卷 504-509页

作者：谢冰川张瑞王欢欢王勇耿志辉廖云峰杨修东中国科学院空天信息创新研究院高功率微波源与技术重点实验室北京100190 中国科学院大学电子电气与通信工程学院北京100049 中国科学院大学材料科学与光电技术学院北京100049

提出了一种工作在TM_(310)模式下的用于高次模式速调管的新型谐振腔。通过对侧腔电场的离散化,可以有效地增强中间腔和侧腔的电场。当两腔均工作在TM_(310)模式时,新型谐振腔的特性阻抗均高于传统的哑铃型腔。对两种腔体进行了尺寸敏感... 详细信息

提出了一种工作在TM_(310)模式下的用于高次模式速调管的新型谐振腔。通过对侧腔电场的离散化,可以有效地增强中间腔和侧腔的电场。当两腔均工作在TM_(310)模式时,新型谐振腔的特性阻抗均高于传统的哑铃型腔。对两种腔体进行了尺寸敏感性分析。在此基础上,设计了一个W频段的射频电路。当向射频电路注入45 mW的输入功率时,获得了52.4 dB的高增益和7.8 kW的峰值输出功率。互作用电路由25 kV、2 A的圆形电子注驱动。该互作用电路的电子效率和3-dB带宽分别为15.6%和120 MHz。

关键词：扩展互作用速调管高次模腔场离散化哑铃型腔敏感性分析

Semi-Quantitatively Designing Two-Photon High-Performance Fluorescent Probes for Glutathione S-Transferases

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Research 2020年第1期2020卷 1191-1201页

作者： Xue-Xiang Zhang Huan Qi Mei-Heng Lu Song-Qiu Yang Peng Li Hai-long Piao Ke-Li Han State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Molecular Sciences and Engineering Shandong UniversityQingdao 266237China

Glutathione S-transferases(GSTs),detoxification enzymes that catalyze the addition of glutathione(GSH)to diverse electrophilic molecules,are often overexpressed in various tumor *** fluorescent probes for GSTs have often adopted the 2,4-dinitrobenzenesulfonyl(DNs)group as the receptor unit,they usually suffer from considerable background reaction noise with GSH due to excessive electron ***,weakening this reactivity is generally accompanied by loss of sensitivity for GSTs,and therefore,finely turning down the reactivity while maintaining certain sensitivity is critical for developing a practical ***,we report a rational semiquantitative strategy for designing such a practical two-photon probe by introducing a parameter adopted from the conceptual density functional theory(CDFT),the local electrophilicityω_(k),to characterize this *** expected,kinetic studies establishedω_(k)as efficient to predict the reactivity with GSH,and probe NI3 showing the best performance was successfully applied to detecting GST activities in live cells and tissue sections with high sensitivity and signal-to-noise *** electron transfer of naphthalimide-based probes,captured by femtosecond transient absorption for the first time and unraveled by theoretical calculations,also contributes to the negligible background noise.

关键词： reactivity Probe negligible

Programming the lifestyles of engineered bacteria for cancer therapy

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National Science Review 2023年第5期10卷 138-153页

作者： Shengwei Fu Rongrong Zhang Yanmei Gao Jiarui Xiong Ye Li Lu Pu Aiguo Xia Fan Jin Hefei National Research Center for Physical Sciences at the Microscale Department of Polymer Science and Engineering University of Science and Technology of China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences West China School of Medicine West China Hospital of Sichuan University

Bacteria can be genetically engineered to act as therapeutic delivery vehicles in the treatment of tumors,killing cancer cells or activating the immune *** is known as bacteria-mediated cancer therapy(BMCT).Tumor invasion,colonization and tumor regression are major biological events,which are directly associated with antitumor effects and are uncontrollable due to the influence of tumor microenvironments during the BMCT ***,we developed a genetic circuit for dynamically programming bacterial lifestyles(planktonic,biofilm or lysis),to precisely manipulate the process of bacterial adhesion,colonization and drug release in the BMCT process,via hierarchical modulation of the lighting power density of near-infrared(NIR) *** deep tissue penetration of NIR offers us a modality for spatio-temporal and non-invasive control of bacterial genetic circuits in *** combining computational modeling with a high-throughput characterization device,we optimized the genetic circuits in engineered bacteria to program the process of bacterial lifestyle transitions by altering the illumination scheme of *** results showed that programming intratumoral bacterial lifestyle transitions allows precise control of multiple key steps throughout the BMCT process and therapeutic efficacy can be greatly improved by controlling the localization and dosage of therapeutic agents via optimizing the illumination scheme.

关键词： genetic engineering drug delivery cancer therapy optogenetics synthetic biology

Effects of growth temperature and metamorphic buffer on electron mobility of InAs film grown on Si substrate by molecular beam epitaxy

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Chinese Physics B 2019年第2期28卷 428-433页

作者： Jing Zhang Hongliang Lv Haiqiao Ni Shizheng Yang Xiaoran Cui Zhichuan Niu Yimen Zhang Yuming Zhang School of Microelectronics Xidian University and the State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences

The growth of the InAs film directly on the Si substrate deflected from the plane(100) at 4° towards(110) has been performed using a two-step procedure. The effect of the growth and annealing temperature on the electron mobility and surface topography has been investigated for a set of samples. The results show that the highest electron mobility is4640 cm^2/V·s in the sample, in which the 10-nm InAs nucleation layer is grown at a low temperature of 320 ℃ followed by ramping up to 560 ℃, and the nucleation layer was annealed for 15 min and the second layer of InAs is grown at 520 ℃.The influence of different buffer layers on the electron mobility of the samples has also been investigated, which shows that the highest electron mobility of 9222 cm^2/V·s at 300 K is obtained in the sample grown on a thick and linearly graded InGaAlAs metamorphic buffer layer deposited at 420 ℃.

关键词： InAs Si high electron mobility growth temperature InGaAlAs metamorphic buffer

Recent advances and research progress on microsystems and bioeffects of terahertz neuromodulation

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Microsystems & Nanoengineering 2023年第6期9卷 25-41页

作者： Meiting Liu Juntao Liu Wei Liang Botao Lu Penghui Fan Yilin Song Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049China

Terahertz waves can interact with the nervous system of organisms under certain *** to common optical modulation methods,terahertz waves have the advantages of low photon energy and low risk;therefore,the use of terahertz waves to regulate the nervous system is a promising new method of ***,most of the research has focused on the use of terahertz technology for biodetection,while relatively little research has been carried out on the biological effects of terahertz radiation on the nervous system,and there are almost no review papers on this *** the present article,we begin by reviewing principles and objects of research regarding the biological effects of terahertz radiation and summarizing the current state of related research from a variety of aspects,including the bioeffects of terahertz radiation on neurons in vivo and in vitro,novel regulation and detection methods with terahertz radiation devices and neural microelectrode arrays,and theoretical simulations of neural information encoding and *** addition,we discuss the main problems and their possible causes and give some recommendations on possible future *** paper will provide insight and assistance to researchers in the fields of neuroscience,terahertz technology and biomedicine.

关键词： breakthrough neural microelectrode

Fire Detection Method Based on Improved Fruit Fly Optimization-Based SVM

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Computers, Materials & Continua 2020年第1期62卷 199-216页

作者： Fangming Bi Xuanyi Fu Wei Chen Weidong Fang Xuzhi Miao Biruk Assefa College of Computer Science and Technology China University of Mining and TechnologyXuzhou221116China College of Computer Science and Technology Mine Digitization Engineering Research Center of the Ministry of EducationChina University of Mining and TechnologyXuzhou221116China College of Computer Science and Technology Xi’an University of Science and TechnologyXi’an710054China Key Laboratory of Wireless Sensor Network&Communication Shanghai Institute of Micro-System and Information TechnologyChinese Academy of SciencesShanghai201899China Infromation Communication Technology Department Wollo UniversityDessie EthiopiaP.o Box 1145Ethiopia

Aiming at the defects of the traditional fire detection methods,which are caused by false positives and false negatives in large space buildings,a fire identification detection method based on video images is *** algorithm first uses the hybrid Gaussian background modeling method and the RGB color model to perform fire prejudgment on the video image,which can eliminate most non-fire ***,the traditional regional growth algorithm is improved and the fire image segmentation effect is effectively ***,based on the segmented image,the dynamic and static features of the fire flame are further analyzed and extracted in the area of the suspected fire ***,the dynamic features of the extracted fire flame images were fused and classified by improved fruit fly optimization support vector machine,and the recognition results were *** video-based fire detection method proposed in this paper greatly improves the accuracy of fire detection and is suitable for fire detection and identification in large space scenarios.

关键词： Fire detection image segmentation feature extraction fruit fly optimization support vector machine

In-situ optical pumping for polarizing 3He neutron spin filters at the China Spallation Neutron Source

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 49-54页

作者： Junpei Zhang Chuyi Huang Zecong Qin Fan Ye Syed Mohd Amir Ahmed Salman Yuchen Dong Long Tian Zachary Norris Buck Wolfgang Kreuzpaintner Matthew Musgrave Xin Qi Tianhao Wang Xin Tong Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Institute of Standards and Technology Boulder 80305USA

In this paper,we present the performance of a recently developed in-situ spin-exchange optically pumped^(3)He-neutron spin filter system at the China Spallation Neutron Source(CSNS).The system achieved a^(3)He polarization of over 74%at the beamline *** of neutron transmission experiment results reveals a neutron polarization of>90%and an average transmission of 27%for 2.2Åneutrons,which were maintained for a duration of 120 h of beam *** the best of our knowledge,this is the first in-situ hyperpolarized^(3)He system incorporated on a neutron beamline in *** technology is expected to provide stable,wide-angle,and highly polarized neutrons at the CSNS for materials research and fundamental neutron physics.

关键词： spin-exchange optical pumping ^(3)He polarization neutron spin filter neutron polarization