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Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

World Journal of Gastroenterology 2024年第9期30卷 1189-1212页

作者： Jin-Lian Jiang Yi-Yang Zhou Wei-Wei Zhong Lin-Yan Luo Si-Ying Liu Xiao-Yu Xie Mao-Yuan Mu Zhi-Gang Jiang Yuan Xue Jian Zhang Yi-Huai He Department of Infectious Diseases Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Respiratory Medicine Anshun People’s HospitalAnshun 561099Guizhou ProvinceChina Department of General Practice Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Intervention Radiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Liver Diseases Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Digestion Dafang County People’s HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1(UGT1A1)plays a crucial role in metabolizing and detoxifying endogenous and exogenous ***,its contribution to the progression of liver damage remains *** To determine the role and mechanism of UGT1A1 in liver damage *** We investigated the relationship between UGT1A1 expression and liver injury through clinical ***,the impact and mechanism of UGT1A1 on the progression of liver injury was analyzed through a mouse model *** Patients with UGT1A1 gene mutations showed varying degrees of liver damage,while patients with acute-onchronic liver failure(ACLF)exhibited relatively reduced levels of UGT1A1 protein in the liver as compared to patients with chronic *** suggests that low UGT1A1 levels may be associated with the progression of liver *** mouse models of liver injury induced by carbon tetrachloride(CCl_(4))and concanavalin A(ConA),the hepatic levels of UGT1A1 protein were found to be *** mice with lipopolysaccharide or liver steatosis-mediated liver-injury progression,the hepatic protein levels of UGT1A1 were decreased,which is consistent with the observations in patients with ***1A1 knockout exacerbated CCl_(4)-and ConA-induced liver injury,hepatocyte apoptosis and necroptosis in mice,intensified hepatocyte endoplasmic reticulum(ER)stress and oxidative stress,and disrupted lipid *** UGT1A1 is upregulated as a compensatory response during liver injury,and interference with this upregulation process may worsen liver ***1A1 reduces ER stress,oxidative stress,and lipid metabolism disorder,thereby mitigating hepatocyte apoptosis and necroptosis.

关键词： Uridine diphosphate glucuronosyltransferase 1A1 Liver injury progression Endoplasmic reticulum stress Oxidative stress Lipid metabolism disorders

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Simultaneous high-performance detection and removal of tetracycline with a polyoxomolybdate-based coordination polymer

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Progress in Natural science:Materials International 2023年第3期33卷 335-342页

作者： Yanqiu Zhang Minrui Sun Yang Lu Xia Xu Erdeng Du Mingguo Peng School of Environmental science and Engineering Changzhou University School of Urban Construction Changzhou University

The excessive residues of tetracycline(TC) have been found to cause persistent adverse effects on both human beings and the environment. In this study, a polyoxomolybdate-based coordination polymer(BUC-14) with negative surface and functional group(-NH2) was selected as a multifunctional platform for the detection and removal of TC. The fluorescence emission of BUC-14 at 468 nm was observed to be quenched by TC in a wide concentration range of 7–107 μM attributed to the inner filter effect(IFE) and photo-induced electron transfer(PET) with a detection limit(LOD) of 38.7 n M. The adsorption properties for TC were thoroughly studied through kinetic and equilibrium experiments. And the excellent adsorption performance significantly can promote the preconcentration of TC, thereby enhancing the sensing performance. Possible mechanisms of adsorption including electrostatic attraction, hydrogen bonding and π-π interactions were studied. Furthermore, the practicality of BUC-14 was confirmed by successfully sensing TC in real water samples with satisfactory recovery from 90.61% to103.53%, and a relative standard deviation(RSD) ≤ 5.12%.

关键词： Fluorescence detection Adsorption BUC-14 Tetracycline

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Effect of existence state of asphaltenes on the asphaltenes-wax interaction in wax deposition

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Petroleum science 2023年第1期20卷 507-514页

作者： Yun Lei Han Wang Shuang-Shuang Li Xue-Qian Liu Hao-Ran Zhu Yu-Ming Gao Hao-Ping Peng Peng-Fei Yu Jiangsu Key Laboratory of Oil and Gas Storage&Transportation technology Changzhou UniversityJiangsu213164China

Asphaltenes are the most elusive substances in waxy crude oil,especially the complex structures,which leads to significant precipitation and aggregation characteristics of asphaltenes,and affects the asphaltenes-wax *** this study,the concept of the existence state of asphaltenes was introduced to semi-quantitatively investigate the precipitation and aggregation characteristics of *** this basis,the influence of the existence state of asphaltenes on wax deposition was studied by coldfinger device and high-temperature gas chromatography,and the composition and properties of the deposits were *** main findings were made:(1)As the asphaltene concentration increases,the existence state of asphaltenes gradually transitions from dispersed state to aggregated state,and the asphaltene concentration of 0.30 wt%in this study is the starting point of the transition.(2)The existence state of asphaltenes in crude oil does affect the process of wax deposition,as shown in the fact that the dispersed asphaltenes promote the occurrence of wax deposition,while the aggregated asphaltenes can inhibit wax deposition.(3)In the presence of the aggregated asphaltenes,that is,when the asphaltene concentration is higher than 0.30 wt%,the shedding phenomenon of deposit layer was observed,and with the increase of aggregated asphaltenes,the deposit layer fell off earlier.(4)With the increase of the dispersed asphaltenes,the wax appearance temperature(WAT)and wax content of the deposits all showed an increasing trend,while with the appearance of the aggregated asphaltenes,the above situation was *** findings of this study can help for better understanding of the interaction between the asphaltenes and wax in wax deposition.

关键词： Asphaltenes Precipitation/aggregation Existence state of asphaltenes Deposition

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Murine double minute gene 2(MDM2)promoted hepatocellular carcinoma(HCC)cell growth by targeting fructose-1,6-bisphosphatase(FBP1)for degradation

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BIOCELL 2022年第6期46卷 1483-1491页

作者： YAO XU BIN WU JING YANG SHENG ZHANG LONGGEN LIU SUOBAO XU JIAKAI JIANG Department of Intensive Care Unit Changzhou No.3 People’s HospitalChangzhou213000China Department of General Surgery Changzhou No.3 People’s HospitalChangzhou213000China Department of Gastroenterology Changzhou No.1 People’s HospitalChangzhou213000China Department of Liver Disease Changzhou No.3 People’s HospitalChangzhou213000China

To study the roles and association of murine double minute gene 2(MDM2)and fructose-1,6-biphosphatase(FBP1)in human hepatocellular carcinoma(HCC),growth response of human HCC cells was assessed using proliferation and apoptosis ***-survival AKT signaling associated proteins(p-AKT,survivin and cleaved caspase 3)were assessed using western *** correlation between MDM2 and FBP1 was assessed using coimmunoprecipitation combined with ubiquitination *** data suggested that low expression of FBP1 was correlated with high levels of MDM2 in HCC cell lines(Huh7 and Hep3B).Overexpression of FBP1 resulted in antiproliferation,pro-apoptosis,the up-regulation of cleaved caspase 3 while the downregulation of survivin and phosphor(p)-AKT,however,knockdown of FBP1 led to the ***,overexpression of MDM2 potently reversed FBP1-induced proliferation inhibition and apoptosis,while Nutlin-3(an MDM2 inhibitor)reversed the change trends induced by FBP1 knockdown in the aforementioned ***,but not least importantly,our data elucidated that MDM2 binds directly to FBP1 and promotes FBP1 *** conclusion,our data firstly suggested the involvement of FBP1 and its association with MDM2 in HCC cell ***2-FBP1-regulated HCC cell growth and the activation of AKT were mediated,at least in part,through FBP1 degradation.

关键词： Human hepatocellular carcinoma MDM2 FBP1 FBP1 ubiquitination

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Transductive Transfer Dictionary Learning Algorithm for Remote Sensing Image Classification

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Computer Modeling in Engineering & sciences 2023年第12期137卷 2267-2283页

作者： Jiaqun Zhu Hongda Chen Yiqing Fan Tongguang Ni Aliyun School of Big Data Changzhou UniversityChangzhou213164China Hua Lookeng Honors College Changzhou UniversityChangzhou213164China

To create a green and healthy living environment,people have put forward higher requirements for the refined management of ecological resources.A variety of technologies,including satellite remote sensing,Internet of Things,artificial intelligence,and big data,can build a smart environmental monitoring *** sensing image classification is an important research content in ecological environmental *** sensing images contain rich spatial information andmulti-temporal information,but also bring challenges such as difficulty in obtaining classification labels and low classification *** solve this problem,this study develops a transductive transfer dictionary learning(TTDL)*** the TTDL,the source and target domains are transformed fromthe original sample space to a common *** trains a shared discriminative dictionary in this subspace,establishes associations between domains,and also obtains sparse representations of source and target domain *** obtain an effective shared discriminative dictionary,triple-induced ordinal locality preserving term,Fisher discriminant term,and graph Laplacian regularization termare introduced into the *** triplet-induced ordinal locality preserving term on sub-space projection preserves the local structure of data in low-dimensional *** Fisher discriminant term on dictionary improves differences among different sub-dictionaries through intra-class and inter-class *** graph Laplacian regularization term on sparse representation maintains the manifold structure using a semi-supervised weight graphmatrix,which can indirectly improve the discriminative performance of the *** TTDL is tested on several remote sensing image datasets and has strong discrimination classification performance.

关键词： Classification dictionary learning remote sensing image transductive transfer learning

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The fabrication strategies and enhanced performances of metal-organic frameworks and carbon dots composites: State of the art review

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Chinese Chemical Letters 2023年第3期34卷 7-23页

作者： Yanqiu Zhang Minrui Sun Mingguo Peng Erdeng Du Xia Xu Chong-Chen Wang School of Environmental and Safety Engineering Changzhou UniversityChangzhou 213164China Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation/Beijing Energy Conservation&Sustainable Urban and Rural Development Provincial and Ministry Co-construction Collaboration Innovation Center Beijing University of Civil Engineering and ArchitectureBeijing 100044China

Metal-organic frameworks(MOFs) with large specific surface area, considerable pore volume, controllable structure, and high concentration of active metal sites have been applied widely in researches like catalysis and sensing. However, potential applications of MOFs in both photocatalysis and luminescence sensors are facing major challenges arising from their severe charge recombination, low utilization of solar energy, low quantum yield, limited charge transfer between the metal ions/clusters and the *** studies revealed that rational introduction of carbon dots(CDs) with excellent optical properties,unique quantum confinement and high conductivity can greatly enhance the functions of MOFs. In this paper, typical synthesis methods of these CD-MOF composites as well as their potential applications in photocatalysis and sensing are reviewed with emphasis. Representative examples of these CD-MOF composites are discussed, and key features and advantages of CD-MOF composites that will facilitate future applications are highlighted.

关键词： Carbons dots Metal-organic frameworks Synthesis Photocatalysis Sensors

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Cross-Domain TSK Fuzzy System Based on Semi-Supervised Learning for Epilepsy Classification

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Computer Modeling in Engineering & sciences 2023年第11期137卷 1613-1633页

作者： Zaihe Cheng Yuwen Tao Xiaoqing Gu Yizhang Jiang Pengjiang Qian School of Internet of Things Wuxi Institute of TechnologyWuxi214121China School of Artificial Intelligence and Computer science Jiangnan UniversityWuxi214122China School of Computer science and Artificial Intelligence Changzhou UniversityChangzhou213164China

Through semi-supervised learning and knowledge inheritance,a novel Takagi-Sugeno-Kang(TSK)fuzzy system framework is proposed for epilepsy data classification in this *** new method is based on the maximum mean discrepancy(MMD)method and TSK fuzzy system,as a basic model for the classification of epilepsy ***,formedical data,the interpretability of TSK fuzzy systems can ensure that the prediction results are traceable and ***,in view of the deviation in the data distribution between the real source domain and the target domain,MMD is used to measure the distance between different data *** objective function is constructed according to the MMD distance,and the distribution distance of different datasets is minimized to find the similar characteristics of different *** introduce semi-supervised learning to further explore the relationship between *** on the MMD method,a semi-supervised learning(SSL)-MMD method is constructed by using pseudo-tags to realize the data distribution alignment of the same *** addition,the idea of knowledge dissemination is used to learn pseudo-tags as additional data ***,for epilepsy classification,the cross-domain TSK fuzzy system uses the cross-entropy function as the objective function and adopts the back-propagation strategy to optimize the *** experimental results show that the new method can process complex epilepsy data and identify whether patients have epilepsy.

关键词： Takagi-Sugeno-Kang fuzzy systems back propagation semi-supervised learning inheritancemechanism transfer learning

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Brain Functional Networks with Dynamic Hypergraph Manifold Regularization for Classification of End-Stage Renal Disease Associated with Mild Cognitive Impairment

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Computer Modeling in Engineering & sciences 2023年第6期135卷 2243-2266页

作者： Zhengtao Xi Chaofan Song Jiahui Zheng Haifeng Shi Zhuqing Jiao School of Microelectronics and Control Engineering Changzhou UniversityChangzhou213164China School of Computer science and Artificial Intelligence Changzhou UniversityChangzhou213164China Department of Radiology Changzhou Second People’s Hospital Affiliated to Nanjing Medical UniversityChangzhou213003China

The structure and function of brain networks have been altered in patients with end-stage renal disease(ESRD).Manifold regularization(MR)only considers the pairing relationship between two brain regions and cannot represent functional interactions or higher-order relationships between multiple brain *** solve this issue,we developed a method to construct a dynamic brain functional network(DBFN)based on dynamic hypergraph MR(DHMR)and applied it to the classification of ESRD associated with mild cognitive impairment(ESRDaMCI).The construction of DBFN with Pearson’s correlation(PC)was transformed into an optimization *** convolution and hyperedge convolution superposition were adopted to dynamically modify the hypergraph structure,and then got the dynamic hypergraph to form the manifold regular terms of the dynamic *** DHMR and L_(1) norm regularization were introduced into the PC-based optimization model to obtain the final DHMR-based DBFN(DDBFN).Experiment results demonstrated the validity of the DDBFN method by comparing the classification results with several related brain functional network construction *** work not only improves better classification performance but also reveals the discriminative regions of ESRDaMCI,providing a reference for clinical research and auxiliary diagnosis of concomitant cognitive impairments.

关键词： End-stage renal disease mild cognitive impairment brain functional network dynamic hypergraph manifold regularization classification

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Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma:A meta-analysis 14812 subjects

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 171-185页

作者： Jia-Kai Jiang Han-Shen Chen Wei-Feng Tang Yu Chen Jing Lin Department of General Surgery Changzhou No.3 People’s HospitalChangzhou 213000Jiangsu ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Cancer Bio-Immunotherapy Center Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina College of Chemistry Fuzhou UniversityFuzhou 350000Fujian ProvinceChina

BACKGROUND Recently,many investigations have suggested that the rs3746444 T>C locus in the microRNA(miR)-499 gene may contribute to the occurrence of ***,reports on the association between rs3746444 and hepatocellular carcinoma(HCC)are *** To further understand and explore the potential correlation between the singlenucleotide polymorphism of rs3746444 and the incidence of *** In this meta-analysis,we obtained electronic literature by searching the PubMed,Embase and Chinese BioMedical Disc databases(through May 20,2022).All eligible case-control,prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95%confidence intervals were *** Ultimately,a total of 17 independent studies were *** identified that rs3746444 was associated with the development of HCC(C vs T:P=0.019 and CC/CT vs TT:P=0.016).In Asian individuals,rs3746444 was associated with susceptibility to HCC(C vs T:P=0.013 and CC/CT vs TT:P=0.016).In addition,this study identified that the miR-499 rs3746444 locus was associated with susceptibility to HCC in the normal/healthy control subgroup(C vs T:P=0.034 and CC/CT vs TT:P=0.024).CONCLUSION In summary,this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC,especially in Asian individuals.

关键词： Polymorphism MicroRNA-499 Hepatocellular carcinoma Meta-analysis Susceptibility

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MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells

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BIOCELL 2020年第1期44卷 73-80页

作者： Wensong LIU Yunjie LU Dong ZHANG Longqing SHI Guangchen ZU Haijiao YAN Donglin SUN Department of Hepatobiliary Surgery the Third Affiliated Hospital of Soochow UniversityChangzhou213003China Department of Oncology the Third Affiliated Hospital of Soochow UniversityChangzhou213003China

Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high *** studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic *** this study,we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell ***-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion,while enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 *** reporter assay showed that miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer *** pancreatic cancer tissues,survivin protein was highly expressed and negatively correlated with miR-708 ***,the restoration of survivin expression could partially antagonize proliferation inhibition and apoptosis induction by miR-708 in pancreatic cancer *** Panc-1 cells with overexpression of miR-708 also showed decreased proliferation capability in nude mouse model compared with parental *** conclusion,our results suggest that miR-708 inhibits pancreatic cancer and could be a novel potential candidate to treat pancreatic cancer.

关键词： Chemosensitivity MicroRNA-708 Pancreatic cancer Proliferation Survivin

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