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Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG TONY GKLEIJN ZHAOYONG WU BING LIU YUJIN MA BAOYUE DING DONGFENG YIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and *** treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic *** improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone ***(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size *** in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX *** micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated *** binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis *** vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic *** conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

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青藏高原冻土区高寒草甸能量分配及蒸散发影响因子

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Journal of Plant Ecology 2024年第1期17卷 121-134页

作者： Zhaoyong Hu Genxu Wang Xiangyang Sun Kewei Huang Chunlin Song Yang Li Shouqin Sun Juying Sun Shan Lin State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China Hubei Key Laboratory of Basin Water Security Changjiang SurveyPlanningDesign and Research Co.Ltd.Wuhan 430010China

高寒草甸的能量分配和蒸散发对青藏高原多年冻土区水循环至关重要。然而,能量分配、蒸散发及其驱动因素的季节变化(冻融循环)仍需要明确。因此,本研究在位于青藏高原风火山流域的高寒草甸进行了为期4年的能量通量(包括潜热和感热)观测,... 详细信息

高寒草甸的能量分配和蒸散发对青藏高原多年冻土区水循环至关重要。然而,能量分配、蒸散发及其驱动因素的季节变化(冻融循环)仍需要明确。因此,本研究在位于青藏高原风火山流域的高寒草甸进行了为期4年的能量通量(包括潜热和感热)观测,并估算了大气边界参数(包括表面导度,解耦系数和Priestley-Taylor系数)。研究结果表明,研究区日均潜热(27.45±23.89 W/m^(2))和显热(32.51±16.72W/m^(2))分别占可利用能量的31.71%和50.14%。在降雨期,更多可利用能量被分配到潜热;而在冻结期,67.54±28.44%的可利用能量分配给显热。显热在降雨期间是潜热的一半,而由于冻结期较低的土壤水分含量及植被盖度,显热在冻结期间是潜热的7倍。研究区年均蒸散发为347.34±8.39 mm/year,接近年均降水量。较低的日均解耦系数(0.45±0.23)和Priestley-Taylor系数(0.60±0.29)表明高寒草甸的蒸散发受水分供应限制。然而,在降雨期由于降水充足,蒸散发受到可利用能量的限制。在过渡期,蒸散发和降水之间存在较大差异,表明在该季节上游冰川和雪的融水通过侧向流动补给到土壤中。本研究的结果表明,在未来模拟多年冻土区水和能量通量时应考虑大气边界参数的季节变化。

关键词：潜热通量显热通量冻融循环大气边界参数高寒草甸

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Tough Hydrogen Bonding Crosslinked Poly (3-fluorothiophene) Network via Electrosynthesis for High-performance Electrochromic Supercapacitors

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Chinese Journal of Polymer science 2024年第11期 1749-1757页

作者： Chun-Hui Du Yu-Hua Xu Hui Li Zhi-Xin Wu Han-Jun Yang Xi-Mei Liu Bao-Yang Lu Guang-Ming Nie Ge Zhang Jiangxi Key Lab of Flexible Electronics Flexible Electronics Innovation InstituteJiangxi Science & Technology Normal University Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life science MOEState Key Laboratory Base of Eco-chemical EngineeringCollege of Chemistry and Molecular EngineeringQingdao University of Science and Technology

As a type of bi-functional device,electrochromic supercapacitors （EC-SCs） have attracted extensive attention in diverse applications such as flexible ***,despite recent encouraging progress,rational design and development of high-performance EC-SC materials with desirable stability remain challenging for practical ***,we propose a fluorination strategy to develop high-performance EC-SC materials with tough hydrogen bonding cross-linked intermolecular polymer network by one-step electrosynthesis of *** electrosynthesized free-standing poly（3-fluorothiophene）(PFT) films simultaneously achieve high electrochromic performance （optical contrast 42%at 560 nm with reversible color changes between purple and blue）,and good capacitance property (290 F·g-1,1 A·g-1),as well as outstanding cyclic stability （<2%reduction after 20000 cycles）.We further demonstrate the fabrication of PFT-based flexible electrochromic supercapacitor devices （FESDs）,and the resultant devices can be used to visually monitor the energy storage state in real-time and maintain outstanding stability under mechanical distortion like *** a tough fluorination hydrogen bonding cross-linking strategy may provide a new design concept for high-performance EC-SC materials and reliable FESDs toward practical applications.

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Discharge properties of Mg-Sn-Y alloys as anodes for Mg-air batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1705-1715页

作者： Hua-bao Yang Liang Wu Bin Jiang Bin Lei Ming Yuan Hong-mei Xie Andrej Atrens Jiang-feng Song Guang-sheng Huang Fu-sheng Pan State Key Laboratory of Mechanical Transmissions College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials science and Engineering Yangtze Normal UniversityChongqing 408100China School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQld 4072Australia

Mg-Sn-Y alloys with different Sn contents(wt%)were assessed as anode candidates for Mg-air *** relationship between microstructure(including the second phase,grain size,and texture)and discharge properties of the Mg-Sn-Y alloys was examined using microstructure observation,electrochemical measurements,and galvanostatic discharge *** Mg-0.7Sn-1.4Y alloy had a high steady discharge voltage of 1.5225 V and a high anodic efficiency of 46.6% at 2.5 mA·cm^(-2).These good properties were related to its microstructure:small grain size of 3.8μm,uniform distribution of small second phase particles of 0.6μm,and a high content(vol%)of(1120)/(1010)orientated *** scanning Kelvin probe force microscopy(SKPFM)indicated that the Sn_(3)Y_(5) and MgSnY phases were effective cathodes causing micro-galvanic corrosion which promoted the dissolution of Mg matrix during the discharge process.

关键词： magnesium-stannum-yttrium alloy microstructure micro-galvanic corrosion discharge properties magnesium-air battery

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Thermal conductivity and mechanical properties of high density polyethylene composites filled with silicon carbide whiskers modified by cross-linked poly (vinyl alcohol)

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Journal of Materials science & technology 2018年第12期34卷 2407-2414页

作者： Jiaming Fan Shiai Xu School of Materials science and Engineering East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering Qinghai UniversityXining 810016China

A thin layer of poly(vinyl alcohol)(PVA) was coated on the surface of silicon carbide whiskers(SCWs)and crosslinked by glutaraldehyde, and then these modified whiskers(mSCWs) were incorporated into high density polyethylene(HDPE) to prepare HDPE/mSCW composites with a high thermal *** thermal conductivity, mechanical properties, heat resistance, thermal stability and morphology of HDPE/mSCW and HDPE/SCW composites were characterized and compared. The results reveal that the thermal conductivity of both HDPE/SCW and HDPE/mSCW composites increases with the increase of filler loading, and reaches a maximum of 1.48 and 1.69 W/(m K) at 40 wt% filler loading, which is 251.20% and 300.75% higher than that of HDPE, respectively. Significantly, HDPE/mSCW composites have a higher thermal conductivity than their HDPE/SCW counterparts with the same filler loading. In addition, the heat resistance, Young’s modulus and yield strength of both HDPE/SCW and HDPE/mSCW composites are also improved compared with that of HDPE. mSCW can be homogenously dispersed in the HDPE matrix, which contributes to the formation of thermally conductive networks by the inter-connection of mSCWs.

关键词： Polyethylene composites Silicon carbide Whisker Thermal conductivity

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Mechanical Properties and Interfacial Interaction of Modified Calcium Sulfate Whisker]Poly(Vinyl Chloride)Composites

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Journal of Materials science & technology 2016年第12期32卷 1352-1360页

作者： Wenjin Yuan Jiayang Cui Shiai Xu The Chemical Engineering College of qinghai University Xining 810016 China Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China

Calcium sulfate whiskers（CSWs） modified with glutaraldehyde-crosslinked poly（vinyl alcohol）（PVA） or traditional surface modifiers,including silane coupling agent,titanate coupling agent and stearic acid,were used to strengthen poly（vinyl chloride）（PVC）,and the morphologies,mechanical and heat resistant properties of the resulting composites were *** results clearly show that glutaraldehyde cross-linked PVA modified CSW/PVC composite（c PVA@CSW/PVC） has the strongest interfacial interaction,good and stable mechanical and heat resistant ***＇s modified Kerner＇s equation for Young＇s modulus is better than other models examined for the CSW/PVC *** half debonding angle θ of c PVA@CSW/PVC composite is lower than that of other composites except silane coupling agent modified CSW/PVC composites,indicating a very strong interfacial adhesion between c PVA@CSW and *** general,cross-linked PVA is effective and environmentally friendly in modifying inorganic fillers.

关键词： Poly(vinyl chloride) composites Calcium sulfate whisker Surface treatment Interface Mechanical properties

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铅、锌、镉同位素示踪技术在沉积物重金属污染源解析中的应用:综述与展望

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盐湖研究 2024年第1期32卷 128-138页

作者：高春亮文进心成艾颖闵秀云魏海成中国科学院青海盐湖研究所中国科学院盐湖资源综合高效利用重点实验室青海西宁810008 青海省盐湖地质与环境重点实验室青海西宁810008 中国科学院大学北京100049

沉积物重金属污染防治的关键在于识别其污染源,采用铅、锌、镉多元同位素示踪技术是对其进行污染源解析的最佳手段之一。铅同位素示踪技术较为成熟且应用广泛,锌和镉同位素示踪技术作为新兴技术,在重金属污染源解析研究中可作为有力补... 详细信息

沉积物重金属污染防治的关键在于识别其污染源,采用铅、锌、镉多元同位素示踪技术是对其进行污染源解析的最佳手段之一。铅同位素示踪技术较为成熟且应用广泛,锌和镉同位素示踪技术作为新兴技术,在重金属污染源解析研究中可作为有力补充。本文系统概述了Pb-Zn-Cd同位素的示踪机理、组成特征及其在沉积物重金属污染溯源中的应用,提出未来研究工作的重点是采用多元同位素示踪技术,并结合沉积物形态中重金属稳定同位素的组成示踪污染源。

关键词：铅、锌、镉同位素沉积物重金属污染源解析示踪技术

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Impact of time lags on diurnal estimates of canopy transpiration and canopy conductance from sap-flow measurements of Populus cathayana in the qinghai–Tibetan Plateau

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Journal of Forestry Research 2017年第3期28卷 481-490页

作者： Hui Wang Kangning He Runjie Li Zhuping Sheng Yun Tian Jun Wen Bo Chang Key Laboratory of State Forestry Administration on Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China Institute of Water Resources and Hydropower of qinghai Province Xining 810001China Texas A&M AgriLife Research Texas A&M UniversityEL PasoCollege StationTX 77843USA

Recently, canopy transpiration （Ec） has been often estimated by xylem sap-flow measurements. However, there is a significant time lag between sap flow measured at the base of the stem and canopy transpiration due to the capacitive exchange between the transpiration stream and stem water storage. Significant errors will be introduced in canopy conductance （gc） and canopy transpiration estimation if the time lag is neglected. In this study, a cross-correlation analysis was used to quantify the time lag, and the sap flowbased transpiration was measured to pararneterize Jarvistype models of gc and thus to simulate Ec of Populus cathayana using the Penman-Monteith equation. The results indicate that solar radiation （Rs） and vapor pressure deficit （VPD） are not fully coincident with sap flow and have an obvious lag effect; the sap flow lags behind Rs and precedes VPD, and there is a 1-h time shift between Eo and sap flow in the 30-min interval data set. A parameterized Jarvis-type gc model is suitable to predict P. cathayana transpiration and explains more than 80% of the variation observed in go, and the relative error was less than 25%, which shows a preferable simulation effect. The root mean square error （RMSEs） between the predicted and measured Ec were 1.91×10^-3 （with the time lag） and 3.12×10^-3cm h^-1 （without the time lag）. More importantly, Ec simulation precision that incorporates time lag is improved by 6% compared to the results without the time lag, with the mean relative error （MRE） of only 8.32% and the mean absolute error （MAE） of 1.48 × 10^-3 cm h^-1.

关键词： Canopy transpiration Model - Populuscathayana qinghai-Tibetan Plateau Sap flow Time lags

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Preparation and properties of superfine Mg(OH)_2 flame retardant

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中国有色金属学会会刊：英文版 2006年第2期16卷 488-492页

作者：徐徽邓新荣 School of Metallurgical science and Engineering Central South University Changsha 410083 China

Preparation of superfine magnesium hydroxide with the bittern and ammonia was studied. The properties of the products were analyzed by laser granularity, X-ray diffraction, scanning electron microscope, the limiting oxygen index and the wetting angle measurements. The results show that the mean particle size of the magnesium hydroxide is about 230 nm with a platelet shape and the specific surface area is about 48 m2/g when the temperature is 55 ℃ , and the ammonia and bittern are instilled simultaneously during the reaction process. After the modification, the limiting oxygen index and physical chemistry performance of the magnesium hydroxide were examined. The results show that the contact angle of magnesium hydroxide is 132.5? and the limiting oxygen index is 31.5 %, indicating that the modified magnesium hydroxide is an effective flame retardant and can be applied as flame retardant additives of the macromolecule compounds such as plastic, synthetic rubber and synthetic fibre.

关键词：阻燃剂卤水氨水氢氧化镁制备性能

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Enhanced mechanical properties of Mg-1Al-12Y alloy containing long period stacking ordered phase

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Journal of Magnesium and Alloys 2023年第12期11卷 4679-4688页

作者： Shuai Yuan Jinhui Wang Xiaoqiang Li Hongbin Ma Lei Zhang Peipeng Jin qinghai Provincial Key Laboratory of New Light Alloys Qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and FormingQinghai University251 ningda roadChengbei District.Xining 810016China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

In this study, a systematic investigation on the effect of solution treatment time(2–8 h) at 540℃ on the microstructure and mechanical properties in as-cast Mg-1Al-12Y(AY112, wt.%) alloy was performed. The results showed that the solution treatment did not cause the growth of grains and the change of texture;however, the mechanical properties had been significantly improved, which was mainly attributed to the precipitation of 18R long period ordered stacking(LPSO) phase in the solution-treated alloys. In addition, the dissolution of β-Mg_(24)Y_(5)phase and the diffusion of solute atoms during the solution treatment were both beneficial to the mechanical properties. When the as-cast alloy was solution-treated at 540℃ for 4 h(T4-4h alloy), the mechanical properties of the alloy are optimal. Compared with the as-cast alloy,the ultimate tensile strength(UTS) and elongation of the T4-4h alloy are increased by ~23% and ~179%, respectively. The deformation of the T4-4h alloys was dominated by a combination of basal slip and non-basal slip, and the presence of the LPSO phase effectively inhibited the nucleation of extension twin. Besides, the LPSO phase can also hinder the activation of basal dislocations and the movement of non-basal dislocations. Therefore, the LPSO phase simultaneously improves the strength and plasticity of the alloy.

关键词： Solution treatment LPSO phase Mechanical properties Deformation mechanism

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