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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Simulations of electron zebra stripes in the inner radiation belt using a composite empirical electric field model

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science China Earth sciences 2025年第1期 27-38页

作者： Ziyang WANG Ying LIU Qiugang ZONG Hong ZOU Yuguang YE Xuzhi ZHOU Chao YUE Shan WANG Institute of Space Physics and Applied technology Peking University State Key Laboratory of Lunar and Planetary science Macau University of Science and Technology

The phenomenon termed “zebra stripes” manifests as regular patterns in the energy-space(L shell) spectrum of energetic electrons(ranging from tens to hundreds ke V) within the inner radiation belt. These structures exhibit drift-periodic behavior and commonly arise from large-scale electric field perturbations near the substorm onsets. In this study, we introduce a composite electric field model and replicate the formation, structure, and evolution of zebra stripes using a bounce-averaged test particle code under this electric field model. High-resolution measurements of energetic electrons obtained from the Van Allen Probes and the recently launched macao science Satellites-1 are used as initial conditions and served to validate our test particle simulations. Comparative analyses between observed data and simulations demonstrate our test particle method's efficacy in capturing zebra stripes' general behavior. Moreover, the composite model proves capable of reproducing realistic variations in the electric field within the inner radiation belt to a certain extent. Nevertheless, subtle differences emerge in the flux strength and the positions of stripes. These disparities primarily stem from limitations inherent in the electric field model and the initial conditions of the simulation. Acknowledging that the model represents an average case, it is conceivable that real-world scenarios may deviate from the average, thereby introducing variations in the observed phenomena.

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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

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Frontiers of Environmental science & Engineering 2021年第6期15卷 241-258页

作者： Yangyang Liang Qingbin Song Naiqi Wu Jinhui Li Yuan Zhong Wenlei Zeng macao Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China macao Environmental Research Institute Macao University of Science and TechnologyMacao 999078China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China

It has been over ten months since the beginning of the 2019 coronavirus disease(COVID-2019),and its impact on solid waste management,especially medical waste,is becoming *** study systematically reviews the potential influences of the COVID-19 pandemic on medical waste,personal protection equipment waste and municipal solid waste(MSW),and discusses the corresponding measures and policies of solid waste management in typical *** results show that the generation of medical waste from the pandemic increased significantly,with 18%‒425%*** is estimated that the daily output of COVID-19 medical waste increased from 200 t/d on Feb.22 to over 29000 t/d at the end of September 2020 throughout the *** use of personal protective equipment will continue to grow in the long-term,while the blockade and isolation measures greatly reduced the volume of commercial waste,especially for tourist cities,and part of this waste was transferred to household ***’attitudes and behavior toward food waste have changed due to the COVID-19 *** response to the pandemic,international organizations and several countries have issued new policies and guidelines and adjusted their management strategies for medical waste and MSW *** pandemic has brought specific challenges to the disposal capacity of medical waste *** has also brought about the stagnation of policies related to the reduction of plastic products and waste *** study will provide some useful information for managers and governmental officials on effective solid waste management during and after the COVID-19 pandemic.

关键词： COVID-19 Medical waste Personal protective equipment Municipal solid waste Waste management

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BGLS-based method of estimating the rotational periods of asteroids

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Research in Astronomy and Astrophysics 2021年第7期21卷 107-114页

作者： Yan-Qiong Ren Xiao-Ping Lu Yong Liang School of Computer science and Communication Engineering Jiangsu UniversityZhenjiang 212013China macao University of science and technology Macao 999078China Guangdong-Hong Kong-macao Joint Laboratory for Smart Discrete Manufacturing Guangzhou 510006China

As the asteroid rotational period is important to the study of the properties of asteroids(e.g.,super-fast rotators have structures owing an internal cohesion(rather than being rubble piles bounded by gravity only) so as not to fly apart), constructing an effective and fast method used to search the period attracts much researchers' attention. Recently, the Bayesian generalized Lomb–Scargle(BGLS)periodogram was developed to improve the convergence efficiency of the Lomb–Scargle method. However,the result of BGLS varies with the frequency range and cannot meet the two minimum/maximum requirements for a complete rotation of the asteroid. We propose a robust BGLS-based method that efficiently determines rotational periods. The proposed method employs a polynomial series to fit folded light curves with potential periods, initially calculated using the BGLS periodogram, and adopts a merit function to estimate and refine best-fit periods. We estimate the rotational periods of 30 asteroids applying the new method to light curves from the Palomar Transient Factory. Results confirm the effectiveness of the BGLS-based method in deriving rotational periods from ground-based observations of asteroids. Further application of the BGLS-based method to sparse light curves, such as Gaia data, is discussed.

关键词： methods:data analysis asteroids:general techniques:photometric

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Steps Toward Industry 5.0:Building“6S”Parallel Industries With Cyber-Physical-Social Intelligence

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IEEE/CAA Journal of Automatica Sinica 2023年第8期10卷 1692-1703页

作者： Xingxia Wang Jing Yang Yutong Wang Qinghai Miao Fei-Yue Wang Aijun Zhao Jian-Ling Deng Lingxi Li Xiaoxiang Na Ljubo Vlacic School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China IEEE macao University of science and technology Macao 999078China Beijing Engineering Research Center of Intelligent Systems and technology Chinese Academy of SciencesBeijing 100098 State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China North Automatic Control technology Institute Taiyuan 030006China China Huaneng Group Co. Ltd.Beijing 100031China Department of Electrical and Computer Engineering Indiana University-Purdue University Indianapolis(IUPUI)IndianapolisIN 46202 USA Department of Engineering University of CambridgeCambridgeCB21PZUK School of Engineering and Built Environment Griffith UniversityGold CoastQLD 4222Australia

Very recently,intensive discussions and studies on Industry 5.0 have sprung up and caused the attention of researchers,entrepreneurs,and policymakers from various sectors around the ***,there is no consensus on why and what is Industry 5.0 *** this paper,we define Industry 5.0from its philosophical and historical origin and evolution,emphasize its new thinking on virtual-real duality and human-machine interaction,and introduce its new theory and technology based on parallel intelligence(PI),artificial societies,computational experiments,and parallel execution(the ACP method),and cyber-physical-social systems(CPSS).Case studies and applications of Industry 5.0 over the last decade have been briefly summarized and analyzed with suggestions for its future *** believe that Industry 5.0 of virtual-real interactive parallel industries has great potentials and is critical for building smart *** are outlined to ensure a roadmap that would lead to a smooth transition from CPS-based Industry 4.0 to CPSS-based Industry 5.0 for a better world which is Safe in physical spaces,S ecure in cyberspaces,Sustainable in ecology,Sensitive in individual privacy and rights,Service for all,and Smartness of all.

关键词： ACP artificial intelligence CPS CPSS Industry 4.0 Industry 5.0 parallel industries parallel intelligence

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New Control Paradigm for Industry 5.0:From Big Models to Foundation Control and Management

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IEEE/CAA Journal of Automatica Sinica 2023年第8期10卷 1643-1646页

作者： Fei-Yue Wang IEEE the State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China

DO we need a fundamental change in our professional culture and knowledge foundation for control and automation?If so,what are necessary and critical steps we must take to ensure such a change would take place effecti... 详细信息

关键词： smoothly steps culture

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Effects of initial velocity on the sinking of ilmenite-bearing cumulates in the early lunar mantle:Insight from the theory of Rayleigh-Taylor instability

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Research in Astronomy and Astrophysics 2021年第1期21卷 207-219页

作者： Shuo-Ran Yu Xiao-Ping Zhang State Key Laboratory of Lunar and Planetary sciences Macao University of Science and TechnologyMacao SARChina

The early lunar mantle overturn,associated with the sinking of the dense ilmenite-bearing cumulate(IBC)crystallized at the shallow lunar mantle,provides satisfactory explanations for the origination of high-Ti basalt,the abnormally strong magnetic field between~3.9 and~3.6 Ga and the low-viscosity zone in the deep lunar mantle,but still poses a debate regarding the initial state of IBC in the early lunar *** the sinking of IBC initiated before the end of lunar magma ocean crystallization,the solidified IBC can acquire a greater thickness and a higher initial velocity at the IBC-mantle *** variation of initial velocity can affect the strain rate of IBC and,correspondingly,the dislocation creep components at the shallow lunar *** this work,we analyze the effects of initial velocity on the dynamics of early lunar mantle by using the theory of Rayleigh-Taylor *** couple the effects of diffusion creep and dislocation creep for all major minerals in the lunar mantle,we exploit an improved Minimized Power Geometric(IMPG)model and isostress mixing model to characterize the upper limit and lower limit for the viscosity of the lunar mantle comprising four major minerals,***,orthopyroxene,clinopyroxene and *** modeling results suggest that a high initial velocity,in any case,can shorten the onset time,tending to promote the early lunar mantle overturn even in a rheologically-strong lunar *** effect of initial velocity on the overturn wavelength shows a strong dependence on the rheological mixing *** the isostress mixing model,the increase of initial velocity tends to elongate the overturn *** the IMPG mixing model,the overturn wavelength is insensitive to the variation of initial *** the actual lunar mantle rheology sandwiches between the rheologies predicted by isostress mixing model and IMPG model,it can be anticipated that the increase of initial velocity tends to elongate the overturn waveleng

关键词： planets and satellites:Moon planets and satellites:interiors planets and satellites:tectonics planets and satellites:composition

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Sensitive and Specific Y-Shaped Ratio Biosensor for Detecting Serum mi R-18a:Potential Early Scanning Tool for Non-Small Cell Lung Cancer

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Journal of Analysis and Testing 2024年第2期8卷 237-244页

作者： Fei Yu Yue Wang Caiyuan Yu Wei Zhang Xuefeng Bai State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao999078China Baotou Cancer Hospital Baotou014040Inner MongoliaChina

miR-18a has been identified as a significantly expressed microRNA(miRNA)in non-small cell lung cancer(NSCLC)and plays a vital role in cancer cell transformation,metastasis,and ***,a pair of binary probes from numerous probe pairs based on single nucleotide polymorphism analyses of miR-18a and miR-18b was first designed and screened to develop a Y-shaped ratio biosensor for accurate detection of serum miR-18a in *** special structure of the binary probes combined with the hairpin showed strong specificity for miR-18a,which was confirmed by polyacrylamide gel electrophoresis assay and square wave voltammetry ***,it is beneficial to immobilize single-stranded DNA(ssDNA)probes due to the large specific surface area of nanoporous gold,thereby improving the sensitivity of the *** Y-shaped ratio biosensor exhibited a wide detection range and can quantify the concentration of miR-18a in the range of 10 fmol/L–100 pmol/L,with a limit of detection of 0.211 fmol/L(S/N=3).Moreover,it exhibits excellent detection capabilities in serum samples since the biosensor showed a high selectivity toward the coexistence of miR-18a and ***,the prepared Y-shaped ratio biosensor is a highly sensitive and specific miR-18a detection tool,capable of identifying microscopic amounts of miR-18a in serum samples,providing great potential for early screening of NSCLC.

关键词： Nanoporous gold Y-shaped biosensor miR-18a NSCLC

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The ChatGPT After: Building Knowledge Factories for Knowledge Workers with Knowledge Automation

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IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2041-2044页

作者： Yutong Wang Xiao Wang Xingxia Wang Jing Yang Oliver Kwan Lingxi Li Fei-Yue Wang State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence Anhui UniversityHefei 230039China Motion G Inc068898Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndiana 46202-5132 USA IEEE

Briefing: This perspective introduces the concept and framework of knowledge factories with knowledge machines for knowledge workers to achieve knowledge automation for Industry 5.0 and intelligent *** The big hit of Chat GPT makes it imperative to contemplate the practical applications of big or foundation models [1]-[5]. However, as compared to conventional models, there is now an increasingly urgent need for foundation intelligence of foundation models for real-world industrial applications.

关键词： Automation template Chat GPT

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Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

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