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DNA methylation markers in the diagnosis and prognosis of common leukemias

Signal Transduction and Targeted Therapy 2020年第1期5卷 2468-2477页

作者： Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China State Key Laboratory of Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Statistics and Institute for Integrative Genome Biology University of California RiversideRiversideCA 92521USA Shanghai Center for Plant Stress Biology Shanghai Institute for Biological SciencesChinese Academy of SciencesShanghai 210602China Faculty of Medicine Macao University of Science and TechnologyTaipaMacaoChina

The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of *** genome-wide methylation profiling and machine learning methods,we investigated the utility of CpG methylation status to differentiate blood from patients with acute lymphocytic leukemia(ALL)or acute myelogenous leukemia(AML)from normal *** established a CpG methylation panel that can distinguish ALL and AML blood from normal blood as well as ALL blood from AML blood with high sensitivity and *** then developed a methylation-based survival classifier with 23 CpGs for ALL and 20 CpGs for AML that could successfully divide patients into high-risk and low-risk groups,with significant differences in clinical outcome in each leukemia ***,these findings demonstrate that methylation profiles can be highly sensitive and specific in the accurate diagnosis of ALL and AML,with implications for the prediction of prognosis and treatment selection.

关键词： diagnosis prognosis acute

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Inter-facet composition modulation of III-nitride nanowires over pyramid textured Si substrates by stationary molecular beam epitaxy

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Nano Research 2021年第5期14卷 1502-1511页

作者： Peng Wang Hedong Chen Hao Wang Dan Wang Changkun Song Xingyu Wang Hongjie Yin Lujia Rao Guofu Zhou Richard Nötzel Guangdong Provincial Key Laboratory of Optical information Materials and technology South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China National Center for International Research on Green Optoelectronics South China Normal UniversityGuangzhou510006China Department of Physics Xiamen UniversityXiamen361005China Analysis&Testing Center South China Normal UniversityGuangzhou510631China Academy of Shenzhen Guohua Optoelectronics Shenzhen518110China

InGaN nanowires (NWs) are grown on pyramid textured Si substrates by stationary plasma-assisted molecular beam epitaxy (PA-MBE). The incidence angles of the highly directional source beams vary for different pyramid facets, inducing a distinct inter-facet modulation of the In content of the InGaN NWs, which is verified by spatial element distribution analysis. The resulting multi-wavelength emission is confirmed by photoluminescence (PL) and cathodoluminescence (CL). Pure GaN phase formation dominates on certain facets, which is attributed to extreme local growth conditions, such as low active N flux. On the same facets, InGaN NWs exhibit a morphology change close to the pyramid ridge, indicating inter-facet atom migration. This cross-talk effect due to inter-facet atom migration is verified by a decrease of the inter-facet In content modulation amplitude with shrinking pyramid size. A detailed analysis of the In content variation across individual pyramid facets and element distribution line profiles reveals that the cross-talk effect originates mainly from the inter-facet atom migration over the convex pyramid ridge facet boundaries rather than the concave base line facet boundaries. This is understood by first-principles calculations showing that the pyramid baseline facet boundary acts as an energy barrier for atom migration, which is much higher than that of the ridge facet boundary. The influence of the growth temperature on the inter-facet In content modulation is also presented. This work gives deep insight into the composition modulation for the realization of multi-color light-emitting devices based on the monolithic growth of InGaN NWs on pyramid textured Si substrates.

关键词： pyramid textured Si substrate composition modulation III-nitride nanowire molecular beam epitaxy stationary growth cross talk

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Establishment of a new molecular model for mercury determination verified by single crystal X-ray diffraction,spectroscopic analysis and biological potentials

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Chinese Chemical Letters 2021年第1期32卷 87-91页

作者： Jiapei Gu Feifan Zhang Ziman Zheng Xiangqian Li Runxuan Deng Zhan Zhou Lufang Ma Wanqiang Liu Qianming Wang College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Guangdong Provincial Key Laboratory of Optical information Materials and technology&Institute of Electric Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China

A wide variety of molecular probes have been developed for real-time analysis,but most of organic fluorophores possess small Stokes shifts and self-absorption or inner filter effect that could not be *** this study,a new dicyanoisophorone-based derivative(E)-0-(4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl)diphenylphosphinothioate(λ_(ex)=405 nm,X_(em)=551 nm,denoted as ICM-S) with strong push-pull electron effect has been afforded and it exhibits red shift for absorption from 407 nm to 426 nm with distinct color change from pale yellow to deep yellow upon exposure to Hg~(2+).Moreover,an easily distinguishable fluorescence color change follows the route from green,yellow to red in the presence of Hg~(2+) over the range of 0-90 μmol/L(detection limit=137 nmol/L)can be observed by the naked eye under a UV lamp *** and sublimedsulfur are incorpo rated as re s ponsive sites and P-O bond has been cleaved upon the addition of mercu ry *** the recognition process,such dicyanoisophorone dye(ICM-S) has been evolved to 2-(3-(4-hydroxystyryl)-5,5-dimethylcyclohex-2-enylidene) malononitrile(ICM-OH).Clear evidences in the chemical processes can be identified via single crystal X-ray diffraction,spectroscopic analysis,photophysical studies and titration *** the aim of exploring its potential in biological systems,its in vitro responses to Hg~(2+) have been evaluated in 293 T cells and the effectiveness in zebrafish model has also been verified.

关键词： Dicyanoisophorone Ratiometric fluorescent probe Mercury ions Cell imaging Zebrafish

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Efficacy of Phacovitrectomy Combined with Internal Limiting Membrane Peeling for Macular Diseases

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Eye science 2012年第1期27卷 25-29页

作者： Zheming Wu Jinglin Zhang Yun Chen Rulong Gao Zhende Lin Aier Eye Hospital Group Co. Ltd. Guangzhou Aier Eye Hospital Guangzhou 510080 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose:To observe the efficacy of vitrectomy with internal limiting membrane.(ILM) peeling combined with phacoemulsification with intraocular lens.(IOL) implantation in the treatment of cataract with co-existing macular ***:A total of 28 cataract patients (28 eyes) with coexisting macular diseases were admitted to Aier Eye Hospital between May 2008 and May *** clinical characteristics were analyzed in this *** included 6 men and 22 women,aged from 56 to 77 years (mean 64 years),with duration of disease ranging from 2 to 36 months (mean 9.3 months).All patients underwent phacoemulsification with implantation of a hydrophobic acrylic IOL into the capsular bag and pars plana vitrectomy with ILM ***:Postoperatively,patients underwent 3-to 18-months of follow-up.(mean 7.2 months).Only one eye had macular hole failing to *** macular structure was restored in the other 27 *** presenting visual acuity and best corrected visual acuity.(BCVA) did not differ significantly (t =-1.724,P =0.096),with the BCVA in 27 eyes.(96.4%).improving by 2 lines or *** improvement in minimum angle of resolution.(MAR).was > 0.3 in 21 eyes,≥0.1 in 6 eyes and<0.1 in 1 *** mean spherical equivalent.(SE) was-4.67±5.98D preoperatively and-0.38±0.69D postoperatively (t=4.157,P<0.005).Conclusion:Combined phacovitrectomy surgery is a reliable and safe procedure in the treatment of cataract complicated by macular disease.

关键词：黄斑病变疗效剥离膜水性丙烯酸白内障人工林

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Transitions between epithelial and mesenchymal states during cell fate conversions

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Protein & Cell 2014年第8期5卷 580-591页

作者： Xiang Li Duanqing Pei Hui Zheng CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China

Cell fate conversion is considered as the changing of one type of cells to another type including somatic cell reprogramming （de-differentiation）, differentiation, and trans-differentiation, Epithelial and mesenchymal cells are two major types of cells and the transitions between these two cell states as epithelial-mesenchymal transi- tion （EMT） and mesenchymal-epithelial transition （MET） have been observed during multiple cell fate conversions including embryonic development, tumor progression and somatic cell reprogramming. In addition, MET and sequential EMT-MET during the generation of induced pluripotent stem cells （iPSC） from fibroblasts have been reported recently. Such observation is consistent with multiple rounds of sequential EMT-MET during embryonic development which could be considered as a reversed process of reprogramming at least partially. Therefore in current review, we briefly discussed the potential roles played by EMT, MET, or even sequential EMT-MET during different kinds of cell fate conversions. We also provided some preliminary hypotheses on the mechanisms that connect cell state transitions and cell fate conversions based on results collected from cell cycle, epigenetic regulation, and sternness acquisition.

关键词： EMT MET cell states cell fateconversion iPSC generation trans-differentiation,differentiation

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Aerosol scattering coefficients and major chemical compositions of fine particles observed at a rural site in the central Pearl River Delta,South China

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Journal of Environmental sciences 2012年第1期24卷 72-77页

作者： Xinming Wang Xiang Ding Xiaoxin Fu Quanfu He Shaoyi Wang Francois Bernard Xiuying Zhao Dui Wu State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of Sciences Guangzhou 510640China Graduate University of Chinese Academy of sciences Beijing 100049China guangzhou Environmental Monitoring Center Guangzhou 510030China Institute of Tropical and Marine Meteorology China Meteorological AgencyGuangzhou 510080China

During November–December 2010 aerosol scattering coefficients were monitored using a single-waved （525 nm） Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle （PM 2.5） samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon （OC）,elemental carbon （EC）,sulfate,nitrate and *** average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% （OC）,19% （SO 4 2 -）,12% （NO 3 -）,8.4% （NH 4＋） and 3.7% （EC）,to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass *** extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively.

关键词： scattering coefficients visibility fine particle (PM 2.5) chemical compositions

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Photo-responsive functional materials based on light-driven molecular motors

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Light(science & Applications) 2024年第3期13卷 407-420页

作者： Yanping Deng Guiying Long Yang Zhang Wei Zhao Guofu Zhou Ben L.Feringa Jiawen Chen SCNU-UG International Joint Laboratory of Molecular science and Displays National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Stratingh Institute for Chemistry University of GroningenNijenborgh 49747AG GroningenThe Netherlands

In the past two decades,the research and development of light-triggered molecular machines have mainly focused on developing molecular devices at the nanoscale.A key scientific issue in the field is how to amplify the controlled motion of molecules at the nanoscale along multiple length scales,such as the mesoscopic or the macroscopic scale,or in a more practical perspective,how to convert molecular motion into changes of properties of a macroscopic ***-driven molecular motors are able to perform repetitive unidirectional rotation upon irradiation,which offers unique opportunities for responsive macroscopic *** several reviews that focus on the design,synthesis and operation of the motors at the nanoscale,photo-responsive macroscopic materials based on light-driven molecular motors have not been comprehensively *** the present review,we first discuss the strategy of confining absolute molecular rotation into relative rotation by grafting motors on ***,examples of self-assemble motors in supramolecular polymers with high internal order are ***,we will focus on building of motors in a covalently linked system such as polymeric gels and polymeric liquid crystals to generate complex responsive ***,a perspective toward future developments and opportunities is *** review helps us getting a more and more clear picture and understanding on how complex movement can be programmed in light-responsive systems and how man-made adaptive materials can be invented,which can serve as an important guideline for further design of complex and advanced responsive materials.

关键词： functions materials material

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Physical property improvement of fluid shortening using peanut oil-based diacylglycerols and their applications in sponge cake

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Grain & Oil science and technology 2024年第3期7卷 150-158页

作者： Yilin Du Shuo Zou Yee-Ying Lee Yong Wang Zhen Zhang JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety Department of Food Science and EngineeringJinan UniversityGuangzhouGuangdong 510632China School of science Monash University MalaysiaBandar Sunway 47500SelangorMalaysia

Fluid shortening is an important ingredient in the production of sponge cake. Peanut oil with 0, 43% and 85% of diacylglycerol content was used as the base oil. Different emulsifiers, such as glycerol monostearate, soy lecithin and sucrose ester, and their respective amounts, were investigated. It was found that the addition of emulsifiers had a positive effect on water-absorbing capacity, air-absorbing capacity and viscosity of the oils. Glycerol monostearate was the preferred emulsifier for fluid shortening with a recommended addition of 1.5%. The effects of different diacylglycerol content on fluid shortening and their impact on sponge cake production was also investigated. The onset oxidation temperature of the oil could be increased from 253.21 ℃ for PO-TAG-based fluid shortening to 263.70 ℃ for PO-DAG85-based fluid shortening. And the increase in diacylglycerol content leading to a lower specific gravity of the batter, which was 1.06 g/mL, 1.02 g/mL and 0.98 g/mL prepared by PO-DAG, PO-DAG43 and PO-DAG85 shortening, respectively. The results showed that diacylglycerols can be used as base oils in fluid shortening to improve the crystal network and stability of fluid shortenings, thereby reducing the specific gravity of the batter and improving the structural properties of the cake. This will extend the potential applications of diacylglycerols and increase the variety of base oils available for fluid shortening preparation.

关键词： Fluid shortening Diacylglycerol Emulsifier Sponge cake

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Germplasm Diversity of Chinese Kale in China

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Horticultural Plant Journal 2017年第3期3卷 101-104页

作者： LEI Jianjun CHEN Guoju CHEN Changming CAO Bihao Key Laboratory of Biology Innovation and Utilization for Germplasm Resources in Horticultural Crops in Southern China College of HorticultureSouth China Agricultural University

Chinese kale is an important vegetable crop in China, especially in South China where the majority of varieties are grown. It originated in South China and spread throughout Southeast Asia thereafter. Chinese kale can be classified into two types according to whether the petals are white or yellow. There are also three main cultivated types based on the edible organs, including the stalk and leaf type, the stalk type,and the leaf type. Two primary types have also been defined based on stalk color, including green stalks and red stalks. They are also cultivated based on the type of stalk, including main stalk and lateral stalk types. Significant differences have also been observed in glucosinolate content among the varieties, and a 40-fold difference in neoindle-3-methyl glucosinolate was detected across the cultivars.

关键词： Chinese kale Brassica alboglabra Bailey diversity

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Fast UV-vis-NIR photoresponse of self-oriented F_(16)CuPc nanoribbons

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Nano Research 2023年第7期16卷 9561-9568页

作者： Lingyu Zhang Xingyu Wang Wei Zhou Hao Wang Jiaxun Song Zihao Zhao Jihui Liao Jian Song Yajun Li Jinyou Xu Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Department of Materials and Interfaces Weizmann Institute of ScienceRehovot 76100Israel

Controlling the vapor-deposited nanoribbons to grow along a consistent orientation will enable the desired in situ integration of functional devices,representing a major technological advance compared to post-growth processing *** this work,ntype F_(16)CuPc molecules are self-assembled into horizontally-oriented nanoribbons with a consistent growth axis after creating periodic hydrophobic nanogrooves on a sapphire ***,electrodes are deposited directly on the growth substrate to enable in situ fabrication of *** on the deposited electrodes,these horizontally-oriented nanoribbons are connected to form a monolithic photodetector with a large sensing area or an on-chip array of photodetectors with multiple detector *** in situ integration strategy avoids potential structural damage and contamination from impurities associated with post-growth processing ***,the vapor-deposited nanoribbons can retain their high quality during the device manufacturing process,which contributes to performance *** a result,the in-situ integrated F_(16)CuPc photodetectors exhibit a sensitive response in the ultraviolet-visible-near-infrared(UV-vis-NIR)*** response time is on the order of tens of milliseconds,the fastest record ever for the F_(16)CuPc-based ***,statistics from an array of 6×6 photodetectors show little variation in their sensitivity and response time,and hence this in situ fabrication scheme will contribute to the implementation of on-chip integrated photodetectors with consistent performance based on bottom-up ***,this self-oriented growth provides a versatile option to achieve desired in-situ integrated functional devices based on bottom-up nanoribbons.

关键词： fluorinated copper phthalocyanine nanoribbon planar array photodetector in situ integration

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